Project

avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZNF423

Z-value: 0.53

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Transcription factors associated with ZNF423

Gene Symbol Gene ID Gene Info
ZNF423
ENSG00000102935.12 ZNF423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF423hg38_v1_chr16_-_49664225_49664298-0.152.3e-02Click!

Activity profile of ZNF423 motif

Sorted Z-values of ZNF423 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF423

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_+_49171918 8.74 ENST00000376322.7
PLP2
proteolipid protein 2
chr5_+_136049513 6.88 ENST00000514554.5
TGFBI
transforming growth factor beta induced
chr19_-_41353044 6.29 ENST00000600196.2
ENST00000677934.1
TGFB1
transforming growth factor beta 1
chr5_+_151020438 5.20 ENST00000622181.4
ENST00000614343.4
ENST00000388825.9
ENST00000521650.5
ENST00000517973.1
GPX3
glutathione peroxidase 3
chr1_+_26317950 4.73 ENST00000374213.3
CD52
CD52 molecule
chr9_+_109780292 3.94 ENST00000374530.7
PALM2AKAP2
PALM2 and AKAP2 fusion
chr20_+_33993904 3.91 ENST00000246194.8
RALY
RALY heterogeneous nuclear ribonucleoprotein
chrX_+_49171889 3.72 ENST00000376327.6
PLP2
proteolipid protein 2
chr19_-_11578937 3.67 ENST00000592659.1
ENST00000592828.6
ENST00000218758.9
ENST00000412435.6
ACP5
acid phosphatase 5, tartrate resistant
chr9_+_109780312 3.24 ENST00000483909.5
ENST00000413420.5
ENST00000302798.7
PALM2AKAP2
PALM2 and AKAP2 fusion
chr8_+_22165358 3.23 ENST00000306349.13
ENST00000306385.10
BMP1
bone morphogenetic protein 1
chr10_-_119536533 3.23 ENST00000392865.5
RGS10
regulator of G protein signaling 10
chr19_+_14433284 3.20 ENST00000242783.11
PKN1
protein kinase N1
chr20_-_21397513 2.88 ENST00000351817.5
NKX2-4
NK2 homeobox 4
chr16_-_11587162 2.77 ENST00000570904.5
ENST00000574701.5
LITAF
lipopolysaccharide induced TNF factor
chr8_+_22165140 2.72 ENST00000397814.7
ENST00000354870.5
BMP1
bone morphogenetic protein 1
chr11_-_61891381 2.62 ENST00000525588.5
FADS3
fatty acid desaturase 3
chr19_+_41264345 2.51 ENST00000378215.8
ENST00000392006.8
ENST00000617774.1
ENST00000602130.5
ENST00000617305.4
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U like 1
chrX_-_107775951 2.47 ENST00000315660.8
ENST00000372384.6
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family member 3
chr5_+_53480619 2.36 ENST00000396947.7
ENST00000256759.8
FST
follistatin
chr11_-_61891534 2.22 ENST00000278829.7
FADS3
fatty acid desaturase 3
chr5_+_171309239 2.21 ENST00000296921.6
TLX3
T cell leukemia homeobox 3
chrX_-_107775740 2.17 ENST00000372383.9
TSC22D3
TSC22 domain family member 3
chr17_+_79024142 2.16 ENST00000579760.6
ENST00000339142.6
C1QTNF1
C1q and TNF related 1
chr9_-_127980976 2.09 ENST00000373095.6
FAM102A
family with sequence similarity 102 member A
chr6_+_42929430 2.08 ENST00000372836.5
CNPY3
canopy FGF signaling regulator 3
chr16_+_27313879 2.00 ENST00000562142.5
ENST00000561742.5
ENST00000543915.6
ENST00000395762.7
ENST00000563002.5
IL4R
interleukin 4 receptor
chr11_-_44950151 1.90 ENST00000533940.5
ENST00000533937.1
TP53I11
tumor protein p53 inducible protein 11
chr19_-_46714269 1.87 ENST00000600194.5
PRKD2
protein kinase D2
chr17_+_79024243 1.86 ENST00000311661.4
C1QTNF1
C1q and TNF related 1
chr19_-_10339610 1.79 ENST00000589261.5
ENST00000160262.10
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
ICAM3
intercellular adhesion molecule 3
chr11_-_64742937 1.77 ENST00000394428.5
ENST00000394429.5
RASGRP2
RAS guanyl releasing protein 2
chr19_-_49867251 1.74 ENST00000631020.2
ENST00000596014.5
ENST00000636994.1
PNKP
polynucleotide kinase 3'-phosphatase
chr8_+_30384511 1.68 ENST00000339877.8
ENST00000320203.8
ENST00000287771.9
ENST00000397323.9
RBPMS
RNA binding protein, mRNA processing factor
chr20_+_33993646 1.56 ENST00000375114.7
ENST00000448364.5
RALY
RALY heterogeneous nuclear ribonucleoprotein
chr11_-_44950839 1.52 ENST00000395648.7
ENST00000531928.6
TP53I11
tumor protein p53 inducible protein 11
chr11_-_63015804 1.52 ENST00000535878.5
ENST00000545207.5
SLC22A8
solute carrier family 22 member 8
chr11_-_63015831 1.51 ENST00000430500.6
ENST00000336232.7
SLC22A8
solute carrier family 22 member 8
chr11_-_44950867 1.48 ENST00000528290.5
ENST00000525680.6
ENST00000530035.5
ENST00000527685.5
TP53I11
tumor protein p53 inducible protein 11
chr6_+_33621313 1.47 ENST00000605930.3
ITPR3
inositol 1,4,5-trisphosphate receptor type 3
chr11_-_67353503 1.37 ENST00000539074.1
ENST00000530584.5
ENST00000531239.2
ENST00000312419.8
ENST00000529704.5
POLD4
DNA polymerase delta 4, accessory subunit
chr16_-_11587450 1.36 ENST00000571688.5
LITAF
lipopolysaccharide induced TNF factor
chr19_-_42242526 1.33 ENST00000222330.8
ENST00000676537.1
GSK3A
glycogen synthase kinase 3 alpha
chr3_+_138349209 1.30 ENST00000474559.1
MRAS
muscle RAS oncogene homolog
chr1_+_1471751 1.25 ENST00000673477.1
ENST00000308647.8
ATAD3B
ATPase family AAA domain containing 3B
chr15_-_75368578 1.24 ENST00000569482.5
ENST00000565683.5
ENST00000561615.1
ENST00000563622.5
ENST00000568374.5
ENST00000267978.10
ENST00000566256.5
MAN2C1
mannosidase alpha class 2C member 1
chr7_+_20330893 1.20 ENST00000222573.5
ITGB8
integrin subunit beta 8
chr19_+_45079195 1.19 ENST00000591607.1
ENST00000591747.5
ENST00000270257.9
ENST00000391951.2
ENST00000587566.5
GEMIN7
MARK4
gem nuclear organelle associated protein 7
microtubule affinity regulating kinase 4
chr22_-_42649332 1.15 ENST00000352397.10
CYB5R3
cytochrome b5 reductase 3
chr3_+_9917185 1.09 ENST00000413608.2
ENST00000451165.6
IL17RC
interleukin 17 receptor C
chr9_-_16870662 1.08 ENST00000380672.9
BNC2
basonuclin 2
chr6_+_109440695 1.07 ENST00000258052.8
SMPD2
sphingomyelin phosphodiesterase 2
chr7_-_5530581 1.05 ENST00000676397.1
ENST00000645576.1
ENST00000674681.1
ENST00000646664.1
ENST00000493945.6
ENST00000676319.1
ENST00000473257.3
ENST00000647275.1
ENST00000432588.6
ACTB
actin beta
chr8_+_22565655 1.05 ENST00000523965.5
SORBS3
sorbin and SH3 domain containing 3
chr8_+_22565236 1.04 ENST00000523900.5
SORBS3
sorbin and SH3 domain containing 3
chr10_+_133527355 1.03 ENST00000252945.8
ENST00000421586.5
ENST00000418356.1
CYP2E1
cytochrome P450 family 2 subfamily E member 1
chr11_+_832887 1.02 ENST00000524748.6
ENST00000397420.9
ENST00000397421.5
ENST00000322008.9
ENST00000525718.6
ENST00000529810.5
ENST00000526693.5
ENST00000525333.5
ENST00000527341.5
CD151
CD151 molecule (Raph blood group)
chr8_-_42377227 1.01 ENST00000220812.3
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr1_-_165445220 0.93 ENST00000619224.1
RXRG
retinoid X receptor gamma
chr6_-_35512863 0.92 ENST00000428978.1
ENST00000614066.4
ENST00000322263.8
TULP1
TUB like protein 1
chr16_+_3046552 0.92 ENST00000336577.9
MMP25
matrix metallopeptidase 25
chr3_+_9917074 0.91 ENST00000416074.6
ENST00000383812.9
ENST00000438091.5
ENST00000295981.7
ENST00000403601.8
ENST00000436503.5
ENST00000455057.5
IL17RC
interleukin 17 receptor C
chr19_-_56671746 0.85 ENST00000537055.4
ENST00000601659.1
ZNF835
zinc finger protein 835
chr8_-_132481057 0.84 ENST00000388996.10
KCNQ3
potassium voltage-gated channel subfamily Q member 3
chr10_+_97319250 0.83 ENST00000371021.5
FRAT1
FRAT regulator of WNT signaling pathway 1
chr10_+_123154414 0.80 ENST00000368858.9
BUB3
BUB3 mitotic checkpoint protein
chr10_+_74824919 0.78 ENST00000648828.1
ENST00000648725.1
KAT6B
lysine acetyltransferase 6B
chr12_-_57129001 0.73 ENST00000556155.5
STAT6
signal transducer and activator of transcription 6
chr1_+_155308930 0.71 ENST00000465559.5
ENST00000612683.1
FDPS
farnesyl diphosphate synthase
chrX_+_137566119 0.68 ENST00000287538.10
ZIC3
Zic family member 3
chr1_+_155308748 0.65 ENST00000611010.4
ENST00000447866.5
ENST00000368356.9
ENST00000467076.5
ENST00000491013.5
ENST00000356657.10
FDPS
farnesyl diphosphate synthase
chr20_+_44401397 0.64 ENST00000682427.1
ENST00000681977.1
ENST00000684136.1
ENST00000684046.1
ENST00000684476.1
ENST00000619550.5
ENST00000682169.1
HNF4A
hepatocyte nuclear factor 4 alpha
chr19_-_15200902 0.62 ENST00000601011.1
ENST00000263388.7
NOTCH3
notch receptor 3
chr10_+_74825445 0.60 ENST00000649006.1
ENST00000649463.1
ENST00000372725.6
KAT6B
lysine acetyltransferase 6B
chr5_+_141923813 0.60 ENST00000194118.8
ENST00000432126.7
DELE1
DAP3 binding cell death enhancer 1
chr7_+_20330678 0.59 ENST00000537992.5
ITGB8
integrin subunit beta 8
chr8_-_79767843 0.59 ENST00000337919.9
HEY1
hes related family bHLH transcription factor with YRPW motif 1
chr6_-_109440504 0.58 ENST00000520723.5
ENST00000518648.1
ENST00000417394.6
ENST00000521072.7
PPIL6
peptidylprolyl isomerase like 6
chr6_-_35512882 0.58 ENST00000229771.11
TULP1
TUB like protein 1
chr4_-_119628007 0.56 ENST00000420633.1
ENST00000394439.5
PDE5A
phosphodiesterase 5A
chr9_-_96619378 0.56 ENST00000375240.7
ENST00000463569.5
CDC14B
cell division cycle 14B
chr5_+_69492767 0.54 ENST00000681041.1
ENST00000680098.1
ENST00000680784.1
ENST00000396442.7
ENST00000681895.1
OCLN
occludin
chr1_-_165445088 0.54 ENST00000359842.10
RXRG
retinoid X receptor gamma
chr1_+_1512137 0.53 ENST00000378756.8
ENST00000378755.9
ATAD3A
ATPase family AAA domain containing 3A
chr2_+_27496830 0.53 ENST00000264717.7
GCKR
glucokinase regulator
chr9_-_16870702 0.52 ENST00000380667.6
ENST00000545497.5
ENST00000486514.5
BNC2
basonuclin 2
chr20_+_44401222 0.52 ENST00000316099.9
HNF4A
hepatocyte nuclear factor 4 alpha
chr3_-_52897541 0.50 ENST00000355083.11
ENST00000504329.1
STIMATE
STIMATE-MUSTN1
STIM activating enhancer
STIMATE-MUSTN1 readthrough
chr2_-_206086057 0.47 ENST00000403263.6
INO80D
INO80 complex subunit D
chr6_-_31112566 0.46 ENST00000259870.4
C6orf15
chromosome 6 open reading frame 15
chr19_+_48393657 0.45 ENST00000263269.4
GRIN2D
glutamate ionotropic receptor NMDA type subunit 2D
chr12_+_7189845 0.42 ENST00000412720.6
ENST00000396637.7
PEX5
peroxisomal biogenesis factor 5
chr20_+_31475278 0.40 ENST00000201979.3
REM1
RRAD and GEM like GTPase 1
chr17_+_2337622 0.39 ENST00000574563.5
SGSM2
small G protein signaling modulator 2
chr19_-_5622768 0.38 ENST00000252542.9
SAFB2
scaffold attachment factor B2
chr14_+_64914361 0.33 ENST00000607599.6
ENST00000548752.7
ENST00000551947.6
ENST00000549115.7
ENST00000552002.7
ENST00000551093.6
ENST00000549987.1
CHURC1
CHURC1-FNTB
churchill domain containing 1
CHURC1-FNTB readthrough
chr7_-_100158679 0.31 ENST00000456769.5
ENST00000316937.8
TRAPPC14
trafficking protein particle complex 14
chr8_-_79767462 0.29 ENST00000674295.1
ENST00000518733.1
ENST00000674418.1
ENST00000674358.1
ENST00000354724.8
HEY1
hes related family bHLH transcription factor with YRPW motif 1
chr11_-_30586344 0.29 ENST00000358117.10
MPPED2
metallophosphoesterase domain containing 2
chr17_-_44376169 0.27 ENST00000587295.5
ITGA2B
integrin subunit alpha 2b
chr20_+_44401269 0.26 ENST00000443598.6
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4 alpha
chr10_+_123154364 0.25 ENST00000368859.6
ENST00000368865.9
BUB3
BUB3 mitotic checkpoint protein
chr2_+_170929198 0.23 ENST00000234160.5
GORASP2
golgi reassembly stacking protein 2
chr6_+_30163188 0.23 ENST00000619857.4
TRIM15
tripartite motif containing 15
chr11_+_61828280 0.20 ENST00000521849.5
ENST00000278840.9
FADS2
fatty acid desaturase 2
chr16_+_70114306 0.19 ENST00000288050.9
ENST00000398122.7
ENST00000568530.5
PDPR
pyruvate dehydrogenase phosphatase regulatory subunit
chr10_+_123154768 0.16 ENST00000407911.2
BUB3
BUB3 mitotic checkpoint protein
chr19_-_12881460 0.15 ENST00000592506.1
DNASE2
deoxyribonuclease 2, lysosomal
chr9_+_128787331 0.15 ENST00000223865.8
TBC1D13
TBC1 domain family member 13
chr12_+_52079700 0.13 ENST00000546390.2
SMIM41
small integral membrane protein 41
chr19_-_11481044 0.11 ENST00000359227.8
ELAVL3
ELAV like RNA binding protein 3
chrX_-_18354672 0.10 ENST00000251900.9
SCML2
Scm polycomb group protein like 2
chr6_-_142147122 0.09 ENST00000258042.2
NMBR
neuromedin B receptor
chr10_+_112950240 0.09 ENST00000627217.3
ENST00000534894.5
ENST00000538897.5
ENST00000536810.5
ENST00000355995.8
ENST00000542695.5
ENST00000543371.5
TCF7L2
transcription factor 7 like 2
chr19_+_19900935 0.09 ENST00000588146.1
ENST00000343769.6
ZNF93
zinc finger protein 93
chr11_-_1036706 0.08 ENST00000421673.7
MUC6
mucin 6, oligomeric mucus/gel-forming
chr16_+_2964216 0.07 ENST00000572045.5
ENST00000571007.5
ENST00000575885.5
ENST00000303746.10
ENST00000319500.10
KREMEN2
kringle containing transmembrane protein 2
chr2_+_134254065 0.04 ENST00000281923.4
MGAT5
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
chr19_+_45251249 0.04 ENST00000262891.9
ENST00000300843.8
MARK4
microtubule affinity regulating kinase 4
chr1_+_1287109 0.03 ENST00000379099.3
SCNN1D
sodium channel epithelial 1 subunit delta
chr1_-_155207886 0.01 ENST00000368378.7
ENST00000541990.5
ENST00000457183.6
ENST00000541576.5
THBS3
thrombospondin 3

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
1.6 6.3 GO:0046732 ossification involved in bone remodeling(GO:0043932) induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528) negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.8 4.0 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.8 3.2 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.7 3.7 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.6 4.6 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.5 2.0 GO:1990834 negative regulation of T-helper 1 cell differentiation(GO:0045626) response to odorant(GO:1990834)
0.4 1.7 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.4 1.5 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.3 1.0 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.3 1.3 GO:0071879 UDP-glucose catabolic process(GO:0006258) positive regulation of adrenergic receptor signaling pathway(GO:0071879) negative regulation of type B pancreatic cell development(GO:2000077)
0.3 5.9 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.3 0.9 GO:0061027 umbilical cord morphogenesis(GO:0036304) umbilical cord development(GO:0061027)
0.3 6.9 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.3 2.0 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.3 1.4 GO:0033383 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.2 1.9 GO:0089700 protein kinase D signaling(GO:0089700)
0.2 1.0 GO:0010193 response to ozone(GO:0010193)
0.2 1.0 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.2 0.7 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.2 1.5 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.2 3.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 2.4 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.2 1.2 GO:0006013 mannose metabolic process(GO:0006013)
0.2 0.6 GO:0072103 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 0.4 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 1.7 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.1 2.2 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.1 4.7 GO:0045730 respiratory burst(GO:0045730)
0.1 0.7 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 4.1 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1 0.6 GO:0055118 negative regulation of striated muscle contraction(GO:0045988) negative regulation of cardiac muscle contraction(GO:0055118) positive regulation of oocyte development(GO:0060282)
0.1 0.5 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 1.8 GO:0001573 ganglioside metabolic process(GO:0001573)
0.1 3.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 5.0 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.1 1.1 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1 0.3 GO:0018343 protein farnesylation(GO:0018343)
0.1 1.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.1 0.9 GO:0060022 hard palate development(GO:0060022)
0.1 1.6 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.5 GO:0070673 response to interleukin-18(GO:0070673)
0.0 6.9 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.8 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 1.4 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.0 1.5 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 1.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.8 GO:1904886 beta-catenin destruction complex disassembly(GO:1904886)
0.0 1.2 GO:0071173 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.1 GO:1901253 mesodermal cell fate determination(GO:0007500) negative regulation of intracellular transport of viral material(GO:1901253)
0.0 2.1 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 1.2 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 1.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.4 GO:0001964 startle response(GO:0001964)
0.0 0.4 GO:0060008 Sertoli cell differentiation(GO:0060008)
0.0 2.1 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.1 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.3 GO:0002687 positive regulation of leukocyte migration(GO:0002687)
0.0 9.8 GO:0006935 chemotaxis(GO:0006935) taxis(GO:0042330)
0.0 0.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 3.5 GO:0002758 innate immune response-activating signal transduction(GO:0002758)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.6 4.1 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.4 1.2 GO:1990298 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.3 1.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.2 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 1.4 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.3 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 1.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.1 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.0 GO:0097433 dense body(GO:0097433)
0.1 1.7 GO:0005685 U1 snRNP(GO:0005685)
0.1 6.3 GO:0005902 microvillus(GO:0005902)
0.1 1.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 7.5 GO:0005604 basement membrane(GO:0005604)
0.1 4.0 GO:0005581 collagen trimer(GO:0005581)
0.0 3.2 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 5.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.8 GO:0043194 axon initial segment(GO:0043194)
0.0 1.5 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 3.2 GO:0043197 dendritic spine(GO:0043197)
0.0 1.3 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 1.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.1 GO:0071664 beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664)
0.0 0.5 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.1 GO:0005901 caveola(GO:0005901)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.8 3.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.5 4.6 GO:0043426 MRF binding(GO:0043426)
0.4 1.8 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.4 1.7 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.4 5.2 GO:0008430 selenium binding(GO:0008430)
0.4 1.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.4 1.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.3 1.0 GO:0098918 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.3 1.7 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.3 12.5 GO:0019956 chemokine binding(GO:0019956)
0.3 2.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 3.7 GO:0008199 ferric iron binding(GO:0008199)
0.3 1.4 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.2 0.9 GO:0035939 microsatellite binding(GO:0035939)
0.2 0.5 GO:0070052 collagen V binding(GO:0070052)
0.1 0.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 1.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 2.4 GO:0048185 activin binding(GO:0048185)
0.1 3.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.8 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 3.0 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 1.2 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.1 10.4 GO:0005518 collagen binding(GO:0005518)
0.1 4.1 GO:0050699 WW domain binding(GO:0050699)
0.1 0.3 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 1.9 GO:0004697 protein kinase C activity(GO:0004697)
0.1 2.1 GO:0017166 vinculin binding(GO:0017166)
0.1 0.3 GO:0070051 fibrinogen binding(GO:0070051)
0.1 6.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.2 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.0 0.2 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 1.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 1.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 1.0 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 1.3 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 1.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 1.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 2.8 GO:0005178 integrin binding(GO:0005178)
0.0 1.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.6 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 2.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.3 PID IL27 PATHWAY IL27-mediated signaling events
0.2 2.0 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 8.7 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 3.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 1.7 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.5 ST GAQ PATHWAY G alpha q Pathway
0.0 1.9 PID BMP PATHWAY BMP receptor signaling
0.0 1.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.8 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.7 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 6.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 1.1 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.9 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.3 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.6 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.0 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.2 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 0.5 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.3 6.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 5.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 3.0 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 1.5 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 6.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 2.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 0.6 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 4.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 1.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 1.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.2 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 1.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 2.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 3.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.8 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.7 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.0 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.1 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.2 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 2.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription