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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZNF8

Z-value: 3.45

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Transcription factors associated with ZNF8

Gene Symbol Gene ID Gene Info
ZNF8
ENSG00000278129.2 ZNF8
ZNF8
ENSG00000278129.2 ZNF8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF8hg38_v1_chr19_+_58278948_58278992-0.561.9e-19Click!

Activity profile of ZNF8 motif

Sorted Z-values of ZNF8 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF8

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_46268989 26.12 ENST00000549049.5
ENST00000439706.5
ENST00000398637.10
SLC38A1
solute carrier family 38 member 1
chr6_+_29723421 11.90 ENST00000259951.12
ENST00000434407.6
HLA-F
major histocompatibility complex, class I, F
chr6_+_29723340 11.87 ENST00000334668.8
HLA-F
major histocompatibility complex, class I, F
chr7_+_100706061 10.86 ENST00000303151.5
POP7
POP7 homolog, ribonuclease P/MRP subunit
chr1_-_70205531 9.12 ENST00000370952.4
LRRC40
leucine rich repeat containing 40
chr1_+_70205680 9.09 ENST00000370951.5
SRSF11
serine and arginine rich splicing factor 11
chr7_-_100100716 8.34 ENST00000354230.7
ENST00000425308.5
MCM7
minichromosome maintenance complex component 7
chr1_-_235128819 8.17 ENST00000366607.5
TOMM20
translocase of outer mitochondrial membrane 20
chr8_+_26291758 7.99 ENST00000522535.5
ENST00000665949.1
PPP2R2A
protein phosphatase 2 regulatory subunit Balpha
chr8_-_108248700 7.84 ENST00000220849.10
ENST00000678937.1
ENST00000678901.1
ENST00000678243.1
ENST00000677674.1
ENST00000521297.2
ENST00000677272.1
ENST00000522352.6
ENST00000678042.1
ENST00000519627.2
ENST00000521440.6
ENST00000678773.1
ENST00000676698.1
ENST00000518345.2
ENST00000677447.1
ENST00000676548.1
ENST00000519030.6
ENST00000518442.5
EIF3E
eukaryotic translation initiation factor 3 subunit E
chr4_-_76148382 7.24 ENST00000264883.8
ENST00000514987.5
ENST00000514901.5
NUP54
nucleoporin 54
chr2_+_130182224 6.98 ENST00000651060.1
ENST00000409255.1
ENST00000281871.11
ENST00000455239.1
MZT2B
mitotic spindle organizing protein 2B
chr13_+_52455429 6.93 ENST00000468284.1
ENST00000378034.7
ENST00000378037.9
ENST00000258607.10
CKAP2
cytoskeleton associated protein 2
chr2_+_197500398 6.56 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr16_+_21953341 6.25 ENST00000268379.9
ENST00000561553.5
ENST00000565331.5
UQCRC2
ubiquinol-cytochrome c reductase core protein 2
chr12_+_52069967 6.02 ENST00000336854.9
ENST00000550604.1
ENST00000553049.5
ENST00000548915.1
ATG101
autophagy related 101
chr1_+_70205708 5.97 ENST00000370950.7
SRSF11
serine and arginine rich splicing factor 11
chr17_-_58514617 5.63 ENST00000682306.1
MTMR4
myotubularin related protein 4
chr6_+_44246166 5.48 ENST00000620073.4
HSP90AB1
heat shock protein 90 alpha family class B member 1
chr2_+_197500371 4.46 ENST00000409468.1
ENST00000233893.10
HSPE1
heat shock protein family E (Hsp10) member 1
chr7_+_118184105 4.27 ENST00000424702.1
LSM8
LSM8 homolog, U6 small nuclear RNA associated
chr1_+_186375813 4.15 ENST00000419367.8
ENST00000287859.11
ENST00000367470.8
ODR4
odr-4 GPCR localization factor homolog
chr5_-_138575359 3.85 ENST00000297185.9
ENST00000678300.1
ENST00000677425.1
ENST00000677064.1
ENST00000507115.6
HSPA9
heat shock protein family A (Hsp70) member 9
chr22_+_29767351 3.79 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr6_-_107459504 3.37 ENST00000369037.9
ENST00000369031.4
PDSS2
decaprenyl diphosphate synthase subunit 2
chr19_-_18281612 3.31 ENST00000252818.5
JUND
JunD proto-oncogene, AP-1 transcription factor subunit
chr1_+_25338294 2.70 ENST00000374358.5
TMEM50A
transmembrane protein 50A
chr10_+_988425 2.51 ENST00000360803.9
GTPBP4
GTP binding protein 4
chr13_-_25287457 2.38 ENST00000381801.6
MTMR6
myotubularin related protein 6
chr2_-_105329685 2.22 ENST00000393359.7
TGFBRAP1
transforming growth factor beta receptor associated protein 1
chr13_+_21176629 1.91 ENST00000309594.5
MRPL57
mitochondrial ribosomal protein L57
chr6_-_26056460 1.89 ENST00000343677.4
H1-2
H1.2 linker histone, cluster member
chrX_+_1268828 1.74 ENST00000432318.8
ENST00000381509.8
ENST00000494969.7
ENST00000355805.7
ENST00000355432.8
CSF2RA
colony stimulating factor 2 receptor subunit alpha
chrX_+_130401962 1.64 ENST00000305536.11
ENST00000370947.1
RBMX2
RNA binding motif protein X-linked 2
chr5_+_103120264 1.61 ENST00000358359.8
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr4_-_185425941 1.39 ENST00000264689.11
ENST00000505357.1
UFSP2
UFM1 specific peptidase 2
chr14_+_105474781 1.20 ENST00000550577.5
ENST00000538259.2
ENST00000329146.9
CRIP2
cysteine rich protein 2
chr6_-_81752671 1.13 ENST00000320172.11
ENST00000369754.7
ENST00000369756.3
TENT5A
terminal nucleotidyltransferase 5A
chr3_-_57079287 0.92 ENST00000338458.8
ENST00000468727.5
ARHGEF3
Rho guanine nucleotide exchange factor 3
chr15_+_84980440 0.91 ENST00000310298.8
ENST00000557957.5
PDE8A
phosphodiesterase 8A
chr19_-_55140922 0.83 ENST00000589745.5
TNNT1
troponin T1, slow skeletal type
chr4_+_169620527 0.74 ENST00000360642.7
ENST00000512813.5
ENST00000513761.6
CLCN3
chloride voltage-gated channel 3
chr17_+_50547089 0.72 ENST00000619622.4
ENST00000356488.8
ENST00000006658.11
SPATA20
spermatogenesis associated 20
chr17_+_35809474 0.49 ENST00000604879.5
ENST00000603427.5
ENST00000603777.5
ENST00000605844.6
ENST00000604841.5
TAF15
TATA-box binding protein associated factor 15
chr17_+_77185210 0.42 ENST00000431431.6
SEC14L1
SEC14 like lipid binding 1
chr20_+_38748448 0.38 ENST00000243903.6
ACTR5
actin related protein 5
chr11_-_46617170 0.29 ENST00000326737.3
HARBI1
harbinger transposase derived 1
chr4_+_169620509 0.05 ENST00000347613.8
CLCN3
chloride voltage-gated channel 3
chr19_+_35248879 0.03 ENST00000347609.8
LSR
lipolysis stimulated lipoprotein receptor

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 23.8 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
2.0 8.2 GO:0035927 RNA import into mitochondrion(GO:0035927)
1.8 5.5 GO:1901388 regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389)
1.6 6.3 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.9 7.8 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.8 10.9 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.6 8.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.6 7.2 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.6 26.1 GO:0001504 neurotransmitter uptake(GO:0001504)
0.4 3.9 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.4 3.8 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.4 8.0 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.3 3.5 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 2.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.2 6.9 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 0.8 GO:0048388 endosomal lumen acidification(GO:0048388)
0.2 4.5 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.2 3.4 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.2 15.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 3.3 GO:0002076 osteoblast development(GO:0002076)
0.1 1.6 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.8 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 6.0 GO:0000045 autophagosome assembly(GO:0000045)
0.1 2.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.4 GO:0015871 choline transport(GO:0015871)
0.0 0.9 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 2.5 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 1.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 1.4 GO:0033146 regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0 6.6 GO:0006457 protein folding(GO:0006457)
0.0 1.6 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.4 GO:0070914 UV-damage excision repair(GO:0070914)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 23.8 GO:0042612 MHC class I protein complex(GO:0042612)
1.8 5.5 GO:1990917 sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917)
1.8 10.9 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.0 8.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.9 7.0 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.8 10.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.6 8.3 GO:0042555 MCM complex(GO:0042555)
0.6 2.2 GO:0033263 CORVET complex(GO:0033263)
0.4 7.2 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.4 3.3 GO:0035976 AP1 complex(GO:0035976)
0.3 4.3 GO:0005688 U6 snRNP(GO:0005688)
0.3 7.8 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.2 8.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 6.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 6.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.6 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.8 GO:0005861 troponin complex(GO:0005861)
0.0 6.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.9 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 0.4 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 9.8 GO:0016607 nuclear speck(GO:0016607)
0.0 8.4 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 23.8 GO:0046979 TAP2 binding(GO:0046979)
1.8 5.5 GO:0002135 CTP binding(GO:0002135)
1.0 8.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.9 10.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.8 26.1 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.5 3.8 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.4 8.0 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.3 1.6 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.3 8.0 GO:0048156 tau protein binding(GO:0048156)
0.2 7.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 4.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 0.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.2 8.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 7.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 3.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.4 GO:0039552 RIG-I binding(GO:0039552)
0.1 0.8 GO:0031014 troponin T binding(GO:0031014)
0.1 8.3 GO:0051082 unfolded protein binding(GO:0051082)
0.1 6.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.4 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 3.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 2.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.7 GO:0004896 cytokine receptor activity(GO:0004896)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 8.3 PID ATR PATHWAY ATR signaling pathway
0.1 10.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 3.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 5.5 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.9 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 23.8 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.6 8.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.5 26.1 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.4 5.6 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.3 22.3 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.3 5.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 12.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 8.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 7.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 6.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction