Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for YY1_YY2
Z-value: 10.07
Motif logo
Transcription factors associated with YY1_YY2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
YY1
|
ENSG00000100811.14 | YY1 |
|
YY2
|
ENSG00000230797.3 | YY2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| YY1 | hg38_v1_chr14_+_100239121_100239196 | 0.60 | 7.6e-23 | Click! |
| YY2 | hg38_v1_chrX_+_21855987_21855987 | -0.50 | 2.8e-15 | Click! |
Activity profile of YY1_YY2 motif
Sorted Z-values of YY1_YY2 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of YY1_YY2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 19.0 | 56.9 | GO:0003064 | regulation of heart rate by hormone(GO:0003064) negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 15.1 | 45.3 | GO:0044376 | RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022) |
| 14.7 | 58.8 | GO:0006169 | adenosine salvage(GO:0006169) dATP biosynthetic process(GO:0006175) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216) |
| 13.3 | 39.8 | GO:1902822 | lysosomal membrane organization(GO:0097212) regulation of late endosome to lysosome transport(GO:1902822) |
| 12.8 | 38.3 | GO:0070476 | RNA (guanine-N7)-methylation(GO:0036265) rRNA (guanine-N7)-methylation(GO:0070476) |
| 12.7 | 63.5 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
| 12.5 | 37.6 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 11.7 | 11.7 | GO:0006679 | glucosylceramide biosynthetic process(GO:0006679) |
| 11.5 | 57.3 | GO:1902904 | negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 10.5 | 52.6 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 9.1 | 36.5 | GO:0030472 | mitotic spindle organization in nucleus(GO:0030472) |
| 8.8 | 35.1 | GO:0000961 | negative regulation of mitochondrial RNA catabolic process(GO:0000961) |
| 8.5 | 76.7 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 8.2 | 24.6 | GO:0018312 | peptidyl-serine ADP-ribosylation(GO:0018312) |
| 8.2 | 40.9 | GO:0006167 | AMP biosynthetic process(GO:0006167) |
| 8.1 | 24.4 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 7.8 | 125.6 | GO:0043248 | proteasome assembly(GO:0043248) |
| 7.7 | 69.6 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
| 7.2 | 35.9 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 7.1 | 35.7 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 7.1 | 28.5 | GO:0035927 | RNA import into mitochondrion(GO:0035927) |
| 6.9 | 20.8 | GO:1905051 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 6.9 | 27.6 | GO:0019918 | peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) |
| 6.8 | 6.8 | GO:0061290 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 6.7 | 20.1 | GO:0046504 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 6.6 | 99.4 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 6.6 | 19.7 | GO:0032707 | negative regulation of interleukin-23 production(GO:0032707) |
| 6.3 | 19.0 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
| 6.3 | 18.9 | GO:0034476 | U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047) |
| 6.2 | 6.2 | GO:0043633 | polyadenylation-dependent RNA catabolic process(GO:0043633) polyadenylation-dependent ncRNA catabolic process(GO:0043634) nuclear ncRNA surveillance(GO:0071029) nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035) nuclear polyadenylation-dependent ncRNA catabolic process(GO:0071046) |
| 6.0 | 47.9 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 6.0 | 23.9 | GO:1904117 | response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117) |
| 5.9 | 17.6 | GO:0043461 | proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272) |
| 5.6 | 16.8 | GO:1904247 | positive regulation of polynucleotide adenylyltransferase activity(GO:1904247) |
| 5.4 | 21.6 | GO:2000434 | regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
| 5.4 | 26.8 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 5.2 | 15.7 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 5.2 | 15.6 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) |
| 5.2 | 20.7 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 5.2 | 67.1 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 5.1 | 15.2 | GO:0034402 | recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402) |
| 4.8 | 43.3 | GO:0007008 | outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040) |
| 4.8 | 38.3 | GO:0043144 | snoRNA processing(GO:0043144) |
| 4.6 | 41.7 | GO:1904885 | beta-catenin destruction complex assembly(GO:1904885) |
| 4.6 | 46.4 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 4.6 | 301.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 4.6 | 27.6 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 4.5 | 27.1 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 4.5 | 13.5 | GO:0010520 | meiotic gene conversion(GO:0006311) regulation of reciprocal meiotic recombination(GO:0010520) |
| 4.4 | 325.3 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 4.3 | 30.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 4.2 | 12.5 | GO:0007174 | epidermal growth factor catabolic process(GO:0007174) |
| 4.1 | 12.2 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 4.0 | 19.9 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
| 4.0 | 15.9 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 3.9 | 27.6 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 3.9 | 55.1 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 3.9 | 15.7 | GO:0009181 | purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181) ribonucleoside diphosphate catabolic process(GO:0009191) |
| 3.8 | 23.0 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 3.8 | 7.7 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 3.8 | 15.1 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 3.8 | 18.8 | GO:0006620 | posttranslational protein targeting to membrane(GO:0006620) |
| 3.7 | 33.7 | GO:0061484 | hematopoietic stem cell homeostasis(GO:0061484) |
| 3.7 | 48.6 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 3.7 | 21.9 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
| 3.6 | 10.9 | GO:0044313 | protein K6-linked deubiquitination(GO:0044313) |
| 3.6 | 21.6 | GO:0051305 | chromosome movement towards spindle pole(GO:0051305) |
| 3.6 | 14.3 | GO:0010286 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 3.6 | 10.7 | GO:0090155 | negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) |
| 3.6 | 24.9 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 3.5 | 24.4 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 3.4 | 13.8 | GO:0019418 | sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221) |
| 3.3 | 10.0 | GO:0003162 | atrioventricular node development(GO:0003162) |
| 3.3 | 56.6 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 3.3 | 49.7 | GO:0000338 | protein deneddylation(GO:0000338) |
| 3.3 | 9.9 | GO:1902269 | positive regulation of polyamine transmembrane transport(GO:1902269) |
| 3.3 | 16.5 | GO:0010621 | negative regulation of transcription by transcription factor localization(GO:0010621) |
| 3.3 | 3.3 | GO:0045053 | protein retention in Golgi apparatus(GO:0045053) |
| 3.3 | 9.8 | GO:0070901 | mitochondrial tRNA methylation(GO:0070901) |
| 3.2 | 28.4 | GO:0060699 | regulation of endoribonuclease activity(GO:0060699) |
| 3.2 | 280.9 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 3.1 | 12.5 | GO:0046203 | spermidine catabolic process(GO:0046203) |
| 3.1 | 9.3 | GO:0098974 | postsynaptic actin cytoskeleton organization(GO:0098974) |
| 3.1 | 30.9 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 3.1 | 12.3 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 3.1 | 27.6 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
| 3.0 | 15.1 | GO:0002545 | chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880) |
| 3.0 | 14.9 | GO:0003164 | His-Purkinje system development(GO:0003164) |
| 3.0 | 23.9 | GO:1900864 | mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864) |
| 3.0 | 5.9 | GO:0097695 | establishment of RNA localization to telomere(GO:0097694) establishment of macromolecular complex localization to telomere(GO:0097695) |
| 2.9 | 2.9 | GO:1903094 | regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157) |
| 2.9 | 8.6 | GO:0070407 | oxidation-dependent protein catabolic process(GO:0070407) |
| 2.9 | 8.6 | GO:2000681 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 2.8 | 5.6 | GO:0034085 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 2.8 | 24.9 | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) |
| 2.7 | 10.9 | GO:0021691 | cerebellar Purkinje cell layer maturation(GO:0021691) |
| 2.7 | 18.9 | GO:0097577 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 2.7 | 58.4 | GO:1904874 | positive regulation of telomerase RNA localization to Cajal body(GO:1904874) |
| 2.6 | 5.3 | GO:0031990 | mRNA export from nucleus in response to heat stress(GO:0031990) |
| 2.6 | 26.4 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 2.6 | 15.8 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
| 2.6 | 7.8 | GO:1900110 | negative regulation of histone H3-K9 dimethylation(GO:1900110) |
| 2.6 | 23.4 | GO:1904263 | positive regulation of TORC1 signaling(GO:1904263) |
| 2.6 | 18.2 | GO:1900045 | negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
| 2.6 | 18.0 | GO:0007144 | female meiosis I(GO:0007144) |
| 2.5 | 20.3 | GO:0036444 | calcium ion transmembrane import into mitochondrion(GO:0036444) |
| 2.5 | 5.0 | GO:2001168 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 2.5 | 9.8 | GO:1900535 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 2.4 | 98.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 2.4 | 40.3 | GO:0030497 | fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761) |
| 2.4 | 26.1 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 2.3 | 9.3 | GO:0010044 | response to aluminum ion(GO:0010044) |
| 2.3 | 9.3 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 2.3 | 4.6 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 2.3 | 29.7 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
| 2.3 | 11.4 | GO:0008295 | spermidine biosynthetic process(GO:0008295) |
| 2.3 | 9.1 | GO:0002501 | peptide antigen assembly with MHC protein complex(GO:0002501) |
| 2.2 | 330.6 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 2.2 | 17.8 | GO:0010835 | regulation of protein ADP-ribosylation(GO:0010835) nitric oxide homeostasis(GO:0033484) |
| 2.2 | 8.9 | GO:0051697 | protein delipidation(GO:0051697) |
| 2.2 | 21.9 | GO:2000002 | negative regulation of DNA damage checkpoint(GO:2000002) |
| 2.2 | 39.3 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 2.2 | 8.6 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 2.1 | 14.9 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 2.1 | 4.2 | GO:0000350 | generation of catalytic spliceosome for second transesterification step(GO:0000350) |
| 2.1 | 31.3 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 2.1 | 10.4 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 2.1 | 28.8 | GO:0048262 | determination of dorsal/ventral asymmetry(GO:0048262) |
| 2.0 | 79.2 | GO:0045841 | negative regulation of mitotic metaphase/anaphase transition(GO:0045841) |
| 2.0 | 6.1 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 2.0 | 16.0 | GO:1904798 | positive regulation of core promoter binding(GO:1904798) |
| 2.0 | 10.0 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 2.0 | 31.8 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 2.0 | 3.9 | GO:0006382 | adenosine to inosine editing(GO:0006382) |
| 2.0 | 7.9 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 1.9 | 13.6 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 1.9 | 29.1 | GO:0000466 | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466) |
| 1.9 | 58.0 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 1.9 | 19.2 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 1.9 | 24.1 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 1.8 | 1.8 | GO:2000767 | positive regulation of cytoplasmic translation(GO:2000767) |
| 1.8 | 21.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 1.8 | 3.6 | GO:0043335 | protein unfolding(GO:0043335) |
| 1.8 | 10.8 | GO:1903224 | regulation of endodermal cell differentiation(GO:1903224) |
| 1.8 | 28.5 | GO:0072321 | chaperone-mediated protein transport(GO:0072321) |
| 1.8 | 8.8 | GO:1902966 | terminal web assembly(GO:1902896) regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966) |
| 1.8 | 8.8 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 1.7 | 7.0 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
| 1.7 | 24.1 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 1.7 | 3.4 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
| 1.7 | 3.4 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) |
| 1.7 | 15.2 | GO:0010265 | SCF complex assembly(GO:0010265) |
| 1.7 | 22.0 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 1.7 | 6.7 | GO:0044571 | [2Fe-2S] cluster assembly(GO:0044571) |
| 1.7 | 18.3 | GO:0046689 | response to mercury ion(GO:0046689) |
| 1.7 | 6.6 | GO:0018201 | N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201) |
| 1.7 | 6.6 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 1.7 | 14.9 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 1.6 | 3.3 | GO:0090158 | endoplasmic reticulum membrane organization(GO:0090158) |
| 1.6 | 16.3 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 1.6 | 3.2 | GO:1902415 | regulation of mRNA binding(GO:1902415) regulation of RNA binding(GO:1905214) |
| 1.6 | 26.8 | GO:0035458 | cellular response to interferon-beta(GO:0035458) |
| 1.5 | 9.3 | GO:0042780 | tRNA 3'-end processing(GO:0042780) |
| 1.5 | 4.6 | GO:0044205 | 'de novo' UMP biosynthetic process(GO:0044205) |
| 1.5 | 9.3 | GO:0097384 | cellular lipid biosynthetic process(GO:0097384) |
| 1.5 | 10.7 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 1.5 | 9.1 | GO:0015853 | adenine transport(GO:0015853) |
| 1.5 | 15.1 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) |
| 1.5 | 13.5 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 1.5 | 29.4 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 1.5 | 46.6 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
| 1.4 | 9.9 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
| 1.4 | 12.7 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 1.4 | 71.8 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 1.4 | 7.0 | GO:1900016 | negative regulation of cytokine production involved in inflammatory response(GO:1900016) |
| 1.4 | 7.0 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 1.4 | 19.4 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 1.4 | 24.7 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) |
| 1.4 | 8.2 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 1.4 | 17.7 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 1.4 | 5.4 | GO:0051182 | coenzyme transport(GO:0051182) |
| 1.4 | 6.8 | GO:0070131 | positive regulation of mitochondrial translation(GO:0070131) |
| 1.3 | 30.9 | GO:0022904 | respiratory electron transport chain(GO:0022904) |
| 1.3 | 22.7 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
| 1.3 | 5.2 | GO:0000451 | rRNA 2'-O-methylation(GO:0000451) |
| 1.3 | 13.0 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
| 1.3 | 7.7 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 1.3 | 11.5 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 1.3 | 3.8 | GO:1904772 | hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772) |
| 1.3 | 8.9 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 1.3 | 16.4 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 1.3 | 11.3 | GO:0042182 | ketone catabolic process(GO:0042182) |
| 1.3 | 3.8 | GO:1903233 | regulation of calcium ion-dependent exocytosis of neurotransmitter(GO:1903233) |
| 1.3 | 2.5 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 1.3 | 52.5 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 1.2 | 3.7 | GO:0090176 | microtubule cytoskeleton organization involved in establishment of planar polarity(GO:0090176) |
| 1.2 | 28.4 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 1.2 | 9.8 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 1.2 | 7.3 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 1.2 | 4.9 | GO:0007538 | primary sex determination(GO:0007538) |
| 1.2 | 17.9 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 1.2 | 15.5 | GO:0006449 | regulation of translational termination(GO:0006449) |
| 1.2 | 9.5 | GO:0050703 | interleukin-1 alpha secretion(GO:0050703) |
| 1.2 | 17.8 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 1.2 | 4.7 | GO:0032595 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 1.2 | 17.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.2 | 3.5 | GO:1901389 | regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389) |
| 1.2 | 8.3 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 1.2 | 1.2 | GO:0032627 | interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) |
| 1.2 | 53.9 | GO:1902475 | L-alpha-amino acid transmembrane transport(GO:1902475) |
| 1.2 | 4.7 | GO:0061668 | mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 1.2 | 4.7 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 1.2 | 30.2 | GO:2000637 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
| 1.2 | 9.2 | GO:0030091 | protein repair(GO:0030091) |
| 1.1 | 34.2 | GO:0006414 | translational elongation(GO:0006414) |
| 1.1 | 20.4 | GO:0035435 | phosphate ion transmembrane transport(GO:0035435) |
| 1.1 | 5.7 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 1.1 | 2.2 | GO:0040031 | snRNA modification(GO:0040031) |
| 1.1 | 5.6 | GO:0044806 | G-quadruplex DNA unwinding(GO:0044806) |
| 1.1 | 34.7 | GO:0032201 | telomere maintenance via semi-conservative replication(GO:0032201) |
| 1.1 | 16.7 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 1.1 | 2.2 | GO:1901355 | response to rapamycin(GO:1901355) |
| 1.1 | 6.6 | GO:0052205 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 1.1 | 32.8 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 1.1 | 8.5 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 1.0 | 4.2 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 1.0 | 2.1 | GO:0060528 | secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528) |
| 1.0 | 22.7 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 1.0 | 86.6 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 1.0 | 4.1 | GO:0042255 | ribosome assembly(GO:0042255) |
| 1.0 | 25.4 | GO:2000009 | negative regulation of protein localization to cell surface(GO:2000009) |
| 1.0 | 2.0 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 1.0 | 3.0 | GO:1990253 | cellular response to leucine starvation(GO:1990253) |
| 1.0 | 10.1 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 1.0 | 12.0 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
| 1.0 | 27.9 | GO:0001921 | positive regulation of receptor recycling(GO:0001921) |
| 1.0 | 3.0 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 1.0 | 5.0 | GO:0060613 | fat pad development(GO:0060613) |
| 1.0 | 4.9 | GO:1900223 | positive regulation of beta-amyloid clearance(GO:1900223) |
| 1.0 | 8.8 | GO:0031053 | primary miRNA processing(GO:0031053) |
| 1.0 | 9.7 | GO:0045116 | protein neddylation(GO:0045116) |
| 1.0 | 7.7 | GO:0006264 | mitochondrial DNA replication(GO:0006264) |
| 1.0 | 12.5 | GO:0002192 | IRES-dependent translational initiation(GO:0002192) |
| 1.0 | 2.9 | GO:0003104 | positive regulation of glomerular filtration(GO:0003104) |
| 1.0 | 5.7 | GO:0039526 | suppression by virus of host apoptotic process(GO:0019050) modulation by virus of host apoptotic process(GO:0039526) |
| 0.9 | 12.1 | GO:0045292 | mRNA cis splicing, via spliceosome(GO:0045292) |
| 0.9 | 6.5 | GO:0007621 | negative regulation of female receptivity(GO:0007621) |
| 0.9 | 2.8 | GO:0045896 | regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897) |
| 0.9 | 17.4 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 0.9 | 27.4 | GO:0006221 | pyrimidine nucleotide biosynthetic process(GO:0006221) |
| 0.9 | 12.7 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.9 | 13.5 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
| 0.9 | 15.2 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.9 | 3.6 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade(GO:0070885) |
| 0.9 | 22.2 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.9 | 14.2 | GO:0042921 | glucocorticoid receptor signaling pathway(GO:0042921) |
| 0.9 | 4.3 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.9 | 4.3 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.9 | 4.3 | GO:0030309 | poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.9 | 17.9 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 0.8 | 19.5 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.8 | 4.2 | GO:1901090 | regulation of protein tetramerization(GO:1901090) negative regulation of protein tetramerization(GO:1901091) regulation of protein homotetramerization(GO:1901093) negative regulation of protein homotetramerization(GO:1901094) |
| 0.8 | 2.5 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.8 | 2.5 | GO:0070625 | zymogen granule exocytosis(GO:0070625) |
| 0.8 | 2.5 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.8 | 25.3 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.8 | 4.0 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 0.8 | 10.2 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.8 | 7.9 | GO:0010310 | regulation of hydrogen peroxide metabolic process(GO:0010310) regulation of mast cell chemotaxis(GO:0060753) |
| 0.8 | 115.3 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.8 | 6.2 | GO:0035507 | regulation of myosin-light-chain-phosphatase activity(GO:0035507) |
| 0.8 | 1.6 | GO:0033182 | regulation of histone ubiquitination(GO:0033182) |
| 0.8 | 10.0 | GO:0032875 | regulation of DNA endoreduplication(GO:0032875) |
| 0.8 | 52.3 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.8 | 0.8 | GO:0010536 | positive regulation of activation of Janus kinase activity(GO:0010536) |
| 0.8 | 9.1 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.8 | 8.3 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.7 | 7.5 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.7 | 8.1 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.7 | 5.9 | GO:0046459 | short-chain fatty acid metabolic process(GO:0046459) |
| 0.7 | 11.6 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
| 0.7 | 3.6 | GO:0032025 | response to cobalt ion(GO:0032025) |
| 0.7 | 2.1 | GO:0060278 | negative regulation of B cell differentiation(GO:0045578) regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.7 | 3.6 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.7 | 6.4 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.7 | 5.7 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
| 0.7 | 2.8 | GO:0035989 | tendon development(GO:0035989) |
| 0.7 | 4.1 | GO:1903232 | melanosome assembly(GO:1903232) |
| 0.7 | 0.7 | GO:0003257 | positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) |
| 0.7 | 2.7 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.7 | 8.8 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.7 | 9.2 | GO:0006490 | oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) |
| 0.6 | 1.3 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.6 | 33.6 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.6 | 4.5 | GO:0072718 | response to cisplatin(GO:0072718) |
| 0.6 | 4.5 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
| 0.6 | 3.8 | GO:0000715 | nucleotide-excision repair, DNA damage recognition(GO:0000715) |
| 0.6 | 2.5 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.6 | 2.5 | GO:0070417 | cellular response to cold(GO:0070417) |
| 0.6 | 18.0 | GO:0030033 | microvillus assembly(GO:0030033) |
| 0.6 | 4.3 | GO:0001878 | response to yeast(GO:0001878) |
| 0.6 | 1.8 | GO:0060672 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.6 | 11.0 | GO:0001881 | receptor recycling(GO:0001881) |
| 0.6 | 10.3 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 0.6 | 4.2 | GO:0010225 | response to UV-C(GO:0010225) |
| 0.6 | 1.8 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 0.6 | 8.3 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.6 | 4.1 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.6 | 3.5 | GO:0098704 | fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539) |
| 0.6 | 4.7 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.6 | 2.9 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.6 | 3.5 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 0.6 | 10.9 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.6 | 10.4 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
| 0.6 | 4.6 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.6 | 9.0 | GO:0021514 | ventral spinal cord interneuron differentiation(GO:0021514) |
| 0.6 | 19.6 | GO:0017144 | drug metabolic process(GO:0017144) |
| 0.6 | 20.1 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.6 | 2.8 | GO:2001295 | malonyl-CoA biosynthetic process(GO:2001295) |
| 0.5 | 2.7 | GO:1901350 | cell-cell signaling involved in cell-cell junction organization(GO:1901350) |
| 0.5 | 11.9 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.5 | 3.3 | GO:0015680 | intracellular copper ion transport(GO:0015680) |
| 0.5 | 5.4 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.5 | 8.5 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.5 | 4.2 | GO:0048102 | autophagic cell death(GO:0048102) |
| 0.5 | 58.0 | GO:0006413 | translational initiation(GO:0006413) |
| 0.5 | 8.4 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.5 | 13.0 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.5 | 2.1 | GO:0000415 | negative regulation of histone H3-K36 methylation(GO:0000415) |
| 0.5 | 1.5 | GO:1904899 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.5 | 8.2 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.5 | 9.2 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) |
| 0.5 | 15.8 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.5 | 3.4 | GO:0042407 | cristae formation(GO:0042407) |
| 0.5 | 5.3 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.5 | 131.3 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.5 | 2.4 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
| 0.5 | 2.4 | GO:0061734 | parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734) |
| 0.5 | 3.3 | GO:0032096 | negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099) |
| 0.5 | 4.6 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 0.5 | 33.6 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.5 | 7.8 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.5 | 5.0 | GO:0042026 | protein refolding(GO:0042026) |
| 0.5 | 4.1 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) glycosylceramide biosynthetic process(GO:0046476) |
| 0.5 | 1.4 | GO:0034499 | late endosome to Golgi transport(GO:0034499) |
| 0.4 | 3.5 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 0.4 | 3.1 | GO:0090315 | negative regulation of protein targeting to membrane(GO:0090315) |
| 0.4 | 21.0 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.4 | 3.9 | GO:0009146 | purine nucleoside triphosphate catabolic process(GO:0009146) |
| 0.4 | 13.5 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.4 | 1.7 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.4 | 1.7 | GO:0072205 | metanephric collecting duct development(GO:0072205) |
| 0.4 | 13.8 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA transport(GO:0051031) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.4 | 0.9 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 0.4 | 14.5 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.4 | 1.3 | GO:0036466 | synaptic vesicle recycling via endosome(GO:0036466) |
| 0.4 | 2.1 | GO:1902659 | regulation of glucose mediated signaling pathway(GO:1902659) |
| 0.4 | 34.5 | GO:0051897 | positive regulation of protein kinase B signaling(GO:0051897) |
| 0.4 | 37.4 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.4 | 3.7 | GO:0002934 | desmosome organization(GO:0002934) |
| 0.4 | 5.7 | GO:0045213 | neurotransmitter receptor metabolic process(GO:0045213) |
| 0.4 | 5.6 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.4 | 4.8 | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190) |
| 0.4 | 9.1 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.4 | 0.8 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 0.4 | 2.3 | GO:0072553 | terminal button organization(GO:0072553) |
| 0.4 | 7.6 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.4 | 5.3 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.4 | 3.7 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) |
| 0.4 | 21.8 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.4 | 1.8 | GO:0034398 | telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.4 | 7.8 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.4 | 1.4 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.4 | 1.1 | GO:0048250 | mitochondrial iron ion transport(GO:0048250) |
| 0.3 | 6.3 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
| 0.3 | 6.6 | GO:0043631 | mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631) |
| 0.3 | 1.0 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.3 | 2.7 | GO:0015886 | heme transport(GO:0015886) |
| 0.3 | 21.6 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.3 | 4.0 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.3 | 1.7 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.3 | 3.3 | GO:0015781 | pyrimidine nucleotide-sugar transport(GO:0015781) |
| 0.3 | 1.3 | GO:0031064 | negative regulation of histone deacetylation(GO:0031064) |
| 0.3 | 22.5 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.3 | 2.8 | GO:0045579 | positive regulation of B cell differentiation(GO:0045579) |
| 0.3 | 11.1 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.3 | 9.8 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.3 | 1.5 | GO:0042421 | norepinephrine biosynthetic process(GO:0042421) |
| 0.3 | 0.9 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.3 | 3.4 | GO:0019852 | L-ascorbic acid metabolic process(GO:0019852) |
| 0.3 | 7.7 | GO:0015988 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.3 | 35.3 | GO:0006457 | protein folding(GO:0006457) |
| 0.3 | 2.8 | GO:0055095 | lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) |
| 0.3 | 2.5 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.3 | 9.8 | GO:0032272 | negative regulation of protein polymerization(GO:0032272) |
| 0.3 | 3.0 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.3 | 2.7 | GO:0046149 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.3 | 14.1 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
| 0.3 | 6.8 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.3 | 0.8 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.3 | 1.3 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.3 | 22.1 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 0.3 | 0.3 | GO:0042109 | lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109) |
| 0.3 | 2.6 | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway(GO:0060340) |
| 0.3 | 2.3 | GO:0045408 | regulation of interleukin-6 biosynthetic process(GO:0045408) |
| 0.3 | 11.6 | GO:0042267 | natural killer cell mediated cytotoxicity(GO:0042267) |
| 0.3 | 3.0 | GO:0060445 | branching involved in salivary gland morphogenesis(GO:0060445) |
| 0.2 | 2.2 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.2 | 4.6 | GO:0045851 | pH reduction(GO:0045851) |
| 0.2 | 2.6 | GO:0060576 | intestinal epithelial cell development(GO:0060576) |
| 0.2 | 3.3 | GO:0033622 | integrin activation(GO:0033622) |
| 0.2 | 2.6 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 0.2 | 0.5 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 0.2 | 8.0 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
| 0.2 | 1.4 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.2 | 0.9 | GO:0051799 | negative regulation of hair follicle development(GO:0051799) |
| 0.2 | 0.9 | GO:0060712 | spongiotrophoblast layer development(GO:0060712) |
| 0.2 | 1.1 | GO:0017182 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.2 | 20.8 | GO:0070268 | cornification(GO:0070268) |
| 0.2 | 8.4 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.2 | 2.6 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.2 | 7.3 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.2 | 4.6 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.2 | 2.6 | GO:0016024 | CDP-diacylglycerol biosynthetic process(GO:0016024) |
| 0.2 | 11.1 | GO:0006901 | vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.2 | 4.7 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 2.2 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.2 | 1.1 | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation(GO:0010801) |
| 0.2 | 4.2 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.2 | 2.6 | GO:0031111 | negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111) |
| 0.2 | 1.2 | GO:0045602 | negative regulation of endothelial cell differentiation(GO:0045602) |
| 0.2 | 2.4 | GO:0036109 | alpha-linolenic acid metabolic process(GO:0036109) |
| 0.2 | 5.0 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.2 | 0.2 | GO:1902954 | regulation of early endosome to recycling endosome transport(GO:1902954) |
| 0.2 | 0.8 | GO:0003068 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.2 | 1.4 | GO:0043247 | telomere maintenance in response to DNA damage(GO:0043247) |
| 0.2 | 0.6 | GO:1904526 | regulation of microtubule binding(GO:1904526) |
| 0.2 | 1.9 | GO:0006754 | ATP biosynthetic process(GO:0006754) |
| 0.2 | 0.6 | GO:0044336 | canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336) |
| 0.2 | 5.0 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.2 | 0.9 | GO:0090136 | epithelial cell-cell adhesion(GO:0090136) |
| 0.1 | 0.3 | GO:0090230 | regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234) |
| 0.1 | 4.7 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.1 | 0.7 | GO:0061101 | neuroendocrine cell differentiation(GO:0061101) |
| 0.1 | 1.9 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 0.1 | 0.8 | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) |
| 0.1 | 4.1 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.1 | 4.2 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 2.3 | GO:0060065 | uterus development(GO:0060065) |
| 0.1 | 0.4 | GO:0061536 | glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537) |
| 0.1 | 20.1 | GO:0001649 | osteoblast differentiation(GO:0001649) |
| 0.1 | 1.4 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.1 | 1.9 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 0.2 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.1 | 0.7 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.1 | 1.0 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) |
| 0.1 | 1.0 | GO:0033599 | regulation of mammary gland epithelial cell proliferation(GO:0033599) |
| 0.1 | 3.0 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.1 | 0.7 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.1 | 0.6 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.1 | 1.3 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.1 | 0.4 | GO:0006817 | phosphate ion transport(GO:0006817) |
| 0.1 | 1.8 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397) |
| 0.1 | 2.7 | GO:0043304 | regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304) |
| 0.1 | 1.1 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.1 | 2.3 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
| 0.1 | 1.1 | GO:0046337 | phosphatidylethanolamine metabolic process(GO:0046337) |
| 0.1 | 6.3 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.1 | 0.5 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.1 | 0.5 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
| 0.1 | 0.2 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.1 | 0.4 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
| 0.1 | 0.3 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.1 | 7.4 | GO:0070585 | protein localization to mitochondrion(GO:0070585) |
| 0.1 | 0.5 | GO:0048703 | embryonic viscerocranium morphogenesis(GO:0048703) |
| 0.1 | 0.4 | GO:0007549 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.1 | 0.7 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
| 0.1 | 0.2 | GO:0048496 | maintenance of organ identity(GO:0048496) |
| 0.0 | 0.6 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.0 | 1.5 | GO:0046579 | positive regulation of Ras protein signal transduction(GO:0046579) |
| 0.0 | 1.0 | GO:0050766 | positive regulation of phagocytosis(GO:0050766) |
| 0.0 | 2.8 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 0.2 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.0 | 0.2 | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain(GO:0050966) |
| 0.0 | 0.1 | GO:1902668 | negative regulation of axon guidance(GO:1902668) |
| 0.0 | 0.5 | GO:0032480 | negative regulation of type I interferon production(GO:0032480) |
| 0.0 | 0.0 | GO:0042418 | epinephrine metabolic process(GO:0042414) epinephrine biosynthetic process(GO:0042418) |
| 0.0 | 0.4 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.0 | 0.1 | GO:0033563 | dorsal/ventral axon guidance(GO:0033563) negative regulation of synapse assembly(GO:0051964) |
| 0.0 | 0.2 | GO:0061141 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) lung ciliated cell differentiation(GO:0061141) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.0 | 0.7 | GO:0009712 | catecholamine metabolic process(GO:0006584) catechol-containing compound metabolic process(GO:0009712) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.6 | 61.8 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 12.1 | 48.3 | GO:0071920 | cleavage body(GO:0071920) |
| 10.9 | 152.8 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 10.8 | 75.5 | GO:0016272 | prefoldin complex(GO:0016272) |
| 9.7 | 77.9 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 9.2 | 100.7 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 8.2 | 24.7 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 8.2 | 49.0 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 8.2 | 106.0 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 8.0 | 23.9 | GO:1990723 | cytoplasmic periphery of the nuclear pore complex(GO:1990723) |
| 7.8 | 46.8 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 7.7 | 38.6 | GO:0045273 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 7.5 | 74.8 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 7.3 | 65.8 | GO:0042382 | paraspeckles(GO:0042382) |
| 7.1 | 28.6 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 6.8 | 61.1 | GO:1990630 | IRE1-RACK1-PP2A complex(GO:1990630) |
| 6.6 | 26.5 | GO:0071159 | NF-kappaB complex(GO:0071159) |
| 6.6 | 59.4 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 6.5 | 26.1 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
| 6.3 | 25.1 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 6.2 | 24.8 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 6.1 | 30.5 | GO:0070470 | plasma membrane respiratory chain complex I(GO:0045272) plasma membrane respiratory chain(GO:0070470) |
| 5.8 | 40.6 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 5.2 | 25.9 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 5.0 | 54.6 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 4.8 | 14.4 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 4.8 | 14.3 | GO:1903349 | omegasome membrane(GO:1903349) |
| 4.7 | 18.9 | GO:0070288 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
| 4.7 | 23.4 | GO:0089701 | U2AF(GO:0089701) |
| 4.7 | 130.5 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 4.6 | 46.3 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 4.5 | 72.7 | GO:0034709 | methylosome(GO:0034709) |
| 4.4 | 17.4 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 4.4 | 256.8 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 4.3 | 29.8 | GO:0016589 | NURF complex(GO:0016589) |
| 4.2 | 12.5 | GO:0032419 | extrinsic component of lysosome membrane(GO:0032419) |
| 4.1 | 16.6 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 4.0 | 56.5 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 4.0 | 56.2 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 3.8 | 11.5 | GO:0061574 | ASAP complex(GO:0061574) |
| 3.8 | 48.8 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 3.7 | 40.6 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 3.6 | 10.8 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 3.6 | 10.8 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 3.5 | 156.0 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 3.5 | 27.6 | GO:0000796 | condensin complex(GO:0000796) |
| 3.4 | 10.2 | GO:0035370 | UBC13-UEV1A complex(GO:0035370) |
| 3.3 | 9.8 | GO:0034657 | GID complex(GO:0034657) |
| 3.2 | 58.1 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 3.2 | 25.5 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 3.2 | 12.7 | GO:0071817 | MMXD complex(GO:0071817) |
| 3.1 | 28.2 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 3.1 | 21.9 | GO:0005687 | U4 snRNP(GO:0005687) |
| 3.0 | 27.3 | GO:0097452 | GAIT complex(GO:0097452) |
| 2.9 | 8.8 | GO:0044393 | microspike(GO:0044393) |
| 2.9 | 11.5 | GO:1990246 | uniplex complex(GO:1990246) |
| 2.9 | 28.7 | GO:0097255 | R2TP complex(GO:0097255) |
| 2.9 | 34.4 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 2.9 | 14.3 | GO:0000835 | ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836) |
| 2.8 | 56.4 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 2.7 | 35.6 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 2.7 | 19.1 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 2.7 | 19.0 | GO:0072588 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661) |
| 2.7 | 13.5 | GO:0032301 | MutSalpha complex(GO:0032301) MutSbeta complex(GO:0032302) |
| 2.7 | 32.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 2.7 | 26.9 | GO:0070552 | BRISC complex(GO:0070552) |
| 2.7 | 32.0 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 2.6 | 18.4 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 2.6 | 28.5 | GO:0005638 | lamin filament(GO:0005638) |
| 2.6 | 12.9 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 2.6 | 23.1 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 2.5 | 32.9 | GO:0042555 | MCM complex(GO:0042555) |
| 2.5 | 72.9 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 2.4 | 26.8 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 2.4 | 19.4 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 2.4 | 23.5 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 2.3 | 9.4 | GO:0031415 | NatA complex(GO:0031415) |
| 2.3 | 18.6 | GO:0031371 | ubiquitin conjugating enzyme complex(GO:0031371) |
| 2.3 | 6.9 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
| 2.3 | 244.1 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 2.2 | 6.7 | GO:0030289 | protein phosphatase 4 complex(GO:0030289) |
| 2.2 | 11.0 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 2.2 | 50.3 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 2.2 | 26.0 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 2.1 | 21.1 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 2.1 | 22.8 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 2.1 | 8.3 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 2.1 | 8.2 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 2.0 | 16.4 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
| 2.0 | 6.1 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 2.0 | 6.1 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 2.0 | 6.0 | GO:0016938 | kinesin I complex(GO:0016938) |
| 2.0 | 18.0 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 2.0 | 43.6 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 2.0 | 15.7 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 1.9 | 23.3 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 1.9 | 16.9 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 1.9 | 7.4 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 1.8 | 24.0 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 1.8 | 22.0 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 1.8 | 39.3 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 1.8 | 5.3 | GO:0098799 | outer mitochondrial membrane protein complex(GO:0098799) |
| 1.7 | 28.3 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 1.6 | 4.9 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 1.6 | 105.1 | GO:0015935 | small ribosomal subunit(GO:0015935) |
| 1.6 | 6.4 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 1.6 | 14.0 | GO:0090543 | Flemming body(GO:0090543) |
| 1.5 | 81.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 1.5 | 6.1 | GO:1990423 | RZZ complex(GO:1990423) |
| 1.5 | 6.1 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 1.5 | 9.1 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 1.5 | 10.6 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 1.5 | 31.4 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 1.5 | 87.5 | GO:0005840 | ribosome(GO:0005840) |
| 1.5 | 25.1 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 1.5 | 51.4 | GO:0000502 | proteasome complex(GO:0000502) |
| 1.4 | 17.0 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 1.4 | 12.5 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 1.4 | 42.7 | GO:0030057 | desmosome(GO:0030057) |
| 1.4 | 8.2 | GO:0070545 | PeBoW complex(GO:0070545) |
| 1.3 | 6.6 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 1.3 | 22.5 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 1.3 | 5.3 | GO:0071986 | Ragulator complex(GO:0071986) |
| 1.3 | 15.7 | GO:0005869 | dynactin complex(GO:0005869) |
| 1.3 | 16.9 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 1.3 | 7.7 | GO:0005816 | spindle pole body(GO:0005816) |
| 1.3 | 34.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 1.3 | 3.8 | GO:0034455 | t-UTP complex(GO:0034455) |
| 1.3 | 27.6 | GO:0005684 | U2-type spliceosomal complex(GO:0005684) |
| 1.2 | 49.9 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 1.2 | 63.1 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 1.2 | 12.1 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 1.2 | 32.3 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 1.2 | 9.5 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 1.1 | 8.0 | GO:1990635 | proximal dendrite(GO:1990635) |
| 1.1 | 31.9 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 1.1 | 12.4 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 1.1 | 14.4 | GO:0030677 | ribonuclease P complex(GO:0030677) |
| 1.1 | 7.6 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 1.1 | 23.6 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 1.0 | 5.2 | GO:0032044 | DSIF complex(GO:0032044) |
| 1.0 | 9.2 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 1.0 | 3.0 | GO:0043259 | laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260) |
| 1.0 | 47.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 1.0 | 6.9 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 1.0 | 25.7 | GO:0031305 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.9 | 4.7 | GO:0035061 | interchromatin granule(GO:0035061) |
| 0.9 | 7.5 | GO:0070187 | telosome(GO:0070187) |
| 0.9 | 2.8 | GO:0005592 | collagen type XI trimer(GO:0005592) |
| 0.9 | 6.3 | GO:1990752 | microtubule end(GO:1990752) |
| 0.9 | 4.5 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.9 | 9.7 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.8 | 4.1 | GO:0031905 | early endosome lumen(GO:0031905) |
| 0.8 | 10.7 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.8 | 4.9 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.8 | 8.7 | GO:0010369 | chromocenter(GO:0010369) |
| 0.8 | 7.8 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.8 | 26.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.8 | 12.1 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.8 | 15.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.7 | 11.2 | GO:0097433 | dense body(GO:0097433) |
| 0.7 | 2.1 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.7 | 14.0 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.7 | 55.3 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.7 | 42.7 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.7 | 20.2 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.7 | 20.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.7 | 7.8 | GO:0033202 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.7 | 37.1 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.6 | 1.3 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 0.6 | 43.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.6 | 2.5 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.6 | 30.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.6 | 2.9 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.6 | 7.6 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.6 | 14.0 | GO:0005844 | polysome(GO:0005844) |
| 0.6 | 84.2 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.5 | 3.7 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.5 | 132.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.5 | 45.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.5 | 5.0 | GO:0032059 | bleb(GO:0032059) |
| 0.5 | 2.9 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.5 | 43.4 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.4 | 1.3 | GO:0020016 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
| 0.4 | 8.0 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.4 | 4.3 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.4 | 2.6 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.4 | 9.1 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.4 | 4.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.4 | 1.3 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.4 | 18.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.4 | 8.2 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.4 | 52.6 | GO:0030496 | midbody(GO:0030496) |
| 0.4 | 19.6 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.4 | 9.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.4 | 1.9 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
| 0.4 | 15.3 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.4 | 10.8 | GO:0005902 | microvillus(GO:0005902) |
| 0.4 | 17.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.4 | 41.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.4 | 7.9 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.4 | 37.9 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.3 | 1.7 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.3 | 3.2 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.3 | 4.7 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.3 | 3.5 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.3 | 2.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.3 | 13.2 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.3 | 15.6 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.3 | 9.4 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.3 | 0.3 | GO:0098798 | mitochondrial protein complex(GO:0098798) |
| 0.3 | 4.1 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.3 | 26.0 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.3 | 0.8 | GO:0070195 | growth hormone receptor complex(GO:0070195) |
| 0.3 | 3.0 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.2 | 1.2 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.2 | 4.9 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.2 | 4.3 | GO:0030120 | vesicle coat(GO:0030120) |
| 0.2 | 2.5 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.2 | 11.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.2 | 3.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.2 | 5.0 | GO:0002102 | podosome(GO:0002102) |
| 0.2 | 10.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 1.4 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.2 | 2.0 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.2 | 2.6 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.2 | 5.6 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.2 | 19.4 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.2 | 1.3 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.2 | 11.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 1.0 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 4.6 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.1 | 0.5 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 6.5 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 0.5 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 8.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 5.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 0.4 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.1 | 3.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 1.6 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 0.6 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.1 | 2.2 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.1 | 0.7 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 0.3 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.1 | 11.8 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.1 | 7.4 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 0.1 | 2.8 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 0.7 | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908) |
| 0.1 | 1.7 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 2.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 4.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 1.3 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.1 | 1.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 0.3 | GO:0032449 | CBM complex(GO:0032449) lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 14.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 0.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.5 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.0 | 0.4 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 0.5 | GO:0044447 | axoneme part(GO:0044447) |
| 0.0 | 43.1 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 0.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.7 | 58.8 | GO:0004001 | adenosine kinase activity(GO:0004001) |
| 14.1 | 56.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 12.7 | 63.5 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
| 11.7 | 46.9 | GO:0033677 | DNA/RNA helicase activity(GO:0033677) |
| 9.6 | 57.7 | GO:0016435 | rRNA (guanine) methyltransferase activity(GO:0016435) |
| 9.5 | 75.9 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 9.4 | 28.3 | GO:0080023 | 3R-hydroxyacyl-CoA dehydratase activity(GO:0080023) |
| 8.8 | 26.5 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 8.7 | 60.9 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 8.3 | 24.8 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 7.7 | 38.6 | GO:0000104 | succinate dehydrogenase activity(GO:0000104) |
| 7.4 | 22.3 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
| 7.3 | 36.5 | GO:0008160 | protein tyrosine phosphatase activator activity(GO:0008160) |
| 7.1 | 42.3 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 7.0 | 20.9 | GO:0043035 | chromatin insulator sequence binding(GO:0043035) |
| 6.9 | 27.6 | GO:0035243 | protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
| 6.8 | 20.4 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 6.6 | 184.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 6.6 | 59.4 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 6.2 | 24.8 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 6.1 | 61.1 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 5.7 | 22.8 | GO:0070404 | NADH binding(GO:0070404) |
| 5.5 | 16.6 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 5.3 | 31.9 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 5.3 | 15.9 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 5.2 | 15.7 | GO:0047631 | ADP-ribose diphosphatase activity(GO:0047631) |
| 5.2 | 57.3 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 5.2 | 15.6 | GO:0098808 | mRNA cap binding(GO:0098808) |
| 5.1 | 276.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 5.1 | 20.4 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) |
| 5.1 | 15.2 | GO:0052836 | inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 5.0 | 25.2 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 4.9 | 48.6 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 4.8 | 14.4 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 4.6 | 32.4 | GO:0035368 | selenocysteine insertion sequence binding(GO:0035368) |
| 4.6 | 41.3 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 4.5 | 17.9 | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 4.4 | 13.2 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 4.4 | 13.1 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 4.4 | 17.4 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 4.3 | 46.8 | GO:0070181 | small ribosomal subunit rRNA binding(GO:0070181) |
| 4.2 | 25.4 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 4.2 | 16.7 | GO:0004853 | uroporphyrinogen decarboxylase activity(GO:0004853) |
| 4.1 | 16.5 | GO:0004738 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 4.1 | 24.7 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 3.8 | 11.4 | GO:0004766 | spermidine synthase activity(GO:0004766) |
| 3.7 | 175.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 3.3 | 16.7 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 3.3 | 26.5 | GO:0050733 | RS domain binding(GO:0050733) |
| 3.3 | 9.8 | GO:0004639 | phosphoribosylaminoimidazole carboxylase activity(GO:0004638) phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639) |
| 3.2 | 44.5 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 3.2 | 22.3 | GO:0008079 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 3.1 | 9.3 | GO:0098918 | structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973) |
| 3.1 | 9.3 | GO:0035605 | peptidyl-cysteine S-nitrosylase activity(GO:0035605) |
| 3.1 | 12.3 | GO:0043515 | kinetochore binding(GO:0043515) |
| 3.1 | 24.6 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 3.1 | 24.4 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 3.0 | 47.9 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 2.9 | 20.5 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 2.9 | 11.6 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 2.9 | 8.6 | GO:0070361 | mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364) |
| 2.8 | 19.7 | GO:0051021 | GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022) |
| 2.8 | 2.8 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 2.7 | 24.7 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 2.7 | 11.0 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 2.7 | 19.0 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 2.7 | 27.1 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 2.7 | 13.5 | GO:0032143 | double-strand/single-strand DNA junction binding(GO:0000406) single thymine insertion binding(GO:0032143) dinucleotide repeat insertion binding(GO:0032181) |
| 2.6 | 20.7 | GO:0004308 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 2.5 | 32.6 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 2.5 | 12.5 | GO:0051998 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 2.5 | 488.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.4 | 34.2 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 2.4 | 43.7 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 2.4 | 18.9 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 2.4 | 82.5 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 2.3 | 39.8 | GO:0016004 | phospholipase activator activity(GO:0016004) |
| 2.3 | 32.5 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 2.3 | 18.4 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 2.3 | 9.1 | GO:0005471 | ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207) |
| 2.2 | 13.5 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 2.2 | 19.9 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 2.2 | 10.8 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 2.2 | 17.3 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 2.2 | 12.9 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 2.1 | 134.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 2.1 | 10.6 | GO:0015319 | sodium:inorganic phosphate symporter activity(GO:0015319) |
| 2.1 | 6.4 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 2.1 | 12.4 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 2.1 | 8.3 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 2.0 | 3.9 | GO:0016422 | mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422) |
| 1.9 | 7.7 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 1.9 | 17.1 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 1.9 | 51.1 | GO:0070628 | proteasome binding(GO:0070628) |
| 1.9 | 18.8 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 1.8 | 9.1 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 1.8 | 9.0 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 1.8 | 5.4 | GO:0008523 | sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) |
| 1.8 | 34.0 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 1.8 | 5.3 | GO:0031753 | endothelial differentiation G-protein coupled receptor binding(GO:0031753) Edg-2 lysophosphatidic acid receptor binding(GO:0031755) |
| 1.7 | 6.9 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 1.7 | 15.5 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 1.7 | 5.1 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 1.7 | 13.5 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 1.7 | 15.1 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 1.7 | 6.6 | GO:0004379 | glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107) |
| 1.6 | 8.1 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 1.6 | 12.5 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 1.6 | 6.2 | GO:0001884 | pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551) |
| 1.6 | 56.0 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 1.6 | 9.3 | GO:0030620 | U2 snRNA binding(GO:0030620) |
| 1.5 | 9.3 | GO:0051996 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 1.5 | 35.3 | GO:0005537 | mannose binding(GO:0005537) |
| 1.5 | 42.7 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 1.5 | 6.1 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 1.5 | 12.1 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 1.5 | 12.0 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 1.5 | 29.6 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 1.5 | 61.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 1.5 | 11.7 | GO:0015288 | porin activity(GO:0015288) |
| 1.5 | 7.3 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
| 1.5 | 52.6 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 1.4 | 17.3 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 1.4 | 48.4 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 1.4 | 14.2 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 1.4 | 5.7 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 1.4 | 9.9 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 1.4 | 72.3 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 1.4 | 4.1 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 1.4 | 52.1 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 1.4 | 67.8 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 1.3 | 33.2 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 1.3 | 31.8 | GO:0051430 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 1.3 | 10.5 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 1.3 | 3.9 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 1.3 | 37.9 | GO:0043022 | ribosome binding(GO:0043022) |
| 1.3 | 5.2 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 1.3 | 22.8 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 1.3 | 3.8 | GO:0071535 | RING-like zinc finger domain binding(GO:0071535) |
| 1.3 | 10.1 | GO:0004532 | exoribonuclease activity(GO:0004532) |
| 1.2 | 4.8 | GO:0005163 | nerve growth factor receptor binding(GO:0005163) |
| 1.2 | 11.9 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 1.2 | 9.5 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 1.2 | 19.9 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 1.2 | 4.7 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 1.1 | 3.4 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 1.1 | 21.1 | GO:0070717 | poly-purine tract binding(GO:0070717) |
| 1.1 | 7.7 | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) |
| 1.1 | 6.5 | GO:0015266 | protein channel activity(GO:0015266) |
| 1.1 | 8.6 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 1.1 | 6.4 | GO:0030911 | TPR domain binding(GO:0030911) |
| 1.1 | 8.6 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 1.1 | 13.8 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 1.1 | 42.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 1.1 | 7.4 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 1.0 | 12.6 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 1.0 | 4.2 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211) |
| 1.0 | 5.2 | GO:0051731 | polynucleotide 5'-hydroxyl-kinase activity(GO:0051731) |
| 1.0 | 34.0 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 1.0 | 9.2 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 1.0 | 8.1 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 1.0 | 7.1 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 1.0 | 4.0 | GO:0035473 | lipase binding(GO:0035473) |
| 1.0 | 24.7 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 1.0 | 36.5 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 1.0 | 6.9 | GO:0000150 | recombinase activity(GO:0000150) |
| 1.0 | 7.8 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.9 | 21.4 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.9 | 2.8 | GO:0055100 | adiponectin binding(GO:0055100) |
| 0.9 | 32.9 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.9 | 6.4 | GO:0044388 | small protein activating enzyme binding(GO:0044388) |
| 0.9 | 6.4 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.9 | 4.5 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.9 | 3.5 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.9 | 8.8 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 0.9 | 9.6 | GO:0097027 | ubiquitin-protein transferase activator activity(GO:0097027) |
| 0.9 | 2.6 | GO:0003985 | acetyl-CoA C-acetyltransferase activity(GO:0003985) |
| 0.9 | 4.3 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.9 | 4.3 | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532) |
| 0.9 | 76.8 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.8 | 48.4 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.8 | 10.9 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 0.8 | 4.2 | GO:0008410 | CoA-transferase activity(GO:0008410) |
| 0.8 | 51.2 | GO:0009055 | electron carrier activity(GO:0009055) |
| 0.8 | 3.3 | GO:0017018 | myosin phosphatase activity(GO:0017018) |
| 0.8 | 9.8 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 0.8 | 4.1 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
| 0.8 | 3.3 | GO:0016532 | superoxide dismutase copper chaperone activity(GO:0016532) |
| 0.8 | 2.4 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.8 | 5.6 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.8 | 4.0 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.8 | 37.9 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.8 | 14.2 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.8 | 3.1 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.8 | 3.1 | GO:0003976 | UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976) |
| 0.8 | 54.7 | GO:0019003 | GDP binding(GO:0019003) |
| 0.7 | 4.5 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.7 | 14.1 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.7 | 12.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.7 | 1.5 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.7 | 2.9 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.7 | 14.5 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.7 | 4.4 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.7 | 5.7 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.7 | 4.2 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.7 | 14.2 | GO:0070878 | primary miRNA binding(GO:0070878) |
| 0.7 | 2.0 | GO:0055077 | gap junction hemi-channel activity(GO:0055077) |
| 0.7 | 6.6 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.7 | 8.5 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.7 | 18.2 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.6 | 5.2 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.6 | 10.9 | GO:0052659 | inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659) |
| 0.6 | 13.2 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.6 | 9.9 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.6 | 16.0 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.6 | 25.8 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.6 | 3.1 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.6 | 9.8 | GO:0015114 | phosphate ion transmembrane transporter activity(GO:0015114) |
| 0.6 | 12.2 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.6 | 20.1 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.6 | 3.0 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.6 | 4.2 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.6 | 3.5 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) |
| 0.6 | 2.9 | GO:0071253 | connexin binding(GO:0071253) |
| 0.6 | 9.5 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.6 | 13.3 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.6 | 2.8 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
| 0.6 | 2.2 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.5 | 12.0 | GO:0046961 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.5 | 5.5 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
| 0.5 | 2.2 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.5 | 15.2 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.5 | 3.7 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.5 | 13.8 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.5 | 11.5 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.5 | 3.9 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.5 | 5.3 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.5 | 7.0 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.5 | 9.8 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.5 | 14.0 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.5 | 7.8 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.4 | 25.8 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.4 | 3.6 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.4 | 4.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.4 | 1.7 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
| 0.4 | 1.3 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.4 | 4.1 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.4 | 2.9 | GO:0036435 | K48-linked polyubiquitin binding(GO:0036435) |
| 0.4 | 3.3 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.4 | 4.0 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 0.4 | 3.5 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.4 | 21.7 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.4 | 4.6 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.4 | 3.0 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.4 | 61.8 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.4 | 13.9 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.4 | 5.0 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
| 0.4 | 6.7 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.3 | 1.4 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.3 | 2.7 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.3 | 5.0 | GO:0033549 | MAP kinase phosphatase activity(GO:0033549) |
| 0.3 | 5.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857) |
| 0.3 | 7.9 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.3 | 0.7 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.3 | 2.9 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.3 | 0.6 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.3 | 8.3 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.3 | 12.4 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.3 | 1.4 | GO:0031544 | peptidyl-proline 3-dioxygenase activity(GO:0031544) |
| 0.3 | 59.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.3 | 1.3 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
| 0.2 | 4.7 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.2 | 3.5 | GO:0043125 | ErbB-3 class receptor binding(GO:0043125) |
| 0.2 | 2.7 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.2 | 1.7 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.2 | 1.2 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.2 | 6.1 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.2 | 10.8 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.2 | 2.1 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.2 | 3.1 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.2 | 1.6 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.2 | 3.0 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.2 | 8.9 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 3.1 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.2 | 1.8 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.2 | 5.1 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.2 | 18.9 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.2 | 0.8 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 0.2 | 1.9 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.2 | 1.1 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.2 | 3.0 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.2 | 7.7 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.2 | 3.9 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.2 | 23.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 0.9 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.2 | 4.0 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.2 | 6.6 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.2 | 17.7 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.2 | 32.6 | GO:0008201 | heparin binding(GO:0008201) |
| 0.2 | 0.9 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.2 | 10.1 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.2 | 10.9 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.2 | 1.8 | GO:0044213 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.2 | 1.8 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.2 | 1.7 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.2 | 0.5 | GO:0047756 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) chondroitin 4-sulfotransferase activity(GO:0047756) |
| 0.2 | 1.4 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.2 | 2.8 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.2 | 3.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.2 | 1.5 | GO:0035251 | UDP-glucosyltransferase activity(GO:0035251) |
| 0.1 | 2.2 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 4.6 | GO:0090484 | drug transporter activity(GO:0090484) |
| 0.1 | 0.4 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 0.1 | 0.8 | GO:0089720 | caspase binding(GO:0089720) |
| 0.1 | 0.8 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 0.7 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.1 | 7.5 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.1 | 0.8 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 58.3 | GO:0003779 | actin binding(GO:0003779) |
| 0.1 | 3.7 | GO:0044390 | ubiquitin-like protein conjugating enzyme binding(GO:0044390) |
| 0.1 | 1.0 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.1 | 3.3 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 2.7 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 1.0 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
| 0.1 | 4.5 | GO:0016209 | antioxidant activity(GO:0016209) |
| 0.1 | 1.0 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 2.3 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.1 | 9.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 1.1 | GO:0005381 | iron ion transmembrane transporter activity(GO:0005381) |
| 0.1 | 0.6 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.1 | 1.5 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.1 | 3.4 | GO:0008375 | acetylglucosaminyltransferase activity(GO:0008375) |
| 0.1 | 0.8 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.1 | 17.3 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.1 | 1.4 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 3.0 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.1 | 7.8 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 0.4 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.1 | 9.8 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.4 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 1.0 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.0 | 1.7 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 0.5 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 0.6 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 3.0 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.1 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.0 | 1.3 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.1 | GO:0048495 | Roundabout binding(GO:0048495) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 99.7 | PID ARF 3PATHWAY | Arf1 pathway |
| 3.1 | 9.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 2.6 | 108.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 2.4 | 77.8 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 2.0 | 121.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 1.9 | 109.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.6 | 81.3 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 1.6 | 40.6 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 1.5 | 8.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 1.4 | 23.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 1.3 | 10.3 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 1.2 | 32.7 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 1.1 | 63.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.1 | 40.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 1.0 | 15.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 1.0 | 29.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.9 | 24.8 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.8 | 17.0 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.8 | 38.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.8 | 56.8 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.7 | 87.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.7 | 37.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.7 | 52.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 22.4 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.6 | 20.2 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.6 | 68.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.6 | 15.5 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.5 | 33.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.4 | 14.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.4 | 18.2 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.4 | 12.3 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.4 | 2.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.4 | 10.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.4 | 7.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.4 | 8.0 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.3 | 6.2 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.3 | 10.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 3.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.3 | 10.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 10.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 8.9 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.2 | 14.1 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.2 | 6.8 | PID FOXO PATHWAY | FoxO family signaling |
| 0.2 | 3.7 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.2 | 5.8 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 6.0 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.2 | 9.3 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.2 | 5.4 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.2 | 5.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 4.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 10.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.3 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 1.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 2.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 1.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 3.5 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 2.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 2.1 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 2.5 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 0.9 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.1 | 1.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 1.1 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.1 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 1.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.0 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.1 | 108.6 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 6.0 | 65.8 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 5.4 | 374.6 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 5.4 | 456.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 3.8 | 22.9 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 3.5 | 259.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 3.3 | 135.6 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 3.2 | 67.7 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 3.1 | 30.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 3.0 | 36.5 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 3.0 | 89.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 2.7 | 357.1 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 2.4 | 58.8 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 2.4 | 19.3 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 2.4 | 50.3 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 2.4 | 57.4 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 2.3 | 49.3 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 2.3 | 34.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 2.3 | 9.1 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 2.1 | 27.2 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 2.0 | 34.4 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 2.0 | 22.2 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 2.0 | 54.0 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 2.0 | 31.9 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 2.0 | 31.7 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 2.0 | 29.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 1.9 | 14.9 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 1.8 | 97.1 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 1.8 | 47.9 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 1.8 | 47.4 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 1.7 | 25.9 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 1.7 | 51.4 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 1.7 | 64.6 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 1.7 | 23.7 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 1.6 | 68.1 | REACTOME MRNA SPLICING MINOR PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 1.6 | 70.6 | REACTOME INFLUENZA LIFE CYCLE | Genes involved in Influenza Life Cycle |
| 1.6 | 52.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 1.5 | 53.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 1.5 | 80.6 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 1.5 | 81.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 1.5 | 41.0 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 1.4 | 22.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 1.4 | 8.5 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 1.4 | 50.8 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 1.4 | 27.2 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 1.3 | 22.4 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 1.3 | 6.6 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 1.3 | 9.2 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 1.3 | 20.2 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.2 | 9.9 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 1.2 | 18.1 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 1.2 | 33.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 1.2 | 65.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.2 | 38.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.1 | 27.4 | REACTOME TRANSLATION | Genes involved in Translation |
| 1.1 | 9.1 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 1.1 | 3.4 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 1.1 | 20.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 1.1 | 23.3 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 1.1 | 19.3 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 1.1 | 19.1 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 1.0 | 10.1 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 1.0 | 24.7 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 1.0 | 19.3 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.9 | 7.5 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.9 | 3.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.9 | 18.9 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.9 | 5.2 | REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.8 | 48.7 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.7 | 5.0 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.7 | 31.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.7 | 10.5 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.7 | 57.0 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.7 | 21.5 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.6 | 96.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.6 | 11.7 | REACTOME HOST INTERACTIONS OF HIV FACTORS | Genes involved in Host Interactions of HIV factors |
| 0.6 | 15.1 | REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.6 | 5.2 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.5 | 18.5 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.5 | 16.0 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.5 | 13.1 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.5 | 14.8 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.4 | 5.6 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.4 | 6.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.4 | 2.5 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.4 | 14.9 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.4 | 9.4 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.4 | 23.6 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.4 | 12.9 | REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.4 | 3.8 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.4 | 24.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.4 | 3.5 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.3 | 1.7 | REACTOME ADP SIGNALLING THROUGH P2RY1 | Genes involved in ADP signalling through P2Y purinoceptor 1 |
| 0.3 | 0.3 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.3 | 2.5 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.3 | 12.2 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.3 | 10.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.3 | 17.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.3 | 8.6 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.2 | 5.9 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.2 | 25.1 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.2 | 2.4 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.2 | 4.1 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.2 | 8.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.2 | 10.1 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 2.3 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 3.8 | REACTOME GLOBAL GENOMIC NER GG NER | Genes involved in Global Genomic NER (GG-NER) |
| 0.2 | 0.9 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.2 | 1.1 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 10.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 3.6 | REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |
| 0.2 | 4.4 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.2 | 5.7 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.2 | 2.1 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 3.5 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.2 | 3.3 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.2 | 4.4 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.2 | 1.8 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.2 | 2.9 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 5.0 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 12.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 3.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 5.0 | REACTOME SIGNALING BY NOTCH1 | Genes involved in Signaling by NOTCH1 |
| 0.1 | 2.6 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.1 | 5.7 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 0.6 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 2.7 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.1 | 2.5 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 3.0 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 0.3 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 0.3 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.4 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.2 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 1.0 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 1.0 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.4 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.2 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |