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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ATF5
Z-value: 1.03
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Transcription factors associated with ATF5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF5 | hg19_v2_chr19_+_50432400_50432479 | -0.38 | 9.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 10.6 | GO:0045086 | positive regulation of interleukin-2 biosynthetic process(GO:0045086) |
| 0.5 | 5.4 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.2 | 4.3 | GO:0021957 | corticospinal tract morphogenesis(GO:0021957) |
| 0.6 | 4.2 | GO:1902162 | mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164) |
| 0.2 | 4.2 | GO:0097119 | postsynaptic density protein 95 clustering(GO:0097119) |
| 0.2 | 4.2 | GO:0006704 | glucocorticoid biosynthetic process(GO:0006704) |
| 0.1 | 4.2 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 4.2 | GO:0009267 | cellular response to starvation(GO:0009267) |
| 0.5 | 4.1 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.2 | 3.7 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.8 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.2 | 6.1 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 5.2 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 4.8 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 4.5 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.2 | 4.1 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 3.9 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 3.5 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.1 | 3.3 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.0 | 3.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.5 | GO:0044213 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.3 | 6.4 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.0 | 5.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 4.9 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 4.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.4 | 4.2 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.2 | 4.2 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.1 | 3.9 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 3.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 3.6 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 5.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 4.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 4.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 4.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 3.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 3.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.3 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 3.0 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.1 | 4.7 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 4.6 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 4.5 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.1 | 4.2 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 4.2 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 3.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 3.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 3.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 3.3 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |