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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for VDR

Z-value: 2.88

Motif logo

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Transcription factors associated with VDR

Gene Symbol Gene ID Gene Info
VDR
ENSG00000111424.12 VDR

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
VDRhg38_v1_chr12_-_47905003_479050430.453.3e-12Click!

Activity profile of VDR motif

Sorted Z-values of VDR motif

Network of associatons between targets according to the STRING database.

First level regulatory network of VDR

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_+_94581407 25.87 ENST00000553511.1
ENST00000329597.12
ENST00000554633.5
ENST00000555681.1
ENST00000554276.1
SERPINA5
serpin family A member 5
chr19_-_12484773 18.58 ENST00000397732.8
ZNF709
zinc finger protein 709
chr2_+_110732584 15.50 ENST00000340561.8
ACOXL
acyl-CoA oxidase like
chr11_+_57597563 12.87 ENST00000619430.2
ENST00000457869.1
ENST00000340687.10
ENST00000278407.9
ENST00000378323.8
ENST00000378324.6
ENST00000403558.1
SERPING1
serpin family G member 1
chr11_+_6863057 11.45 ENST00000641461.1
OR10A2
olfactory receptor family 10 subfamily A member 2
chr14_+_94581388 10.90 ENST00000554866.5
ENST00000556775.5
SERPINA5
serpin family A member 5
chr3_+_101849505 10.74 ENST00000326151.9
ENST00000326172.9
NFKBIZ
NFKB inhibitor zeta
chr6_-_32589833 10.30 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr3_-_122564253 9.22 ENST00000492382.5
ENST00000682323.1
ENST00000462315.5
PARP9
poly(ADP-ribose) polymerase family member 9
chr17_-_38068634 8.56 ENST00000622206.2
TBC1D3C
TBC1 domain family member 3C
chr17_-_37989048 8.39 ENST00000617678.2
ENST00000612727.5
TBC1D3L
TBC1 domain family member 3L
chr17_-_36264514 8.32 ENST00000618620.4
ENST00000621034.1
TBC1D3I
TBC1 domain family member 3I
chr19_+_57584131 8.28 ENST00000536878.6
ENST00000597219.1
ENST00000598689.1
ENST00000597850.2
ZIK1
zinc finger protein interacting with K protein 1
chr17_+_38003976 8.26 ENST00000616101.4
TBC1D3D
TBC1 domain family member 3D
chr17_-_38192555 8.21 ENST00000620215.3
TBC1D3
TBC1 domain family member 3
chr17_-_36439566 8.19 ENST00000620210.1
TBC1D3F
TBC1 domain family member 3F
chr17_+_36323884 8.15 ENST00000569055.2
TBC1D3G
TBC1 domain family member 3G
chr7_+_144048948 8.09 ENST00000641693.1
OR2A5
olfactory receptor family 2 subfamily A member 5
chr17_+_37924415 8.08 ENST00000620247.1
TBC1D3K
TBC1 domain family member 3K
chr17_-_76240289 7.72 ENST00000647930.1
ENST00000592271.1
ENST00000319945.10
RNF157
ring finger protein 157
chr3_+_45030130 7.65 ENST00000428034.1
CLEC3B
C-type lectin domain family 3 member B
chr7_-_100428657 7.46 ENST00000360951.8
ENST00000398027.6
ENST00000684423.1
ENST00000472716.1
ZCWPW1
zinc finger CW-type and PWWP domain containing 1
chr1_-_183590439 7.24 ENST00000367535.8
NCF2
neutrophil cytosolic factor 2
chr17_-_36388423 7.04 ENST00000610350.3
TBC1D3H
TBC1 domain family member 3H
chr22_-_17199609 6.97 ENST00000330232.8
ADA2
adenosine deaminase 2
chr12_-_7088848 6.85 ENST00000649804.1
C1R
complement C1r
chr1_-_183590596 6.66 ENST00000418089.5
ENST00000413720.5
NCF2
neutrophil cytosolic factor 2
chr18_-_6414885 6.49 ENST00000317931.12
ENST00000400104.7
L3MBTL4
L3MBTL histone methyl-lysine binding protein 4
chr11_-_60183191 6.15 ENST00000412309.6
MS4A6A
membrane spanning 4-domains A6A
chr7_-_36724543 6.09 ENST00000612871.4
AOAH
acyloxyacyl hydrolase
chr7_-_36724457 6.07 ENST00000617537.5
ENST00000435386.1
AOAH
acyloxyacyl hydrolase
chr14_-_35404650 6.06 ENST00000553342.1
ENST00000557140.5
ENST00000216797.10
NFKBIA
NFKB inhibitor alpha
chr7_-_36724380 6.05 ENST00000617267.4
AOAH
acyloxyacyl hydrolase
chr1_+_91949343 5.93 ENST00000448194.6
ENST00000470955.6
ENST00000362005.7
ENST00000370389.6
ENST00000394530.7
ENST00000423434.5
ENST00000440509.5
ENST00000426141.6
BRDT
bromodomain testis associated
chr1_+_198638968 5.65 ENST00000348564.11
ENST00000530727.5
ENST00000442510.8
ENST00000645247.1
ENST00000367367.8
ENST00000367364.5
ENST00000413409.6
PTPRC
protein tyrosine phosphatase receptor type C
chr9_-_91423819 5.64 ENST00000297689.4
NFIL3
nuclear factor, interleukin 3 regulated
chr19_+_49513353 5.64 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr1_+_91949395 5.29 ENST00000449584.5
ENST00000427104.5
ENST00000355011.7
ENST00000399546.7
ENST00000450792.5
ENST00000548992.5
ENST00000552654.1
ENST00000457265.1
BRDT
bromodomain testis associated
chr14_+_22515623 5.28 ENST00000390509.1
TRAJ28
T cell receptor alpha joining 28
chr20_+_57329801 5.28 ENST00000371263.8
ENST00000345868.8
ENST00000371260.8
ENST00000418127.5
SPO11
SPO11 initiator of meiotic double stranded breaks
chr3_+_44584953 5.15 ENST00000441021.5
ENST00000322734.2
ZNF660
zinc finger protein 660
chr17_-_36176636 5.12 ENST00000611257.5
ENST00000616006.1
TBC1D3B
TBC1 domain family member 3B
chr11_+_7513966 4.76 ENST00000299492.9
PPFIBP2
PPFIA binding protein 2
chr11_+_65386611 4.74 ENST00000531296.1
ENST00000533782.5
ENST00000355991.9
ENST00000317568.10
ENST00000416776.6
ENST00000526201.1
FRMD8
FERM domain containing 8
chr17_+_38127951 4.56 ENST00000621587.2
TBC1D3E
TBC1 domain family member 3E
chr22_+_19131271 4.50 ENST00000399635.4
TSSK2
testis specific serine kinase 2
chrX_-_66033664 4.50 ENST00000427538.5
VSIG4
V-set and immunoglobulin domain containing 4
chr3_+_156674579 4.48 ENST00000295924.12
TIPARP
TCDD inducible poly(ADP-ribose) polymerase
chr20_-_23751256 4.48 ENST00000398402.1
CST1
cystatin SN
chr11_+_28108248 4.38 ENST00000406787.7
ENST00000403099.5
ENST00000407364.8
METTL15
methyltransferase like 15
chr13_-_37598750 4.28 ENST00000379743.8
ENST00000379742.4
ENST00000379749.8
ENST00000379747.9
ENST00000541179.5
ENST00000541481.5
POSTN
periostin
chr11_-_60952067 4.14 ENST00000681275.1
SLC15A3
solute carrier family 15 member 3
chr22_+_36863091 4.12 ENST00000650698.1
NCF4
neutrophil cytosolic factor 4
chr9_+_108862255 4.06 ENST00000333999.5
ACTL7A
actin like 7A
chr6_+_31948956 4.02 ENST00000483004.1
CFB
complement factor B
chr19_-_54222978 3.96 ENST00000245620.13
ENST00000346401.10
ENST00000445347.1
LILRB3
leukocyte immunoglobulin like receptor B3
chr4_+_78057570 3.83 ENST00000502446.6
ENST00000325942.11
FRAS1
Fraser extracellular matrix complex subunit 1
chr11_-_60952559 3.79 ENST00000538739.2
SLC15A3
solute carrier family 15 member 3
chr4_-_74099187 3.77 ENST00000508487.3
CXCL2
C-X-C motif chemokine ligand 2
chr11_+_64230726 3.77 ENST00000321460.5
DNAJC4
DnaJ heat shock protein family (Hsp40) member C4
chr19_+_38335775 3.69 ENST00000410018.5
ENST00000409235.8
ENST00000409410.6
CATSPERG
cation channel sperm associated auxiliary subunit gamma
chr5_+_134526176 3.58 ENST00000681820.1
ENST00000512386.6
ENST00000612830.2
JADE2
jade family PHD finger 2
chr19_-_54339146 3.54 ENST00000291759.5
LILRA4
leukocyte immunoglobulin like receptor A4
chr1_-_54053192 3.53 ENST00000371337.3
ENST00000234831.10
TMEM59
transmembrane protein 59
chr6_+_31615984 3.51 ENST00000376049.4
AIF1
allograft inflammatory factor 1
chr5_-_180810086 3.42 ENST00000506889.1
ENST00000393340.7
MGAT1
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
chr6_-_31158073 3.38 ENST00000507751.5
ENST00000448162.6
ENST00000502557.5
ENST00000503420.5
ENST00000507892.1
ENST00000507226.1
ENST00000513222.1
ENST00000503934.5
ENST00000396263.6
ENST00000508683.5
ENST00000428174.1
ENST00000448141.6
ENST00000507829.5
ENST00000455279.6
ENST00000376266.9
CCHCR1
coiled-coil alpha-helical rod protein 1
chrX_+_150568595 3.38 ENST00000370396.7
ENST00000424519.1
MTM1
myotubularin 1
chr15_+_75201873 3.31 ENST00000394987.5
C15orf39
chromosome 15 open reading frame 39
chr2_-_202871747 3.30 ENST00000358299.7
ICA1L
islet cell autoantigen 1 like
chr3_-_41961989 3.30 ENST00000420927.5
ENST00000301831.9
ENST00000414606.1
ULK4
unc-51 like kinase 4
chr7_+_100101657 3.26 ENST00000421755.5
AP4M1
adaptor related protein complex 4 subunit mu 1
chr1_-_201023694 3.25 ENST00000332129.6
ENST00000422435.2
ENST00000461742.7
KIF21B
kinesin family member 21B
chr1_+_103745323 3.23 ENST00000684141.1
AMY1C
amylase alpha 1C
chr19_+_10655023 3.23 ENST00000590009.5
ILF3
interleukin enhancer binding factor 3
chr17_-_7179544 3.21 ENST00000619926.4
ASGR1
asialoglycoprotein receptor 1
chr1_+_54053573 3.18 ENST00000234827.6
TCEANC2
transcription elongation factor A N-terminal and central domain containing 2
chr20_+_3820515 3.14 ENST00000246041.6
ENST00000379573.6
ENST00000379567.6
ENST00000455742.5
ENST00000615891.2
AP5S1
adaptor related protein complex 5 subunit sigma 1
chr7_-_105389365 3.13 ENST00000482897.5
SRPK2
SRSF protein kinase 2
chr15_-_80989792 3.13 ENST00000261758.6
ENST00000561312.5
MESD
mesoderm development LRP chaperone
chr11_+_94973640 3.12 ENST00000335080.6
ENST00000536741.1
KDM4D
lysine demethylase 4D
chr16_+_28822982 3.05 ENST00000336783.9
ENST00000340394.12
ENST00000325215.10
ENST00000382686.8
ENST00000395547.6
ENST00000564304.5
ATXN2L
ataxin 2 like
chr11_-_60952134 3.05 ENST00000679573.1
ENST00000681882.1
ENST00000681951.1
ENST00000227880.8
SLC15A3
solute carrier family 15 member 3
chr1_+_99646025 3.03 ENST00000263174.9
ENST00000605497.5
ENST00000615664.1
PALMD
palmdelphin
chr12_-_124914108 3.03 ENST00000541645.1
ENST00000540351.1
UBC
ubiquitin C
chr2_-_202871611 2.97 ENST00000392237.6
ENST00000416760.5
ENST00000412210.5
ICA1L
islet cell autoantigen 1 like
chr1_+_153778178 2.97 ENST00000532853.5
SLC27A3
solute carrier family 27 member 3
chr18_-_48409292 2.96 ENST00000589194.5
ENST00000591279.5
ENST00000590855.5
ENST00000587107.5
ENST00000588970.5
ENST00000586525.5
ENST00000592387.5
ENST00000590800.6
ZBTB7C
zinc finger and BTB domain containing 7C
chr17_-_35578535 2.88 ENST00000225873.9
PEX12
peroxisomal biogenesis factor 12
chr2_+_169069537 2.88 ENST00000428522.5
ENST00000450153.1
ENST00000674881.1
ENST00000421653.5
DHRS9
dehydrogenase/reductase 9
chr3_-_146460440 2.86 ENST00000610787.5
PLSCR2
phospholipid scramblase 2
chr15_+_75206014 2.86 ENST00000567617.1
C15orf39
chromosome 15 open reading frame 39
chr15_+_68930488 2.86 ENST00000310673.4
ENST00000448182.7
ENST00000260364.9
SPESP1
NOX5
sperm equatorial segment protein 1
NADPH oxidase 5
chr2_+_112584586 2.85 ENST00000409719.1
CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr12_-_113966306 2.83 ENST00000545145.6
ENST00000392561.7
ENST00000261741.10
RBM19
RNA binding motif protein 19
chr17_-_78782257 2.82 ENST00000591455.5
ENST00000446868.7
ENST00000361101.8
ENST00000589296.5
CYTH1
cytohesin 1
chr6_+_35259703 2.77 ENST00000373953.8
ENST00000339411.5
ZNF76
zinc finger protein 76
chr6_-_30556477 2.75 ENST00000376621.8
GNL1
G protein nucleolar 1 (putative)
chr3_+_13480215 2.73 ENST00000446613.6
ENST00000402259.5
ENST00000402271.5
ENST00000295757.8
ENST00000404548.5
ENST00000404040.5
HDAC11
histone deacetylase 11
chr21_-_14546351 2.70 ENST00000619120.4
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr3_+_57556244 2.70 ENST00000311180.9
ENST00000487257.1
PDE12
phosphodiesterase 12
chr18_-_66604076 2.69 ENST00000540086.5
ENST00000580157.2
ENST00000262150.7
CDH19
cadherin 19
chr9_-_127854636 2.68 ENST00000344849.4
ENST00000373203.9
ENG
endoglin
chr1_-_221742074 2.68 ENST00000366899.4
DUSP10
dual specificity phosphatase 10
chr5_-_39270623 2.67 ENST00000512138.1
ENST00000646045.2
FYB1
FYN binding protein 1
chr16_+_19067606 2.61 ENST00000321998.10
COQ7
coenzyme Q7, hydroxylase
chr16_+_590200 2.61 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr7_+_129375643 2.59 ENST00000490911.5
AHCYL2
adenosylhomocysteinase like 2
chr2_-_202871433 2.58 ENST00000457524.5
ENST00000421334.1
ENST00000617388.4
ICA1L
islet cell autoantigen 1 like
chr21_-_14546297 2.54 ENST00000400566.6
ENST00000400564.5
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr12_-_25195074 2.54 ENST00000354189.9
ENST00000676236.1
ENST00000545133.5
ENST00000554347.1
ENST00000674567.1
ENST00000395987.8
ENST00000320267.13
ENST00000395990.6
CFAP94
cilia and flagella associated protein 94
chr2_-_229921903 2.54 ENST00000389045.7
ENST00000409677.5
TRIP12
thyroid hormone receptor interactor 12
chr2_-_216695540 2.52 ENST00000233813.5
IGFBP5
insulin like growth factor binding protein 5
chr19_+_40799155 2.49 ENST00000303961.9
EGLN2
egl-9 family hypoxia inducible factor 2
chr2_-_231464475 2.47 ENST00000322723.9
ENST00000678828.1
ENST00000679348.1
ENST00000678246.1
ENST00000678364.1
ENST00000676690.1
NCL
nucleolin
chr19_+_16720004 2.43 ENST00000673803.1
ENST00000549814.5
NWD1
NACHT and WD repeat domain containing 1
chr3_+_50155305 2.42 ENST00000002829.8
ENST00000426511.5
SEMA3F
semaphorin 3F
chr3_+_122564327 2.42 ENST00000296161.9
ENST00000383661.3
DTX3L
deltex E3 ubiquitin ligase 3L
chr19_+_1407517 2.41 ENST00000336761.10
ENST00000233078.9
ENST00000592522.5
DAZAP1
DAZ associated protein 1
chr19_+_54966343 2.36 ENST00000537859.5
ENST00000585500.5
ENST00000427260.6
ENST00000448584.7
ENST00000263437.10
NLRP2
NLR family pyrin domain containing 2
chr4_-_121381007 2.32 ENST00000394427.3
QRFPR
pyroglutamylated RFamide peptide receptor
chr16_+_19067989 2.32 ENST00000569127.1
COQ7
coenzyme Q7, hydroxylase
chr12_+_52301833 2.31 ENST00000293525.5
KRT86
keratin 86
chr7_-_95396349 2.28 ENST00000427422.5
ENST00000451904.5
ENST00000265627.10
PON3
paraoxonase 3
chr5_-_63962438 2.26 ENST00000323865.5
ENST00000506598.1
HTR1A
5-hydroxytryptamine receptor 1A
chr16_+_19067639 2.25 ENST00000568985.5
ENST00000566110.5
COQ7
coenzyme Q7, hydroxylase
chr11_-_6603571 2.23 ENST00000534343.1
ENST00000254605.11
RRP8
ribosomal RNA processing 8
chr3_+_119579676 2.19 ENST00000357003.7
ADPRH
ADP-ribosylarginine hydrolase
chr5_-_147831663 2.19 ENST00000296695.10
SPINK1
serine peptidase inhibitor Kazal type 1
chr8_+_17577179 2.17 ENST00000251630.11
PDGFRL
platelet derived growth factor receptor like
chr2_-_85398734 2.13 ENST00000453973.5
CAPG
capping actin protein, gelsolin like
chr5_-_115262851 2.11 ENST00000379615.3
ENST00000419445.6
PGGT1B
protein geranylgeranyltransferase type I subunit beta
chr6_+_170554333 2.11 ENST00000540980.5
ENST00000616883.4
ENST00000392092.7
ENST00000230354.10
TBP
TATA-box binding protein
chr19_+_54573781 2.11 ENST00000391738.8
ENST00000251376.7
ENST00000391737.3
ENST00000629481.1
LILRA2
leukocyte immunoglobulin like receptor A2
chr15_-_72271244 2.10 ENST00000287196.13
PARP6
poly(ADP-ribose) polymerase family member 6
chr15_+_84603896 2.07 ENST00000541040.5
ENST00000538076.5
ENST00000485222.2
ZSCAN2
zinc finger and SCAN domain containing 2
chr11_-_4608226 2.07 ENST00000300747.10
ENST00000526337.5
TRIM68
tripartite motif containing 68
chr16_+_2026834 2.06 ENST00000424542.7
ENST00000432365.6
SLC9A3R2
SLC9A3 regulator 2
chr16_-_87765899 2.04 ENST00000353170.9
ENST00000561825.1
ENST00000562261.1
ENST00000347925.9
ENST00000270583.10
ENST00000622456.4
KLHDC4
kelch domain containing 4
chr19_+_48619528 2.01 ENST00000598088.5
SPHK2
sphingosine kinase 2
chr3_+_94062974 1.99 ENST00000314622.9
NSUN3
NOP2/Sun RNA methyltransferase 3
chr6_+_78867524 1.96 ENST00000369940.7
IRAK1BP1
interleukin 1 receptor associated kinase 1 binding protein 1
chr10_+_102394488 1.96 ENST00000369966.8
NFKB2
nuclear factor kappa B subunit 2
chr19_+_48619489 1.93 ENST00000245222.9
SPHK2
sphingosine kinase 2
chr2_+_230416190 1.91 ENST00000340126.9
ENST00000432979.5
SP100
SP100 nuclear antigen
chr2_+_110732539 1.91 ENST00000676595.1
ENST00000389811.8
ENST00000439055.6
ACOXL
acyl-CoA oxidase like
chr22_+_22711689 1.90 ENST00000390308.2
IGLV3-21
immunoglobulin lambda variable 3-21
chr19_+_16719841 1.83 ENST00000524140.7
NWD1
NACHT and WD repeat domain containing 1
chr19_+_48619291 1.81 ENST00000340932.7
ENST00000601712.5
ENST00000600537.5
SPHK2
sphingosine kinase 2
chr11_-_111512339 1.79 ENST00000525791.5
ENST00000456861.2
ENST00000356018.6
BTG4
BTG anti-proliferation factor 4
chr21_-_46155567 1.78 ENST00000291670.9
ENST00000397748.5
ENST00000397743.1
ENST00000397746.8
FTCD
formimidoyltransferase cyclodeaminase
chr1_-_54053461 1.75 ENST00000371341.5
TMEM59
transmembrane protein 59
chr10_-_5499544 1.74 ENST00000380332.5
CALML5
calmodulin like 5
chr1_+_35883189 1.73 ENST00000674304.1
ENST00000373204.6
ENST00000674426.1
AGO1
argonaute RISC component 1
chrX_+_123860262 1.73 ENST00000355640.3
XIAP
X-linked inhibitor of apoptosis
chr12_-_13981544 1.73 ENST00000609686.4
GRIN2B
glutamate ionotropic receptor NMDA type subunit 2B
chrX_+_13569593 1.70 ENST00000361306.6
ENST00000380602.3
EGFL6
EGF like domain multiple 6
chr22_+_29268316 1.70 ENST00000414183.6
ENST00000333395.10
ENST00000455726.5
ENST00000332035.10
EWSR1
EWS RNA binding protein 1
chr17_-_3609411 1.69 ENST00000572705.2
TRPV1
transient receptor potential cation channel subfamily V member 1
chr19_-_19821704 1.69 ENST00000443905.6
ENST00000590766.5
ENST00000587452.5
ENST00000545006.1
ENST00000590319.1
ENST00000587461.5
ENST00000450683.6
ENST00000540806.7
ENST00000590274.1
ZNF506
ENSG00000267581.1
zinc finger protein 506
novel transcript
chr1_+_28887166 1.68 ENST00000347529.7
EPB41
erythrocyte membrane protein band 4.1
chr13_+_46553157 1.67 ENST00000311191.10
ENST00000389797.8
ENST00000389798.7
LRCH1
leucine rich repeats and calponin homology domain containing 1
chr12_+_113221429 1.67 ENST00000551096.5
ENST00000551099.5
ENST00000552897.5
ENST00000550785.5
ENST00000549279.1
ENST00000335509.11
TPCN1
two pore segment channel 1
chr22_+_50185894 1.65 ENST00000380909.9
ENST00000303434.8
TRABD
TraB domain containing
chr17_-_2711633 1.64 ENST00000435359.5
CLUH
clustered mitochondria homolog
chr2_-_229921963 1.64 ENST00000343290.5
ENST00000389044.8
ENST00000675453.1
ENST00000675903.1
ENST00000283943.9
TRIP12
thyroid hormone receptor interactor 12
chr3_+_54123452 1.59 ENST00000620722.4
ENST00000490478.5
CACNA2D3
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr11_-_120120880 1.58 ENST00000526881.1
TRIM29
tripartite motif containing 29
chr13_-_52739769 1.57 ENST00000448904.6
ENST00000377962.8
CNMD
chondromodulin
chr1_-_45686501 1.57 ENST00000355105.8
ENST00000290795.7
GPBP1L1
GC-rich promoter binding protein 1 like 1
chr16_+_19067893 1.56 ENST00000544894.6
ENST00000561858.5
COQ7
coenzyme Q7, hydroxylase
chr16_+_57358775 1.56 ENST00000219235.5
CCL22
C-C motif chemokine ligand 22
chr7_+_94907584 1.55 ENST00000433360.6
ENST00000340694.8
ENST00000424654.5
PPP1R9A
protein phosphatase 1 regulatory subunit 9A
chr8_+_24440930 1.55 ENST00000441335.6
ENST00000175238.10
ENST00000380789.5
ADAM7
ADAM metallopeptidase domain 7
chr16_+_69924984 1.53 ENST00000568684.1
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr8_-_92103217 1.51 ENST00000615601.4
ENST00000523629.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr16_+_590056 1.50 ENST00000248139.8
ENST00000568586.5
ENST00000538492.5
RAB40C
RAB40C, member RAS oncogene family
chr3_+_132317399 1.49 ENST00000475741.5
ENST00000336375.10
ENST00000351273.11
ACP3
acid phosphatase 3
chr1_-_243843164 1.49 ENST00000491219.6
ENST00000680056.1
ENST00000492957.2
AKT3
AKT serine/threonine kinase 3
chr3_-_38816217 1.47 ENST00000449082.3
ENST00000655275.1
SCN10A
sodium voltage-gated channel alpha subunit 10
chr18_-_47023927 1.43 ENST00000675219.1
ENSG00000288607.1
elongin A3 family member B
chr19_+_589873 1.43 ENST00000251287.3
HCN2
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
chr19_+_40191410 1.42 ENST00000253055.8
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr16_+_15949549 1.42 ENST00000399408.7
ENST00000572882.3
ENST00000677164.1
ABCC1
ATP binding cassette subfamily C member 1
chr6_+_33620329 1.40 ENST00000374316.9
ITPR3
inositol 1,4,5-trisphosphate receptor type 3
chr5_-_147831627 1.40 ENST00000510027.2
SPINK1
serine peptidase inhibitor Kazal type 1
chr16_-_28925172 1.40 ENST00000544477.5
ENST00000357573.10
ENST00000358201.9
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr3_+_119579577 1.39 ENST00000478927.5
ADPRH
ADP-ribosylarginine hydrolase
chr19_+_49527988 1.38 ENST00000270645.8
RCN3
reticulocalbin 3
chr8_+_74824526 1.35 ENST00000649643.1
ENST00000260113.7
PI15
peptidase inhibitor 15
chr1_+_28887072 1.32 ENST00000647103.1
ENST00000642937.2
ENST00000646189.1
ENST00000644342.1
ENST00000373800.7
ENST00000649717.1
EPB41
erythrocyte membrane protein band 4.1
chr1_-_54053394 1.29 ENST00000452421.5
ENST00000420738.5
ENST00000440019.5
TMEM59
transmembrane protein 59
chr2_+_222424520 1.28 ENST00000321276.8
SGPP2
sphingosine-1-phosphate phosphatase 2
chrX_+_15507302 1.28 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr7_+_30911845 1.28 ENST00000652696.1
ENST00000311813.11
AQP1
aquaporin 1 (Colton blood group)
chr3_+_50155024 1.25 ENST00000414301.5
ENST00000450338.5
ENST00000413852.5
SEMA3F
semaphorin 3F
chr3_+_48223325 1.23 ENST00000296435.2
CAMP
cathelicidin antimicrobial peptide
chr3_-_54928044 1.23 ENST00000273286.6
LRTM1
leucine rich repeats and transmembrane domains 1
chr22_-_29267965 1.23 ENST00000216085.12
RHBDD3
rhomboid domain containing 3
chr17_-_66229380 1.19 ENST00000205948.11
APOH
apolipoprotein H

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 36.8 GO:0061107 seminal vesicle development(GO:0061107)
4.3 12.9 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
3.7 11.2 GO:0001207 histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
2.6 10.3 GO:0002399 MHC class II protein complex assembly(GO:0002399)
2.2 6.6 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
1.9 5.7 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
1.9 5.6 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
1.8 5.3 GO:1990918 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
1.4 5.8 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
1.4 7.0 GO:0006154 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
1.3 9.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
1.1 3.4 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
1.0 2.9 GO:0043012 regulation of fusion of sperm to egg plasma membrane(GO:0043012)
0.9 17.4 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.9 2.7 GO:0001300 chronological cell aging(GO:0001300)
0.9 2.7 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.9 6.1 GO:0070417 cellular response to cold(GO:0070417) nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.9 3.4 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.9 4.3 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.8 2.5 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.8 3.9 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.8 75.1 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.8 3.1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.8 2.3 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.8 2.3 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.7 3.5 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.7 7.7 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.7 2.0 GO:0034635 glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.7 2.0 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.6 1.8 GO:0045062 extrathymic T cell selection(GO:0045062)
0.6 3.6 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.6 4.2 GO:1900045 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.6 1.7 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.5 3.1 GO:0035063 nuclear speck organization(GO:0035063)
0.5 1.6 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.5 2.0 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.5 18.0 GO:0045730 respiratory burst(GO:0045730)
0.5 8.7 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.5 2.3 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.4 3.0 GO:0036484 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.4 3.8 GO:0070475 rRNA base methylation(GO:0070475)
0.4 1.3 GO:0072019 nitric oxide transport(GO:0030185) cerebrospinal fluid secretion(GO:0033326) positive regulation of saliva secretion(GO:0046878) cellular response to mercury ion(GO:0071288) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229)
0.4 8.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.4 1.7 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.4 1.1 GO:1904933 regulation of cell proliferation in midbrain(GO:1904933)
0.4 1.4 GO:0050916 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.3 2.9 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3 2.2 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.3 1.5 GO:0021997 neural plate axis specification(GO:0021997)
0.3 1.7 GO:0090625 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.3 2.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.2 1.0 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.2 0.7 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.2 2.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.2 1.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.2 2.9 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.2 3.0 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.2 1.2 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.2 20.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2 0.6 GO:1901052 sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053)
0.2 0.6 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.2 3.1 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.2 4.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 1.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.2 0.5 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.2 0.7 GO:0051140 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.2 0.5 GO:0036047 protein demalonylation(GO:0036046) peptidyl-lysine demalonylation(GO:0036047) protein desuccinylation(GO:0036048) peptidyl-lysine desuccinylation(GO:0036049) protein deglutarylation(GO:0061698) peptidyl-lysine deglutarylation(GO:0061699)
0.2 4.3 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.2 2.9 GO:0017121 phospholipid scrambling(GO:0017121)
0.2 4.5 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.2 2.5 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.2 1.8 GO:0070305 response to cGMP(GO:0070305)
0.2 2.1 GO:0051873 killing by host of symbiont cells(GO:0051873)
0.1 3.0 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1 1.2 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.1 4.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.4 GO:1903015 regulation of exo-alpha-sialidase activity(GO:1903015)
0.1 2.2 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
0.1 3.0 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.1 3.3 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 3.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 1.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 0.9 GO:0036343 psychomotor behavior(GO:0036343)
0.1 1.5 GO:0086043 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.1 5.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.1 1.1 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 2.7 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 0.6 GO:1904693 midbrain morphogenesis(GO:1904693)
0.1 5.2 GO:0002820 negative regulation of adaptive immune response(GO:0002820)
0.1 2.3 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 1.3 GO:0034311 sphingosine metabolic process(GO:0006670) diol metabolic process(GO:0034311)
0.1 2.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 1.3 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 2.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 2.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.4 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1 2.4 GO:0050718 positive regulation of interleukin-1 beta secretion(GO:0050718)
0.1 8.7 GO:0030449 regulation of complement activation(GO:0030449)
0.1 2.8 GO:0040019 positive regulation of embryonic development(GO:0040019)
0.1 3.7 GO:0035036 sperm-egg recognition(GO:0035036)
0.1 3.8 GO:0003338 metanephros morphogenesis(GO:0003338)
0.1 10.2 GO:0007286 spermatid development(GO:0007286)
0.1 4.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 0.8 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.1 2.7 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.1 0.7 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 2.2 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 2.1 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.1 0.4 GO:0046086 AMP catabolic process(GO:0006196) adenosine biosynthetic process(GO:0046086)
0.1 2.4 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 1.1 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1 4.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 3.2 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.4 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.7 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.6 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 3.4 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.8 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.5 GO:0050942 positive regulation of pigment cell differentiation(GO:0050942)
0.0 4.7 GO:0015992 proton transport(GO:0015992)
0.0 0.6 GO:0043536 positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.0 0.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 21.3 GO:0006954 inflammatory response(GO:0006954)
0.0 2.3 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.2 GO:0090166 Golgi disassembly(GO:0090166)
0.0 0.5 GO:0034505 tooth mineralization(GO:0034505)
0.0 1.7 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 1.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 1.6 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.7 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 1.6 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.0 1.0 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 6.2 GO:0002250 adaptive immune response(GO:0002250)
0.0 2.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.7 GO:0031102 neuron projection regeneration(GO:0031102)
0.0 1.7 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.9 GO:0032411 positive regulation of transporter activity(GO:0032411)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
12.3 36.8 GO:0036028 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
2.0 18.0 GO:0032010 phagolysosome(GO:0032010)
1.3 6.6 GO:0005797 Golgi medial cisterna(GO:0005797)
1.0 4.9 GO:0001652 granular component(GO:0001652)
0.9 2.7 GO:0072563 endothelial microparticle(GO:0072563)
0.7 3.7 GO:0036128 CatSper complex(GO:0036128)
0.7 2.1 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.7 3.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.6 8.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.5 10.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.4 2.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.4 3.9 GO:0030870 Mre11 complex(GO:0030870)
0.4 2.1 GO:0001940 male pronucleus(GO:0001940)
0.3 1.3 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.3 17.4 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 4.1 GO:0001673 male germ cell nucleus(GO:0001673)
0.3 2.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 1.8 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 19.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 2.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 1.6 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 4.3 GO:0005682 U5 snRNP(GO:0005682)
0.2 3.1 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 1.5 GO:0071439 clathrin complex(GO:0071439)
0.1 1.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 3.5 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 12.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 3.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.4 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 3.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 2.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 10.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 1.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 3.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 13.1 GO:0072562 blood microparticle(GO:0072562)
0.1 0.7 GO:0031906 late endosome lumen(GO:0031906)
0.1 0.6 GO:0070449 elongin complex(GO:0070449)
0.1 7.0 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 2.0 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 5.4 GO:0036464 cytoplasmic ribonucleoprotein granule(GO:0036464)
0.0 5.5 GO:0005814 centriole(GO:0005814)
0.0 0.7 GO:0044613 nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
0.0 2.2 GO:0005871 kinesin complex(GO:0005871)
0.0 1.6 GO:0045095 keratin filament(GO:0045095)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.0 0.4 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 4.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 2.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.7 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 6.0 GO:0001726 ruffle(GO:0001726)
0.0 2.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 8.7 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.5 GO:1904115 axon cytoplasm(GO:1904115)
0.0 3.6 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 5.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 7.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 1.5 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.8 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.2 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
4.1 36.8 GO:0032190 acrosin binding(GO:0032190)
2.9 17.4 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
2.3 18.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
1.8 11.0 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
1.8 5.3 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
1.4 5.6 GO:0019770 IgG receptor activity(GO:0019770)
1.1 4.4 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.9 3.6 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.9 3.4 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.8 5.8 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.8 2.4 GO:0032090 Pyrin domain binding(GO:0032090)
0.8 7.0 GO:0031685 adenosine receptor binding(GO:0031685)
0.7 2.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.7 2.1 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.7 2.1 GO:0001034 RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.6 2.3 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.5 2.0 GO:0015198 oligopeptide transporter activity(GO:0015198) oligopeptide transmembrane transporter activity(GO:0035673)
0.5 2.9 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.5 2.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.5 3.2 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.4 2.6 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.4 16.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.4 1.3 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.4 79.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.4 2.0 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.4 2.5 GO:0019826 oxygen sensor activity(GO:0019826)
0.4 1.4 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.4 1.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.3 10.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.3 1.7 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.3 2.7 GO:0005534 galactose binding(GO:0005534)
0.3 2.3 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.3 3.9 GO:0070087 chromo shadow domain binding(GO:0070087)
0.3 2.5 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.3 1.2 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.3 4.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.3 1.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.3 11.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.3 1.1 GO:0045569 TRAIL binding(GO:0045569)
0.3 2.9 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 0.7 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.2 0.7 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.2 1.3 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.2 0.6 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.2 2.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 20.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 0.6 GO:0046997 sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.2 3.7 GO:0038191 neuropilin binding(GO:0038191)
0.2 2.3 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.2 3.4 GO:0019215 intermediate filament binding(GO:0019215)
0.2 2.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.2 2.7 GO:0048273 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273)
0.2 5.7 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 3.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 1.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 2.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.2 3.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.2 6.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 16.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 4.8 GO:0001848 complement binding(GO:0001848)
0.1 1.0 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.1 0.7 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.1 2.4 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 1.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.4 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.1 4.2 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 5.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 2.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 1.7 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.1 1.7 GO:0035198 miRNA binding(GO:0035198)
0.1 0.5 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 11.3 GO:0008201 heparin binding(GO:0008201)
0.1 0.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 6.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 1.6 GO:0008009 chemokine activity(GO:0008009)
0.0 3.0 GO:0030507 spectrin binding(GO:0030507)
0.0 0.7 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 1.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.2 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.8 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.9 GO:0005537 mannose binding(GO:0005537)
0.0 0.9 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 1.0 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 4.0 GO:0004497 monooxygenase activity(GO:0004497)
0.0 8.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 3.5 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 1.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.0 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.7 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 2.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 1.8 GO:0005125 cytokine activity(GO:0005125)
0.0 1.6 GO:0005262 calcium channel activity(GO:0005262)
0.0 2.1 GO:0003823 antigen binding(GO:0003823)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 2.8 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.0 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.0 ST GAQ PATHWAY G alpha q Pathway
0.2 7.8 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.2 58.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 10.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 1.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 7.9 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.1 9.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 3.8 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 4.1 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.1 2.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 12.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.7 PID ALK1 PATHWAY ALK1 signaling events
0.1 3.0 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.1 13.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.7 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.4 ST ADRENERGIC Adrenergic Pathway
0.0 1.7 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.1 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 2.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 2.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 2.1 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.7 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.7 PID CONE PATHWAY Visual signal transduction: Cones
0.0 2.1 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.6 PID ARF6 PATHWAY Arf6 signaling events
0.0 5.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.7 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 16.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.5 12.9 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.5 6.5 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.3 13.0 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.3 3.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.3 4.9 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.2 7.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 20.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.2 3.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.2 2.3 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.2 1.4 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 11.9 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 1.5 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 2.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.3 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 5.9 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 0.6 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 2.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 2.1 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1 1.1 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 1.7 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 2.0 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.8 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 3.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.0 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 1.7 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 1.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 3.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.6 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.0 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 2.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 6.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 9.4 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.9 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 3.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.7 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 2.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse