Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for VAX1_GSX2
Z-value: 0.36
Motif logo
Transcription factors associated with VAX1_GSX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
VAX1
|
ENSG00000148704.13 | VAX1 |
|
GSX2
|
ENSG00000180613.11 | GSX2 |
Activity profile of VAX1_GSX2 motif
Sorted Z-values of VAX1_GSX2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of VAX1_GSX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 9.7 | GO:2000866 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 2.6 | 10.4 | GO:0010645 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 2.2 | 6.6 | GO:2000097 | chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 1.9 | 19.5 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 1.5 | 4.6 | GO:0031550 | positive regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031550) |
| 1.5 | 4.4 | GO:0034183 | negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 1.3 | 10.8 | GO:0060087 | relaxation of vascular smooth muscle(GO:0060087) |
| 1.1 | 3.4 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 1.1 | 3.2 | GO:1902955 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 1.0 | 3.9 | GO:0036135 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) |
| 0.9 | 7.1 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 0.8 | 2.4 | GO:0034769 | basement membrane disassembly(GO:0034769) |
| 0.8 | 3.1 | GO:1904823 | pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823) |
| 0.7 | 2.2 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.7 | 13.9 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.6 | 1.9 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.6 | 2.3 | GO:0036058 | filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) |
| 0.5 | 1.6 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 0.5 | 1.5 | GO:0010166 | wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) |
| 0.5 | 3.6 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.5 | 3.9 | GO:0071847 | TNFSF11-mediated signaling pathway(GO:0071847) |
| 0.5 | 1.4 | GO:1901355 | response to rapamycin(GO:1901355) |
| 0.4 | 1.3 | GO:0036466 | synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149) |
| 0.4 | 3.0 | GO:0051552 | flavone metabolic process(GO:0051552) |
| 0.4 | 1.6 | GO:0009753 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.4 | 2.7 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.4 | 2.2 | GO:0009438 | methylglyoxal metabolic process(GO:0009438) |
| 0.3 | 1.0 | GO:1903774 | mitotic cytokinesis checkpoint(GO:0044878) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.3 | 3.4 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.3 | 4.8 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.3 | 4.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.3 | 3.2 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.2 | 1.4 | GO:0061743 | motor learning(GO:0061743) |
| 0.2 | 1.6 | GO:0045653 | histone H4-R3 methylation(GO:0043985) negative regulation of megakaryocyte differentiation(GO:0045653) positive regulation of hemoglobin biosynthetic process(GO:0046985) |
| 0.2 | 5.3 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.2 | 5.2 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.2 | 10.0 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.2 | 1.4 | GO:0008215 | spermine metabolic process(GO:0008215) |
| 0.2 | 2.8 | GO:1904869 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 0.2 | 0.7 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.2 | 2.5 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) |
| 0.1 | 1.2 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.1 | 3.7 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.1 | 2.2 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.1 | 0.7 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.1 | 2.4 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.1 | 1.0 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.1 | 0.3 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.1 | 0.9 | GO:0006203 | dGTP catabolic process(GO:0006203) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) |
| 0.1 | 0.8 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.1 | 0.7 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.1 | 0.3 | GO:0002668 | negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017) |
| 0.1 | 2.2 | GO:0042789 | mRNA transcription from RNA polymerase II promoter(GO:0042789) |
| 0.1 | 0.4 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 5.7 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 0.9 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.1 | 1.0 | GO:0039702 | viral budding via host ESCRT complex(GO:0039702) |
| 0.1 | 3.1 | GO:0051642 | centrosome localization(GO:0051642) |
| 0.1 | 1.6 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 0.7 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.1 | 1.7 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 2.5 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 0.6 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.0 | 3.5 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 7.9 | GO:0002062 | chondrocyte differentiation(GO:0002062) |
| 0.0 | 0.1 | GO:0051228 | mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230) |
| 0.0 | 0.8 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 0.8 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.0 | 2.1 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.0 | 2.8 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.0 | 1.3 | GO:0006458 | 'de novo' protein folding(GO:0006458) |
| 0.0 | 0.4 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.0 | 0.8 | GO:1901998 | toxin transport(GO:1901998) |
| 0.0 | 1.7 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 35.8 | GO:0007417 | central nervous system development(GO:0007417) |
| 0.0 | 1.1 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.2 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.0 | 0.4 | GO:0035588 | G-protein coupled purinergic receptor signaling pathway(GO:0035588) |
| 0.0 | 0.1 | GO:1990168 | protein K33-linked deubiquitination(GO:1990168) |
| 0.0 | 0.4 | GO:0006105 | succinate metabolic process(GO:0006105) |
| 0.0 | 0.1 | GO:0050955 | thermoception(GO:0050955) |
| 0.0 | 0.3 | GO:0042407 | cristae formation(GO:0042407) |
| 0.0 | 0.9 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 7.0 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 1.1 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 0.8 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 1.7 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.0 | 0.1 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 0.0 | 0.8 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.5 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.0 | 0.4 | GO:0002763 | positive regulation of myeloid leukocyte differentiation(GO:0002763) |
| 0.0 | 1.0 | GO:0006446 | regulation of translational initiation(GO:0006446) |
| 0.0 | 0.4 | GO:0007566 | embryo implantation(GO:0007566) |
| 0.0 | 0.8 | GO:0001892 | embryonic placenta development(GO:0001892) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.4 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.6 | 10.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.5 | 7.1 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.3 | 2.4 | GO:0036021 | endolysosome lumen(GO:0036021) |
| 0.3 | 3.6 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 2.8 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.2 | 1.4 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.2 | 3.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.2 | 3.9 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 38.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 3.2 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 7.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 1.9 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 13.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 1.7 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.1 | 1.0 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 10.8 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 1.6 | GO:0034709 | methylosome(GO:0034709) |
| 0.1 | 3.4 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 0.4 | GO:0045257 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.1 | 2.1 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.7 | GO:0032541 | cortical endoplasmic reticulum(GO:0032541) |
| 0.1 | 1.1 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 2.7 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 1.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 11.6 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 0.7 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 0.3 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.1 | 0.7 | GO:0071664 | beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664) |
| 0.1 | 1.5 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 5.0 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 10.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 4.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 9.0 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) |
| 0.0 | 19.7 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 0.4 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 2.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 18.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.0 | 3.0 | GO:0030666 | endocytic vesicle membrane(GO:0030666) |
| 0.0 | 0.4 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 0.6 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.0 | 0.2 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 4.8 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 0.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.5 | GO:0032040 | small-subunit processome(GO:0032040) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 13.9 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 1.7 | 10.4 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 1.5 | 4.4 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 1.4 | 19.5 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 1.2 | 4.6 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 1.0 | 3.1 | GO:0015265 | urea channel activity(GO:0015265) |
| 0.5 | 1.6 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
| 0.5 | 1.5 | GO:0080019 | fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019) |
| 0.4 | 1.6 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.4 | 2.0 | GO:0051998 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 0.4 | 10.0 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.4 | 10.8 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.4 | 1.4 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.3 | 4.3 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.3 | 1.0 | GO:0052796 | exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796) |
| 0.3 | 8.3 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.3 | 0.9 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.3 | 24.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 1.6 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 0.2 | 3.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.2 | 0.7 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.2 | 1.3 | GO:0000285 | 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285) |
| 0.2 | 4.8 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.2 | 3.2 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.2 | 5.2 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.2 | 1.7 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.2 | 7.1 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.2 | 2.2 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.2 | 3.7 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.2 | 38.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 1.6 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.1 | 3.4 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.1 | 4.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 3.9 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 4.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 1.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 2.5 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.1 | 0.7 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.1 | 0.4 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538) |
| 0.1 | 0.8 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 2.8 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 3.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 2.2 | GO:0071949 | FAD binding(GO:0071949) |
| 0.1 | 1.4 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 0.4 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.1 | 2.3 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 1.3 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 3.0 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 1.9 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 2.1 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.1 | 6.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 0.3 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 0.1 | 2.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 3.6 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 2.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 0.5 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.0 | 0.5 | GO:0005549 | odorant binding(GO:0005549) |
| 0.0 | 2.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 1.8 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.8 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 2.2 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.7 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.0 | 0.9 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.8 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.4 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.0 | 0.7 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.4 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 7.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 6.3 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.1 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 0.0 | 0.4 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 1.4 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.0 | 0.4 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 0.5 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.8 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 3.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.2 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.3 | 17.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 16.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 6.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 2.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 4.3 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 3.6 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 2.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 5.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 2.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.4 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 1.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 2.2 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.0 | 4.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 0.4 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.0 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 0.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 10.4 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 4.1 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.3 | 12.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 3.1 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 2.4 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 18.2 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 3.9 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 4.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 12.1 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 6.6 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 2.5 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.1 | 4.1 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.1 | 1.7 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 7.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 1.4 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 2.8 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 1.0 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.1 | 2.6 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 0.8 | REACTOME GAB1 SIGNALOSOME | Genes involved in GAB1 signalosome |
| 0.1 | 2.7 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 0.7 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 10.6 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.1 | 1.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 1.1 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.1 | 3.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.0 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 1.5 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 1.9 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 1.7 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 6.8 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.0 | 0.8 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.8 | REACTOME CELL CELL JUNCTION ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.0 | 2.6 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 1.0 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.2 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 0.3 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.0 | 1.3 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |
| 0.0 | 0.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.8 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.4 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.6 | REACTOME REGULATION OF APOPTOSIS | Genes involved in Regulation of Apoptosis |