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avrg: GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZSCAN4

Z-value: 1.84

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Transcription factors associated with ZSCAN4

Gene Symbol Gene ID Gene Info
ZSCAN4
ENSG00000180532.11 ZSCAN4

Activity profile of ZSCAN4 motif

Sorted Z-values of ZSCAN4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ZSCAN4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_10368645 9.32 ENST00000613496.4
HPCAL1
hippocalcin like 1
chr6_-_41941795 9.05 ENST00000372991.9
CCND3
cyclin D3
chr6_-_41941728 8.86 ENST00000414200.6
CCND3
cyclin D3
chr6_-_41941507 8.78 ENST00000372987.8
CCND3
cyclin D3
chr14_+_52707192 6.01 ENST00000445930.7
ENST00000555339.5
ENST00000556813.1
PSMC6
proteasome 26S subunit, ATPase 6
chr3_-_53255990 5.88 ENST00000423525.6
TKT
transketolase
chr14_+_52707178 5.82 ENST00000612399.4
PSMC6
proteasome 26S subunit, ATPase 6
chr1_-_154608140 5.78 ENST00000529168.2
ENST00000368474.9
ENST00000680305.1
ENST00000648231.2
ADAR
adenosine deaminase RNA specific
chr7_-_10940123 5.71 ENST00000339600.6
NDUFA4
NDUFA4 mitochondrial complex associated
chr3_-_53256009 5.68 ENST00000296289.10
ENST00000462138.6
ENST00000423516.5
TKT
transketolase
chr11_+_72227881 5.45 ENST00000538751.5
ENST00000541756.5
INPPL1
inositol polyphosphate phosphatase like 1
chr17_+_2796404 4.74 ENST00000366401.8
ENST00000254695.13
ENST00000542807.1
RAP1GAP2
RAP1 GTPase activating protein 2
chr11_-_125592448 4.70 ENST00000648911.1
FEZ1
fasciculation and elongation protein zeta 1
chr19_-_10420121 4.69 ENST00000593124.1
CDC37
cell division cycle 37, HSP90 cochaperone
chr16_+_4624811 4.56 ENST00000415496.5
ENST00000262370.12
ENST00000587747.5
ENST00000399577.9
ENST00000588994.5
ENST00000586183.5
MGRN1
mahogunin ring finger 1
chr13_+_30422487 4.52 ENST00000638137.1
ENST00000635918.2
UBE2L5
ubiquitin conjugating enzyme E2 L5
chr8_-_133102477 4.37 ENST00000522119.5
ENST00000523610.5
ENST00000338087.10
ENST00000521302.5
ENST00000519558.5
ENST00000519747.5
ENST00000517648.5
SLA
Src like adaptor
chr11_-_75351609 4.33 ENST00000420843.7
ARRB1
arrestin beta 1
chr7_-_99466148 4.12 ENST00000394186.3
ENST00000359832.8
ENST00000449683.5
ENST00000292475.8
ENST00000488775.5
ENST00000523680.1
ENST00000430982.1
ENST00000413834.5
ATP5MF
PTCD1
ATP5MF-PTCD1
ATP synthase membrane subunit f
pentatricopeptide repeat domain 1
ATP5MF-PTCD1 readthrough
chr8_+_26390362 4.11 ENST00000518611.5
BNIP3L
BCL2 interacting protein 3 like
chr1_-_161631152 4.04 ENST00000421702.3
ENST00000650385.1
FCGR3B
Fc fragment of IgG receptor IIIb
chr19_+_29606274 3.84 ENST00000586420.5
ENST00000585603.6
ENST00000221770.7
ENST00000590688.1
POP4
POP4 homolog, ribonuclease P/MRP subunit
chr19_+_571274 3.80 ENST00000545507.6
ENST00000346916.9
BSG
basigin (Ok blood group)
chr8_-_133102874 3.80 ENST00000395352.7
SLA
Src like adaptor
chr2_-_99336306 3.66 ENST00000264255.8
ENST00000409434.5
ENST00000434323.5
TXNDC9
thioredoxin domain containing 9
chr1_-_161631032 3.58 ENST00000534776.1
ENST00000613418.4
ENST00000614870.4
FCGR3B
Fc fragment of IgG receptor IIIb
chr1_-_161549793 3.49 ENST00000443193.6
FCGR3A
Fc fragment of IgG receptor IIIa
chr11_-_125496122 3.48 ENST00000527534.1
ENST00000278919.8
ENST00000366139.3
FEZ1
fasciculation and elongation protein zeta 1
chr1_+_13060769 3.45 ENST00000617807.3
HNRNPCL3
heterogeneous nuclear ribonucleoprotein C like 3
chr11_-_78079773 3.29 ENST00000612612.5
ENST00000614236.2
NDUFC2-KCTD14
NDUFC2-KCTD14 readthrough
chr11_-_33753394 3.20 ENST00000532057.5
ENST00000531080.5
FBXO3
F-box protein 3
chr17_+_4715438 3.17 ENST00000571206.1
ARRB2
arrestin beta 2
chr3_+_130850585 3.15 ENST00000505330.5
ENST00000504381.5
ENST00000507488.6
ATP2C1
ATPase secretory pathway Ca2+ transporting 1
chr1_-_161549892 3.06 ENST00000426740.7
FCGR3A
Fc fragment of IgG receptor IIIa
chr12_+_65824475 2.98 ENST00000403681.7
HMGA2
high mobility group AT-hook 2
chr3_+_50246888 2.96 ENST00000451956.1
GNAI2
G protein subunit alpha i2
chr1_+_13061158 2.93 ENST00000681473.1
HNRNPCL3
heterogeneous nuclear ribonucleoprotein C like 3
chr14_-_22815421 2.93 ENST00000674313.1
ENST00000555959.1
SLC7A7
solute carrier family 7 member 7
chr1_+_94418375 2.85 ENST00000370214.9
ABCD3
ATP binding cassette subfamily D member 3
chr12_+_15911324 2.84 ENST00000524480.5
ENST00000428559.7
ENST00000531803.5
ENST00000532964.5
DERA
deoxyribose-phosphate aldolase
chr7_+_121873317 2.81 ENST00000651863.1
ENST00000652298.1
ENST00000449182.1
PTPRZ1
protein tyrosine phosphatase receptor type Z1
chr19_-_17405554 2.74 ENST00000252593.7
BST2
bone marrow stromal cell antigen 2
chr1_+_231241195 2.66 ENST00000436239.5
ENST00000366647.9
ENST00000416000.1
GNPAT
glyceronephosphate O-acyltransferase
chr10_-_100229550 2.63 ENST00000370397.8
CHUK
component of inhibitor of nuclear factor kappa B kinase complex
chr1_+_51729870 2.34 ENST00000462759.5
ENST00000486942.5
OSBPL9
oxysterol binding protein like 9
chr1_-_177164673 2.33 ENST00000424564.2
ENST00000361833.7
ASTN1
astrotactin 1
chr4_-_167234552 2.27 ENST00000512648.5
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr1_-_153626948 2.16 ENST00000392622.3
S100A13
S100 calcium binding protein A13
chr1_-_153627211 2.15 ENST00000392623.5
S100A13
S100 calcium binding protein A13
chr19_+_735026 2.08 ENST00000592155.5
ENST00000590161.2
PALM
paralemmin
chr4_-_103198331 2.00 ENST00000265148.9
ENST00000514974.1
CENPE
centromere protein E
chrX_+_1268828 1.99 ENST00000432318.8
ENST00000381509.8
ENST00000494969.7
ENST00000355805.7
ENST00000355432.8
CSF2RA
colony stimulating factor 2 receptor subunit alpha
chr4_+_94489030 1.89 ENST00000510099.5
PDLIM5
PDZ and LIM domain 5
chr21_-_44801813 1.79 ENST00000345496.7
UBE2G2
ubiquitin conjugating enzyme E2 G2
chr16_+_16379055 1.77 ENST00000530217.2
NPIPA7
nuclear pore complex interacting protein family member A7
chr5_-_83673544 1.73 ENST00000503117.1
ENST00000510978.5
HAPLN1
hyaluronan and proteoglycan link protein 1
chr6_+_30720335 1.71 ENST00000327892.13
TUBB
tubulin beta class I
chr13_+_113584683 1.70 ENST00000375370.10
TFDP1
transcription factor Dp-1
chr12_+_6924449 1.65 ENST00000356654.8
ATN1
atrophin 1
chr1_-_184037695 1.63 ENST00000361927.9
ENST00000649786.1
COLGALT2
collagen beta(1-O)galactosyltransferase 2
chr1_+_209756032 1.60 ENST00000400959.7
ENST00000367025.8
TRAF3IP3
TRAF3 interacting protein 3
chrX_+_1268786 1.60 ENST00000501036.7
ENST00000417535.7
CSF2RA
colony stimulating factor 2 receptor subunit alpha
chr7_+_66921217 1.59 ENST00000341567.8
ENST00000607045.5
TMEM248
transmembrane protein 248
chr7_+_103347635 1.57 ENST00000679250.1
ENST00000292644.5
ENST00000425206.6
PSMC2
proteasome 26S subunit, ATPase 2
chr16_+_29679132 1.57 ENST00000395384.9
ENST00000562473.1
QPRT
quinolinate phosphoribosyltransferase
chr7_-_78771265 1.56 ENST00000630991.2
ENST00000629359.2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr3_-_58587033 1.48 ENST00000447756.2
FAM107A
family with sequence similarity 107 member A
chr11_+_111937320 1.47 ENST00000440460.7
DIXDC1
DIX domain containing 1
chr1_+_115641945 1.39 ENST00000355485.7
ENST00000369510.8
VANGL1
VANGL planar cell polarity protein 1
chr22_+_44026283 1.35 ENST00000619710.4
PARVB
parvin beta
chr20_-_1184473 1.34 ENST00000381894.3
TMEM74B
transmembrane protein 74B
chr19_+_55640966 1.31 ENST00000590190.1
ENST00000325333.10
ENST00000585995.1
ENST00000592996.5
ZNF580
ZNF581
CCDC106
zinc finger protein 580
zinc finger protein 581
coiled-coil domain containing 106
chr6_-_31592952 1.30 ENST00000376073.8
ENST00000376072.7
NCR3
natural cytotoxicity triggering receptor 3
chr8_+_43056409 1.21 ENST00000525699.5
ENST00000529687.5
FNTA
farnesyltransferase, CAAX box, alpha
chr19_+_30372364 1.21 ENST00000355537.4
ZNF536
zinc finger protein 536
chrX_+_1268807 1.20 ENST00000381524.8
ENST00000381529.9
ENST00000412290.6
CSF2RA
colony stimulating factor 2 receptor subunit alpha
chr2_+_203238965 1.16 ENST00000429815.6
CYP20A1
cytochrome P450 family 20 subfamily A member 1
chr11_-_73142308 1.13 ENST00000409418.9
FCHSD2
FCH and double SH3 domains 2
chr13_-_79406175 1.13 ENST00000438724.5
ENST00000622611.4
ENST00000438737.3
RBM26
RNA binding motif protein 26
chr11_-_75351686 1.12 ENST00000360025.7
ARRB1
arrestin beta 1
chr9_+_125748175 1.11 ENST00000491787.7
ENST00000447726.6
PBX3
PBX homeobox 3
chr16_+_15643267 1.08 ENST00000396355.5
NDE1
nudE neurodevelopment protein 1
chr11_-_111879425 1.07 ENST00000622211.4
ENSG00000258529.5
novel protein
chrX_-_6227180 1.06 ENST00000381093.6
NLGN4X
neuroligin 4 X-linked
chr10_+_113679159 1.01 ENST00000621345.4
ENST00000429617.5
ENST00000369331.8
CASP7
caspase 7
chr1_-_247458105 1.01 ENST00000641149.1
ENST00000641527.1
OR2B11
olfactory receptor family 2 subfamily B member 11
chr12_+_120650492 1.01 ENST00000351200.6
CABP1
calcium binding protein 1
chr20_-_21514046 0.98 ENST00000377142.5
NKX2-2
NK2 homeobox 2
chr19_+_51127030 0.97 ENST00000599948.1
SIGLEC9
sialic acid binding Ig like lectin 9
chr12_-_96400365 0.97 ENST00000261211.8
ENST00000543119.6
CDK17
cyclin dependent kinase 17
chr1_+_209756149 0.97 ENST00000367026.7
TRAF3IP3
TRAF3 interacting protein 3
chr4_-_167234579 0.94 ENST00000502330.5
ENST00000357154.7
ENST00000421836.6
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr7_-_78771108 0.93 ENST00000626691.2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr19_-_3801791 0.92 ENST00000590849.1
ENST00000395045.6
MATK
megakaryocyte-associated tyrosine kinase
chr8_+_84183534 0.91 ENST00000518566.5
RALYL
RALY RNA binding protein like
chrX_+_49303669 0.91 ENST00000407599.3
GAGE10
G antigen 10
chr4_-_167234426 0.90 ENST00000541354.5
ENST00000509854.5
ENST00000512681.5
ENST00000357545.9
ENST00000510741.5
ENST00000510403.5
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr17_-_19745602 0.90 ENST00000444455.5
ENST00000439102.6
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chr17_-_58328756 0.86 ENST00000268893.10
ENST00000343736.9
TSPOAP1
TSPO associated protein 1
chr15_+_81182579 0.80 ENST00000302987.9
IL16
interleukin 16
chr2_-_212124901 0.79 ENST00000402597.6
ERBB4
erb-b2 receptor tyrosine kinase 4
chr22_+_44752552 0.78 ENST00000389774.6
ENST00000356099.11
ENST00000396119.6
ENST00000336963.8
ENST00000412433.5
ARHGAP8
Rho GTPase activating protein 8
chr20_-_16573433 0.77 ENST00000408042.5
ENST00000636835.1
ENST00000354981.7
KIF16B
kinesin family member 16B
chr20_+_63733219 0.77 ENST00000632538.1
ENSG00000273154.3
novel protein, ZGPAT-LIME1 readthrough
chr17_-_19745369 0.75 ENST00000573368.5
ENST00000457500.6
ALDH3A1
aldehyde dehydrogenase 3 family member A1
chrX_-_75156272 0.70 ENST00000620875.5
ENST00000669573.1
ENST00000339447.8
ENST00000645829.3
ENST00000529949.5
ENST00000373394.8
ENST00000253577.9
ENST00000644766.1
ENST00000534524.5
ABCB7
ATP binding cassette subfamily B member 7
chr11_+_10455292 0.69 ENST00000396553.6
AMPD3
adenosine monophosphate deaminase 3
chr5_+_102808057 0.68 ENST00000684043.1
ENST00000682407.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr4_-_102760976 0.68 ENST00000644159.1
ENST00000642252.1
MANBA
mannosidase beta
chr1_+_32179665 0.61 ENST00000373610.8
TXLNA
taxilin alpha
chr2_+_203239009 0.61 ENST00000613925.4
ENST00000356079.9
ENST00000443941.1
CYP20A1
cytochrome P450 family 20 subfamily A member 1
chr19_+_2360238 0.61 ENST00000649857.1
TMPRSS9
transmembrane serine protease 9
chr18_+_58864866 0.57 ENST00000588456.5
ENST00000591808.6
ENST00000589481.1
ENST00000591049.1
ZNF532
zinc finger protein 532
chr6_-_33580229 0.57 ENST00000374467.4
ENST00000442998.6
ENST00000360661.9
BAK1
BCL2 antagonist/killer 1
chr4_-_102760914 0.53 ENST00000505239.1
ENST00000647097.2
MANBA
mannosidase beta
chr11_-_4393650 0.52 ENST00000254436.8
TRIM21
tripartite motif containing 21
chr14_-_21025490 0.52 ENST00000553442.5
ENST00000555869.5
ENST00000556457.5
ENST00000397844.6
ENST00000554415.5
ENST00000556974.5
ENST00000554419.5
ENST00000298687.9
ENST00000397858.5
ENST00000360463.7
ENST00000350792.7
ENST00000397847.6
NDRG2
NDRG family member 2
chr19_-_42132391 0.50 ENST00000528894.8
ENST00000560804.6
ENST00000560558.5
ENST00000560398.5
ENST00000526816.6
ENST00000625670.2
POU2F2
POU class 2 homeobox 2
chr12_+_54549586 0.50 ENST00000243052.8
PDE1B
phosphodiesterase 1B
chr15_-_37100523 0.46 ENST00000424352.6
ENST00000561208.6
MEIS2
Meis homeobox 2
chrX_-_72714181 0.45 ENST00000339490.7
ENST00000541944.5
ENST00000373539.3
PHKA1
phosphorylase kinase regulatory subunit alpha 1
chr1_+_32180044 0.41 ENST00000373609.1
TXLNA
taxilin alpha
chr22_+_17638584 0.38 ENST00000337612.9
ENST00000418951.6
ENST00000538149.5
ENST00000543133.5
ENST00000611738.4
ENST00000616863.4
ENST00000618481.4
ENST00000317582.10
ENST00000493680.5
BCL2L13
BCL2 like 13
chr5_+_150508110 0.36 ENST00000261797.7
NDST1
N-deacetylase and N-sulfotransferase 1
chr10_-_32935511 0.36 ENST00000423113.5
ITGB1
integrin subunit beta 1
chr11_+_61950343 0.35 ENST00000378043.9
BEST1
bestrophin 1
chr18_+_62523002 0.34 ENST00000269499.10
ZCCHC2
zinc finger CCHC-type containing 2
chr2_+_172860038 0.33 ENST00000538974.5
ENST00000540783.5
RAPGEF4
Rap guanine nucleotide exchange factor 4
chr12_-_95996302 0.33 ENST00000261208.8
ENST00000538703.5
ENST00000541929.5
HAL
histidine ammonia-lyase
chr8_-_121641424 0.32 ENST00000303924.5
HAS2
hyaluronan synthase 2
chr22_+_17638796 0.29 ENST00000355028.4
BCL2L13
BCL2 like 13
chr3_-_195811889 0.29 ENST00000475231.5
MUC4
mucin 4, cell surface associated
chrX_-_142205260 0.24 ENST00000247452.4
MAGEC2
MAGE family member C2
chr11_+_61950370 0.20 ENST00000449131.6
BEST1
bestrophin 1
chr11_-_129947461 0.19 ENST00000526082.5
ENST00000304538.10
PRDM10
PR/SET domain 10
chr8_-_23854796 0.18 ENST00000290271.7
STC1
stanniocalcin 1
chr4_-_167234266 0.16 ENST00000511269.5
ENST00000506697.5
ENST00000512042.1
SPOCK3
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
chr4_+_73853290 0.15 ENST00000226524.4
PF4V1
platelet factor 4 variant 1
chr11_+_124241095 0.13 ENST00000641972.1
OR8G1
olfactory receptor family 8 subfamily G member 1
chr9_+_89605004 0.11 ENST00000252506.11
ENST00000375769.1
GADD45G
growth arrest and DNA damage inducible gamma
chr9_+_122375286 0.09 ENST00000373698.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr18_+_34593312 0.06 ENST00000591816.6
ENST00000588125.5
ENST00000684610.1
ENST00000683705.1
ENST00000598334.5
ENST00000588684.5
ENST00000554864.7
ENST00000399121.9
ENST00000595022.5
DTNA
dystrobrevin alpha
chr10_+_18260715 0.06 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr12_-_85836372 0.05 ENST00000361228.5
RASSF9
Ras association domain family member 9
chr7_+_64045420 0.03 ENST00000647787.1
ENST00000456806.3
ENSG00000285544.1
ZNF727
novel transcript
zinc finger protein 727
chr6_+_29827817 0.03 ENST00000360323.11
ENST00000376818.7
ENST00000376815.3
HLA-G
major histocompatibility complex, class I, G

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.6 GO:0005999 xylulose biosynthetic process(GO:0005999)
1.0 3.0 GO:0090402 oncogene-induced cell senescence(GO:0090402)
1.0 5.8 GO:1900368 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
1.0 8.6 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.9 3.7 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.9 2.7 GO:1901253 negative regulation of intracellular transport of viral material(GO:1901253)
0.9 8.2 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.9 2.7 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.7 2.8 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.7 4.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.7 13.4 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.6 26.7 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.5 3.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.5 4.1 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.5 4.6 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.4 2.9 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
0.4 1.6 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.4 4.3 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.4 1.4 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.3 2.0 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.3 2.6 GO:1902739 interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.3 1.0 GO:0021779 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.3 3.8 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.3 2.1 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.3 5.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 3.8 GO:0046689 response to mercury ion(GO:0046689)
0.3 0.8 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.3 0.5 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.2 2.5 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.2 1.7 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 1.1 GO:0007386 compartment pattern specification(GO:0007386)
0.2 1.3 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.2 4.7 GO:0098779 mitophagy in response to mitochondrial depolarization(GO:0098779)
0.2 1.2 GO:0018343 protein farnesylation(GO:0018343)
0.2 0.6 GO:0002339 B cell selection(GO:0002339)
0.2 2.8 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.2 3.0 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.2 0.7 GO:0031179 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.2 1.3 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
0.2 1.3 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 1.0 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.1 5.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 1.1 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.1 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.7 GO:0006196 AMP catabolic process(GO:0006196)
0.1 0.3 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.1 1.5 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 9.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 1.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 5.9 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.3 GO:0003097 renal water transport(GO:0003097) renal water absorption(GO:0070295) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.1 0.7 GO:0015886 heme transport(GO:0015886)
0.1 1.2 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.1 2.3 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 1.1 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.1 0.4 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.1 2.3 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 3.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.5 GO:0097012 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0 0.4 GO:0006477 protein sulfation(GO:0006477) heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 6.4 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 0.8 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.4 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.5 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 1.3 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
0.0 0.9 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.0 4.7 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 1.7 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 1.7 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 1.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 1.0 GO:0042308 negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein import(GO:1904590)
0.0 0.5 GO:0007274 neuromuscular synaptic transmission(GO:0007274)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 13.4 GO:0031595 nuclear proteasome complex(GO:0031595)
0.8 5.8 GO:0044530 supraspliceosomal complex(GO:0044530)
0.6 3.8 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.6 2.8 GO:0072534 perineuronal net(GO:0072534)
0.4 5.7 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.4 3.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.4 26.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 1.2 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.2 2.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 2.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 2.5 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 5.4 GO:0031143 pseudopodium(GO:0031143)
0.1 3.8 GO:0002080 acrosomal membrane(GO:0002080)
0.1 0.4 GO:0034677 integrin alpha7-beta1 complex(GO:0034677)
0.1 4.3 GO:0042629 mast cell granule(GO:0042629)
0.1 1.7 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 15.6 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.7 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 11.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 4.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 3.3 GO:0070469 respiratory chain(GO:0070469)
0.0 4.5 GO:0030175 filopodium(GO:0030175)
0.0 3.2 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 9.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 6.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.4 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 3.7 GO:0030496 midbody(GO:0030496)
0.0 2.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 1.1 GO:0031594 neuromuscular junction(GO:0031594)
0.0 8.3 GO:0005874 microtubule(GO:0005874)
0.0 4.6 GO:0005769 early endosome(GO:0005769)
0.0 7.4 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.6 GO:0004802 transketolase activity(GO:0004802)
1.8 5.4 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
1.6 3.2 GO:0031762 alpha-1A adrenergic receptor binding(GO:0031691) follicle-stimulating hormone receptor binding(GO:0031762)
1.5 13.4 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.9 2.6 GO:0008384 IkappaB kinase activity(GO:0008384)
0.8 14.2 GO:0019864 IgG binding(GO:0019864)
0.7 5.8 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.6 3.7 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.6 3.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.5 5.5 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.5 2.0 GO:0043515 kinetochore binding(GO:0043515)
0.4 27.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.4 1.6 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.4 1.2 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.3 3.8 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 7.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.3 2.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 0.9 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.3 1.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.3 9.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 2.9 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 1.6 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.2 2.7 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 5.0 GO:0005537 mannose binding(GO:0005537)
0.2 4.3 GO:0050786 RAGE receptor binding(GO:0050786)
0.2 1.4 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.2 5.7 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.7 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.2 1.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 4.1 GO:0005521 lamin binding(GO:0005521)
0.1 2.8 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 3.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 2.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.1 9.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 4.1 GO:0000049 tRNA binding(GO:0000049)
0.1 0.4 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.1 2.8 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.7 GO:0015232 heme transporter activity(GO:0015232)
0.1 0.5 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 4.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.7 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 3.0 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 2.3 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.8 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 1.9 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 1.7 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 1.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 3.3 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.8 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 1.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 1.0 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.6 GO:0051400 BH domain binding(GO:0051400)
0.0 0.8 GO:0043325 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.7 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 4.8 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 1.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 4.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 1.8 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 26.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.3 11.6 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.2 5.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 6.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 4.8 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.1 6.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 2.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 8.2 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.0 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 5.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.4 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 3.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 28.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.3 4.7 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.3 7.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 2.6 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 13.4 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.2 9.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 3.0 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 6.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 4.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 2.7 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 2.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 6.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 5.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 1.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 11.6 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.1 3.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 5.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 1.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.6 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 4.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.4 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 1.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis