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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for BHLHE40

Z-value: 1.06

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Transcription factors associated with BHLHE40

Gene Symbol Gene ID Gene Info
BHLHE40
ENSG00000134107.4 basic helix-loop-helix family member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE40hg19_v2_chr3_+_5020801_5020952-0.883.3e-07Click!

Activity profile of BHLHE40 motif

Sorted Z-values of BHLHE40 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_32405728 2.38 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
NRG1
neuregulin 1
chr21_+_38071430 2.31 ENST00000290399.6
SIM2
single-minded family bHLH transcription factor 2
chr14_-_45722360 2.12 ENST00000451174.1
MIS18BP1
MIS18 binding protein 1
chr8_+_32405785 1.90 ENST00000287842.3
NRG1
neuregulin 1
chr14_-_45722605 1.66 ENST00000310806.4
MIS18BP1
MIS18 binding protein 1
chr1_+_203830703 1.63 ENST00000414487.2
SNRPE
small nuclear ribonucleoprotein polypeptide E
chr1_-_200589859 1.59 ENST00000367350.4
KIF14
kinesin family member 14
chrX_+_66764375 1.56 ENST00000374690.3
AR
androgen receptor
chr16_+_57844549 1.50 ENST00000564282.1
CTD-2600O9.1
uncharacterized protein LOC388282
chr19_-_16045619 1.35 ENST00000402119.4
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr19_-_16045665 1.34 ENST00000248041.8
CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr17_-_53046058 1.27 ENST00000571584.1
ENST00000299335.3
COX11
cytochrome c oxidase assembly homolog 11 (yeast)
chr2_+_103236004 1.26 ENST00000233969.2
SLC9A2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr17_+_7982800 1.17 ENST00000399413.3
AC129492.6
AC129492.6
chr12_+_65004292 1.14 ENST00000542104.1
ENST00000336061.2
RASSF3
Ras association (RalGDS/AF-6) domain family member 3
chr9_+_131901710 1.11 ENST00000524946.2
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr15_+_77713299 1.11 ENST00000559099.1
HMG20A
high mobility group 20A
chr17_-_74733404 1.10 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
SRSF2
serine/arginine-rich splicing factor 2
chr2_-_136743436 1.03 ENST00000441323.1
ENST00000449218.1
DARS
aspartyl-tRNA synthetase
chr6_+_151561085 1.01 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr2_-_240230890 1.01 ENST00000446876.1
HDAC4
histone deacetylase 4
chr17_+_33307503 0.98 ENST00000378526.4
ENST00000585941.1
ENST00000262327.5
ENST00000592690.1
ENST00000585740.1
LIG3
ligase III, DNA, ATP-dependent
chr9_+_131901661 0.95 ENST00000423100.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr22_-_43411106 0.95 ENST00000453643.1
ENST00000263246.3
ENST00000337959.4
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr2_-_179343226 0.95 ENST00000434643.2
FKBP7
FK506 binding protein 7
chr17_+_53046096 0.94 ENST00000376352.2
ENST00000299341.4
ENST00000405898.1
ENST00000434978.2
ENST00000398391.2
STXBP4
syntaxin binding protein 4
chr13_+_35516390 0.94 ENST00000540320.1
ENST00000400445.3
ENST00000310336.4
NBEA
neurobeachin
chr19_+_54058073 0.92 ENST00000505949.1
ENST00000513265.1
ZNF331
zinc finger protein 331
chr13_+_50656307 0.91 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr1_+_213123976 0.90 ENST00000366965.2
ENST00000366967.2
VASH2
vasohibin 2
chr6_-_36842784 0.89 ENST00000373699.5
PPIL1
peptidylprolyl isomerase (cyclophilin)-like 1
chr1_+_173793777 0.88 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr2_+_183989157 0.88 ENST00000541912.1
NUP35
nucleoporin 35kDa
chr2_+_190649107 0.87 ENST00000441310.2
ENST00000409985.1
ENST00000446877.1
ENST00000418224.3
ENST00000409823.3
ENST00000374826.4
ENST00000424766.1
ENST00000447232.2
ENST00000432292.3
PMS1
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
chr9_+_131902283 0.86 ENST00000436883.1
ENST00000414510.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr2_-_112642267 0.85 ENST00000341068.3
ANAPC1
anaphase promoting complex subunit 1
chr17_+_74732889 0.85 ENST00000591864.1
MFSD11
major facilitator superfamily domain containing 11
chr6_-_136871957 0.84 ENST00000354570.3
MAP7
microtubule-associated protein 7
chr2_+_183989083 0.84 ENST00000295119.4
NUP35
nucleoporin 35kDa
chr16_+_66461175 0.83 ENST00000536005.2
ENST00000299694.8
ENST00000561796.1
BEAN1
brain expressed, associated with NEDD4, 1
chr8_+_99129513 0.82 ENST00000522319.1
ENST00000401707.2
POP1
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
chrX_+_54556633 0.81 ENST00000336470.4
ENST00000360845.2
GNL3L
guanine nucleotide binding protein-like 3 (nucleolar)-like
chr21_+_33784670 0.80 ENST00000300255.2
EVA1C
eva-1 homolog C (C. elegans)
chr2_-_241497390 0.79 ENST00000272972.3
ENST00000401804.1
ENST00000361678.4
ENST00000405523.3
ANKMY1
ankyrin repeat and MYND domain containing 1
chr15_+_77713222 0.78 ENST00000558176.1
HMG20A
high mobility group 20A
chr4_-_57301748 0.78 ENST00000264220.2
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr8_-_99129338 0.75 ENST00000520507.1
HRSP12
heat-responsive protein 12
chr6_+_36410762 0.75 ENST00000483557.1
ENST00000498267.1
ENST00000544295.1
ENST00000449081.2
ENST00000536244.1
ENST00000460983.1
KCTD20
potassium channel tetramerization domain containing 20
chr17_+_72428266 0.74 ENST00000582473.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr8_+_55047763 0.71 ENST00000260102.4
ENST00000519831.1
MRPL15
mitochondrial ribosomal protein L15
chr1_+_213123915 0.70 ENST00000366968.4
ENST00000490792.1
VASH2
vasohibin 2
chr5_-_89770171 0.70 ENST00000514906.1
MBLAC2
metallo-beta-lactamase domain containing 2
chr11_-_57282349 0.70 ENST00000528450.1
SLC43A1
solute carrier family 43 (amino acid system L transporter), member 1
chr2_-_47143160 0.70 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr2_+_207630081 0.70 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr1_+_213123862 0.70 ENST00000366966.2
ENST00000366964.3
VASH2
vasohibin 2
chr8_-_48872686 0.68 ENST00000314191.2
ENST00000338368.3
PRKDC
protein kinase, DNA-activated, catalytic polypeptide
chr4_-_76861392 0.68 ENST00000505594.1
NAAA
N-acylethanolamine acid amidase
chr16_-_19729453 0.67 ENST00000564480.1
KNOP1
lysine-rich nucleolar protein 1
chr12_-_25101920 0.66 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr19_-_40786733 0.66 ENST00000486368.2
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr3_-_51533966 0.66 ENST00000504652.1
VPRBP
Vpr (HIV-1) binding protein
chr10_-_35379241 0.65 ENST00000374748.1
ENST00000374749.3
CUL2
cullin 2
chr11_-_3147835 0.65 ENST00000525498.1
OSBPL5
oxysterol binding protein-like 5
chr2_-_47142884 0.65 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chr10_-_35379524 0.61 ENST00000374751.3
ENST00000374742.1
ENST00000602371.1
CUL2
cullin 2
chr9_-_139258235 0.60 ENST00000371738.3
DNLZ
DNL-type zinc finger
chr5_+_89770664 0.58 ENST00000503973.1
ENST00000399107.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr1_+_210001309 0.57 ENST00000491415.2
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr7_-_138720763 0.56 ENST00000275766.1
ZC3HAV1L
zinc finger CCCH-type, antiviral 1-like
chrX_+_23685653 0.56 ENST00000379331.3
PRDX4
peroxiredoxin 4
chr2_-_241497374 0.56 ENST00000373318.2
ENST00000406958.1
ENST00000391987.1
ENST00000373320.4
ANKMY1
ankyrin repeat and MYND domain containing 1
chr2_-_179343268 0.55 ENST00000424785.2
FKBP7
FK506 binding protein 7
chr5_+_36152091 0.55 ENST00000274254.5
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr11_+_60609537 0.54 ENST00000227520.5
CCDC86
coiled-coil domain containing 86
chr5_+_421030 0.54 ENST00000506456.1
AHRR
aryl-hydrocarbon receptor repressor
chr17_-_17109579 0.54 ENST00000321560.3
PLD6
phospholipase D family, member 6
chr10_+_49514698 0.54 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
MAPK8
mitogen-activated protein kinase 8
chr14_+_73393040 0.53 ENST00000358377.2
ENST00000353777.3
ENST00000394234.2
ENST00000509153.1
ENST00000555042.1
DCAF4
DDB1 and CUL4 associated factor 4
chr4_-_15683118 0.51 ENST00000507899.1
ENST00000510802.1
FBXL5
F-box and leucine-rich repeat protein 5
chr12_-_58165870 0.50 ENST00000257848.7
METTL1
methyltransferase like 1
chr2_+_201676908 0.48 ENST00000409226.1
ENST00000452790.2
BZW1
basic leucine zipper and W2 domains 1
chr12_-_6677422 0.48 ENST00000382421.3
ENST00000545200.1
ENST00000399466.2
ENST00000536124.1
ENST00000540228.1
ENST00000542867.1
ENST00000545492.1
ENST00000322166.5
ENST00000545915.1
NOP2
NOP2 nucleolar protein
chr11_-_61560053 0.48 ENST00000537328.1
TMEM258
transmembrane protein 258
chr12_+_93861282 0.47 ENST00000552217.1
ENST00000393128.4
ENST00000547098.1
MRPL42
mitochondrial ribosomal protein L42
chr5_-_89770582 0.46 ENST00000316610.6
MBLAC2
metallo-beta-lactamase domain containing 2
chr8_+_125985531 0.46 ENST00000319286.5
ZNF572
zinc finger protein 572
chr12_-_25102252 0.44 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr17_+_72428218 0.44 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr11_-_65626753 0.43 ENST00000526975.1
ENST00000531413.1
CFL1
cofilin 1 (non-muscle)
chrX_-_16887963 0.42 ENST00000380084.4
RBBP7
retinoblastoma binding protein 7
chr2_-_10587897 0.42 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr2_-_10588630 0.42 ENST00000234111.4
ODC1
ornithine decarboxylase 1
chr1_+_231376941 0.41 ENST00000436239.1
ENST00000366647.4
ENST00000366646.3
ENST00000416000.1
GNPAT
glyceronephosphate O-acyltransferase
chr1_-_43638168 0.40 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr7_-_107642348 0.38 ENST00000393561.1
LAMB1
laminin, beta 1
chr11_+_6624955 0.37 ENST00000299421.4
ENST00000537806.1
ILK
integrin-linked kinase
chr5_-_71616043 0.36 ENST00000508863.2
ENST00000522095.1
ENST00000513900.1
ENST00000515404.1
ENST00000457646.4
ENST00000261413.5
MRPS27
mitochondrial ribosomal protein S27
chr17_-_61850894 0.35 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chr5_+_172571445 0.35 ENST00000231668.9
ENST00000351486.5
ENST00000352523.6
ENST00000393770.4
BNIP1
BCL2/adenovirus E1B 19kDa interacting protein 1
chr5_+_36152179 0.35 ENST00000508514.1
ENST00000513151.1
ENST00000546211.1
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr12_+_93861264 0.34 ENST00000549982.1
ENST00000361630.2
MRPL42
mitochondrial ribosomal protein L42
chr18_+_55712915 0.34 ENST00000592846.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr16_+_29911864 0.33 ENST00000308748.5
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr2_-_136743039 0.32 ENST00000537273.1
DARS
aspartyl-tRNA synthetase
chrX_+_129040094 0.32 ENST00000425117.2
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr5_+_89770696 0.32 ENST00000504930.1
ENST00000514483.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr2_+_74154032 0.31 ENST00000356837.6
DGUOK
deoxyguanosine kinase
chr3_-_98312548 0.30 ENST00000264193.2
CPOX
coproporphyrinogen oxidase
chr11_+_6624970 0.30 ENST00000420936.2
ENST00000528995.1
ILK
integrin-linked kinase
chr14_+_93389425 0.30 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chrX_+_129040122 0.30 ENST00000394422.3
ENST00000371051.5
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr20_-_42939782 0.29 ENST00000396825.3
FITM2
fat storage-inducing transmembrane protein 2
chr10_+_101491968 0.28 ENST00000370476.5
ENST00000370472.4
CUTC
cutC copper transporter
chr1_-_43637915 0.28 ENST00000236051.2
EBNA1BP2
EBNA1 binding protein 2
chr7_-_229557 0.28 ENST00000514988.1
AC145676.2
Uncharacterized protein
chr7_-_37024665 0.28 ENST00000396040.2
ELMO1
engulfment and cell motility 1
chr19_-_55652290 0.27 ENST00000589745.1
TNNT1
troponin T type 1 (skeletal, slow)
chr17_-_10600818 0.27 ENST00000577427.1
ENST00000255390.5
SCO1
SCO1 cytochrome c oxidase assembly protein
chr2_-_190649023 0.26 ENST00000409519.1
ENST00000458355.1
ORMDL1
ORM1-like 1 (S. cerevisiae)
chr12_-_55042140 0.26 ENST00000293371.6
ENST00000456047.2
DCD
dermcidin
chrX_-_47518498 0.26 ENST00000335890.2
UXT
ubiquitously-expressed, prefoldin-like chaperone
chrX_-_47518527 0.25 ENST00000333119.3
UXT
ubiquitously-expressed, prefoldin-like chaperone
chr15_-_35088340 0.25 ENST00000290378.4
ACTC1
actin, alpha, cardiac muscle 1
chr15_+_68924327 0.24 ENST00000543950.1
CORO2B
coronin, actin binding protein, 2B
chr11_+_6625046 0.24 ENST00000396751.2
ILK
integrin-linked kinase
chr5_-_36152031 0.24 ENST00000296603.4
LMBRD2
LMBR1 domain containing 2
chr3_+_99536663 0.24 ENST00000421999.2
ENST00000463526.1
CMSS1
cms1 ribosomal small subunit homolog (yeast)
chr4_+_57301896 0.23 ENST00000514888.1
ENST00000264221.2
ENST00000505164.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr22_-_30953587 0.23 ENST00000453479.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr17_+_36908984 0.22 ENST00000225426.4
ENST00000579088.1
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr9_-_100881466 0.21 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr22_+_48885272 0.21 ENST00000402357.1
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr3_+_63638372 0.20 ENST00000496807.1
SNTN
sentan, cilia apical structure protein
chr1_+_118472343 0.19 ENST00000369441.3
ENST00000349139.5
WDR3
WD repeat domain 3
chr16_+_19729586 0.18 ENST00000564186.1
ENST00000541926.1
ENST00000433597.2
IQCK
IQ motif containing K
chr5_-_114880533 0.18 ENST00000274457.3
FEM1C
fem-1 homolog c (C. elegans)
chr19_+_56154913 0.18 ENST00000270451.5
ENST00000588537.1
ZNF581
zinc finger protein 581
chr19_+_45909893 0.17 ENST00000592852.1
ENST00000589804.1
ENST00000590794.1
CD3EAP
CD3e molecule, epsilon associated protein
chr20_+_23331373 0.17 ENST00000254998.2
NXT1
NTF2-like export factor 1
chr1_+_9648921 0.16 ENST00000377376.4
ENST00000340305.5
ENST00000340381.6
TMEM201
transmembrane protein 201
chr6_+_5261225 0.16 ENST00000324331.6
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr9_+_130469257 0.16 ENST00000373295.2
C9orf117
chromosome 9 open reading frame 117
chr2_+_105654441 0.16 ENST00000258455.3
MRPS9
mitochondrial ribosomal protein S9
chr17_-_8661860 0.16 ENST00000328794.6
SPDYE4
speedy/RINGO cell cycle regulator family member E4
chr1_-_171621815 0.15 ENST00000037502.6
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response
chr5_+_36152163 0.15 ENST00000274255.6
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr17_+_2699697 0.14 ENST00000254695.8
ENST00000366401.4
ENST00000542807.1
RAP1GAP2
RAP1 GTPase activating protein 2
chr15_+_58724184 0.14 ENST00000433326.2
LIPC
lipase, hepatic
chr9_-_95640218 0.14 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
ZNF484
zinc finger protein 484
chr4_-_100009856 0.13 ENST00000296412.8
ADH5
alcohol dehydrogenase 5 (class III), chi polypeptide
chr6_+_44215603 0.13 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr19_-_3786253 0.12 ENST00000585778.1
MATK
megakaryocyte-associated tyrosine kinase
chr4_-_85418103 0.12 ENST00000515820.2
NKX6-1
NK6 homeobox 1
chr7_+_141463897 0.12 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr15_-_74988281 0.11 ENST00000566828.1
ENST00000563009.1
ENST00000568176.1
ENST00000566243.1
ENST00000566219.1
ENST00000426797.3
ENST00000566119.1
ENST00000315127.4
EDC3
enhancer of mRNA decapping 3
chr8_-_99129384 0.11 ENST00000521560.1
ENST00000254878.3
HRSP12
heat-responsive protein 12
chr1_+_119957554 0.11 ENST00000543831.1
ENST00000433745.1
ENST00000369416.3
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr19_+_51774540 0.11 ENST00000600813.1
CTD-3187F8.11
CTD-3187F8.11
chr1_-_207095324 0.11 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr9_-_99540328 0.10 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr7_-_100493744 0.10 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chr22_+_22681656 0.10 ENST00000390291.2
IGLV1-50
immunoglobulin lambda variable 1-50 (non-functional)
chr6_-_109804412 0.09 ENST00000230122.3
ZBTB24
zinc finger and BTB domain containing 24
chr11_-_65626797 0.09 ENST00000525451.2
CFL1
cofilin 1 (non-muscle)
chr10_-_49459800 0.09 ENST00000305531.3
FRMPD2
FERM and PDZ domain containing 2
chr17_+_61851157 0.09 ENST00000578681.1
ENST00000583590.1
DDX42
DEAD (Asp-Glu-Ala-Asp) box helicase 42
chr5_+_179078298 0.08 ENST00000418535.2
ENST00000425471.1
AC136604.1
Uncharacterized protein
chr16_-_3149229 0.08 ENST00000572431.1
ENST00000572548.1
ZSCAN10
zinc finger and SCAN domain containing 10
chr2_+_74153953 0.07 ENST00000264093.4
ENST00000348222.1
DGUOK
deoxyguanosine kinase
chr7_+_5919458 0.07 ENST00000416608.1
OCM
oncomodulin
chr6_+_13615554 0.07 ENST00000451315.2
NOL7
nucleolar protein 7, 27kDa
chr17_+_61851504 0.06 ENST00000359353.5
ENST00000389924.2
DDX42
DEAD (Asp-Glu-Ala-Asp) box helicase 42
chr5_+_6766004 0.06 ENST00000506093.1
RP11-332J15.3
RP11-332J15.3
chr1_-_26700943 0.05 ENST00000416125.1
ZNF683
zinc finger protein 683
chr11_+_73019282 0.05 ENST00000263674.3
ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chr1_-_231376867 0.05 ENST00000366649.2
ENST00000318906.2
ENST00000366651.3
C1orf131
chromosome 1 open reading frame 131
chr1_-_86174065 0.05 ENST00000370574.3
ENST00000431532.2
ZNHIT6
zinc finger, HIT-type containing 6
chr2_-_136743169 0.04 ENST00000264161.4
DARS
aspartyl-tRNA synthetase
chr3_+_111578583 0.04 ENST00000478922.1
ENST00000477695.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr6_-_154677866 0.04 ENST00000367220.4
IPCEF1
interaction protein for cytohesin exchange factors 1
chr1_+_43637996 0.03 ENST00000528956.1
ENST00000529956.1
WDR65
WD repeat domain 65
chr5_+_149737202 0.03 ENST00000451292.1
ENST00000377797.3
ENST00000445265.2
ENST00000323668.7
ENST00000439160.2
ENST00000394269.3
ENST00000427724.2
ENST00000504761.2
ENST00000513346.1
ENST00000515516.1
TCOF1
Treacher Collins-Franceschetti syndrome 1
chr14_+_101359265 0.03 ENST00000599197.1
AL117190.3
Esophagus cancer-related gene-2 interaction susceptibility protein; Uncharacterized protein
chr1_+_20465805 0.02 ENST00000375102.3
PLA2G2F
phospholipase A2, group IIF
chr7_-_151574191 0.02 ENST00000287878.4
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr4_+_41983713 0.02 ENST00000333141.5
DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr17_-_7193711 0.01 ENST00000571464.1
YBX2
Y box binding protein 2
chr7_-_155326532 0.01 ENST00000406197.1
ENST00000321736.5
CNPY1
canopy FGF signaling regulator 1
chr7_-_73133959 0.01 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A
syntaxin 1A (brain)
chr13_+_111972980 0.00 ENST00000283547.1
TEX29
testis expressed 29
chr8_+_109455845 0.00 ENST00000220853.3
EMC2
ER membrane protein complex subunit 2
chr8_+_109455830 0.00 ENST00000524143.1
EMC2
ER membrane protein complex subunit 2

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0042377 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.5 1.6 GO:0045720 negative regulation of integrin biosynthetic process(GO:0045720)
0.5 4.3 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.3 1.4 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.3 1.6 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.2 0.9 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.2 1.3 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.2 1.0 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.2 1.0 GO:0006288 base-excision repair, DNA ligation(GO:0006288)
0.2 1.1 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 0.5 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.2 0.2 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.1 0.7 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1 0.8 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.1 0.8 GO:0016078 tRNA catabolic process(GO:0016078)
0.1 0.7 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.8 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.5 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.1 2.7 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 0.3 GO:1900738 dense core granule biogenesis(GO:0061110) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.1 4.2 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 0.4 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.1 0.7 GO:0071486 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1 0.4 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1 1.0 GO:0070836 caveola assembly(GO:0070836)
0.1 0.4 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 0.5 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.1 1.0 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 2.3 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.1 0.5 GO:0070475 rRNA base methylation(GO:0070475)
0.1 1.3 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 1.0 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.1 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.9 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
0.1 1.7 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0046294 formaldehyde catabolic process(GO:0046294)
0.0 1.1 GO:0033197 response to vitamin E(GO:0033197)
0.0 0.3 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.2 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.0 2.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.0 0.3 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.9 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.1 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 1.6 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.0 0.3 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.3 GO:0006983 ER overload response(GO:0006983)
0.0 1.5 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.3 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.2 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 2.3 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 0.7 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 1.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.5 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0002325 natural killer cell differentiation involved in immune response(GO:0002325) regulation of natural killer cell differentiation involved in immune response(GO:0032826) regulation of extrathymic T cell differentiation(GO:0033082)
0.0 0.3 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 1.5 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0 1.3 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.5 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 0.7 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.1 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.2 1.6 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.2 1.3 GO:0030891 VCB complex(GO:0030891)
0.2 1.1 GO:0035061 interchromatin granule(GO:0035061)
0.1 0.4 GO:0043257 laminin-8 complex(GO:0043257)
0.1 0.8 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.7 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1 0.9 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.5 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.1 1.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 3.6 GO:0030673 axolemma(GO:0030673)
0.1 0.5 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 1.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 0.3 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 1.4 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.3 GO:0030430 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 0.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.6 GO:0051233 spindle midzone(GO:0051233)
0.0 1.0 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.2 GO:0030686 90S preribosome(GO:0030686)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.5 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.0 1.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.3 GO:0042583 chromaffin granule(GO:0042583)
0.0 1.0 GO:0031672 A band(GO:0031672)
0.0 0.3 GO:0005861 troponin complex(GO:0005861)
0.0 0.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.0 GO:0055038 recycling endosome membrane(GO:0055038)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.3 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.4 4.3 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.3 1.6 GO:0004882 androgen receptor activity(GO:0004882)
0.2 1.1 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 0.5 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.2 1.6 GO:1990446 U1 snRNP binding(GO:1990446)
0.1 0.5 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.1 1.0 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 1.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.6 GO:0034511 U3 snoRNA binding(GO:0034511)
0.1 1.0 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.1 0.5 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.1 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 1.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 2.8 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.8 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 1.5 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.4 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 1.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.7 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.0 0.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.5 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.0 1.0 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.3 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.3 GO:0031014 troponin T binding(GO:0031014)
0.0 0.2 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 1.1 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.1 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.7 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 1.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.6 ST ADRENERGIC Adrenergic Pathway
0.0 0.7 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.0 PID MYC PATHWAY C-MYC pathway
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.9 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 4.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.0 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 1.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.4 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.0 1.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 1.7 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 1.1 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.0 0.9 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 1.7 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.6 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.3 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 0.7 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.7 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane