Project
SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for BACH1_NFE2_NFE2L2
Z-value: 2.66
Motif logo
Transcription factors associated with BACH1_NFE2_NFE2L2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000156273.11 | BTB domain and CNC homolog 1 | |
| ENSG00000123405.9 | nuclear factor, erythroid 2 | |
| ENSG00000116044.11 | nuclear factor, erythroid 2 like 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFE2L2 | hg19_v2_chr2_-_178128199_178128245 | -0.66 | 1.5e-03 | Click! |
| BACH1 | hg19_v2_chr21_+_30671690_30671762 | -0.66 | 1.6e-03 | Click! |
| NFE2 | hg19_v2_chr12_-_54694807_54694905 | 0.07 | 7.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_116840728 Show fit | 15.41 |
ENST00000265132.3
|
alpha-1-microglobulin/bikunin precursor |
|
| chr16_-_69760409 Show fit | 15.21 |
ENST00000561500.1
ENST00000439109.2 ENST00000564043.1 ENST00000379046.2 ENST00000379047.3 |
NAD(P)H dehydrogenase, quinone 1 |
|
| chr12_+_56075330 Show fit | 13.81 |
ENST00000394252.3
|
methyltransferase like 7B |
|
| chr5_-_90610200 Show fit | 13.19 |
ENST00000511918.1
ENST00000513626.1 ENST00000607854.1 |
lung cancer associated transcript 1 (non-protein coding) RP11-213H15.4 |
|
| chr7_+_134212312 Show fit | 12.14 |
ENST00000359579.4
|
aldo-keto reductase family 1, member B10 (aldose reductase) |
|
| chr11_-_2924720 Show fit | 11.04 |
ENST00000455942.2
|
solute carrier family 22 (organic cation transporter), member 18 antisense |
|
| chr10_-_71892555 Show fit | 10.96 |
ENST00000307864.1
|
apoptosis-inducing factor, mitochondrion-associated, 2 |
|
| chr16_+_57844549 Show fit | 9.71 |
ENST00000564282.1
|
uncharacterized protein LOC388282 |
|
| chrX_-_15511438 Show fit | 8.98 |
ENST00000380420.5
|
pirin (iron-binding nuclear protein) |
|
| chr16_-_1429010 Show fit | 8.95 |
ENST00000513783.1
|
unkempt family zinc finger-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of BACH1_NFE2_NFE2L2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 34.7 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.3 | 28.9 | GO:0098869 | cellular oxidant detoxification(GO:0098869) |
| 0.4 | 19.7 | GO:0019430 | removal of superoxide radicals(GO:0019430) |
| 0.0 | 18.0 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 1.2 | 16.8 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 4.0 | 12.1 | GO:0016107 | sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) |
| 0.0 | 10.9 | GO:0032259 | methylation(GO:0032259) |
| 1.1 | 10.7 | GO:0034036 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 0.6 | 10.6 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.8 | 10.5 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.4 | 16.7 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.6 | 15.4 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 12.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 11.7 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.4 | 10.6 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 10.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.2 | 9.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.3 | 9.2 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 9.2 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.1 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 4.4 | 17.5 | GO:0004362 | glutathione-disulfide reductase activity(GO:0004362) |
| 0.6 | 17.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.4 | 15.5 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 5.1 | 15.4 | GO:0019862 | IgA binding(GO:0019862) |
| 3.1 | 15.4 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 5.1 | 15.2 | GO:0003955 | NAD(P)H dehydrogenase (quinone) activity(GO:0003955) |
| 0.1 | 13.2 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 4.0 | 12.1 | GO:0045550 | geranylgeranyl reductase activity(GO:0045550) |
| 3.7 | 11.0 | GO:0004174 | electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 22.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 18.2 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.4 | 17.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 13.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 11.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 10.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 9.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 8.1 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 7.6 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.1 | 6.9 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 34.8 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.8 | 33.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.8 | 15.4 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.2 | 14.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 13.7 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.4 | 11.9 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.4 | 8.5 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.5 | 7.7 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.1 | 7.2 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 6.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |