Project
avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZIC3_ZIC4
Z-value: 1.44
Motif logo
Transcription factors associated with ZIC3_ZIC4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ZIC3
|
ENSG00000156925.12 | ZIC3 |
|
ZIC4
|
ENSG00000174963.18 | ZIC4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZIC3 | hg38_v1_chrX_+_137566119_137566167 | 0.27 | 6.7e-05 | Click! |
Activity profile of ZIC3_ZIC4 motif
Sorted Z-values of ZIC3_ZIC4 motif
Network of associatons between targets according to the STRING database.
First level regulatory network of ZIC3_ZIC4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 9.1 | GO:0033861 | negative regulation of NAD(P)H oxidase activity(GO:0033861) negative regulation of respiratory burst involved in inflammatory response(GO:0060266) |
| 1.9 | 5.8 | GO:0015920 | lipopolysaccharide transport(GO:0015920) |
| 1.9 | 5.7 | GO:0072365 | regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365) |
| 1.5 | 4.5 | GO:0019858 | cytosine metabolic process(GO:0019858) |
| 1.1 | 3.2 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
| 1.1 | 3.2 | GO:0071486 | response to high light intensity(GO:0009644) cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) retinal cell apoptotic process(GO:1990009) |
| 1.0 | 5.2 | GO:0071233 | cellular response to leucine(GO:0071233) |
| 1.0 | 3.1 | GO:0048319 | axial mesoderm morphogenesis(GO:0048319) |
| 0.9 | 3.6 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 0.9 | 3.5 | GO:0006669 | sphinganine-1-phosphate biosynthetic process(GO:0006669) |
| 0.8 | 2.5 | GO:0048213 | Golgi vesicle prefusion complex stabilization(GO:0048213) |
| 0.8 | 3.1 | GO:2000297 | negative regulation of synapse maturation(GO:2000297) |
| 0.8 | 3.9 | GO:2000870 | oocyte growth(GO:0001555) regulation of progesterone secretion(GO:2000870) |
| 0.7 | 2.8 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 0.6 | 2.6 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 0.6 | 3.1 | GO:0045925 | positive regulation of female receptivity(GO:0045925) |
| 0.6 | 3.0 | GO:0015692 | lead ion transport(GO:0015692) |
| 0.6 | 2.2 | GO:0019072 | viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074) |
| 0.5 | 3.3 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 0.5 | 1.5 | GO:0003358 | noradrenergic neuron development(GO:0003358) |
| 0.5 | 1.4 | GO:0044537 | regulation of circulating fibrinogen levels(GO:0044537) |
| 0.4 | 2.2 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.4 | 2.1 | GO:1900738 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) |
| 0.4 | 0.4 | GO:0042938 | dipeptide transport(GO:0042938) |
| 0.4 | 1.6 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
| 0.4 | 2.4 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.4 | 6.6 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.4 | 1.1 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
| 0.4 | 1.1 | GO:0031587 | positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587) |
| 0.4 | 4.3 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.3 | 2.1 | GO:0070829 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 0.3 | 1.0 | GO:1900226 | positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777) |
| 0.3 | 1.9 | GO:0071105 | response to interleukin-11(GO:0071105) |
| 0.3 | 0.9 | GO:0002143 | tRNA wobble position uridine thiolation(GO:0002143) |
| 0.3 | 0.6 | GO:0033091 | positive regulation of immature T cell proliferation(GO:0033091) |
| 0.3 | 1.2 | GO:0003409 | optic cup structural organization(GO:0003409) |
| 0.3 | 0.9 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 0.3 | 3.3 | GO:0045003 | DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003) |
| 0.3 | 1.2 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.3 | 0.9 | GO:0015798 | myo-inositol transport(GO:0015798) |
| 0.3 | 0.9 | GO:0001927 | exocyst assembly(GO:0001927) |
| 0.3 | 1.4 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
| 0.3 | 0.5 | GO:0090187 | positive regulation of pancreatic juice secretion(GO:0090187) |
| 0.3 | 2.1 | GO:0030091 | protein repair(GO:0030091) |
| 0.3 | 0.8 | GO:0048865 | stem cell fate commitment(GO:0048865) |
| 0.3 | 0.8 | GO:0002461 | tolerance induction dependent upon immune response(GO:0002461) |
| 0.3 | 2.5 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.3 | 1.3 | GO:0001315 | age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571) |
| 0.2 | 0.7 | GO:0061027 | umbilical cord morphogenesis(GO:0036304) umbilical cord development(GO:0061027) |
| 0.2 | 0.7 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.2 | 0.7 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 0.2 | 2.6 | GO:2000344 | positive regulation of acrosome reaction(GO:2000344) |
| 0.2 | 6.5 | GO:0022401 | desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) |
| 0.2 | 0.7 | GO:1902809 | skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle fiber differentiation(GO:1902809) |
| 0.2 | 0.7 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
| 0.2 | 4.5 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.2 | 1.1 | GO:0015808 | L-alanine transport(GO:0015808) |
| 0.2 | 1.4 | GO:0006489 | dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465) |
| 0.2 | 1.6 | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 0.2 | 0.6 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.2 | 3.6 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.2 | 0.6 | GO:0051939 | gamma-aminobutyric acid import(GO:0051939) |
| 0.2 | 1.3 | GO:0035434 | copper ion transmembrane transport(GO:0035434) |
| 0.2 | 2.8 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.2 | 2.0 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 0.2 | 3.5 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.2 | 0.9 | GO:1902847 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.2 | 1.1 | GO:0060455 | negative regulation of gastric acid secretion(GO:0060455) |
| 0.2 | 2.2 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.2 | 3.6 | GO:0099514 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.2 | 1.9 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.2 | 2.2 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.2 | 2.5 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.2 | 1.6 | GO:0015870 | acetylcholine transport(GO:0015870) |
| 0.2 | 2.7 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.2 | 2.8 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.2 | 2.1 | GO:0060453 | positive regulation of cardiac muscle contraction(GO:0060452) regulation of gastric acid secretion(GO:0060453) |
| 0.2 | 6.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 1.8 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) |
| 0.1 | 1.2 | GO:0033084 | regulation of immature T cell proliferation in thymus(GO:0033084) negative regulation of immature T cell proliferation in thymus(GO:0033088) |
| 0.1 | 1.5 | GO:0035385 | Roundabout signaling pathway(GO:0035385) |
| 0.1 | 0.9 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.1 | 0.5 | GO:0021637 | trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287) |
| 0.1 | 2.6 | GO:0051583 | dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494) |
| 0.1 | 1.0 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.1 | 0.9 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
| 0.1 | 0.8 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.1 | 0.8 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.1 | 1.1 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.1 | 1.1 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.1 | 2.4 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.1 | 1.3 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.1 | 0.4 | GO:0060214 | endocardium formation(GO:0060214) |
| 0.1 | 1.9 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.1 | 0.5 | GO:0021800 | cerebral cortex tangential migration(GO:0021800) |
| 0.1 | 0.8 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.1 | 0.2 | GO:0099541 | trans-synaptic signaling by lipid(GO:0099541) trans-synaptic signaling by endocannabinoid(GO:0099542) |
| 0.1 | 0.3 | GO:0071502 | cellular response to temperature stimulus(GO:0071502) |
| 0.1 | 0.3 | GO:0061011 | negative regulation of transcription by transcription factor localization(GO:0010621) hepatic duct development(GO:0061011) |
| 0.1 | 0.9 | GO:0046813 | receptor-mediated virion attachment to host cell(GO:0046813) |
| 0.1 | 0.9 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.1 | 1.1 | GO:0021847 | ventricular zone neuroblast division(GO:0021847) |
| 0.1 | 0.3 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.1 | 1.1 | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) |
| 0.1 | 0.4 | GO:0007198 | adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) |
| 0.1 | 0.5 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.1 | 0.5 | GO:0048861 | oncostatin-M-mediated signaling pathway(GO:0038165) leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.1 | 0.8 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.1 | 1.6 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 0.8 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.1 | 0.5 | GO:0060718 | chorionic trophoblast cell differentiation(GO:0060718) |
| 0.1 | 1.0 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.1 | 7.4 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.1 | 1.3 | GO:0035330 | regulation of hippo signaling(GO:0035330) |
| 0.1 | 1.2 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.1 | 1.1 | GO:0030202 | heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210) |
| 0.1 | 0.7 | GO:0034128 | negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128) |
| 0.1 | 2.5 | GO:0097503 | sialylation(GO:0097503) |
| 0.1 | 4.6 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.1 | 0.4 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.1 | 1.2 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.1 | 0.3 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
| 0.1 | 0.2 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
| 0.1 | 0.5 | GO:0015760 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.1 | 1.0 | GO:1901386 | negative regulation of voltage-gated calcium channel activity(GO:1901386) |
| 0.1 | 1.6 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.1 | 1.7 | GO:0043011 | myeloid dendritic cell differentiation(GO:0043011) |
| 0.1 | 0.3 | GO:0048733 | sebaceous gland development(GO:0048733) |
| 0.1 | 0.1 | GO:0060166 | olfactory pit development(GO:0060166) |
| 0.1 | 1.2 | GO:0061154 | endothelial tube morphogenesis(GO:0061154) |
| 0.1 | 2.5 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
| 0.1 | 0.8 | GO:0044130 | negative regulation of growth of symbiont in host(GO:0044130) |
| 0.1 | 0.9 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.1 | 0.5 | GO:0034626 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 2.5 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.1 | 0.7 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.1 | 0.6 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.1 | 0.8 | GO:0006450 | regulation of translational fidelity(GO:0006450) |
| 0.1 | 4.6 | GO:0005977 | glycogen metabolic process(GO:0005977) |
| 0.1 | 0.2 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
| 0.1 | 0.8 | GO:0032494 | response to peptidoglycan(GO:0032494) |
| 0.1 | 3.5 | GO:0046513 | ceramide biosynthetic process(GO:0046513) |
| 0.1 | 0.8 | GO:0048742 | regulation of skeletal muscle fiber development(GO:0048742) |
| 0.1 | 0.3 | GO:0033504 | floor plate development(GO:0033504) |
| 0.1 | 0.6 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817) |
| 0.1 | 0.1 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
| 0.1 | 1.2 | GO:0030299 | intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856) |
| 0.1 | 0.4 | GO:0050713 | negative regulation of interleukin-1 beta secretion(GO:0050713) |
| 0.1 | 1.0 | GO:0043046 | DNA methylation involved in gamete generation(GO:0043046) |
| 0.0 | 0.2 | GO:0030167 | proteoglycan catabolic process(GO:0030167) heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.0 | 0.3 | GO:0021999 | neural plate anterior/posterior regionalization(GO:0021999) |
| 0.0 | 0.9 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.7 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
| 0.0 | 0.1 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.0 | 2.2 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 0.2 | GO:0045872 | positive regulation of rhodopsin gene expression(GO:0045872) |
| 0.0 | 0.6 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.0 | 1.6 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.0 | 0.4 | GO:0014894 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.0 | 0.1 | GO:0006113 | fermentation(GO:0006113) regulation of fermentation(GO:0043465) |
| 0.0 | 2.5 | GO:0001541 | ovarian follicle development(GO:0001541) |
| 0.0 | 0.8 | GO:0097237 | cellular response to toxic substance(GO:0097237) |
| 0.0 | 0.1 | GO:2000174 | regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176) |
| 0.0 | 1.9 | GO:0010165 | response to X-ray(GO:0010165) |
| 0.0 | 0.2 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.0 | 0.4 | GO:0035413 | positive regulation of catenin import into nucleus(GO:0035413) |
| 0.0 | 0.3 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.0 | 2.0 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.7 | GO:0060746 | maternal behavior(GO:0042711) parental behavior(GO:0060746) |
| 0.0 | 0.8 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.0 | 1.4 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 1.4 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 1.1 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.0 | 0.1 | GO:0015860 | purine nucleoside transmembrane transport(GO:0015860) |
| 0.0 | 1.9 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.8 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 2.1 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway(GO:2001238) |
| 0.0 | 0.2 | GO:0051541 | elastin metabolic process(GO:0051541) negative regulation of blood vessel remodeling(GO:0060313) |
| 0.0 | 0.5 | GO:0033008 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 0.0 | 0.9 | GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191) |
| 0.0 | 1.4 | GO:0072661 | protein targeting to plasma membrane(GO:0072661) |
| 0.0 | 0.6 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.0 | 2.1 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 0.0 | 0.3 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.0 | 0.6 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.0 | 3.4 | GO:0042102 | positive regulation of T cell proliferation(GO:0042102) |
| 0.0 | 0.4 | GO:0051775 | response to redox state(GO:0051775) |
| 0.0 | 0.5 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.7 | GO:0033687 | osteoblast proliferation(GO:0033687) |
| 0.0 | 0.3 | GO:0031987 | lysosomal lumen acidification(GO:0007042) locomotion involved in locomotory behavior(GO:0031987) |
| 0.0 | 1.1 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.0 | 1.0 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.9 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 0.2 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.0 | 0.5 | GO:0045880 | positive regulation of smoothened signaling pathway(GO:0045880) |
| 0.0 | 0.6 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.0 | 2.3 | GO:0000725 | double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725) |
| 0.0 | 1.0 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 0.2 | GO:0072553 | terminal button organization(GO:0072553) |
| 0.0 | 1.0 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 0.0 | 0.5 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 0.2 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.0 | 0.6 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.0 | 0.7 | GO:0002092 | positive regulation of receptor internalization(GO:0002092) |
| 0.0 | 0.7 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.0 | 1.5 | GO:0007602 | phototransduction(GO:0007602) |
| 0.0 | 1.0 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 0.0 | 0.8 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.0 | 0.6 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.4 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.0 | 0.8 | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway(GO:2001244) |
| 0.0 | 0.2 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
| 0.0 | 0.1 | GO:0038170 | somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170) |
| 0.0 | 2.6 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 1.0 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
| 0.0 | 0.5 | GO:0060008 | Sertoli cell differentiation(GO:0060008) |
| 0.0 | 0.6 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 1.2 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 1.0 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 0.7 | GO:0098773 | hair follicle development(GO:0001942) skin epidermis development(GO:0098773) |
| 0.0 | 0.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.0 | 0.3 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 0.0 | 0.0 | GO:1902075 | cellular response to salt(GO:1902075) |
| 0.0 | 0.6 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 0.8 | GO:0007004 | telomere maintenance via telomerase(GO:0007004) |
| 0.0 | 0.4 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 0.0 | 0.1 | GO:0061042 | vascular wound healing(GO:0061042) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.5 | GO:0097229 | sperm end piece(GO:0097229) |
| 0.9 | 6.6 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.9 | 5.2 | GO:0034448 | EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.6 | 3.0 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.4 | 3.8 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.3 | 1.6 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.3 | 1.1 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.3 | 3.6 | GO:0030123 | AP-3 adaptor complex(GO:0030123) |
| 0.2 | 3.0 | GO:0045495 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
| 0.2 | 0.7 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.2 | 5.6 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.2 | 2.5 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.2 | 5.8 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.2 | 3.1 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.2 | 2.6 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 1.0 | GO:0033061 | DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.2 | 0.8 | GO:1990031 | pinceau fiber(GO:1990031) |
| 0.2 | 1.9 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 6.2 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 9.1 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 1.6 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 0.4 | GO:0070701 | mucus layer(GO:0070701) |
| 0.1 | 1.8 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 0.6 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.1 | 0.7 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.1 | 1.0 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.1 | 1.4 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 0.3 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.1 | 6.8 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 0.7 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 1.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 1.9 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 0.2 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.1 | 1.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 0.9 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.1 | 1.9 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 0.9 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.1 | 9.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.1 | 5.1 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 1.1 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.1 | 2.4 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.1 | 3.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 1.6 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 3.5 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.1 | 2.3 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 0.9 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 2.7 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 4.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.8 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 3.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 4.6 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 1.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.4 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.4 | GO:0072559 | NLRP3 inflammasome complex(GO:0072559) |
| 0.0 | 0.8 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.4 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.0 | 0.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 3.2 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 1.8 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.2 | GO:0098560 | cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.0 | 1.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 1.6 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 0.4 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.2 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 5.4 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 0.7 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.7 | GO:0031312 | extrinsic component of organelle membrane(GO:0031312) |
| 0.0 | 1.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 3.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 2.5 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 1.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 1.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.2 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 1.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 3.0 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.0 | 1.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.9 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.1 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 6.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.9 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.0 | 1.6 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 0.7 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.5 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 0.4 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 1.1 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.5 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.5 | GO:0032093 | SAM domain binding(GO:0032093) |
| 1.6 | 4.8 | GO:0050254 | rhodopsin kinase activity(GO:0050254) |
| 1.1 | 3.2 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
| 1.0 | 5.8 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.8 | 2.5 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.8 | 2.3 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.7 | 2.6 | GO:0005334 | norepinephrine:sodium symporter activity(GO:0005334) |
| 0.6 | 3.0 | GO:0015087 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.6 | 2.4 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.6 | 4.6 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.5 | 2.2 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.5 | 2.7 | GO:0047280 | nicotinamide phosphoribosyltransferase activity(GO:0047280) |
| 0.5 | 3.5 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.5 | 3.3 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.4 | 3.1 | GO:0086089 | voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089) |
| 0.4 | 2.1 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.4 | 1.6 | GO:0043273 | CTPase activity(GO:0043273) |
| 0.4 | 1.6 | GO:1901375 | acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375) |
| 0.4 | 2.3 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.4 | 1.8 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.4 | 2.8 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.4 | 1.1 | GO:0008900 | hydrogen:potassium-exchanging ATPase activity(GO:0008900) |
| 0.3 | 2.1 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.3 | 1.0 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) |
| 0.3 | 1.3 | GO:0097108 | hedgehog family protein binding(GO:0097108) |
| 0.3 | 1.0 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.3 | 2.5 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.3 | 4.1 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.3 | 1.4 | GO:0016933 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.3 | 4.9 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.3 | 1.1 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.3 | 0.6 | GO:0033142 | progesterone receptor binding(GO:0033142) |
| 0.3 | 0.8 | GO:0004967 | glucagon receptor activity(GO:0004967) |
| 0.3 | 1.0 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.3 | 2.8 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.3 | 5.1 | GO:0005112 | Notch binding(GO:0005112) |
| 0.3 | 1.8 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.2 | 3.1 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.2 | 1.2 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.2 | 2.0 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.2 | 3.6 | GO:0015250 | water channel activity(GO:0015250) |
| 0.2 | 0.7 | GO:0033765 | 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751) |
| 0.2 | 2.0 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.2 | 0.9 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.2 | 1.1 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.2 | 2.2 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 1.1 | GO:0015180 | L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858) |
| 0.2 | 1.1 | GO:0004905 | type I interferon receptor activity(GO:0004905) |
| 0.2 | 0.6 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.2 | 1.3 | GO:0005497 | androgen binding(GO:0005497) |
| 0.2 | 1.3 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 0.2 | 0.7 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.2 | 1.5 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.2 | 0.5 | GO:0004923 | leukemia inhibitory factor receptor activity(GO:0004923) |
| 0.2 | 9.4 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.2 | 2.5 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.2 | 0.8 | GO:0001594 | trace-amine receptor activity(GO:0001594) |
| 0.2 | 1.5 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.2 | 3.4 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.2 | 2.5 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.1 | 0.9 | GO:1904047 | S-adenosyl-L-methionine binding(GO:1904047) |
| 0.1 | 0.4 | GO:0060001 | minus-end directed microfilament motor activity(GO:0060001) |
| 0.1 | 1.7 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 2.2 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.1 | 1.6 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 0.5 | GO:0034191 | apolipoprotein A-I receptor binding(GO:0034191) |
| 0.1 | 0.8 | GO:0002161 | aminoacyl-tRNA editing activity(GO:0002161) |
| 0.1 | 0.5 | GO:0061513 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.1 | 1.3 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.1 | 1.2 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.1 | 0.4 | GO:0032089 | NACHT domain binding(GO:0032089) |
| 0.1 | 0.6 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 0.1 | 1.7 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 0.7 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 1.1 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.1 | 2.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 1.0 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.1 | 1.9 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 0.4 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.1 | 0.4 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.1 | 0.2 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.1 | 0.4 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.1 | 0.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 0.9 | GO:0051434 | protein channel activity(GO:0015266) BH3 domain binding(GO:0051434) |
| 0.1 | 0.6 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.1 | 0.7 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.1 | 0.8 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 1.0 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 4.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 0.2 | GO:0004307 | ethanolaminephosphotransferase activity(GO:0004307) |
| 0.1 | 0.2 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.1 | 0.8 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.1 | 0.9 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 0.1 | 1.1 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.1 | 0.5 | GO:0102337 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 2.5 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 1.9 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.1 | 0.6 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.1 | 0.7 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 0.8 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 0.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 3.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 0.7 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.1 | 1.2 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 1.6 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 0.8 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 0.6 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 0.7 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 3.0 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 2.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 1.6 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.0 | 3.2 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 1.4 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.0 | 0.9 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.6 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 1.1 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.0 | 1.4 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.0 | 0.1 | GO:0015389 | pyrimidine nucleobase transmembrane transporter activity(GO:0005350) pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389) |
| 0.0 | 0.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.7 | GO:0043495 | protein anchor(GO:0043495) |
| 0.0 | 1.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 0.4 | GO:0051378 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.0 | 0.2 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.0 | 0.9 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 0.4 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 1.1 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.2 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.0 | 1.6 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 0.7 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 1.0 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.8 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 0.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 1.1 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.7 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 0.4 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 1.0 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.3 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.0 | 3.7 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.1 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.0 | 0.2 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.5 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 0.1 | GO:0032934 | sterol binding(GO:0032934) |
| 0.0 | 0.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.2 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 0.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.3 | GO:0099604 | calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604) |
| 0.0 | 0.1 | GO:0005315 | inorganic phosphate transmembrane transporter activity(GO:0005315) |
| 0.0 | 1.1 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.2 | 9.6 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.2 | 8.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 3.1 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 0.7 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 1.7 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 1.3 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.1 | 0.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 0.9 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.1 | 3.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 4.3 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 2.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 2.1 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 0.9 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 1.3 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.8 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.3 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.0 | 0.9 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 6.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.0 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 6.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.0 | ST ADRENERGIC | Adrenergic Pathway |
| 0.0 | 1.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.9 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.0 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.8 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 0.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 4.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.1 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.1 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.3 | 3.6 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.3 | 3.2 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.2 | 5.8 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 4.5 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.2 | 4.2 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 5.0 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.2 | 1.3 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 6.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 2.9 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 2.2 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 2.0 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 3.2 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 4.9 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.3 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.1 | 2.3 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 1.1 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.1 | 1.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 4.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.6 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 0.4 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.3 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.1 | 0.9 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.1 | 0.7 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.1 | 3.7 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 1.6 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 2.9 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.1 | 2.4 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.7 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.8 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.1 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 3.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 1.4 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 4.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.7 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.4 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 1.1 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 1.8 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.5 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 1.3 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 2.3 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 1.1 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.2 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 1.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.6 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.8 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 0.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.4 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 2.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.2 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.4 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.4 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.4 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 1.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.4 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.5 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.4 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |