Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation
Downloads

Results for ZBTB16

Z-value: 4.24

Motif logo

logo of

Transcription factors associated with ZBTB16

Gene Symbol Gene ID Gene Info
ZBTB16
ENSG00000109906.15 ZBTB16

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZBTB16hg38_v1_chr11_+_114059702_114059749-0.484.4e-14Click!

Activity profile of ZBTB16 motif

Sorted Z-values of ZBTB16 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB16

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_41286011 46.04 ENST00000661438.1
ENSG00000285920.2
novel protein
chr10_+_60778331 23.06 ENST00000519078.6
ENST00000316629.8
ENST00000395284.8
CDK1
cyclin dependent kinase 1
chr5_+_160421847 13.52 ENST00000352433.10
ENST00000517480.1
ENST00000520452.5
ENST00000393964.1
PTTG1
PTTG1 regulator of sister chromatid separation, securin
chrX_+_119468436 9.07 ENST00000317881.9
SLC25A5
solute carrier family 25 member 5
chr15_+_75336078 9.02 ENST00000567377.5
ENST00000562789.5
ENST00000568301.1
COMMD4
COMM domain containing 4
chr1_-_246193727 9.01 ENST00000391836.3
SMYD3
SET and MYND domain containing 3
chr15_+_75336053 8.29 ENST00000564815.5
ENST00000338995.10
ENST00000267935.13
COMMD4
COMM domain containing 4
chr12_+_118016690 8.27 ENST00000537315.5
ENST00000454402.7
ENST00000484086.6
ENST00000420967.5
ENST00000392542.6
ENST00000535092.1
RFC5
replication factor C subunit 5
chr16_-_85688912 8.25 ENST00000253462.8
GINS2
GINS complex subunit 2
chr15_+_75336018 7.99 ENST00000567195.5
COMMD4
COMM domain containing 4
chr1_+_156126160 7.48 ENST00000448611.6
ENST00000368297.5
LMNA
lamin A/C
chr15_-_55270280 7.23 ENST00000564609.5
RAB27A
RAB27A, member RAS oncogene family
chr1_-_15809348 7.04 ENST00000483273.2
UQCRHL
ubiquinol-cytochrome c reductase hinge protein like
chr12_+_49227874 6.17 ENST00000541364.5
TUBA1C
tubulin alpha 1c
chr19_+_35651245 6.07 ENST00000590618.1
COX6B1
cytochrome c oxidase subunit 6B1
chr4_+_73436244 5.97 ENST00000226359.2
AFP
alpha fetoprotein
chr19_-_45691771 5.91 ENST00000588599.5
ENST00000585392.2
ENST00000590212.1
ENST00000587367.5
ENST00000391932.7
ENST00000342669.8
SNRPD2
small nuclear ribonucleoprotein D2 polypeptide
chrX_-_47659128 5.74 ENST00000333119.7
ENST00000335890.3
UXT
ubiquitously expressed prefoldin like chaperone
chr4_+_73436198 5.61 ENST00000395792.7
AFP
alpha fetoprotein
chr16_+_14632906 5.47 ENST00000563971.5
ENST00000562442.5
ENST00000261658.7
BFAR
bifunctional apoptosis regulator
chr13_+_75549734 5.43 ENST00000563635.5
ENST00000377595.8
ENSG00000261553.5
UCHL3
novel transcript
ubiquitin C-terminal hydrolase L3
chr11_+_112025968 5.37 ENST00000680411.1
DLAT
dihydrolipoamide S-acetyltransferase
chr12_-_26937937 5.23 ENST00000538727.5
ENST00000261191.12
INTS13
integrator complex subunit 13
chr15_-_55270383 5.06 ENST00000396307.6
RAB27A
RAB27A, member RAS oncogene family
chr12_-_75511594 4.79 ENST00000438169.6
ENST00000229214.9
KRR1
KRR1 small subunit processome component homolog
chr1_+_100266195 4.74 ENST00000370128.9
ENST00000260563.4
RTCA
RNA 3'-terminal phosphate cyclase
chr22_-_35840218 4.49 ENST00000414461.6
ENST00000416721.6
ENST00000449924.6
ENST00000262829.11
ENST00000397305.3
RBFOX2
RNA binding fox-1 homolog 2
chr16_-_20806431 4.38 ENST00000357967.9
ENST00000300005.7
ENST00000569729.5
ERI2
ERI1 exoribonuclease family member 2
chrX_-_23907887 4.30 ENST00000379226.9
APOO
apolipoprotein O
chr20_+_32819942 4.14 ENST00000375571.6
MAPRE1
microtubule associated protein RP/EB family member 1
chr3_-_165837412 4.11 ENST00000479451.5
ENST00000488954.1
ENST00000264381.8
BCHE
butyrylcholinesterase
chr1_-_11099830 4.03 ENST00000304457.11
ENST00000376936.9
EXOSC10
exosome component 10
chr17_-_41982321 3.96 ENST00000587727.6
DNAJC7
DnaJ heat shock protein family (Hsp40) member C7
chr11_-_95910665 3.82 ENST00000674610.1
ENST00000675660.1
MTMR2
myotubularin related protein 2
chr12_+_32679269 3.78 ENST00000358214.9
ENST00000553257.6
ENST00000549701.6
ENST00000266481.10
ENST00000551476.5
ENST00000550154.5
ENST00000547312.5
ENST00000381000.8
ENST00000548750.5
DNM1L
dynamin 1 like
chr11_-_95910824 3.74 ENST00000674528.1
ENST00000675477.1
ENST00000675636.1
MTMR2
myotubularin related protein 2
chr11_-_95910748 3.70 ENST00000675933.1
MTMR2
myotubularin related protein 2
chr12_-_10909562 3.62 ENST00000390677.2
TAS2R13
taste 2 receptor member 13
chr8_-_121641424 3.57 ENST00000303924.5
HAS2
hyaluronan synthase 2
chr7_+_120951116 3.51 ENST00000431467.1
ING3
inhibitor of growth family member 3
chr12_+_32679200 3.50 ENST00000452533.6
ENST00000414834.6
DNM1L
dynamin 1 like
chr3_-_187139477 3.32 ENST00000455270.5
ENST00000296277.9
RPL39L
ribosomal protein L39 like
chr2_+_241350087 3.27 ENST00000451310.1
SEPTIN2
septin 2
chr19_+_20776292 3.17 ENST00000360204.5
ENST00000344519.10
ENST00000594534.5
ZNF66
zinc finger protein 66
chr5_-_9630351 3.16 ENST00000382492.4
TAS2R1
taste 2 receptor member 1
chr12_+_53442555 3.16 ENST00000549135.1
PRR13
proline rich 13
chr11_+_120385286 3.10 ENST00000532993.5
ARHGEF12
Rho guanine nucleotide exchange factor 12
chr2_-_187554351 3.10 ENST00000437725.5
ENST00000409676.5
ENST00000233156.9
ENST00000339091.8
ENST00000420747.1
TFPI
tissue factor pathway inhibitor
chr6_+_32844789 2.94 ENST00000414474.5
PSMB9
proteasome 20S subunit beta 9
chr4_-_139302460 2.91 ENST00000394223.2
ENST00000676245.1
NDUFC1
NADH:ubiquinone oxidoreductase subunit C1
chr4_-_139302516 2.83 ENST00000394228.5
ENST00000539387.5
NDUFC1
NADH:ubiquinone oxidoreductase subunit C1
chr4_+_73481737 2.81 ENST00000226355.5
AFM
afamin
chr4_+_37960397 2.59 ENST00000504686.2
PTTG2
pituitary tumor-transforming 2
chr10_+_5094405 2.57 ENST00000380554.5
AKR1C3
aldo-keto reductase family 1 member C3
chr12_-_68302872 2.57 ENST00000539972.5
MDM1
Mdm1 nuclear protein
chr16_+_81037187 2.49 ENST00000564241.5
ENST00000565237.1
ATMIN
ATM interactor
chr5_+_156850292 2.49 ENST00000522232.3
PPP1R2B
PPP1R2 family member B
chr10_+_8054808 2.41 ENST00000346208.4
GATA3
GATA binding protein 3
chr16_-_18896874 2.40 ENST00000565324.5
ENST00000561947.5
SMG1
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
chr1_+_75786246 2.39 ENST00000319942.8
RABGGTB
Rab geranylgeranyltransferase subunit beta
chr8_-_33513077 2.38 ENST00000360742.9
ENST00000523305.1
ENST00000431156.7
ENST00000613904.1
TTI2
TELO2 interacting protein 2
chr6_+_73461578 2.37 ENST00000415954.6
ENST00000681204.1
ENST00000680686.1
ENST00000521156.6
ENST00000498286.6
ENST00000370305.5
ENST00000370300.8
MTO1
mitochondrial tRNA translation optimization 1
chr9_-_128191878 2.34 ENST00000538431.5
CIZ1
CDKN1A interacting zinc finger protein 1
chr1_-_114749900 2.31 ENST00000438362.6
CSDE1
cold shock domain containing E1
chr6_+_26272923 2.27 ENST00000377733.4
H2BC10
H2B clustered histone 10
chr2_-_210303608 2.27 ENST00000341685.8
MYL1
myosin light chain 1
chr9_+_5890872 2.26 ENST00000381477.8
ENST00000381476.5
ENST00000381471.1
MLANA
melan-A
chr16_+_24537693 2.22 ENST00000564314.5
ENST00000567686.5
RBBP6
RB binding protein 6, ubiquitin ligase
chr19_+_21082224 2.16 ENST00000620627.1
ZNF714
zinc finger protein 714
chr17_-_18363504 2.12 ENST00000583780.1
ENST00000316694.8
ENST00000352886.10
SHMT1
serine hydroxymethyltransferase 1
chr16_-_8975320 2.04 ENST00000673704.1
USP7
ubiquitin specific peptidase 7
chr1_+_192636121 1.97 ENST00000543215.5
ENST00000391995.7
RGS13
regulator of G protein signaling 13
chr2_-_241617464 1.97 ENST00000402545.5
ENST00000402136.5
THAP4
THAP domain containing 4
chr9_-_114074969 1.94 ENST00000466610.6
AMBP
alpha-1-microglobulin/bikunin precursor
chr3_-_138594319 1.91 ENST00000489254.5
ENST00000474781.5
ENST00000462419.5
CEP70
centrosomal protein 70
chr17_-_39451243 1.91 ENST00000300651.11
ENST00000394287.7
MED1
mediator complex subunit 1
chr4_-_98929092 1.85 ENST00000280892.10
ENST00000511644.5
ENST00000504432.5
ENST00000450253.7
ENST00000505992.1
EIF4E
eukaryotic translation initiation factor 4E
chr10_-_32935511 1.68 ENST00000423113.5
ITGB1
integrin subunit beta 1
chr3_-_138594129 1.64 ENST00000485115.1
ENST00000484888.5
ENST00000468900.5
ENST00000481834.5
ENST00000264982.8
CEP70
centrosomal protein 70
chr7_-_16833411 1.61 ENST00000412973.1
AGR2
anterior gradient 2, protein disulphide isomerase family member
chr11_+_67583803 1.60 ENST00000398606.10
GSTP1
glutathione S-transferase pi 1
chr8_-_73293616 1.58 ENST00000352983.7
ENST00000396467.5
RPL7
ribosomal protein L7
chr2_-_177263800 1.56 ENST00000397063.8
ENST00000421929.5
NFE2L2
nuclear factor, erythroid 2 like 2
chr10_+_8054668 1.54 ENST00000379328.9
GATA3
GATA binding protein 3
chr3_-_120647018 1.51 ENST00000475447.2
HGD
homogentisate 1,2-dioxygenase
chr13_-_75366973 1.44 ENST00000648194.1
TBC1D4
TBC1 domain family member 4
chr22_-_35840577 1.41 ENST00000405409.6
RBFOX2
RNA binding fox-1 homolog 2
chr13_+_102656933 1.41 ENST00000650757.1
TPP2
tripeptidyl peptidase 2
chrX_+_72181676 1.40 ENST00000218432.10
ENST00000664196.1
ENST00000423432.6
PIN4
peptidylprolyl cis/trans isomerase, NIMA-interacting 4
chr3_+_179347686 1.39 ENST00000471841.6
MFN1
mitofusin 1
chr16_+_20764036 1.33 ENST00000440284.6
ACSM3
acyl-CoA synthetase medium chain family member 3
chr8_+_131939865 1.33 ENST00000520362.5
ENST00000519656.1
EFR3A
EFR3 homolog A
chr17_+_48831021 1.29 ENST00000509507.5
ENST00000448105.6
ENST00000570513.5
ENST00000509415.5
ENST00000513119.5
ENST00000416445.6
ENST00000508679.5
ENST00000258947.8
ENST00000505071.5
CALCOCO2
calcium binding and coiled-coil domain 2
chr8_+_73991345 1.26 ENST00000284818.7
ENST00000518893.1
LY96
lymphocyte antigen 96
chr2_+_102001966 1.22 ENST00000457817.5
IL1R2
interleukin 1 receptor type 2
chr10_+_113125536 1.21 ENST00000349937.7
TCF7L2
transcription factor 7 like 2
chr3_-_185254028 1.17 ENST00000440662.1
ENST00000456310.5
ENST00000231887.8
EHHADH
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
chr19_+_9185594 1.11 ENST00000344248.4
OR7D2
olfactory receptor family 7 subfamily D member 2
chr9_-_21240002 1.11 ENST00000380222.4
IFNA14
interferon alpha 14
chr7_-_108130349 1.06 ENST00000205386.8
ENST00000418464.1
ENST00000388781.8
LAMB4
laminin subunit beta 4
chr3_-_134250831 1.03 ENST00000623711.4
RYK
receptor like tyrosine kinase
chr3_-_37174578 1.02 ENST00000336686.9
LRRFIP2
LRR binding FLII interacting protein 2
chr17_+_34270213 0.99 ENST00000378569.2
ENST00000394627.5
ENST00000394630.3
CCL7
C-C motif chemokine ligand 7
chrX_+_116170742 0.96 ENST00000371906.5
ENST00000681852.1
AGTR2
angiotensin II receptor type 2
chrX_-_115017569 0.90 ENST00000243213.2
IL13RA2
interleukin 13 receptor subunit alpha 2
chr11_+_67583742 0.90 ENST00000398603.6
GSTP1
glutathione S-transferase pi 1
chrX_-_74614612 0.89 ENST00000349225.2
ENST00000332687.11
RLIM
ring finger protein, LIM domain interacting
chr7_+_134779663 0.88 ENST00000361901.6
CALD1
caldesmon 1
chr2_-_11466156 0.84 ENST00000381525.8
ENST00000307236.8
ENST00000542100.5
ENST00000546212.2
E2F6
E2F transcription factor 6
chr4_-_82848843 0.84 ENST00000511338.1
SEC31A
SEC31 homolog A, COPII coat complex component
chr2_+_131105296 0.83 ENST00000628582.2
PLEKHB2
pleckstrin homology domain containing B2
chr22_+_37807891 0.81 ENST00000323205.10
ENST00000445195.5
ENST00000248924.11
GCAT
glycine C-acetyltransferase
chr2_+_131105326 0.79 ENST00000438882.6
ENST00000404460.5
PLEKHB2
pleckstrin homology domain containing B2
chr3_-_139678011 0.76 ENST00000646611.1
ENST00000645290.1
ENST00000647257.1
NMNAT3
nicotinamide nucleotide adenylyltransferase 3
chr19_+_44777860 0.73 ENST00000341505.4
ENST00000647358.2
CBLC
Cbl proto-oncogene C
chr17_-_40885232 0.72 ENST00000167588.4
KRT20
keratin 20
chr12_+_21131187 0.63 ENST00000256958.3
SLCO1B1
solute carrier organic anion transporter family member 1B1
chr3_-_165078480 0.59 ENST00000264382.8
SI
sucrase-isomaltase
chr7_+_7566866 0.58 ENST00000405785.5
ENST00000340080.9
ENST00000433635.1
MIOS
meiosis regulator for oocyte development
chr12_+_26011713 0.56 ENST00000542004.5
RASSF8
Ras association domain family member 8
chr9_-_92482499 0.55 ENST00000375544.7
ASPN
asporin
chr2_+_203936755 0.51 ENST00000316386.11
ENST00000435193.1
ICOS
inducible T cell costimulator
chrX_-_2964328 0.48 ENST00000381134.9
ARSL
arylsulfatase L
chr15_-_84654270 0.44 ENST00000434634.7
WDR73
WD repeat domain 73
chr7_+_28685968 0.42 ENST00000396298.6
CREB5
cAMP responsive element binding protein 5
chr4_+_69931066 0.40 ENST00000246891.9
CSN1S1
casein alpha s1
chrX_-_2964252 0.39 ENST00000681963.1
ENST00000684738.1
ENST00000438544.5
ENST00000682184.1
ENST00000545496.6
ENST00000684364.1
ENST00000683677.1
ENST00000683290.1
ENST00000682364.1
ARSL
arylsulfatase L
chr7_+_106865474 0.37 ENST00000359195.3
PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
chr3_+_150408314 0.35 ENST00000361875.7
TSC22D2
TSC22 domain family member 2
chr10_+_7703300 0.33 ENST00000358415.9
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_-_137044269 0.32 ENST00000635289.1
ENST00000541547.5
IL20RA
interleukin 20 receptor subunit alpha
chr1_-_169734064 0.31 ENST00000333360.12
SELE
selectin E
chr6_-_49744378 0.30 ENST00000371159.8
ENST00000263045.9
CRISP3
cysteine rich secretory protein 3
chr6_+_135851681 0.24 ENST00000308191.11
PDE7B
phosphodiesterase 7B
chr6_+_42782020 0.23 ENST00000314073.9
BICRAL
BRD4 interacting chromatin remodeling complex associated protein like
chr3_+_160677152 0.22 ENST00000320767.4
ARL14
ADP ribosylation factor like GTPase 14
chr1_+_196888014 0.20 ENST00000367416.6
ENST00000608469.6
ENST00000251424.8
ENST00000367418.2
CFHR4
complement factor H related 4
chr15_-_50114491 0.19 ENST00000559829.5
ATP8B4
ATPase phospholipid transporting 8B4 (putative)
chr4_-_69653223 0.19 ENST00000286604.8
ENST00000505512.1
ENST00000514019.1
UGT2A1
UDP glucuronosyltransferase family 2 member A1 complex locus
chr19_+_57128643 0.17 ENST00000598197.1
USP29
ubiquitin specific peptidase 29
chr14_+_39233884 0.14 ENST00000553728.1
MIA2
MIA SH3 domain ER export factor 2
chr18_+_616711 0.13 ENST00000579494.1
CLUL1
clusterin like 1
chr18_+_616672 0.13 ENST00000338387.11
CLUL1
clusterin like 1
chrX_-_49233309 0.12 ENST00000376251.5
ENST00000323022.10
ENST00000376265.2
CACNA1F
calcium voltage-gated channel subunit alpha1 F
chr12_+_10307950 0.12 ENST00000543420.5
ENST00000543777.5
KLRD1
killer cell lectin like receptor D1
chr17_+_76467597 0.12 ENST00000392492.8
AANAT
aralkylamine N-acetyltransferase
chr1_+_210328244 0.10 ENST00000541565.5
ENST00000413764.6
HHAT
hedgehog acyltransferase
chr4_+_95091462 0.02 ENST00000264568.8
BMPR1B
bone morphogenetic protein receptor type 1B

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 23.1 GO:0014038 regulation of Schwann cell differentiation(GO:0014038) Golgi disassembly(GO:0090166)
2.4 7.3 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149)
2.0 12.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
1.7 8.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.5 9.1 GO:0015853 adenine transport(GO:0015853)
1.4 4.1 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
1.4 4.1 GO:0014016 neuroblast differentiation(GO:0014016)
1.3 4.0 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
1.3 4.0 GO:0061289 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
1.3 5.2 GO:0080154 regulation of fertilization(GO:0080154)
1.2 7.5 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
1.0 8.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
1.0 11.3 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.9 2.6 GO:0016107 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
0.8 5.9 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.8 2.5 GO:0035732 nitric oxide storage(GO:0035732)
0.8 5.5 GO:1903895 negative regulation of IRE1-mediated unfolded protein response(GO:1903895)
0.7 3.6 GO:0070295 renal water absorption(GO:0070295) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.6 11.6 GO:0042448 ovulation from ovarian follicle(GO:0001542) progesterone metabolic process(GO:0042448)
0.5 2.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.5 7.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.5 2.3 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.4 1.6 GO:1903786 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.4 1.9 GO:0070316 regulation of G0 to G1 transition(GO:0070316)
0.4 4.3 GO:0042407 cristae formation(GO:0042407)
0.4 2.1 GO:0019264 L-serine catabolic process(GO:0006565) glycine biosynthetic process from serine(GO:0019264)
0.3 3.1 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.3 16.1 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.3 2.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.3 1.6 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.3 1.0 GO:0032304 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) negative regulation of icosanoid secretion(GO:0032304)
0.3 6.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 1.2 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.3 5.4 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.3 0.8 GO:0006566 threonine metabolic process(GO:0006566)
0.3 2.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.3 6.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.3 1.0 GO:0061643 chemorepulsion of dopaminergic neuron axon(GO:0036518) chemorepulsion of axon(GO:0061643)
0.2 2.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.2 1.7 GO:0010710 calcium-independent cell-matrix adhesion(GO:0007161) regulation of collagen catabolic process(GO:0010710)
0.2 10.9 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.2 4.0 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.2 2.6 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.2 1.4 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.2 0.8 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.2 1.5 GO:0006572 tyrosine catabolic process(GO:0006572)
0.2 1.3 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.2 1.3 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.2 5.7 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.2 1.0 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.2 1.6 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 1.9 GO:0046149 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1 0.9 GO:0007549 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.1 3.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 4.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.9 GO:0043305 negative regulation of mast cell degranulation(GO:0043305)
0.1 0.6 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 1.2 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 4.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 5.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.6 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 0.5 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.4 GO:0035747 natural killer cell chemotaxis(GO:0035747)
0.1 0.6 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 0.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.7 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1 1.2 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 2.8 GO:0051180 vitamin transport(GO:0051180)
0.0 1.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 6.2 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 1.8 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 2.9 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 2.3 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 1.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.5 GO:0002517 T cell tolerance induction(GO:0002517)
0.0 2.2 GO:0061053 somite development(GO:0061053)
0.0 2.4 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 0.8 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.6 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 1.3 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.3 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 5.7 GO:0043687 post-translational protein modification(GO:0043687)
0.0 1.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 23.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
2.3 9.1 GO:0071817 MMXD complex(GO:0071817)
2.1 8.2 GO:0000811 GINS complex(GO:0000811)
1.4 8.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.9 12.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.9 5.4 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.9 3.5 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.8 5.9 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.8 4.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.7 4.3 GO:0061617 MICOS complex(GO:0061617)
0.7 7.5 GO:0005638 lamin filament(GO:0005638)
0.6 2.5 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.6 2.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.6 1.7 GO:0034677 integrin alpha7-beta1 complex(GO:0034677)
0.5 7.0 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.4 2.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.3 4.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 5.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 4.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 1.9 GO:0033391 chromatoid body(GO:0033391)
0.1 2.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 1.3 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 4.8 GO:0032040 small-subunit processome(GO:0032040)
0.1 1.4 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.1 0.4 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.1 1.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 18.5 GO:0008021 synaptic vesicle(GO:0008021)
0.1 5.7 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.6 GO:0061700 GATOR2 complex(GO:0061700)
0.1 6.1 GO:0031970 organelle envelope lumen(GO:0031970)
0.1 0.9 GO:0030478 actin cap(GO:0030478)
0.1 2.3 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.8 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 4.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.9 GO:0016592 mediator complex(GO:0016592)
0.0 1.3 GO:0000421 autophagosome membrane(GO:0000421)
0.0 11.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.8 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 1.2 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.6 GO:0005814 centriole(GO:0005814)
0.0 3.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.1 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
1.3 5.4 GO:0016418 S-acetyltransferase activity(GO:0016418)
1.2 3.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.2 4.7 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
1.2 8.3 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.0 23.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
1.0 4.1 GO:0003990 acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265)
0.9 2.8 GO:0008431 vitamin E binding(GO:0008431)
0.9 9.0 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.9 7.0 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.9 2.6 GO:0045550 geranylgeranyl reductase activity(GO:0045550) delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.8 2.5 GO:0035731 S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731)
0.6 6.8 GO:0033038 bitter taste receptor activity(GO:0033038)
0.6 5.5 GO:0089720 caspase binding(GO:0089720)
0.6 5.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.6 8.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.6 4.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.5 2.1 GO:0070905 serine binding(GO:0070905)
0.5 11.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.5 2.4 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.5 1.9 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.5 12.3 GO:0031489 myosin V binding(GO:0031489)
0.4 1.2 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.4 1.9 GO:0019862 IgA binding(GO:0019862)
0.4 7.3 GO:0051400 BH domain binding(GO:0051400)
0.3 1.4 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.2 1.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.2 1.7 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 6.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 1.0 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.2 0.8 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.2 1.9 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 4.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 0.8 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.2 1.3 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.2 13.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 1.0 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 5.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.3 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 4.0 GO:0070034 telomerase RNA binding(GO:0070034)
0.1 4.0 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.6 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.1 5.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.5 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.1 2.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 2.5 GO:0070840 dynein complex binding(GO:0070840)
0.1 1.6 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.2 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 2.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 3.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.0 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.3 GO:0033691 sialic acid binding(GO:0033691) oligosaccharide binding(GO:0070492)
0.0 3.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.9 GO:0005523 tropomyosin binding(GO:0005523)
0.0 7.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.4 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 2.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 4.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.9 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 7.6 GO:0003924 GTPase activity(GO:0003924)
0.0 1.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.7 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.6 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 2.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 2.6 GO:0008017 microtubule binding(GO:0008017)
0.0 1.0 GO:0004984 olfactory receptor activity(GO:0004984)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 23.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 5.9 ST G ALPHA S PATHWAY G alpha s Pathway
0.2 8.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 11.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 0.9 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.1 4.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 4.0 PID IL27 PATHWAY IL27-mediated signaling events
0.1 7.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 6.5 PID E2F PATHWAY E2F transcription factor network
0.1 3.1 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 3.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.2 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 2.0 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 2.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.2 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 23.1 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.6 10.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.5 8.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.5 8.3 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.5 12.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 5.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3 5.9 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.2 4.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 1.9 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.2 18.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 6.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 16.5 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.2 7.6 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 7.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 3.6 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.7 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.3 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 3.1 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.1 2.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 3.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 7.3 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.1 1.9 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 5.1 REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.0 0.6 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 2.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 2.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.9 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 1.2 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 4.0 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 1.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.5 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.0 1.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway