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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ACUGGCC

Z-value: 0.45

Motif logo

miRNA associated with seed ACUGGCC

NamemiRBASE accession
MIMAT0000459
MIMAT0002819

Activity profile of ACUGGCC motif

Sorted Z-values of ACUGGCC motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_14772810 1.26 ENST00000295092.2
ENST00000331243.4
family with sequence similarity 84, member A
chr1_+_77333117 0.72 ENST00000477717.1
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr3_-_124774802 0.66 ENST00000311127.4
heart development protein with EGF-like domains 1
chr1_+_183155373 0.63 ENST00000493293.1
ENST00000264144.4
laminin, gamma 2
chr2_+_12857015 0.56 ENST00000155926.4
tribbles pseudokinase 2
chr3_-_52090461 0.52 ENST00000296483.6
ENST00000495880.1
dual specificity phosphatase 7
chr22_+_24951436 0.50 ENST00000215829.3
small nuclear ribonucleoprotein D3 polypeptide 18kDa
chr18_-_53255766 0.46 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
transcription factor 4
chr11_+_128563652 0.45 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr3_-_128902729 0.42 ENST00000451728.2
ENST00000446936.2
ENST00000502976.1
ENST00000500450.2
ENST00000441626.2
CCHC-type zinc finger, nucleic acid binding protein
chr22_+_40390930 0.41 ENST00000333407.6
family with sequence similarity 83, member F
chr4_-_87770416 0.41 ENST00000273905.6
solute carrier family 10 (sodium/bile acid cotransporter), member 6
chr17_-_65241281 0.40 ENST00000358691.5
ENST00000580168.1
helicase with zinc finger
chr12_+_11802753 0.39 ENST00000396373.4
ets variant 6
chr18_+_55711575 0.37 ENST00000356462.6
ENST00000400345.3
ENST00000589054.1
ENST00000256832.7
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr11_+_120207787 0.36 ENST00000397843.2
ENST00000356641.3
Rho guanine nucleotide exchange factor (GEF) 12
chr12_-_57030115 0.35 ENST00000379441.3
ENST00000179765.5
ENST00000551812.1
bromodomain adjacent to zinc finger domain, 2A
chr8_-_57123815 0.34 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
pleiomorphic adenoma gene 1
chr1_+_182992545 0.34 ENST00000258341.4
laminin, gamma 1 (formerly LAMB2)
chr10_+_75670862 0.33 ENST00000446342.1
ENST00000372764.3
ENST00000372762.4
plasminogen activator, urokinase
chr11_-_62494821 0.32 ENST00000301785.5
heterogeneous nuclear ribonucleoprotein U-like 2
chr4_-_87281224 0.32 ENST00000395169.3
ENST00000395161.2
mitogen-activated protein kinase 10
chr12_+_110437328 0.31 ENST00000261739.4
ankyrin repeat domain 13A
chr9_+_131644388 0.29 ENST00000372600.4
leucine rich repeat containing 8 family, member A
chr5_-_124080203 0.29 ENST00000504926.1
zinc finger protein 608
chr6_+_86159821 0.26 ENST00000369651.3
5'-nucleotidase, ecto (CD73)
chr6_-_47277634 0.26 ENST00000296861.2
tumor necrosis factor receptor superfamily, member 21
chr3_-_176914238 0.25 ENST00000430069.1
ENST00000428970.1
transducin (beta)-like 1 X-linked receptor 1
chr13_+_98794810 0.25 ENST00000595437.1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr13_-_99404875 0.24 ENST00000376503.5
solute carrier family 15 (oligopeptide transporter), member 1
chr8_-_101965146 0.24 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr3_-_57199397 0.23 ENST00000296318.7
interleukin 17 receptor D
chr11_-_77532050 0.23 ENST00000308488.6
remodeling and spacing factor 1
chr9_-_95527079 0.21 ENST00000356884.6
ENST00000375512.3
bicaudal D homolog 2 (Drosophila)
chr1_+_111991474 0.21 ENST00000369722.3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr1_+_145507587 0.21 ENST00000330165.8
ENST00000369307.3
RNA binding motif protein 8A
chr5_+_177540444 0.21 ENST00000274605.5
NEDD4 binding protein 3
chr12_-_104234966 0.20 ENST00000392876.3
5'-nucleotidase domain containing 3
chr5_+_179921430 0.19 ENST00000393356.1
CCR4-NOT transcription complex, subunit 6
chr13_+_111365602 0.19 ENST00000333219.7
inhibitor of growth family, member 1
chr12_-_96794143 0.17 ENST00000543119.2
cyclin-dependent kinase 17
chr14_-_50698276 0.16 ENST00000216373.5
son of sevenless homolog 2 (Drosophila)
chr22_+_24666763 0.16 ENST00000437398.1
ENST00000421374.1
ENST00000314328.9
ENST00000541492.1
sperm antigen with calponin homology and coiled-coil domains 1-like
chrX_+_110339439 0.15 ENST00000372010.1
ENST00000519681.1
ENST00000372007.5
p21 protein (Cdc42/Rac)-activated kinase 3
chr7_+_104654623 0.15 ENST00000311117.3
ENST00000334877.4
ENST00000257745.4
ENST00000334914.7
ENST00000478990.1
ENST00000495267.1
ENST00000476671.1
lysine (K)-specific methyltransferase 2E
chr20_-_14318248 0.14 ENST00000378053.3
ENST00000341420.4
fibronectin leucine rich transmembrane protein 3
chr19_-_14629224 0.14 ENST00000254322.2
DnaJ (Hsp40) homolog, subfamily B, member 1
chr17_+_68165657 0.14 ENST00000243457.3
potassium inwardly-rectifying channel, subfamily J, member 2
chr1_+_26126667 0.14 ENST00000361547.2
ENST00000354177.4
ENST00000374315.1
selenoprotein N, 1
chr1_-_67519782 0.14 ENST00000235345.5
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr11_-_128392085 0.14 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr11_+_69455855 0.14 ENST00000227507.2
ENST00000536559.1
cyclin D1
chr10_-_62149433 0.13 ENST00000280772.2
ankyrin 3, node of Ranvier (ankyrin G)
chr1_-_117210290 0.13 ENST00000369483.1
ENST00000369486.3
immunoglobulin superfamily, member 3
chr2_-_208030647 0.13 ENST00000309446.6
Kruppel-like factor 7 (ubiquitous)
chr12_+_56137064 0.12 ENST00000257868.5
ENST00000546799.1
growth differentiation factor 11
chr17_+_61086917 0.12 ENST00000424789.2
ENST00000389520.4
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr6_-_2634820 0.12 ENST00000296847.3
chromosome 6 open reading frame 195
chr11_+_118307179 0.12 ENST00000534358.1
ENST00000531904.2
ENST00000389506.5
ENST00000354520.4
lysine (K)-specific methyltransferase 2A
chr8_-_95961578 0.11 ENST00000448464.2
ENST00000342697.4
tumor protein p53 inducible nuclear protein 1
chr5_-_133512683 0.11 ENST00000353411.6
S-phase kinase-associated protein 1
chr1_+_109792641 0.10 ENST00000271332.3
cadherin, EGF LAG seven-pass G-type receptor 2
chr1_-_150552006 0.10 ENST00000307940.3
ENST00000369026.2
myeloid cell leukemia sequence 1 (BCL2-related)
chr5_+_78532003 0.10 ENST00000396137.4
junction mediating and regulatory protein, p53 cofactor
chr11_+_34073195 0.10 ENST00000341394.4
cell cycle associated protein 1
chr17_+_48796905 0.09 ENST00000505658.1
ENST00000393227.2
ENST00000240304.1
ENST00000311571.3
ENST00000505619.1
ENST00000544170.1
ENST00000510984.1
LUC7-like 3 (S. cerevisiae)
chr14_+_23775971 0.09 ENST00000250405.5
BCL2-like 2
chr1_+_15853308 0.09 ENST00000375838.1
ENST00000375847.3
ENST00000375849.1
DnaJ (Hsp40) homolog, subfamily C, member 16
chr3_+_132136331 0.08 ENST00000260818.6
DnaJ (Hsp40) homolog, subfamily C, member 13
chr15_-_41408409 0.08 ENST00000361937.3
INO80 complex subunit
chr22_-_32146106 0.08 ENST00000327423.6
ENST00000397493.2
ENST00000434485.1
ENST00000412743.1
proline rich 14-like
chr16_-_4166186 0.08 ENST00000294016.3
adenylate cyclase 9
chr1_+_203764742 0.08 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
zinc finger CCCH-type containing 11A
chr15_+_64443905 0.08 ENST00000325881.4
sorting nexin 22
chr11_+_33563821 0.07 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549-like
chr4_+_126237554 0.07 ENST00000394329.3
FAT atypical cadherin 4
chr18_+_46065393 0.07 ENST00000256413.3
CBP80/20-dependent translation initiation factor
chrX_-_40594755 0.07 ENST00000324817.1
mediator complex subunit 14
chr14_+_57046500 0.07 ENST00000261556.6
transmembrane protein 260
chr2_-_206950781 0.07 ENST00000403263.1
INO80 complex subunit D
chr2_+_242641442 0.06 ENST00000313552.6
ENST00000406941.1
inhibitor of growth family, member 5
chr4_+_55524085 0.06 ENST00000412167.2
ENST00000288135.5
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr10_-_99052382 0.06 ENST00000453547.2
ENST00000316676.8
ENST00000358308.3
ENST00000466484.1
ENST00000358531.4
ARHGAP19-SLIT1 readthrough (NMD candidate)
Rho GTPase activating protein 19
chr5_+_172483347 0.06 ENST00000522692.1
ENST00000296953.2
ENST00000540014.1
ENST00000520420.1
CREB3 regulatory factor
chr20_+_57226284 0.06 ENST00000458280.1
ENST00000355957.5
ENST00000361770.5
ENST00000312283.8
ENST00000412911.1
ENST00000359617.4
ENST00000371141.4
syntaxin 16
chr2_-_180726232 0.05 ENST00000410066.1
zinc finger protein 385B
chr5_+_65222299 0.05 ENST00000284037.5
erbb2 interacting protein
chr10_+_70480963 0.05 ENST00000265872.6
ENST00000535016.1
ENST00000538031.1
ENST00000543719.1
ENST00000539539.1
ENST00000543225.1
ENST00000536012.1
ENST00000494903.2
cell division cycle and apoptosis regulator 1
chr2_-_69870835 0.05 ENST00000409085.4
ENST00000406297.3
AP2 associated kinase 1
chr15_+_84322827 0.05 ENST00000286744.5
ENST00000567476.1
ADAMTS-like 3
chr3_-_33481835 0.05 ENST00000283629.3
upstream binding protein 1 (LBP-1a)
chr11_-_124670550 0.05 ENST00000239614.4
Myb/SANT-like DNA-binding domain containing 2
chr18_-_47013586 0.05 ENST00000318240.3
ENST00000579820.1
chromosome 18 open reading frame 32
chr16_-_28074822 0.05 ENST00000395724.3
ENST00000380898.2
ENST00000447459.2
GSG1-like
chr2_+_113931513 0.05 ENST00000245796.6
ENST00000441564.3
pleckstrin and Sec7 domain containing 4
chr9_-_135819987 0.05 ENST00000298552.3
ENST00000403810.1
tuberous sclerosis 1
chr17_+_44668035 0.04 ENST00000398238.4
ENST00000225282.8
N-ethylmaleimide-sensitive factor
chr17_-_27621125 0.04 ENST00000579665.1
ENST00000225388.4
nuclear fragile X mental retardation protein interacting protein 2
chr2_-_131850951 0.03 ENST00000409185.1
ENST00000389915.3
family with sequence similarity 168, member B
chr2_-_213403565 0.03 ENST00000342788.4
ENST00000436443.1
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
chr17_-_38020392 0.03 ENST00000346872.3
ENST00000439167.2
ENST00000377945.3
ENST00000394189.2
ENST00000377944.3
ENST00000377958.2
ENST00000535189.1
ENST00000377952.2
IKAROS family zinc finger 3 (Aiolos)
chr9_-_3525968 0.03 ENST00000382004.3
ENST00000302303.1
ENST00000449190.1
regulatory factor X, 3 (influences HLA class II expression)
chr12_-_25403737 0.03 ENST00000256078.4
ENST00000556131.1
ENST00000311936.3
ENST00000557334.1
Kirsten rat sarcoma viral oncogene homolog
chr12_-_56236711 0.03 ENST00000409200.3
matrix metallopeptidase 19
chr4_+_41992489 0.03 ENST00000264451.7
solute carrier family 30 (zinc transporter), member 9
chr1_+_151584544 0.03 ENST00000458013.2
ENST00000368843.3
sorting nexin family member 27
chr8_-_91095099 0.03 ENST00000265431.3
calbindin 1, 28kDa
chr1_-_169863016 0.02 ENST00000367772.4
ENST00000367771.6
SCY1-like 3 (S. cerevisiae)
chr12_-_111021110 0.02 ENST00000354300.3
PTC7 protein phosphatase homolog (S. cerevisiae)
chr6_+_39760783 0.02 ENST00000398904.2
ENST00000538976.1
dishevelled associated activator of morphogenesis 2
chrX_-_47479246 0.02 ENST00000295987.7
ENST00000340666.4
synapsin I
chr10_-_38146510 0.02 ENST00000395867.3
zinc finger protein 248
chr14_+_102228123 0.02 ENST00000422945.2
ENST00000554442.1
ENST00000556260.2
ENST00000328724.5
ENST00000557268.1
protein phosphatase 2, regulatory subunit B', gamma
chr18_+_67068228 0.02 ENST00000382713.5
docking protein 6
chr4_-_23891693 0.02 ENST00000264867.2
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr20_+_42086525 0.02 ENST00000244020.3
serine/arginine-rich splicing factor 6
chr1_+_183605200 0.01 ENST00000304685.4
ral guanine nucleotide dissociation stimulator-like 1
chr16_+_56225248 0.01 ENST00000262493.6
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr11_-_71823796 0.01 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
anaphase promoting complex subunit 15
chr21_-_35831880 0.01 ENST00000399289.3
ENST00000432085.1
potassium voltage-gated channel, Isk-related family, member 1
chr12_-_50297638 0.01 ENST00000320634.3
Fas apoptotic inhibitory molecule 2
chr12_+_68042495 0.01 ENST00000344096.3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr2_+_29204161 0.01 ENST00000379558.4
ENST00000403861.2
family with sequence similarity 179, member A
chr7_-_26904317 0.01 ENST00000345317.2
src kinase associated phosphoprotein 2
chr14_-_68283291 0.01 ENST00000555452.1
ENST00000347230.4
zinc finger, FYVE domain containing 26
chr17_+_61627814 0.01 ENST00000310827.4
ENST00000431926.1
ENST00000415273.2
DDB1 and CUL4 associated factor 7
chr15_-_61521495 0.00 ENST00000335670.6
RAR-related orphan receptor A

Network of associatons between targets according to the STRING database.

First level regulatory network of ACUGGCC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 0.6 GO:0045081 negative regulation of interleukin-10 biosynthetic process(GO:0045081)
0.1 0.3 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.2 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.3 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.1 0.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.3 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.0 0.4 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.1 GO:1904761 negative regulation of myofibroblast differentiation(GO:1904761)
0.0 1.0 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.2 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.1 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.0 0.2 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.3 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.3 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:0038162 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.1 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
0.0 0.1 GO:2001038 regulation of cellular response to drug(GO:2001038)
0.0 0.1 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.0 0.3 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.1 GO:0030578 PML body organization(GO:0030578)
0.0 0.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.2 GO:0060613 fat pad development(GO:0060613)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.4 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.2 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.0 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.0 0.1 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.1 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.5 GO:0008334 histone mRNA metabolic process(GO:0008334)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.3 GO:0005606 laminin-1 complex(GO:0005606)
0.2 0.6 GO:0005607 laminin-2 complex(GO:0005607)
0.1 0.5 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.1 0.2 GO:0031213 RSF complex(GO:0031213)
0.0 0.3 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0071209 U7 snRNA binding(GO:0071209)
0.1 0.2 GO:0015322 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.1 0.7 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 0.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.6 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.4 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.3 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors