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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZNF282

Z-value: 2.43

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Transcription factors associated with ZNF282

Gene Symbol Gene ID Gene Info
ZNF282
ENSG00000170265.12 ZNF282

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF282hg38_v1_chr7_+_149195537_1491955590.358.8e-08Click!

Activity profile of ZNF282 motif

Sorted Z-values of ZNF282 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF282

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_+_58244821 13.51 ENST00000216455.9
ENST00000412908.6
ENST00000557508.5
PSMA3
proteasome 20S subunit alpha 3
chr2_+_241350087 13.44 ENST00000451310.1
SEPTIN2
septin 2
chr17_-_63896621 13.40 ENST00000453363.7
CSH1
chorionic somatomammotropin hormone 1
chr17_+_68512878 13.14 ENST00000585981.5
ENST00000589480.5
ENST00000585815.5
PRKAR1A
protein kinase cAMP-dependent type I regulatory subunit alpha
chr6_-_79234619 12.83 ENST00000344726.9
ENST00000275036.11
HMGN3
high mobility group nucleosomal binding domain 3
chr6_+_10747753 12.26 ENST00000612333.4
TMEM14B
transmembrane protein 14B
chr17_-_63896568 12.01 ENST00000610991.1
ENST00000316193.13
ENST00000329882.8
CSH1
chorionic somatomammotropin hormone 1
chr17_-_63918817 11.02 ENST00000458650.6
ENST00000351388.8
ENST00000342364.8
ENST00000617086.1
ENST00000323322.10
ENST00000392824.8
GH1
CSHL1
growth hormone 1
chorionic somatomammotropin hormone like 1
chr17_-_63911236 10.71 ENST00000438387.6
ENST00000346606.10
ENST00000309894.6
ENST00000561003.5
ENST00000450719.3
ENST00000259003.14
CSHL1
chorionic somatomammotropin hormone like 1
chr17_-_63881842 9.08 ENST00000449787.6
ENST00000456543.6
ENST00000622506.4
ENST00000332800.7
ENST00000423893.7
GH2
growth hormone 2
chr17_-_63873676 8.73 ENST00000613718.3
ENST00000392886.7
ENST00000345366.8
ENST00000336844.9
ENST00000560142.5
CSH2
chorionic somatomammotropin hormone 2
chr6_+_10747765 8.57 ENST00000461342.5
ENST00000475942.5
ENST00000379542.10
ENST00000379530.7
ENST00000473276.5
ENST00000481240.5
ENST00000467317.5
TMEM14B
transmembrane protein 14B
chr14_+_55123917 8.15 ENST00000553493.5
LGALS3
galectin 3
chr19_-_39846329 7.95 ENST00000599134.1
ENST00000597634.5
ENST00000598417.5
ENST00000601274.5
ENST00000594309.5
ENST00000221801.8
FBL
fibrillarin
chr18_-_56651122 7.70 ENST00000590954.5
TXNL1
thioredoxin like 1
chr19_-_48617797 7.64 ENST00000546623.5
ENST00000084795.9
RPL18
ribosomal protein L18
chr17_+_38870050 7.62 ENST00000318008.11
ENST00000435347.7
LASP1
LIM and SH3 protein 1
chr20_-_35284715 7.37 ENST00000374436.7
ENST00000675032.1
EIF6
eukaryotic translation initiation factor 6
chr20_-_35284745 7.06 ENST00000374443.7
ENST00000374450.8
EIF6
eukaryotic translation initiation factor 6
chr1_+_40258202 6.89 ENST00000372759.4
ZMPSTE24
zinc metallopeptidase STE24
chr4_+_87422800 6.58 ENST00000440591.6
NUDT9
nudix hydrolase 9
chr15_-_83067199 5.99 ENST00000261721.9
BTBD1
BTB domain containing 1
chr17_-_78903193 5.92 ENST00000322630.3
ENST00000586713.5
CEP295NL
CEP295 N-terminal like
chr17_+_8288637 5.82 ENST00000407006.8
ENST00000226105.11
ENST00000580434.5
ENST00000439238.3
RANGRF
RAN guanine nucleotide release factor
chrX_+_154429092 5.79 ENST00000619046.5
ATP6AP1
ATPase H+ transporting accessory protein 1
chr1_+_47333774 5.66 ENST00000371873.10
CMPK1
cytidine/uridine monophosphate kinase 1
chr12_-_49189053 5.54 ENST00000550767.6
ENST00000546918.1
ENST00000679733.1
ENST00000552924.2
ENST00000301071.12
TUBA1A
tubulin alpha 1a
chr1_-_108192818 5.53 ENST00000370041.4
SLC25A24
solute carrier family 25 member 24
chr19_-_42877988 5.22 ENST00000597058.1
PSG1
pregnancy specific beta-1-glycoprotein 1
chr19_+_29606274 4.89 ENST00000586420.5
ENST00000585603.6
ENST00000221770.7
ENST00000590688.1
POP4
POP4 homolog, ribonuclease P/MRP subunit
chr1_+_2073986 4.73 ENST00000461106.6
PRKCZ
protein kinase C zeta
chr7_-_158704740 4.71 ENST00000409339.3
ENST00000356309.8
ENST00000409423.5
NCAPG2
non-SMC condensin II complex subunit G2
chr17_+_44345291 4.51 ENST00000593167.5
ENST00000585512.5
ENST00000591740.5
ENST00000592783.5
ENST00000587387.5
ENST00000588237.5
ENST00000053867.8
ENST00000589265.5
GRN
granulin precursor
chr1_+_2073462 4.44 ENST00000400921.6
PRKCZ
protein kinase C zeta
chr6_+_32970888 4.08 ENST00000374831.8
BRD2
bromodomain containing 2
chr18_-_49491586 4.02 ENST00000584895.5
ENST00000580210.5
ENST00000579408.5
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chrX_+_47145240 3.85 ENST00000628161.2
ENST00000345781.10
RBM10
RNA binding motif protein 10
chr22_+_31082860 3.75 ENST00000619644.4
SMTN
smoothelin
chr2_+_232550643 3.72 ENST00000409514.5
ENST00000409098.5
ENST00000409495.5
ENST00000409167.7
ENST00000258416.8
ENST00000409322.5
ENST00000409394.5
ENST00000454501.1
EIF4E2
eukaryotic translation initiation factor 4E family member 2
chr4_+_168832005 3.59 ENST00000393726.7
ENST00000507735.6
PALLD
palladin, cytoskeletal associated protein
chr1_-_235128819 3.55 ENST00000366607.5
TOMM20
translocase of outer mitochondrial membrane 20
chr11_-_6612141 3.44 ENST00000527248.2
ENST00000299424.9
TAF10
TATA-box binding protein associated factor 10
chr6_-_159745186 3.37 ENST00000537657.5
SOD2
superoxide dismutase 2
chr5_+_168291599 3.24 ENST00000265293.9
WWC1
WW and C2 domain containing 1
chrX_+_47145200 3.18 ENST00000377604.8
RBM10
RNA binding motif protein 10
chr17_+_57105899 3.15 ENST00000576295.5
AKAP1
A-kinase anchoring protein 1
chr20_-_44521989 3.10 ENST00000342374.5
ENST00000255175.5
SERINC3
serine incorporator 3
chr5_-_7868995 3.08 ENST00000264669.10
ENST00000507572.1
ENST00000504695.1
FASTKD3
FAST kinase domains 3
chr2_-_196799642 3.03 ENST00000409364.3
ENST00000263956.8
GTF3C3
general transcription factor IIIC subunit 3
chr8_+_73976182 2.75 ENST00000312184.6
ENST00000517439.1
TMEM70
transmembrane protein 70
chr6_+_10585748 2.59 ENST00000265012.5
GCNT2
glucosaminyl (N-acetyl) transferase 2 (I blood group)
chr2_-_187513641 2.34 ENST00000392365.5
ENST00000435414.5
TFPI
tissue factor pathway inhibitor
chr7_-_2242164 2.29 ENST00000242257.14
MRM2
mitochondrial rRNA methyltransferase 2
chr10_-_112446932 2.28 ENST00000682195.1
ENST00000683505.1
ENST00000683895.1
ENST00000682839.1
ENST00000682055.1
ZDHHC6
zinc finger DHHC-type palmitoyltransferase 6
chr18_-_49492305 2.21 ENST00000615479.4
ENST00000583637.5
ENST00000618613.5
ENST00000615760.4
ENST00000578528.1
ENST00000578532.5
ENST00000580387.5
ENST00000579248.5
ENST00000580261.6
ENST00000581373.5
ENST00000618619.4
ENST00000617346.4
ENST00000583036.5
ENST00000332968.11
RPL17
RPL17-C18orf32
ribosomal protein L17
RPL17-C18orf32 readthrough
chr11_-_112086727 1.99 ENST00000504148.3
ENST00000541231.1
TIMM8B
translocase of inner mitochondrial membrane 8 homolog B
chr16_+_66552558 1.90 ENST00000345436.8
ENST00000351137.8
ENST00000362093.4
ENST00000264001.9
ENST00000417030.2
ENST00000527729.5
ENST00000532838.1
ENST00000615332.5
ENST00000616804.5
CKLF
CKLF-CMTM1
chemokine like factor
CKLF-CMTM1 readthrough
chr14_-_24442241 1.80 ENST00000555355.5
ENST00000553343.5
ENST00000556523.1
ENST00000556249.1
ENST00000538105.6
ENST00000555225.5
SDR39U1
short chain dehydrogenase/reductase family 39U member 1
chr17_-_79950828 1.74 ENST00000572862.5
ENST00000573782.5
ENST00000574427.1
ENST00000570373.5
ENST00000340848.11
ENST00000576768.5
TBC1D16
TBC1 domain family member 16
chr8_-_23404076 1.68 ENST00000524168.1
ENST00000389131.8
ENST00000523833.2
ENST00000519243.1
LOXL2
lysyl oxidase like 2
chr11_+_112086853 1.65 ENST00000528182.5
ENST00000528048.5
ENST00000375549.8
ENST00000528021.6
ENST00000526592.5
ENST00000525291.5
SDHD
succinate dehydrogenase complex subunit D
chr7_+_2242256 1.59 ENST00000397046.5
ENST00000397048.5
ENST00000454650.1
NUDT1
nudix hydrolase 1
chr10_-_112446734 1.56 ENST00000684507.1
ZDHHC6
zinc finger DHHC-type palmitoyltransferase 6
chr1_-_145927447 1.54 ENST00000632555.1
ENST00000369307.4
ENST00000583313.7
RBM8A
RNA binding motif protein 8A
chr10_-_112446891 1.53 ENST00000369404.3
ENST00000369405.7
ENST00000626395.2
ZDHHC6
zinc finger DHHC-type palmitoyltransferase 6
chr18_+_56651335 1.49 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WDR7
WD repeat domain 7
chr15_-_55289756 1.38 ENST00000336787.6
RAB27A
RAB27A, member RAS oncogene family
chr7_+_2242207 1.35 ENST00000356714.6
NUDT1
nudix hydrolase 1
chr8_-_109644766 1.24 ENST00000533065.5
ENST00000276646.14
SYBU
syntabulin
chr17_+_43171187 1.18 ENST00000542611.5
ENST00000590996.6
ENST00000589872.1
NBR1
NBR1 autophagy cargo receptor
chrX_-_13817346 1.17 ENST00000356942.9
GPM6B
glycoprotein M6B
chr13_+_30735523 1.02 ENST00000380490.5
ALOX5AP
arachidonate 5-lipoxygenase activating protein
chr6_+_44219527 0.95 ENST00000651428.1
SLC29A1
solute carrier family 29 member 1 (Augustine blood group)
chr19_+_38899680 0.94 ENST00000576510.5
ENST00000392079.7
NFKBIB
NFKB inhibitor beta
chr1_+_35268663 0.91 ENST00000314607.11
ZMYM4
zinc finger MYM-type containing 4
chr1_-_160343235 0.85 ENST00000368069.7
ENST00000241704.8
ENST00000647683.1
ENST00000649787.1
COPA
COPI coat complex subunit alpha
chr5_+_7869104 0.78 ENST00000264668.6
ENST00000514220.5
ENST00000440940.7
ENST00000502550.5
ENST00000506877.1
MTRR
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chrX_-_13817027 0.76 ENST00000493677.5
ENST00000355135.6
ENST00000316715.9
GPM6B
glycoprotein M6B
chr6_+_39793008 0.73 ENST00000398904.6
DAAM2
dishevelled associated activator of morphogenesis 2
chr17_-_58527980 0.58 ENST00000583114.5
SEPTIN4
septin 4
chr1_-_9069572 0.45 ENST00000377414.7
SLC2A5
solute carrier family 2 member 5
chr18_+_56651385 0.44 ENST00000615645.4
WDR7
WD repeat domain 7
chr15_-_44663644 0.43 ENST00000559511.6
ENST00000427534.6
ENST00000559193.5
ENST00000261866.12
ENST00000535302.6
ENST00000684235.1
ENST00000682065.1
ENST00000682669.1
ENST00000558319.5
SPG11
SPG11 vesicle trafficking associated, spatacsin
chr1_-_53838276 0.36 ENST00000371429.4
NDC1
NDC1 transmembrane nucleoporin
chr11_+_63536801 0.35 ENST00000255688.8
ENST00000439013.6
PLAAT4
phospholipase A and acyltransferase 4
chr3_+_45886537 0.30 ENST00000357632.7
ENST00000422395.1
CCR9
C-C motif chemokine receptor 9
chr3_+_45886501 0.28 ENST00000395963.2
CCR9
C-C motif chemokine receptor 9
chr14_-_36520222 0.27 ENST00000354822.7
NKX2-1
NK2 homeobox 1
chr4_-_139084289 0.18 ENST00000510408.5
ENST00000379549.7
ENST00000358635.7
ELF2
E74 like ETS transcription factor 2
chr11_-_130428605 0.09 ENST00000257359.7
ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif 8
chr4_+_678189 0.04 ENST00000507804.1
MYL5
myosin light chain 5

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 14.4 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
2.7 8.1 GO:2000521 negative regulation of immunological synapse formation(GO:2000521)
2.6 7.9 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
2.3 6.9 GO:0030327 prenylated protein catabolic process(GO:0030327)
1.9 5.8 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
1.8 9.2 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
1.7 45.5 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
1.6 6.6 GO:0009137 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
1.0 5.8 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.9 13.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.9 2.8 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.9 3.6 GO:0035927 RNA import into mitochondrion(GO:0035927)
0.8 5.5 GO:0015866 ADP transport(GO:0015866)
0.7 5.7 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.7 3.4 GO:0003070 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.6 2.3 GO:0000451 rRNA 2'-O-methylation(GO:0000451)
0.5 1.6 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.4 3.0 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.4 4.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.4 3.1 GO:0009597 detection of virus(GO:0009597)
0.4 2.6 GO:0036438 maintenance of lens transparency(GO:0036438)
0.4 2.9 GO:0046061 dGTP catabolic process(GO:0006203) dATP catabolic process(GO:0046061)
0.3 4.9 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.3 3.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.3 5.4 GO:0018345 protein palmitoylation(GO:0018345)
0.3 2.3 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.2 3.4 GO:0070365 hepatocyte differentiation(GO:0070365)
0.2 1.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.2 0.6 GO:0002305 gamma-delta intraepithelial T cell differentiation(GO:0002304) CD8-positive, gamma-delta intraepithelial T cell differentiation(GO:0002305)
0.2 0.9 GO:0015862 uridine transport(GO:0015862)
0.2 3.6 GO:0003334 keratinocyte development(GO:0003334)
0.2 1.9 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.2 14.1 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.2 0.8 GO:0043418 homocysteine catabolic process(GO:0043418)
0.1 13.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 8.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 2.0 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.1 13.9 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 0.4 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 7.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 1.0 GO:2001300 lipoxin metabolic process(GO:2001300)
0.1 3.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.3 GO:0021759 globus pallidus development(GO:0021759)
0.1 1.7 GO:0046688 response to copper ion(GO:0046688)
0.0 0.8 GO:0030157 pancreatic juice secretion(GO:0030157)
0.0 1.7 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 1.9 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 4.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.2 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 5.5 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 3.7 GO:0006413 translational initiation(GO:0006413)
0.0 6.0 GO:0043393 regulation of protein binding(GO:0043393)
0.0 0.4 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 3.1 GO:0045333 cellular respiration(GO:0045333)
0.0 2.0 GO:0006939 smooth muscle contraction(GO:0006939)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.0 GO:0070195 growth hormone receptor complex(GO:0070195)
1.6 7.9 GO:0001652 dense fibrillar component(GO:0001651) granular component(GO:0001652)
1.1 9.2 GO:0045179 apical cortex(GO:0045179)
1.1 13.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.8 4.9 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.7 13.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.6 4.7 GO:0000796 condensin complex(GO:0000796)
0.5 5.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.5 29.7 GO:0031904 endosome lumen(GO:0031904)
0.4 3.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.4 14.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.4 3.0 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.4 3.4 GO:0000125 PCAF complex(GO:0000125)
0.3 1.6 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.2 3.7 GO:0005845 mRNA cap binding complex(GO:0005845)
0.2 2.0 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 13.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 8.1 GO:0001772 immunological synapse(GO:0001772)
0.1 1.4 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 0.4 GO:0005816 spindle pole body(GO:0005816)
0.1 1.2 GO:0097433 dense body(GO:0097433)
0.1 7.7 GO:0000502 proteasome complex(GO:0000502)
0.1 5.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.8 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 3.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 5.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 7.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 2.8 GO:0002102 podosome(GO:0002102)
0.1 5.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 5.9 GO:0031514 motile cilium(GO:0031514)
0.0 4.5 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 2.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 7.6 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.2 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.0 1.9 GO:0008021 synaptic vesicle(GO:0008021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.0 GO:0005148 prolactin receptor binding(GO:0005148)
2.4 14.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
2.2 6.6 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
1.9 5.7 GO:0009041 uridylate kinase activity(GO:0009041)
1.4 5.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.3 7.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
1.0 8.1 GO:0019863 IgE binding(GO:0019863)
1.0 2.9 GO:0044714 GTP diphosphatase activity(GO:0036219) 2-hydroxy-adenosine triphosphate pyrophosphatase activity(GO:0044713) 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity(GO:0044714) ATP diphosphatase activity(GO:0047693)
0.8 5.5 GO:0015216 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
0.8 3.0 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.7 5.8 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.7 13.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.6 1.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.5 7.9 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.5 13.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 3.6 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.4 1.6 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.4 4.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.4 9.2 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.4 52.7 GO:0005179 hormone activity(GO:0005179)
0.4 2.6 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.3 3.4 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 12.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 5.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 3.1 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.2 1.0 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.2 3.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.2 3.7 GO:0000339 RNA cap binding(GO:0000339)
0.1 4.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 2.3 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.1 3.1 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 6.9 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.1 0.8 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.1 0.9 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 7.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 4.7 GO:0035064 methylated histone binding(GO:0035064)
0.1 13.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 1.4 GO:0031489 myosin V binding(GO:0031489)
0.1 3.4 GO:0030331 estrogen receptor binding(GO:0030331)
0.0 3.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.2 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.6 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 3.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 4.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 5.5 GO:0005125 cytokine activity(GO:0005125)
0.0 0.3 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 15.6 PID RAS PATHWAY Regulation of Ras family activation
0.2 13.5 PID AURORA B PATHWAY Aurora B signaling
0.2 13.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 61.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 5.5 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 2.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 3.4 PID FOXO PATHWAY FoxO family signaling
0.0 3.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 4.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 3.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 45.5 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.4 9.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.4 13.1 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 6.4 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 13.5 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.2 5.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 5.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 3.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 3.0 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1 5.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 13.9 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 0.8 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 3.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.5 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 3.7 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.6 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production