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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for AR_NR3C2

Z-value: 0.53

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
ENSG00000169083.11 androgen receptor
ENSG00000151623.10 nuclear receptor subfamily 3 group C member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARhg19_v2_chrX_+_66764375_66764465-0.912.7e-08Click!
NR3C2hg19_v2_chr4_-_149363662_1493636880.882.3e-07Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_56659687 6.54 ENST00000568293.1
ENST00000330439.6
metallothionein 1E
chr11_+_18287801 4.08 ENST00000532858.1
ENST00000405158.2
serum amyloid A1
chr11_+_18287721 3.73 ENST00000356524.4
serum amyloid A1
chr8_-_49834299 3.34 ENST00000396822.1
snail family zinc finger 2
chr8_-_49833978 3.31 ENST00000020945.1
snail family zinc finger 2
chr16_+_56642489 2.80 ENST00000561491.1
metallothionein 2A
chr16_+_56716336 2.28 ENST00000394485.4
ENST00000562939.1
metallothionein 1X
chr5_-_149792295 2.21 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74 molecule, major histocompatibility complex, class II invariant chain
chr16_+_56642041 1.70 ENST00000245185.5
metallothionein 2A
chr14_-_23623577 1.65 ENST00000422941.2
ENST00000453702.1
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr2_+_102953608 1.63 ENST00000311734.2
ENST00000409584.1
interleukin 1 receptor-like 1
chr2_-_74875432 1.40 ENST00000536235.1
ENST00000421985.1
meiosis 1 associated protein
chr14_-_21493884 1.26 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG family member 2
chr1_-_209979465 1.26 ENST00000542854.1
interferon regulatory factor 6
chr12_+_66582919 1.25 ENST00000545837.1
ENST00000457197.2
interleukin-1 receptor-associated kinase 3
chr14_-_21493649 1.16 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG family member 2
chr1_+_104104379 1.13 ENST00000435302.1
amylase, alpha 2B (pancreatic)
chr15_+_42694573 0.99 ENST00000397200.4
ENST00000569827.1
calpain 3, (p94)
chr18_+_47087055 0.88 ENST00000577628.1
lipase, endothelial
chr19_+_58570605 0.76 ENST00000359978.6
ENST00000401053.4
ENST00000439855.2
ENST00000313434.5
ENST00000511556.1
ENST00000506786.1
zinc finger protein 135
chrX_-_80377162 0.67 ENST00000430960.1
ENST00000447319.1
high mobility group nucleosome binding domain 5
chr12_-_122241812 0.67 ENST00000538335.1
AC084018.1
chrX_-_80377118 0.66 ENST00000373250.3
high mobility group nucleosome binding domain 5
chrX_-_117119243 0.65 ENST00000539496.1
ENST00000469946.1
kelch-like family member 13
chr16_-_4852616 0.61 ENST00000591392.1
ENST00000587711.1
rogdi homolog (Drosophila)
chr16_-_4852915 0.58 ENST00000322048.7
rogdi homolog (Drosophila)
chr18_+_47087390 0.56 ENST00000583083.1
lipase, endothelial
chr19_+_35741466 0.55 ENST00000599658.1
lipolysis stimulated lipoprotein receptor
chr1_+_1846519 0.54 ENST00000378604.3
calmodulin-like 6
chr4_+_75311019 0.54 ENST00000502307.1
amphiregulin
chr17_+_79071365 0.53 ENST00000576756.1
BAI1-associated protein 2
chr12_+_51318513 0.51 ENST00000332160.4
methyltransferase like 7A
chr17_-_6459802 0.50 ENST00000262483.8
PITPNM family member 3
chr3_+_125985620 0.50 ENST00000511512.1
ENST00000512435.1
RP11-71E19.1
chr3_+_13521665 0.50 ENST00000295757.3
ENST00000402259.1
ENST00000402271.1
ENST00000446613.2
ENST00000404548.1
ENST00000404040.1
histone deacetylase 11
chr1_-_10856694 0.49 ENST00000377022.3
ENST00000344008.5
castor zinc finger 1
chr17_+_38333263 0.48 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr4_+_186347388 0.47 ENST00000511138.1
ENST00000511581.1
chromosome 4 open reading frame 47
chr13_+_114462193 0.45 ENST00000375353.3
transmembrane protein 255B
chr4_+_75310851 0.42 ENST00000395748.3
ENST00000264487.2
amphiregulin
chr6_-_111927062 0.42 ENST00000359831.4
TRAF3 interacting protein 2
chr20_+_45947246 0.42 ENST00000599904.1
HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
chr8_+_9046503 0.41 ENST00000512942.2
RP11-10A14.5
chr7_-_96654133 0.41 ENST00000486603.2
ENST00000222598.4
distal-less homeobox 5
chr4_+_75480629 0.39 ENST00000380846.3
amphiregulin B
chr15_-_28344439 0.37 ENST00000431101.1
ENST00000445578.1
ENST00000353809.5
ENST00000382996.2
ENST00000354638.3
oculocutaneous albinism II
chr8_+_91013577 0.36 ENST00000220764.2
2,4-dienoyl CoA reductase 1, mitochondrial
chrX_+_153029633 0.34 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
plexin B3
chr4_+_87928140 0.33 ENST00000307808.6
AF4/FMR2 family, member 1
chrX_+_2609356 0.33 ENST00000381180.3
ENST00000449611.1
CD99 molecule
chr4_+_8442496 0.33 ENST00000389737.4
ENST00000504134.1
tRNA methyltransferase 44 homolog (S. cerevisiae)
chr19_+_57874835 0.33 ENST00000543226.1
ENST00000596755.1
ENST00000282282.3
ENST00000597658.1
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
Uncharacterized protein
chr1_+_112162381 0.32 ENST00000433097.1
ENST00000369709.3
ENST00000436150.2
RAP1A, member of RAS oncogene family
chr12_+_122241928 0.32 ENST00000604567.1
ENST00000542440.1
SET domain containing 1B
chr14_+_105190514 0.31 ENST00000330877.2
adenylosuccinate synthase like 1
chr15_+_31658349 0.28 ENST00000558844.1
Kruppel-like factor 13
chr17_+_79031415 0.27 ENST00000572073.1
ENST00000573677.1
BAI1-associated protein 2
chr2_+_242577097 0.27 ENST00000419606.1
ENST00000474739.2
ENST00000396411.3
ENST00000425239.1
ENST00000400771.3
ENST00000430617.2
autophagy related 4B, cysteine peptidase
chr2_-_75788424 0.26 ENST00000410071.1
eva-1 homolog A (C. elegans)
chrX_+_8433376 0.26 ENST00000440654.2
ENST00000381029.4
variable charge, X-linked 3B
chr2_-_75788428 0.25 ENST00000432649.1
eva-1 homolog A (C. elegans)
chr2_+_242577027 0.25 ENST00000402096.1
ENST00000404914.3
autophagy related 4B, cysteine peptidase
chr1_-_27693349 0.23 ENST00000374040.3
ENST00000357582.2
ENST00000493901.1
mitogen-activated protein kinase kinase kinase 6
chr10_+_26932068 0.23 ENST00000544033.1
ENST00000454991.1
long intergenic non-protein coding RNA 202-2
RP13-16H11.7
chrX_+_2609317 0.22 ENST00000381187.3
ENST00000381184.1
CD99 molecule
chrY_-_16098393 0.22 ENST00000250825.4
variable charge, Y-linked
chrX_+_2609207 0.21 ENST00000381192.3
CD99 molecule
chr17_-_65242063 0.20 ENST00000581159.1
helicase with zinc finger
chr18_-_48346130 0.19 ENST00000592966.1
maestro
chr2_-_166702601 0.19 ENST00000428888.1
AC009495.4
chr1_+_61547405 0.19 ENST00000371189.4
nuclear factor I/A
chr1_+_93811438 0.19 ENST00000370272.4
ENST00000370267.1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr11_+_65851443 0.18 ENST00000533756.1
phosphofurin acidic cluster sorting protein 1
chr18_-_48346298 0.18 ENST00000398439.3
maestro
chr2_-_109605663 0.16 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
ectodysplasin A receptor
chr4_-_69215467 0.14 ENST00000579690.1
YTH domain containing 1
chr3_-_24207039 0.14 ENST00000280696.5
thyroid hormone receptor, beta
chr8_+_91013676 0.14 ENST00000519410.1
ENST00000522161.1
ENST00000517761.1
ENST00000520227.1
2,4-dienoyl CoA reductase 1, mitochondrial
chr19_+_1261106 0.13 ENST00000588411.1
cold inducible RNA binding protein
chrY_+_16168097 0.13 ENST00000250823.4
variable charge, Y-linked 1B
chr11_+_236540 0.12 ENST00000532097.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr4_-_186347099 0.12 ENST00000505357.1
ENST00000264689.6
UFM1-specific peptidase 2
chr4_-_13629269 0.12 ENST00000040738.5
biorientation of chromosomes in cell division 1-like 1
chr6_+_31638156 0.12 ENST00000409525.1
lymphocyte antigen 6 complex, locus G5B
chr2_-_73298802 0.12 ENST00000411783.1
ENST00000410065.1
ENST00000442582.1
ENST00000272433.2
sideroflexin 5
chr16_-_787728 0.11 ENST00000567403.1
ENST00000562421.1
nuclear prelamin A recognition factor-like
chr1_+_76262552 0.11 ENST00000263187.3
mutS homolog 4
chr16_-_25269134 0.10 ENST00000328086.7
zinc finger with KRAB and SCAN domains 2
chr4_-_8442438 0.10 ENST00000356406.5
ENST00000413009.2
acyl-CoA oxidase 3, pristanoyl
chr14_-_106866934 0.09 ENST00000390618.2
immunoglobulin heavy variable 3-38 (non-functional)
chr4_-_185395191 0.09 ENST00000510814.1
ENST00000507523.1
ENST00000506230.1
interferon regulatory factor 2
chr4_-_69215699 0.09 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTH domain containing 1
chr11_-_506316 0.08 ENST00000532055.1
ENST00000531540.1
ribonuclease/angiogenin inhibitor 1
chr14_-_106845789 0.08 ENST00000390617.2
immunoglobulin heavy variable 3-35 (non-functional)
chr12_-_11002063 0.07 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
proline rich 4 (lacrimal)
chr11_+_103907308 0.07 ENST00000302259.3
DNA-damage inducible 1 homolog 1 (S. cerevisiae)
chr1_+_209545365 0.06 ENST00000447257.1
RP11-372M18.2
chr9_-_40792063 0.06 ENST00000377626.3
ENST00000441795.1
ENST00000602553.1
zinc finger protein 658
chr9_-_106087316 0.06 ENST00000411575.1
RP11-341A22.2
chr1_-_204119009 0.05 ENST00000444817.1
ethanolamine kinase 2
chr17_+_41323204 0.05 ENST00000542611.1
ENST00000590996.1
ENST00000389312.4
ENST00000589872.1
neighbor of BRCA1 gene 1
chrX_+_8432871 0.05 ENST00000381032.1
ENST00000453306.1
ENST00000444481.1
variable charge, X-linked 3B
chr16_-_67978016 0.05 ENST00000264005.5
lecithin-cholesterol acyltransferase
chr8_-_23021533 0.04 ENST00000312584.3
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr11_-_5959840 0.03 ENST00000412903.1
tripartite motif containing 5
chr14_+_24616588 0.03 ENST00000324103.6
ENST00000559260.1
ring finger protein 31
chr16_+_25703274 0.03 ENST00000331351.5
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr4_-_69817481 0.03 ENST00000251566.4
UDP glucuronosyltransferase 2 family, polypeptide A3
chr3_+_118865028 0.03 ENST00000460150.1
chromosome 3 open reading frame 30
chr19_+_35630344 0.02 ENST00000455515.2
FXYD domain containing ion transport regulator 1
chr9_+_34957477 0.02 ENST00000544237.1
KIAA1045
chr14_-_106692191 0.02 ENST00000390607.2
immunoglobulin heavy variable 3-21
chr19_-_45657028 0.02 ENST00000429338.1
ENST00000589776.1
NTPase, KAP family P-loop domain containing 1
chr12_-_56615693 0.02 ENST00000394013.2
ENST00000345093.4
ENST00000551711.1
ENST00000552656.1
ring finger protein 41
chr16_+_67207872 0.02 ENST00000563258.1
ENST00000568146.1
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr12_-_56615485 0.02 ENST00000549038.1
ENST00000552244.1
ring finger protein 41
chrX_-_6453159 0.01 ENST00000381089.3
ENST00000398729.1
variable charge, X-linked 3A
chr3_+_118864991 0.00 ENST00000295622.1
chromosome 3 open reading frame 30
chr13_-_40924439 0.00 ENST00000400432.3
RP11-172E9.2
chr3_-_15382875 0.00 ENST00000408919.3
SH3-domain binding protein 5 (BTK-associated)

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.7 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.9 4.5 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.4 2.2 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.4 2.3 GO:0036018 cellular response to erythropoietin(GO:0036018)
0.4 1.4 GO:0010983 positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.2 1.6 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.2 1.4 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.2 1.3 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.2 6.2 GO:0071294 cellular response to zinc ion(GO:0071294)
0.2 1.0 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.2 7.8 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716)
0.1 1.0 GO:0014718 positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718)
0.1 2.4 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 0.4 GO:0060166 olfactory pit development(GO:0060166)
0.1 0.5 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.1 0.8 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.1 0.4 GO:0006726 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.1 0.5 GO:0051697 protein delipidation(GO:0051697)
0.1 0.3 GO:0097327 response to antineoplastic agent(GO:0097327)
0.1 0.3 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.0 1.7 GO:0015695 organic cation transport(GO:0015695)
0.0 1.3 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 1.3 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 0.3 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.0 0.1 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.1 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0 0.4 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.1 GO:0051026 chiasma assembly(GO:0051026)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.2 7.8 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.5 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0005713 recombination nodule(GO:0005713)
0.0 0.4 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 5.7 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0002113 interleukin-33 binding(GO:0002113)
0.3 4.5 GO:0046870 cadmium ion binding(GO:0046870)
0.3 2.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 1.1 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 7.8 GO:0042056 chemoattractant activity(GO:0042056)
0.1 1.7 GO:0019534 toxin transporter activity(GO:0019534)
0.1 0.5 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
0.1 1.4 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.3 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.1 0.4 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.3 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 1.0 GO:0031432 titin binding(GO:0031432)
0.0 0.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 6.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.1 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.5 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.4 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.0 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 6.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 4.5 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.2 PID IL1 PATHWAY IL1-mediated signaling events
0.0 2.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.3 PID EPO PATHWAY EPO signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 7.8 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 5.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 1.7 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.3 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 2.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions