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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZKSCAN3

Z-value: 2.13

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.14 ZKSCAN3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg38_v1_chr6_+_28349907_28349983-0.461.0e-12Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_-_72231583 11.96 ENST00000566809.1
ENST00000567087.5
ENST00000569050.1
ENST00000568883.5
PKM
pyruvate kinase M1/2
chr15_-_72231113 11.33 ENST00000565154.6
ENST00000565184.6
ENST00000335181.10
PKM
pyruvate kinase M1/2
chr1_-_19484635 8.65 ENST00000433834.5
CAPZB
capping actin protein of muscle Z-line subunit beta
chr11_-_64246190 6.17 ENST00000392210.6
PPP1R14B
protein phosphatase 1 regulatory inhibitor subunit 14B
chr11_-_64245816 6.01 ENST00000542235.1
PPP1R14B
protein phosphatase 1 regulatory inhibitor subunit 14B
chr2_+_190880834 5.41 ENST00000338435.8
GLS
glutaminase
chr16_-_28495519 4.87 ENST00000569430.7
CLN3
CLN3 lysosomal/endosomal transmembrane protein, battenin
chr6_-_31540536 4.62 ENST00000376177.6
DDX39B
DExD-box helicase 39B
chr17_+_38752731 4.49 ENST00000619426.5
ENST00000610434.4
PSMB3
proteasome 20S subunit beta 3
chr15_-_41332487 4.46 ENST00000560640.1
ENST00000220514.8
OIP5
Opa interacting protein 5
chr19_-_2328573 4.02 ENST00000587502.2
ENST00000252622.15
ENST00000585409.2
LSM7
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr14_-_106130061 3.51 ENST00000390602.3
IGHV3-13
immunoglobulin heavy variable 3-13
chr12_+_71754834 3.47 ENST00000261263.5
RAB21
RAB21, member RAS oncogene family
chr1_-_19485502 3.46 ENST00000264203.7
ENST00000375144.6
ENST00000674432.1
ENST00000264202.8
CAPZB
capping actin protein of muscle Z-line subunit beta
chr14_-_106675544 3.00 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr1_-_19485468 2.98 ENST00000375142.5
CAPZB
capping actin protein of muscle Z-line subunit beta
chr22_+_49918733 2.79 ENST00000407217.7
ENST00000403427.3
CRELD2
cysteine rich with EGF like domains 2
chr20_-_59042748 2.69 ENST00000355937.9
ENST00000371033.9
PRELID3B
PRELI domain containing 3B
chr14_-_106389858 2.65 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr7_+_155298561 2.55 ENST00000476756.1
INSIG1
insulin induced gene 1
chr1_+_93448108 2.42 ENST00000271234.13
ENST00000260506.12
FNBP1L
formin binding protein 1 like
chr14_-_106593319 2.22 ENST00000390627.3
IGHV3-53
immunoglobulin heavy variable 3-53
chr12_+_109098118 2.19 ENST00000336865.6
UNG
uracil DNA glycosylase
chr1_+_93448155 2.17 ENST00000370253.6
FNBP1L
formin binding protein 1 like
chr22_+_49918626 1.99 ENST00000328268.9
ENST00000404488.7
CRELD2
cysteine rich with EGF like domains 2
chr6_+_32968557 1.86 ENST00000374825.9
BRD2
bromodomain containing 2
chr1_+_226062704 1.59 ENST00000366814.3
ENST00000366815.10
ENST00000655399.1
ENST00000667897.1
H3-3A
H3.3 histone A
chr6_+_42929430 1.04 ENST00000372836.5
CNPY3
canopy FGF signaling regulator 3
chr7_-_151210488 0.51 ENST00000644661.2
H2BE1
H2B.E variant histone 1
chr10_+_122163426 0.51 ENST00000360561.7
TACC2
transforming acidic coiled-coil containing protein 2
chr15_+_74318553 0.43 ENST00000558821.5
ENST00000268082.4
CCDC33
coiled-coil domain containing 33
chr17_+_34270213 0.10 ENST00000378569.2
ENST00000394627.5
ENST00000394630.3
CCL7
C-C motif chemokine ligand 7
chr2_+_190880809 0.03 ENST00000320717.8
GLS
glutaminase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 23.3 GO:0042866 pyruvate biosynthetic process(GO:0042866)
2.2 15.1 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
1.6 4.9 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.9 5.4 GO:0006543 glutamine catabolic process(GO:0006543)
0.8 2.5 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.5 4.6 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.3 4.6 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.2 3.5 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
0.2 2.2 GO:0045008 depyrimidination(GO:0045008)
0.1 4.5 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 4.0 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 11.4 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 4.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 2.7 GO:0015914 phospholipid transport(GO:0015914)
0.0 1.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 15.1 GO:0071203 F-actin capping protein complex(GO:0008290) WASH complex(GO:0071203)
0.7 8.6 GO:0005688 U6 snRNP(GO:0005688)
0.6 2.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.4 3.5 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.3 4.5 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 4.5 GO:0010369 chromocenter(GO:0010369)
0.1 5.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 23.3 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 4.9 GO:0005776 autophagosome(GO:0005776)
0.0 3.5 GO:0072562 blood microparticle(GO:0072562)
0.0 4.6 GO:0005938 cell cortex(GO:0005938)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 23.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.9 5.4 GO:0004359 glutaminase activity(GO:0004359)
0.9 2.7 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.5 4.6 GO:0030621 U4 snRNA binding(GO:0030621)
0.3 4.0 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 12.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 2.2 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.2 4.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 5.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 15.1 GO:0051015 actin filament binding(GO:0051015)
0.0 1.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 3.5 GO:0019003 GDP binding(GO:0019003)
0.0 4.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 5.3 GO:0003823 antigen binding(GO:0003823)
0.0 0.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 12.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 4.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.9 PID RB 1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 4.5 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.0 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 4.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)