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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for VAX2_RHOXF2

Z-value: 4.79

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Transcription factors associated with VAX2_RHOXF2

Gene Symbol Gene ID Gene Info
VAX2
ENSG00000116035.4 VAX2
RHOXF2
ENSG00000131721.6 RHOXF2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
VAX2hg38_v1_chr2_+_70900546_709006170.491.3e-14Click!

Activity profile of VAX2_RHOXF2 motif

Sorted Z-values of VAX2_RHOXF2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of VAX2_RHOXF2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_56579555 16.71 ENST00000371250.4
PLPP3
phospholipid phosphatase 3
chr16_-_55833085 12.07 ENST00000360526.8
CES1
carboxylesterase 1
chr1_-_92486916 12.00 ENST00000294702.6
GFI1
growth factor independent 1 transcriptional repressor
chr19_+_49513353 10.89 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr5_+_67004618 10.14 ENST00000261569.11
ENST00000436277.5
MAST4
microtubule associated serine/threonine kinase family member 4
chr16_-_55833186 9.79 ENST00000361503.8
ENST00000422046.6
CES1
carboxylesterase 1
chr11_-_117876719 8.39 ENST00000529335.6
ENST00000260282.8
FXYD6
FXYD domain containing ion transport regulator 6
chr11_-_117876892 8.23 ENST00000539526.5
FXYD6
FXYD domain containing ion transport regulator 6
chr6_+_26402237 8.02 ENST00000476549.6
ENST00000450085.6
ENST00000425234.6
ENST00000427334.5
ENST00000506698.1
ENST00000289361.11
BTN3A1
butyrophilin subfamily 3 member A1
chr6_+_26402289 7.75 ENST00000414912.2
BTN3A1
butyrophilin subfamily 3 member A1
chr11_-_117877463 7.74 ENST00000527717.5
FXYD6
FXYD domain containing ion transport regulator 6
chr12_-_6124662 7.35 ENST00000261405.10
VWF
von Willebrand factor
chr16_+_72054477 7.33 ENST00000355906.10
ENST00000570083.5
ENST00000228226.12
ENST00000398131.6
ENST00000569639.5
ENST00000564499.5
ENST00000357763.8
ENST00000613898.1
ENST00000562526.5
ENST00000565574.5
ENST00000568417.6
HP
haptoglobin
chr6_+_26440472 6.75 ENST00000494393.5
ENST00000482451.5
ENST00000471353.5
ENST00000361232.7
ENST00000487627.5
ENST00000496719.1
ENST00000244519.7
ENST00000490254.5
ENST00000487272.1
BTN3A3
butyrophilin subfamily 3 member A3
chr4_-_185775271 6.71 ENST00000430503.5
ENST00000319454.10
ENST00000450341.5
SORBS2
sorbin and SH3 domain containing 2
chr11_-_111923722 6.56 ENST00000527950.5
CRYAB
crystallin alpha B
chr2_+_90038848 6.18 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr12_+_26195313 6.03 ENST00000422622.3
SSPN
sarcospan
chr2_+_90209873 5.35 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr1_+_159204860 5.22 ENST00000368122.4
ENST00000368121.6
ACKR1
atypical chemokine receptor 1 (Duffy blood group)
chr12_-_9869345 4.70 ENST00000228438.3
CLEC2B
C-type lectin domain family 2 member B
chr8_-_33567118 4.30 ENST00000256257.2
RNF122
ring finger protein 122
chr10_-_97445850 4.25 ENST00000477692.6
ENST00000485122.6
ENST00000370886.9
ENST00000370885.8
ENST00000370902.8
ENST00000370884.5
EXOSC1
exosome component 1
chr6_+_26365176 4.20 ENST00000377708.7
BTN3A2
butyrophilin subfamily 3 member A2
chr14_+_61187544 4.05 ENST00000555185.5
ENST00000557294.5
ENST00000556778.5
PRKCH
protein kinase C eta
chr6_+_26365159 4.03 ENST00000532865.5
ENST00000396934.7
ENST00000508906.6
ENST00000530653.5
ENST00000527417.5
BTN3A2
butyrophilin subfamily 3 member A2
chr20_+_57561103 4.00 ENST00000319441.6
PCK1
phosphoenolpyruvate carboxykinase 1
chr9_+_122371036 3.86 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr6_+_26365215 3.82 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
BTN3A2
butyrophilin subfamily 3 member A2
chrX_+_10158448 3.67 ENST00000380829.5
ENST00000421085.7
ENST00000674669.1
ENST00000454850.1
CLCN4
chloride voltage-gated channel 4
chr12_+_26195543 3.63 ENST00000242729.7
SSPN
sarcospan
chrX_+_43656289 3.58 ENST00000338702.4
MAOA
monoamine oxidase A
chr14_-_52791597 3.35 ENST00000216410.8
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr16_+_72063226 3.31 ENST00000540303.7
ENST00000356967.6
ENST00000561690.1
HPR
haptoglobin-related protein
chr1_+_34792990 3.18 ENST00000450137.1
ENST00000342280.5
GJA4
gap junction protein alpha 4
chr18_+_34976928 3.08 ENST00000591734.5
ENST00000413393.5
ENST00000589180.5
ENST00000587359.5
MAPRE2
microtubule associated protein RP/EB family member 2
chr11_+_72189528 2.94 ENST00000312293.9
FOLR1
folate receptor alpha
chr8_-_39838201 2.91 ENST00000347580.8
ENST00000379853.6
ENST00000265708.9
ENST00000521880.5
ADAM2
ADAM metallopeptidase domain 2
chr2_+_89884740 2.84 ENST00000509129.1
IGKV1D-37
immunoglobulin kappa variable 1D-37 (non-functional)
chr7_+_50308672 2.83 ENST00000439701.2
ENST00000438033.5
ENST00000492782.6
IKZF1
IKAROS family zinc finger 1
chr2_-_88947820 2.73 ENST00000496168.1
IGKV1-5
immunoglobulin kappa variable 1-5
chr2_+_113005454 2.66 ENST00000259211.7
IL36A
interleukin 36 alpha
chr11_+_72189659 2.64 ENST00000393681.6
FOLR1
folate receptor alpha
chr12_+_119668109 2.59 ENST00000229328.10
ENST00000630317.1
PRKAB1
protein kinase AMP-activated non-catalytic subunit beta 1
chr8_-_39838250 2.56 ENST00000622267.1
ADAM2
ADAM metallopeptidase domain 2
chr15_+_58410543 2.53 ENST00000356113.10
ENST00000414170.7
LIPC
lipase C, hepatic type
chr4_+_87650277 2.36 ENST00000339673.11
ENST00000282479.8
DMP1
dentin matrix acidic phosphoprotein 1
chr2_+_90220727 2.11 ENST00000471857.2
IGKV1D-8
immunoglobulin kappa variable 1D-8
chr12_-_118359105 2.09 ENST00000541186.5
ENST00000539872.5
TAOK3
TAO kinase 3
chr4_+_87832917 2.07 ENST00000395102.8
ENST00000497649.6
ENST00000540395.1
ENST00000560249.5
ENST00000511670.5
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr2_+_169069537 2.02 ENST00000428522.5
ENST00000450153.1
ENST00000674881.1
ENST00000421653.5
DHRS9
dehydrogenase/reductase 9
chr5_-_20575850 2.00 ENST00000507958.5
CDH18
cadherin 18
chr9_-_5339874 1.96 ENST00000223862.2
RLN1
relaxin 1
chr7_+_70596078 1.95 ENST00000644506.1
AUTS2
activator of transcription and developmental regulator AUTS2
chrX_-_155071064 1.90 ENST00000369484.8
ENST00000369476.8
CMC4
MTCP1
C-X9-C motif containing 4
mature T cell proliferation 1
chr5_+_129748091 1.86 ENST00000564719.2
MINAR2
membrane integral NOTCH2 associated receptor 2
chrX_+_136648214 1.79 ENST00000370628.2
CD40LG
CD40 ligand
chr12_-_109021015 1.78 ENST00000546618.2
ENST00000610966.5
SVOP
SV2 related protein
chr2_-_89297785 1.78 ENST00000465170.1
IGKV1-37
immunoglobulin kappa variable 1-37 (non-functional)
chr10_-_17129786 1.71 ENST00000377833.10
CUBN
cubilin
chr11_+_24496988 1.66 ENST00000336930.11
LUZP2
leucine zipper protein 2
chr17_+_42458844 1.63 ENST00000393829.6
ENST00000537728.5
ENST00000343619.9
ENST00000264649.10
ENST00000585525.5
ENST00000544137.5
ENST00000589727.5
ENST00000587824.5
ATP6V0A1
ATPase H+ transporting V0 subunit a1
chr9_-_5304713 1.62 ENST00000381627.4
RLN2
relaxin 2
chr12_+_26195647 1.61 ENST00000535504.1
SSPN
sarcospan
chr9_-_92404559 1.58 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr17_-_42185452 1.57 ENST00000293330.1
HCRT
hypocretin neuropeptide precursor
chr20_+_45416551 1.57 ENST00000639292.1
PIGT
phosphatidylinositol glycan anchor biosynthesis class T
chr1_+_174700413 1.53 ENST00000529145.6
ENST00000325589.9
RABGAP1L
RAB GTPase activating protein 1 like
chr1_-_211134135 1.52 ENST00000638983.1
ENST00000271751.10
ENST00000639952.1
ENSG00000284299.1
KCNH1
novel protein
potassium voltage-gated channel subfamily H member 1
chr11_-_62754141 1.51 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
ZBTB3
zinc finger and BTB domain containing 3
chrX_+_136648138 1.49 ENST00000370629.7
CD40LG
CD40 ligand
chr4_-_145180496 1.44 ENST00000447906.8
OTUD4
OTU deubiquitinase 4
chr4_+_94974984 1.42 ENST00000672698.1
BMPR1B
bone morphogenetic protein receptor type 1B
chr9_+_122370523 1.41 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr2_+_102473219 1.39 ENST00000295269.5
SLC9A4
solute carrier family 9 member A4
chr17_-_10469558 1.28 ENST00000255381.2
MYH4
myosin heavy chain 4
chr14_+_32329256 1.25 ENST00000280979.9
AKAP6
A-kinase anchoring protein 6
chr10_+_18260715 1.21 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr9_+_122371014 1.20 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr18_-_69956924 1.20 ENST00000581982.5
ENST00000280200.8
CD226
CD226 molecule
chr14_+_71933116 1.17 ENST00000553530.5
ENST00000556437.5
RGS6
regulator of G protein signaling 6
chr3_+_178419123 1.08 ENST00000614557.1
ENST00000455307.5
ENST00000436432.1
ENSG00000275163.1
LINC01014
potassium large conductance calcium-activated channel, subfamily M, beta member 2 (KCNMB2-IT1 - KCNMB2 readthrough transcript)
long intergenic non-protein coding RNA 1014
chr15_-_89211803 1.06 ENST00000563254.1
RLBP1
retinaldehyde binding protein 1
chr7_-_44541262 1.02 ENST00000289547.8
ENST00000546276.5
ENST00000423141.1
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chr7_-_44541318 1.01 ENST00000381160.8
NPC1L1
NPC1 like intracellular cholesterol transporter 1
chrX_-_18672101 0.96 ENST00000379984.4
RS1
retinoschisin 1
chr21_-_36542600 0.94 ENST00000399136.5
CLDN14
claudin 14
chr14_+_32329341 0.93 ENST00000557354.5
ENST00000557102.1
ENST00000557272.1
AKAP6
A-kinase anchoring protein 6
chr11_+_33039996 0.88 ENST00000432887.5
ENST00000528898.1
ENST00000531632.6
TCP11L1
t-complex 11 like 1
chr14_+_103385374 0.87 ENST00000678179.1
ENST00000676938.1
ENST00000678619.1
ENST00000440884.7
ENST00000560417.6
ENST00000679330.1
ENST00000556744.2
ENST00000676897.1
ENST00000677560.1
ENST00000561314.6
ENST00000677829.1
ENST00000677133.1
ENST00000676645.1
ENST00000678175.1
ENST00000429436.7
ENST00000677360.1
ENST00000678237.1
ENST00000677347.1
ENST00000677432.1
MARK3
microtubule affinity regulating kinase 3
chr16_-_28597042 0.85 ENST00000533150.5
ENST00000335715.9
SULT1A2
sulfotransferase family 1A member 2
chr19_+_24033399 0.83 ENST00000664647.1
ENST00000656993.1
ENST00000666101.1
ENST00000613065.4
ENSG00000268362.6
ZNF254
novel transcript
zinc finger protein 254
chr12_-_21910853 0.70 ENST00000544039.5
ABCC9
ATP binding cassette subfamily C member 9
chr12_+_80716906 0.69 ENST00000228644.4
MYF5
myogenic factor 5
chr11_-_18046262 0.68 ENST00000682019.1
TPH1
tryptophan hydroxylase 1
chr14_+_103385450 0.63 ENST00000416682.6
MARK3
microtubule affinity regulating kinase 3
chr11_-_35419213 0.59 ENST00000642171.1
ENST00000644050.1
ENST00000643134.1
SLC1A2
solute carrier family 1 member 2
chr19_-_14979848 0.47 ENST00000594383.2
SLC1A6
solute carrier family 1 member 6
chr4_+_150582119 0.42 ENST00000317605.6
MAB21L2
mab-21 like 2
chr4_-_73620629 0.40 ENST00000342081.7
RASSF6
Ras association domain family member 6
chr1_-_152414256 0.39 ENST00000271835.3
CRNN
cornulin
chr1_-_113871665 0.33 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
PTPN22
protein tyrosine phosphatase non-receptor type 22
chr7_-_44082464 0.31 ENST00000335195.10
ENST00000395831.7
ENST00000414235.5
ENST00000242248.10
ENST00000452049.1
POLM
DNA polymerase mu
chr13_-_35476682 0.31 ENST00000379919.6
MAB21L1
mab-21 like 1
chr20_-_52105644 0.30 ENST00000371523.8
ZFP64
ZFP64 zinc finger protein
chr9_-_21228222 0.29 ENST00000413767.2
IFNA17
interferon alpha 17
chr6_-_132714045 0.29 ENST00000367928.5
VNN1
vanin 1
chr12_-_10807286 0.28 ENST00000240615.3
TAS2R8
taste 2 receptor member 8
chr7_+_73830988 0.28 ENST00000340958.4
CLDN4
claudin 4
chr19_+_15728024 0.25 ENST00000305899.5
OR10H2
olfactory receptor family 10 subfamily H member 2
chr8_-_42768602 0.22 ENST00000534622.5
CHRNA6
cholinergic receptor nicotinic alpha 6 subunit
chrX_+_30235894 0.21 ENST00000620842.1
MAGEB3
MAGE family member B3
chr15_+_58138368 0.18 ENST00000219919.9
ENST00000536493.1
AQP9
aquaporin 9
chr5_+_141177790 0.15 ENST00000239444.4
ENST00000623995.1
PCDHB8
ENSG00000279472.1
protocadherin beta 8
novel transcript
chr5_-_150449676 0.05 ENST00000312037.6
RPS14
ribosomal protein S14
chr11_-_35419098 0.03 ENST00000606205.6
ENST00000645303.1
SLC1A2
solute carrier family 1 member 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 12.0 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
3.6 10.9 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
2.4 7.3 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
2.0 21.9 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
1.9 5.6 GO:0060974 neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713)
1.4 16.7 GO:0008354 germ cell migration(GO:0008354)
1.3 4.0 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.9 28.2 GO:0072643 interferon-gamma secretion(GO:0072643)
0.8 4.0 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.7 3.3 GO:0006041 glucosamine metabolic process(GO:0006041)
0.7 2.0 GO:0098582 innate vocalization behavior(GO:0098582)
0.6 1.2 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.4 6.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 2.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.3 6.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.3 7.4 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.3 5.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.2 21.6 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.2 0.7 GO:0042427 serotonin biosynthetic process(GO:0042427)
0.2 2.0 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 1.6 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 3.6 GO:0042420 dopamine catabolic process(GO:0042420)
0.2 1.4 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) negative regulation of chondrocyte proliferation(GO:1902731)
0.2 1.6 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 6.7 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.2 1.7 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.2 3.3 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.2 2.5 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372) phosphatidylcholine catabolic process(GO:0034638)
0.2 2.4 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.2 1.5 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 1.6 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 2.0 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.1 1.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 1.4 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 19.5 GO:0002377 immunoglobulin production(GO:0002377)
0.1 4.3 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 0.6 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1 1.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 2.1 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 0.5 GO:0089712 L-aspartate transport(GO:0070778) L-aspartate transmembrane transport(GO:0089712)
0.1 1.4 GO:0035878 nail development(GO:0035878)
0.1 1.0 GO:0009642 response to light intensity(GO:0009642)
0.1 5.2 GO:0032642 regulation of chemokine production(GO:0032642)
0.1 3.4 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 3.2 GO:0048265 response to pain(GO:0048265)
0.1 6.8 GO:0002456 T cell mediated immunity(GO:0002456)
0.1 0.5 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.7 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 2.7 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.8 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 1.0 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.6 GO:0098712 L-glutamate import across plasma membrane(GO:0098712)
0.0 1.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 1.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.3 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.7 GO:0010107 potassium ion import(GO:0010107)
0.0 12.6 GO:0006936 muscle contraction(GO:0006936)
0.0 9.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 2.8 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.4 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 1.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 1.6 GO:0030819 positive regulation of cAMP biosynthetic process(GO:0030819)
0.0 4.3 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 2.0 GO:0034332 adherens junction organization(GO:0034332)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.6 7.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 6.6 GO:0097512 cardiac myofibril(GO:0097512)
0.4 1.6 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.3 4.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.3 11.3 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 1.7 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.3 2.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.2 5.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 3.3 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 3.2 GO:0005922 connexon complex(GO:0005922)
0.2 1.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 1.4 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 0.7 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 12.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 2.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 6.5 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 22.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.3 GO:0032982 myosin filament(GO:0032982)
0.0 4.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.6 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 1.8 GO:0031526 brush border membrane(GO:0031526)
0.0 5.2 GO:0055037 recycling endosome(GO:0055037)
0.0 3.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.8 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 53.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 1.6 GO:0008021 synaptic vesicle(GO:0008021)
0.0 4.8 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.6 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.7 GO:0072562 blood microparticle(GO:0072562)
0.0 2.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 40.1 GO:0016021 integral component of membrane(GO:0016021)
0.0 4.0 GO:0005911 cell-cell junction(GO:0005911)
0.0 12.1 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 21.9 GO:0047374 sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374)
2.8 16.7 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
2.7 10.9 GO:0019770 IgG receptor activity(GO:0019770)
1.5 10.6 GO:0030492 hemoglobin binding(GO:0030492)
1.4 5.6 GO:0061714 folic acid receptor activity(GO:0061714)
1.3 4.0 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
1.3 6.5 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
1.1 3.3 GO:0005174 CD40 receptor binding(GO:0005174)
0.7 4.0 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.5 2.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.4 1.6 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.4 3.6 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 1.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.3 5.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.3 21.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 7.4 GO:0019865 immunoglobulin binding(GO:0019865)
0.2 6.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 6.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 2.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 2.0 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 0.7 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.2 3.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 2.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.8 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 1.4 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 1.7 GO:0031419 cobalamin binding(GO:0031419)
0.1 2.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 2.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.7 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 1.0 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 0.5 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 4.3 GO:0004532 exoribonuclease activity(GO:0004532)
0.1 2.0 GO:0031489 myosin V binding(GO:0031489)
0.1 0.3 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 16.4 GO:0003823 antigen binding(GO:0003823)
0.1 0.5 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 1.6 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 12.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.2 GO:0015265 urea channel activity(GO:0015265)
0.1 9.0 GO:0005178 integrin binding(GO:0005178)
0.1 1.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.6 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 1.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 10.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 3.3 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 1.3 GO:0000146 microfilament motor activity(GO:0000146)
0.0 2.7 GO:0005179 hormone activity(GO:0005179)
0.0 1.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.3 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 21.9 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 12.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 6.1 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 4.3 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 4.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 11.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.0 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 2.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.4 PID BMP PATHWAY BMP receptor signaling
0.0 4.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.4 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.4 4.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.3 4.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 3.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 3.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 3.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 2.6 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 4.0 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 6.5 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 1.6 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 2.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 4.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 1.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.6 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 2.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors