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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ATF5

Z-value: 1.03

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Transcription factors associated with ATF5

Gene Symbol Gene ID Gene Info
ENSG00000169136.4 activating transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF5hg19_v2_chr19_+_50432400_50432479-0.389.4e-02Click!

Activity profile of ATF5 motif

Sorted Z-values of ATF5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_36988882 5.45 ENST00000498187.2
NK2 homeobox 1
chr1_+_209859510 4.20 ENST00000367028.2
ENST00000261465.1
hydroxysteroid (11-beta) dehydrogenase 1
chr2_-_113542063 4.19 ENST00000263339.3
interleukin 1, alpha
chr1_-_17304771 4.05 ENST00000375534.3
microfibrillar-associated protein 2
chr21_-_28215332 3.94 ENST00000517777.1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr7_-_3083573 3.76 ENST00000396946.4
caspase recruitment domain family, member 11
chr7_-_41740181 3.32 ENST00000442711.1
inhibin, beta A
chr6_+_43738444 2.97 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
vascular endothelial growth factor A
chr5_-_39219641 2.91 ENST00000509072.1
ENST00000504542.1
ENST00000505428.1
ENST00000506557.1
FYN binding protein
chr7_-_127672146 2.87 ENST00000476782.1
leucine rich repeat containing 4
chr5_+_156887027 2.78 ENST00000435489.2
ENST00000311946.7
NIPA-like domain containing 4
chr1_-_46598371 2.74 ENST00000372006.1
ENST00000425892.1
ENST00000420542.1
ENST00000354242.4
ENST00000340332.6
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
chr7_-_3083472 2.65 ENST00000356408.3
caspase recruitment domain family, member 11
chr16_-_65155833 2.52 ENST00000566827.1
ENST00000394156.3
ENST00000562998.1
cadherin 11, type 2, OB-cadherin (osteoblast)
chr1_-_27286897 2.48 ENST00000320567.5
chromosome 1 open reading frame 172
chr10_+_111765562 2.34 ENST00000360162.3
adducin 3 (gamma)
chr14_-_65569244 2.31 ENST00000557277.1
ENST00000556892.1
MYC associated factor X
chr5_+_50678921 2.28 ENST00000230658.7
ISL LIM homeobox 1
chr17_-_5522731 2.20 ENST00000576905.1
NLR family, pyrin domain containing 1
chr1_+_16083154 2.08 ENST00000375771.1
filamin binding LIM protein 1
chr16_-_65155979 2.05 ENST00000562325.1
ENST00000268603.4
cadherin 11, type 2, OB-cadherin (osteoblast)
chrX_+_131157609 2.02 ENST00000496850.1
Serine/threonine-protein kinase MST4
chr1_-_202776392 1.93 ENST00000235790.4
lysine (K)-specific demethylase 5B
chr5_+_138629628 1.91 ENST00000508689.1
ENST00000514528.1
matrin 3
chr9_+_109625378 1.85 ENST00000277225.5
ENST00000457913.1
ENST00000472574.1
zinc finger protein 462
chr5_+_138629337 1.77 ENST00000394805.3
ENST00000512876.1
ENST00000513678.1
matrin 3
chr4_+_2800722 1.76 ENST00000508385.1
SH3-domain binding protein 2
chr11_-_117102768 1.73 ENST00000532301.1
proprotein convertase subtilisin/kexin type 7
chr11_+_58938903 1.65 ENST00000532982.1
deltex homolog 4 (Drosophila)
chr4_+_77172847 1.60 ENST00000515604.1
ENST00000539752.1
ENST00000424749.2
uncharacterized protein LOC100631383
FAM47E-STBD1 readthrough
family with sequence similarity 47, member E
chr12_-_54778444 1.57 ENST00000551771.1
zinc finger protein 385A
chr15_+_78556428 1.55 ENST00000394855.3
ENST00000489435.2
DnaJ (Hsp40) homolog, subfamily A, member 4
chr12_-_54778244 1.53 ENST00000549937.1
zinc finger protein 385A
chr5_+_138629389 1.51 ENST00000504045.1
ENST00000504311.1
ENST00000502499.1
matrin 3
chr3_-_99569821 1.50 ENST00000487087.1
filamin A interacting protein 1-like
chr3_-_69129501 1.48 ENST00000540295.1
ENST00000415609.2
ENST00000361055.4
ENST00000349511.4
ubiquitin-like modifier activating enzyme 3
chr2_-_214016314 1.48 ENST00000434687.1
ENST00000374319.4
IKAROS family zinc finger 2 (Helios)
chr11_-_129062093 1.46 ENST00000310343.9
Rho GTPase activating protein 32
chr6_-_100016678 1.43 ENST00000523799.1
ENST00000520429.1
cyclin C
chr22_-_36236623 1.40 ENST00000405409.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr17_+_38334242 1.39 ENST00000436615.3
Rap guanine nucleotide exchange factor (GEF)-like 1
chr7_-_127671674 1.38 ENST00000478726.1
leucine rich repeat containing 4
chr5_-_39219705 1.33 ENST00000351578.6
FYN binding protein
chr16_-_58663720 1.32 ENST00000564557.1
ENST00000569240.1
ENST00000441024.2
ENST00000569020.1
ENST00000317147.5
CCR4-NOT transcription complex, subunit 1
chr12_-_57030096 1.30 ENST00000549506.1
bromodomain adjacent to zinc finger domain, 2A
chr7_-_102232891 1.28 ENST00000514917.2
RP11-514P8.7
chr7_+_128399002 1.27 ENST00000493278.1
calumenin
chr19_+_41509851 1.27 ENST00000593831.1
ENST00000330446.5
cytochrome P450, family 2, subfamily B, polypeptide 6
chr6_+_87865262 1.26 ENST00000369577.3
ENST00000518845.1
ENST00000339907.4
ENST00000496806.2
zinc finger protein 292
chr1_-_54872059 1.25 ENST00000371320.3
single stranded DNA binding protein 3
chr17_-_79817091 1.25 ENST00000570907.1
prolyl 4-hydroxylase, beta polypeptide
chr7_+_132937820 1.23 ENST00000393161.2
ENST00000253861.4
exocyst complex component 4
chr1_+_101361782 1.21 ENST00000357650.4
solute carrier family 30 (zinc transporter), member 7
chr5_+_82767583 1.20 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
versican
chr16_+_9185450 1.19 ENST00000327827.7
chromosome 16 open reading frame 72
chr4_-_74124502 1.17 ENST00000358602.4
ENST00000330838.6
ENST00000561029.1
ankyrin repeat domain 17
chr3_-_183145873 1.17 ENST00000447025.2
ENST00000414362.2
ENST00000328913.3
MCF.2 cell line derived transforming sequence-like 2
chr14_+_32546145 1.17 ENST00000556611.1
ENST00000539826.2
Rho GTPase activating protein 5
chr5_+_82767487 1.15 ENST00000343200.5
ENST00000342785.4
versican
chr15_+_63481668 1.15 ENST00000321437.4
ENST00000559006.1
ENST00000448330.2
RAB8B, member RAS oncogene family
chr5_+_82767284 1.13 ENST00000265077.3
versican
chr14_-_65569057 1.11 ENST00000555419.1
ENST00000341653.2
MYC associated factor X
chr12_+_56915776 1.09 ENST00000550726.1
ENST00000542360.1
RNA binding motif, single stranded interacting protein 2
chr8_-_131028869 1.09 ENST00000518283.1
ENST00000519110.1
family with sequence similarity 49, member B
chr6_+_44095347 1.07 ENST00000323267.6
transmembrane protein 63B
chr1_-_67896069 1.07 ENST00000370995.2
ENST00000361219.6
SERPINE1 mRNA binding protein 1
chr12_-_54778471 1.07 ENST00000550120.1
ENST00000394313.2
ENST00000547210.1
zinc finger protein 385A
chr14_-_65569186 1.05 ENST00000555932.1
ENST00000358664.4
ENST00000284165.6
ENST00000358402.4
ENST00000246163.2
ENST00000556979.1
ENST00000555667.1
ENST00000557746.1
ENST00000556443.1
MYC associated factor X
chr6_+_44095263 1.04 ENST00000532634.1
transmembrane protein 63B
chr16_+_72127806 1.03 ENST00000566489.1
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr3_-_187454281 1.02 ENST00000232014.4
B-cell CLL/lymphoma 6
chr2_+_191334212 1.01 ENST00000444317.1
ENST00000535751.1
major facilitator superfamily domain containing 6
chr14_+_70918874 1.01 ENST00000603540.1
ADAM metallopeptidase domain 21
chr1_+_16083098 0.98 ENST00000496928.2
ENST00000508310.1
filamin binding LIM protein 1
chr18_-_812517 0.98 ENST00000584307.1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr22_-_36357671 0.97 ENST00000408983.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr5_-_148442584 0.96 ENST00000394358.2
ENST00000512049.1
SH3 domain and tetratricopeptide repeats 2
chr12_+_32655048 0.96 ENST00000427716.2
ENST00000266482.3
FYVE, RhoGEF and PH domain containing 4
chr14_+_96968802 0.96 ENST00000556619.1
ENST00000392990.2
poly(A) polymerase alpha
chr18_-_812231 0.92 ENST00000314574.4
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr19_+_42773371 0.92 ENST00000571942.2
capicua transcriptional repressor
chr6_-_100016527 0.90 ENST00000523985.1
ENST00000518714.1
ENST00000520371.1
cyclin C
chr11_+_27076764 0.88 ENST00000525090.1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr12_+_56915713 0.85 ENST00000262031.5
ENST00000552247.2
RNA binding motif, single stranded interacting protein 2
chr2_-_197036289 0.85 ENST00000263955.4
serine/threonine kinase 17b
chr12_+_32655110 0.85 ENST00000546442.1
ENST00000583694.1
FYVE, RhoGEF and PH domain containing 4
chr20_+_58179582 0.84 ENST00000371015.1
ENST00000395639.4
phosphatase and actin regulator 3
chr1_-_27930102 0.83 ENST00000247087.5
ENST00000374011.2
AT hook, DNA binding motif, containing 1
chr13_-_36944307 0.82 ENST00000355182.4
spastic paraplegia 20 (Troyer syndrome)
chr7_+_44040488 0.81 ENST00000258704.3
speedy/RINGO cell cycle regulator family member E1
chr3_+_190105909 0.81 ENST00000456423.1
claudin 16
chr1_-_67896009 0.78 ENST00000370990.5
SERPINE1 mRNA binding protein 1
chr8_+_79428539 0.77 ENST00000352966.5
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr20_-_52612705 0.76 ENST00000434986.2
breast carcinoma amplified sequence 1
chr2_+_234601512 0.75 ENST00000305139.6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr6_-_39902160 0.75 ENST00000340692.5
molybdenum cofactor synthesis 1
chr5_+_50679506 0.74 ENST00000511384.1
ISL LIM homeobox 1
chr5_-_148442687 0.72 ENST00000515425.1
SH3 domain and tetratricopeptide repeats 2
chr1_+_101361626 0.71 ENST00000370112.4
solute carrier family 30 (zinc transporter), member 7
chr12_+_32654965 0.70 ENST00000472289.1
FYVE, RhoGEF and PH domain containing 4
chr17_+_55055466 0.70 ENST00000262288.3
ENST00000572710.1
ENST00000575395.1
serine carboxypeptidase 1
chr2_-_128642434 0.69 ENST00000393001.1
AMMECR1-like
chr12_-_52967600 0.69 ENST00000549343.1
ENST00000305620.2
keratin 74
chr19_-_15090488 0.67 ENST00000594383.1
ENST00000598504.1
ENST00000597262.1
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr12_-_72057638 0.67 ENST00000552037.1
ENST00000378743.3
zinc finger, C3H1-type containing
chr16_+_72127461 0.64 ENST00000268482.3
ENST00000566794.1
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr2_+_217498105 0.63 ENST00000233809.4
insulin-like growth factor binding protein 2, 36kDa
chr6_+_143999185 0.63 ENST00000542769.1
ENST00000397980.3
phosphatase and actin regulator 2
chr3_+_38206975 0.63 ENST00000446845.1
ENST00000311806.3
oxidative stress responsive 1
chr14_+_32547434 0.63 ENST00000556191.1
ENST00000554090.1
Rho GTPase activating protein 5
chr1_-_22109484 0.63 ENST00000529637.1
ubiquitin specific peptidase 48
chr1_-_151319318 0.61 ENST00000436271.1
ENST00000450506.1
ENST00000422595.1
regulatory factor X, 5 (influences HLA class II expression)
chr11_+_124735282 0.59 ENST00000397801.1
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr1_+_160321120 0.58 ENST00000424754.1
nicastrin
chr12_-_57030115 0.58 ENST00000379441.3
ENST00000179765.5
ENST00000551812.1
bromodomain adjacent to zinc finger domain, 2A
chr12_-_49351303 0.57 ENST00000256682.4
ADP-ribosylation factor 3
chr3_+_193853927 0.56 ENST00000232424.3
hes family bHLH transcription factor 1
chr6_+_76599809 0.56 ENST00000430435.1
myosin VI
chr10_+_103113840 0.55 ENST00000393441.4
ENST00000408038.2
beta-transducin repeat containing E3 ubiquitin protein ligase
chr9_+_127023704 0.55 ENST00000373596.1
ENST00000425237.1
NIMA-related kinase 6
chr18_-_53089723 0.53 ENST00000561992.1
ENST00000562512.2
transcription factor 4
chr2_-_128784846 0.53 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
Sin3A-associated protein, 130kDa
chr19_-_45873642 0.52 ENST00000485403.2
ENST00000586856.1
ENST00000586131.1
ENST00000391940.4
ENST00000221481.6
ENST00000391944.3
ENST00000391945.4
excision repair cross-complementing rodent repair deficiency, complementation group 2
chrX_+_123095546 0.52 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
stromal antigen 2
chr1_+_16083123 0.52 ENST00000510393.1
ENST00000430076.1
filamin binding LIM protein 1
chr1_-_36023251 0.51 ENST00000426982.2
KIAA0319-like
chr7_+_143771275 0.49 ENST00000408898.2
olfactory receptor, family 2, subfamily A, member 25
chr11_-_108408895 0.49 ENST00000443411.1
ENST00000533052.1
exophilin 5
chr5_+_138629417 0.47 ENST00000510056.1
ENST00000511249.1
ENST00000503811.1
ENST00000511378.1
matrin 3
chr5_+_34757309 0.47 ENST00000397449.1
retinoic acid induced 14
chr17_+_33914424 0.46 ENST00000590432.1
adaptor-related protein complex 2, beta 1 subunit
chr11_+_28724129 0.46 ENST00000513853.1
RP11-115J23.1
chr1_-_22109682 0.46 ENST00000400301.1
ENST00000532737.1
ubiquitin specific peptidase 48
chr6_-_100016492 0.45 ENST00000369217.4
ENST00000369220.4
ENST00000482541.2
cyclin C
chr17_+_38337491 0.45 ENST00000538981.1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr12_-_12491608 0.42 ENST00000545735.1
MANSC domain containing 1
chr1_-_205053645 0.42 ENST00000367167.3
transmembrane protein 81
chr1_-_151319283 0.41 ENST00000392746.3
regulatory factor X, 5 (influences HLA class II expression)
chr9_+_2621950 0.39 ENST00000382096.1
very low density lipoprotein receptor
chr12_-_72057571 0.39 ENST00000548100.1
zinc finger, C3H1-type containing
chr5_+_137203465 0.38 ENST00000239926.4
myotilin
chr3_+_19988885 0.37 ENST00000422242.1
RAB5A, member RAS oncogene family
chr1_+_61869748 0.37 ENST00000357977.5
nuclear factor I/A
chr1_+_36023370 0.36 ENST00000356090.4
ENST00000373243.2
neurochondrin
chr3_-_23958402 0.35 ENST00000415901.2
ENST00000416026.2
ENST00000412028.1
ENST00000388759.3
ENST00000437230.1
NFKB inhibitor interacting Ras-like 1
chr3_-_182698381 0.35 ENST00000292782.4
DCN1, defective in cullin neddylation 1, domain containing 1
chr3_-_47950745 0.35 ENST00000429422.1
microtubule-associated protein 4
chr6_+_4773205 0.35 ENST00000440139.1
chromodomain protein, Y-like
chrX_+_47050236 0.34 ENST00000377351.4
ubiquitin-like modifier activating enzyme 1
chr1_+_151739131 0.34 ENST00000400999.1
ornithine decarboxylase antizyme 3
chr9_-_116065551 0.33 ENST00000297894.5
ring finger protein 183
chr14_+_100111447 0.33 ENST00000330710.5
ENST00000357223.2
HHIP-like 1
chr1_+_36023035 0.33 ENST00000373253.3
neurochondrin
chr9_-_23825956 0.33 ENST00000397312.2
ELAV like neuron-specific RNA binding protein 2
chr1_-_156460391 0.32 ENST00000360595.3
myocyte enhancer factor 2D
chr11_-_7904464 0.32 ENST00000502624.2
ENST00000527565.1
RP11-35J10.5
chr3_+_19988566 0.29 ENST00000273047.4
RAB5A, member RAS oncogene family
chr8_+_100025476 0.29 ENST00000355155.1
ENST00000357162.2
ENST00000358544.2
ENST00000395996.1
ENST00000441350.2
vacuolar protein sorting 13 homolog B (yeast)
chr11_-_33891362 0.28 ENST00000395833.3
LIM domain only 2 (rhombotin-like 1)
chr3_-_23958506 0.26 ENST00000425478.2
NFKB inhibitor interacting Ras-like 1
chr4_-_84376953 0.26 ENST00000510985.1
ENST00000295488.3
helicase, POLQ-like
chr1_+_206579736 0.26 ENST00000439126.1
SLIT-ROBO Rho GTPase activating protein 2
chr17_+_44790515 0.26 ENST00000576346.1
N-ethylmaleimide-sensitive factor
chr9_+_19230433 0.25 ENST00000434457.2
ENST00000602925.1
DENN/MADD domain containing 4C
chr17_+_38334501 0.25 ENST00000541245.1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr17_-_73149921 0.24 ENST00000481647.1
ENST00000470924.1
hematological and neurological expressed 1
chr15_+_77287426 0.23 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
proline-serine-threonine phosphatase interacting protein 1
chrX_-_19983260 0.23 ENST00000340625.3
chromosome X open reading frame 23
chr12_+_125811162 0.23 ENST00000299308.3
transmembrane protein 132B
chr5_+_137203541 0.22 ENST00000421631.2
myotilin
chr12_-_25101920 0.22 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
branched chain amino-acid transaminase 1, cytosolic
chr4_-_68620053 0.22 ENST00000420975.2
ENST00000226413.4
gonadotropin-releasing hormone receptor
chr17_+_44668387 0.21 ENST00000576040.1
N-ethylmaleimide-sensitive factor
chr2_+_88047606 0.21 ENST00000359481.4
plasminogen-like B2
chr6_+_114178512 0.20 ENST00000368635.4
myristoylated alanine-rich protein kinase C substrate
chr6_+_31865552 0.19 ENST00000469372.1
ENST00000497706.1
complement component 2
chr16_+_28943260 0.19 ENST00000538922.1
ENST00000324662.3
ENST00000567541.1
CD19 molecule
chr7_-_115670792 0.18 ENST00000265440.7
ENST00000393485.1
transcription factor EC
chrX_+_153409678 0.18 ENST00000369951.4
opsin 1 (cone pigments), long-wave-sensitive
chr5_+_137203557 0.17 ENST00000515645.1
myotilin
chr9_-_23826298 0.17 ENST00000380117.1
ELAV like neuron-specific RNA binding protein 2
chr8_-_623547 0.17 ENST00000522893.1
glutamate-rich 1
chr17_+_33914460 0.16 ENST00000537622.2
adaptor-related protein complex 2, beta 1 subunit
chr5_+_125967372 0.14 ENST00000357147.3
chromosome 5 open reading frame 48
chr8_+_37553261 0.14 ENST00000331569.4
zinc finger protein 703
chr8_-_13134045 0.13 ENST00000512044.2
deleted in liver cancer 1
chr20_-_52612468 0.13 ENST00000422805.1
breast carcinoma amplified sequence 1
chr18_-_53089538 0.13 ENST00000566777.1
transcription factor 4
chr19_+_15160130 0.13 ENST00000427043.3
caspase 14, apoptosis-related cysteine peptidase
chrX_-_122866874 0.13 ENST00000245838.8
ENST00000355725.4
THO complex 2
chr19_-_38916839 0.12 ENST00000433821.2
ENST00000426920.2
ENST00000587753.1
ENST00000454404.2
ENST00000293062.9
RAS guanyl releasing protein 4
chr12_-_48597170 0.12 ENST00000310248.2
olfactory receptor, family 10, subfamily AD, member 1
chr13_-_36871886 0.11 ENST00000491049.2
ENST00000503173.1
ENST00000239860.6
ENST00000379862.2
ENST00000239859.7
ENST00000379864.2
ENST00000510088.1
ENST00000554962.1
ENST00000511166.1
coiled-coil domain containing 169
spermatogenesis and oogenesis specific basic helix-loop-helix 2
CCDC169-SOHLH2 readthrough
chr8_+_107738240 0.11 ENST00000449762.2
ENST00000297447.6
oxidation resistance 1
chr7_-_115670804 0.11 ENST00000320239.7
transcription factor EC
chr10_-_104179682 0.11 ENST00000406432.1
pleckstrin and Sec7 domain containing
chr2_-_208994548 0.11 ENST00000282141.3
crystallin, gamma C
chr11_+_18417948 0.11 ENST00000542179.1
lactate dehydrogenase A
chr22_-_36236265 0.10 ENST00000414461.2
ENST00000416721.2
ENST00000449924.2
ENST00000262829.7
ENST00000397305.3
RNA binding protein, fox-1 homolog (C. elegans) 2
chr11_-_132813566 0.10 ENST00000331898.7
opioid binding protein/cell adhesion molecule-like

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.0 3.0 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.8 3.0 GO:0048936 visceral motor neuron differentiation(GO:0021524) peripheral nervous system neuron axonogenesis(GO:0048936) cardiac cell fate determination(GO:0060913) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
0.7 2.2 GO:1904784 NLRP1 inflammasome complex assembly(GO:1904784)
0.6 4.2 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.6 10.6 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.5 1.5 GO:0007113 endomitotic cell cycle(GO:0007113)
0.5 1.9 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
0.5 5.4 GO:0021759 globus pallidus development(GO:0021759)
0.5 4.1 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.4 1.2 GO:0097065 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.3 1.0 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 2.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.2 2.8 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.2 4.3 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.2 0.6 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.2 0.8 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.2 1.2 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.2 0.6 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.2 3.7 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.2 4.2 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.2 0.5 GO:0032289 central nervous system myelin formation(GO:0032289)
0.2 2.8 GO:0015693 magnesium ion transport(GO:0015693)
0.2 1.1 GO:0051461 positive regulation of corticotropin secretion(GO:0051461)
0.2 4.2 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.1 1.9 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.1 3.5 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 1.3 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 1.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.1 1.7 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 1.3 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.1 0.7 GO:0070778 L-aspartate transport(GO:0070778) L-aspartate transmembrane transport(GO:0089712)
0.1 4.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.8 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.1 0.7 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.1 2.7 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.1 1.9 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 1.2 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.1 0.7 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.1 0.3 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 0.9 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 1.6 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 0.3 GO:0021816 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.1 0.8 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.4 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.1 0.9 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 1.9 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.1 0.6 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 0.5 GO:0035494 SNARE complex disassembly(GO:0035494)
0.0 0.3 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0002372 myeloid dendritic cell cytokine production(GO:0002372)
0.0 0.2 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.2 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 1.7 GO:0016486 peptide hormone processing(GO:0016486)
0.0 1.8 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.0 0.6 GO:0007220 Notch receptor processing(GO:0007220)
0.0 1.0 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.7 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.0 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.0 2.3 GO:0046847 filopodium assembly(GO:0046847)
0.0 2.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 4.2 GO:0009267 cellular response to starvation(GO:0009267)
0.0 0.6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.7 GO:0033598 mammary gland epithelial cell proliferation(GO:0033598)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.6 GO:0030048 actin filament-based movement(GO:0030048)
0.0 0.1 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.3 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789) cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.3 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.3 2.2 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.3 1.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.3 1.9 GO:0033553 rDNA heterochromatin(GO:0033553)
0.2 0.7 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.2 6.1 GO:0042101 T cell receptor complex(GO:0042101)
0.2 4.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.2 GO:0032584 growth cone membrane(GO:0032584)
0.1 1.1 GO:0051286 cell tip(GO:0051286)
0.1 1.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.5 GO:0071817 MMXD complex(GO:0071817)
0.1 1.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.1 4.5 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 2.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 2.8 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.6 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 4.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.7 GO:0036020 endolysosome membrane(GO:0036020)
0.0 3.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 3.9 GO:0005604 basement membrane(GO:0005604)
0.0 3.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.0 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 5.2 GO:0043197 dendritic spine(GO:0043197)
0.0 2.5 GO:0030175 filopodium(GO:0030175)
0.0 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 2.3 GO:0005903 brush border(GO:0005903)
0.0 0.3 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.5 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.0 7.8 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.5 3.0 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.5 1.5 GO:0019781 NEDD8 activating enzyme activity(GO:0019781)
0.5 1.9 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.5 2.9 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 6.5 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.3 6.4 GO:0050700 CARD domain binding(GO:0050700)
0.2 0.9 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 0.6 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.2 2.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 4.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 3.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 2.2 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 4.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 3.6 GO:0031005 filamin binding(GO:0031005)
0.1 0.7 GO:1990254 keratin filament binding(GO:1990254)
0.1 1.1 GO:0030911 TPR domain binding(GO:0030911)
0.1 3.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.7 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 1.0 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.1 0.2 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.1 3.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 0.3 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.4 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.1 1.3 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.1 2.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.5 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.1 1.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 3.2 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 5.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.2 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.7 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 4.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.6 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.0 0.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.8 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.7 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 3.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 3.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.8 GO:0001972 retinoic acid binding(GO:0001972)
0.0 1.5 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.8 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 2.1 GO:0051087 chaperone binding(GO:0051087)
0.0 0.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 2.6 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 3.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 12.4 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 4.5 PID MYC PATHWAY C-MYC pathway
0.1 2.7 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 2.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 3.3 PID ALK1 PATHWAY ALK1 signaling events
0.1 1.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 4.2 PID IL1 PATHWAY IL1-mediated signaling events
0.1 5.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.9 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 4.5 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.2 PID INSULIN PATHWAY Insulin Pathway
0.0 0.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 4.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.5 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 3.0 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 3.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 3.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 6.4 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.1 4.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 4.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 3.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 4.2 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 3.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 4.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 2.5 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 3.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 1.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 2.2 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 4.5 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 2.2 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 2.0 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.7 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 2.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.2 REACTOME OPSINS Genes involved in Opsins
0.0 2.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.8 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.5 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.6 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors