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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF711_TFAP2A_TFAP2D
Z-value: 10.02
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Transcription factors associated with ZNF711_TFAP2A_TFAP2D
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF711 | hg38_v1_chrX_+_85244075_85244121, hg38_v1_chrX_+_85244032_85244073, hg38_v1_chrX_+_85243983_85243997 | -0.49 | 1.5e-14 | Click! |
| TFAP2A | hg38_v1_chr6_-_10412367_10412400, hg38_v1_chr6_-_10415043_10415109 | 0.26 | 1.0e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF711_TFAP2A_TFAP2D
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.4 | 1471.7 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 10.3 | 1298.8 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 13.8 | 1048.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 11.7 | 654.4 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 13.2 | 552.6 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 12.4 | 494.5 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 11.1 | 442.7 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 6.3 | 431.3 | GO:0010257 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 26.0 | 415.9 | GO:0043248 | proteasome assembly(GO:0043248) |
| 18.5 | 407.5 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 2299.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.8 | 1823.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 8.4 | 1206.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 7.0 | 1149.8 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 10.5 | 1124.3 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 9.8 | 1114.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 7.5 | 1088.1 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 1.5 | 1079.6 | GO:0005730 | nucleolus(GO:0005730) |
| 7.0 | 612.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 3.7 | 602.3 | GO:0031968 | mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 2367.7 | GO:0003723 | RNA binding(GO:0003723) |
| 11.0 | 2257.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 5.6 | 2160.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 16.6 | 778.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 23.3 | 651.8 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 6.2 | 460.2 | GO:0019003 | GDP binding(GO:0019003) |
| 4.9 | 455.7 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 8.1 | 445.8 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 24.5 | 440.8 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 13.1 | 418.8 | GO:0008143 | poly(A) binding(GO:0008143) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.3 | 1945.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 9.0 | 771.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 6.8 | 651.7 | PID E2F PATHWAY | E2F transcription factor network |
| 14.8 | 593.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 9.2 | 524.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 9.3 | 511.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 4.7 | 485.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 9.8 | 459.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 6.7 | 436.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 3.0 | 362.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 24.1 | 1759.2 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 11.8 | 1384.8 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 9.0 | 1010.3 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 12.7 | 936.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 25.8 | 850.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 13.0 | 764.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 7.5 | 734.4 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |
| 19.4 | 638.9 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 4.3 | 630.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 7.3 | 617.5 | REACTOME MITOTIC M M G1 PHASES | Genes involved in Mitotic M-M/G1 phases |