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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for BRCA1

Z-value: 0.34

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
BRCA1
ENSG00000012048.15 BRCA1 DNA repair associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg19_v2_chr17_-_41277467_41277510-0.351.4e-01Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_117947782 1.97 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
TMPRSS4
transmembrane protease, serine 4
chr3_-_176914191 1.34 ENST00000437738.1
ENST00000424913.1
ENST00000443315.1
TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
chr14_+_21510385 1.26 ENST00000298690.4
RNASE7
ribonuclease, RNase A family, 7
chr11_+_117947724 1.15 ENST00000534111.1
TMPRSS4
transmembrane protease, serine 4
chr14_-_69261310 0.99 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr17_+_36584662 0.84 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr17_+_74372662 0.68 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr4_-_48782259 0.65 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRYL
FRY-like
chr3_-_176914238 0.64 ENST00000430069.1
ENST00000428970.1
TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
chr7_+_44646177 0.53 ENST00000443864.2
ENST00000447398.1
ENST00000449767.1
ENST00000419661.1
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr11_-_13484713 0.51 ENST00000526841.1
ENST00000529708.1
ENST00000278174.5
ENST00000528120.1
BTBD10
BTB (POZ) domain containing 10
chr5_+_145583107 0.51 ENST00000506502.1
RBM27
RNA binding motif protein 27
chr18_+_55888767 0.50 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr18_-_23671139 0.49 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr10_+_122610853 0.48 ENST00000604585.1
WDR11
WD repeat domain 11
chr12_-_122879969 0.47 ENST00000540304.1
CLIP1
CAP-GLY domain containing linker protein 1
chr10_-_75385711 0.44 ENST00000433394.1
USP54
ubiquitin specific peptidase 54
chr1_-_115301235 0.41 ENST00000525878.1
CSDE1
cold shock domain containing E1, RNA-binding
chr10_+_28822636 0.40 ENST00000442148.1
ENST00000448193.1
WAC
WW domain containing adaptor with coiled-coil
chr13_-_50018241 0.39 ENST00000409308.1
CAB39L
calcium binding protein 39-like
chr5_-_68665084 0.38 ENST00000509462.1
TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr12_-_49418407 0.37 ENST00000526209.1
KMT2D
lysine (K)-specific methyltransferase 2D
chr7_+_44646162 0.36 ENST00000439616.2
OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr13_-_50018140 0.35 ENST00000410043.1
ENST00000347776.5
CAB39L
calcium binding protein 39-like
chr1_-_160232312 0.34 ENST00000440682.1
DCAF8
DDB1 and CUL4 associated factor 8
chr8_-_116681123 0.34 ENST00000519674.1
TRPS1
trichorhinophalangeal syndrome I
chr14_+_32030582 0.34 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr5_+_145583156 0.31 ENST00000265271.5
RBM27
RNA binding motif protein 27
chr5_-_124082279 0.31 ENST00000513986.1
ZNF608
zinc finger protein 608
chr2_+_203879568 0.31 ENST00000449802.1
NBEAL1
neurobeachin-like 1
chr8_-_116681221 0.31 ENST00000395715.3
TRPS1
trichorhinophalangeal syndrome I
chr19_-_37663572 0.28 ENST00000588354.1
ENST00000292841.5
ENST00000355533.2
ENST00000356958.4
ZNF585A
zinc finger protein 585A
chr12_-_67072714 0.28 ENST00000545666.1
ENST00000398016.3
ENST00000359742.4
ENST00000286445.7
ENST00000538211.1
GRIP1
glutamate receptor interacting protein 1
chr1_+_70687079 0.27 ENST00000395136.2
SRSF11
serine/arginine-rich splicing factor 11
chr19_-_37663332 0.24 ENST00000392157.2
ZNF585A
zinc finger protein 585A
chr2_+_223725652 0.24 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr1_-_227505289 0.24 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr6_-_42981651 0.23 ENST00000244711.3
MEA1
male-enhanced antigen 1
chr8_+_22022800 0.22 ENST00000397814.3
BMP1
bone morphogenetic protein 1
chr14_+_103058948 0.21 ENST00000262241.6
RCOR1
REST corepressor 1
chr20_+_9049682 0.21 ENST00000334005.3
ENST00000378473.3
PLCB4
phospholipase C, beta 4
chr8_+_22022653 0.21 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1
bone morphogenetic protein 1
chr5_-_68664989 0.20 ENST00000508954.1
TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr3_+_185303962 0.20 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr12_-_49449107 0.20 ENST00000301067.7
KMT2D
lysine (K)-specific methyltransferase 2D
chr2_-_134326009 0.20 ENST00000409261.1
ENST00000409213.1
NCKAP5
NCK-associated protein 5
chr14_-_75179774 0.19 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr20_+_52105495 0.18 ENST00000439873.2
AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr10_-_61900762 0.18 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr10_+_102295616 0.18 ENST00000299163.6
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr13_+_27825706 0.17 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
RPL21
ribosomal protein L21
chr5_+_140079919 0.16 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2
chr13_-_103046837 0.16 ENST00000607251.1
FGF14-IT1
FGF14 intronic transcript 1 (non-protein coding)
chr5_-_68665469 0.15 ENST00000217893.5
TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr12_-_12491608 0.14 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr2_+_98703595 0.13 ENST00000435344.1
VWA3B
von Willebrand factor A domain containing 3B
chr3_+_184056614 0.13 ENST00000453072.1
FAM131A
family with sequence similarity 131, member A
chrX_-_77150911 0.12 ENST00000373336.3
MAGT1
magnesium transporter 1
chr6_-_66417107 0.12 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr2_+_196521903 0.12 ENST00000541054.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr12_-_95510743 0.12 ENST00000551521.1
FGD6
FYVE, RhoGEF and PH domain containing 6
chr9_+_135457530 0.11 ENST00000263610.2
BARHL1
BarH-like homeobox 1
chr1_+_161736072 0.11 ENST00000367942.3
ATF6
activating transcription factor 6
chr1_-_170043709 0.11 ENST00000367767.1
ENST00000361580.2
ENST00000538366.1
KIFAP3
kinesin-associated protein 3
chr2_-_25194476 0.10 ENST00000534855.1
DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr7_+_73868439 0.09 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr1_-_232598163 0.09 ENST00000308942.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr1_-_160232197 0.08 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
DCAF8
DDB1 and CUL4 associated factor 8
chr10_+_122610687 0.08 ENST00000263461.6
WDR11
WD repeat domain 11
chr4_+_619386 0.08 ENST00000496514.1
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr15_+_67430339 0.08 ENST00000439724.3
SMAD3
SMAD family member 3
chr4_+_619347 0.07 ENST00000255622.6
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr5_-_68665296 0.06 ENST00000512152.1
ENST00000503245.1
ENST00000512561.1
ENST00000380822.4
TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr3_+_193853927 0.06 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr1_-_160232291 0.06 ENST00000368074.1
ENST00000447377.1
DCAF8
DDB1 and CUL4 associated factor 8
chr3_-_27410847 0.05 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
NEK10
NIMA-related kinase 10
chr6_-_137314371 0.05 ENST00000432330.1
ENST00000418699.1
RP11-55K22.5
RP11-55K22.5
chr9_-_124976154 0.04 ENST00000482062.1
LHX6
LIM homeobox 6
chr3_+_187461442 0.04 ENST00000450760.1
RP11-211G3.2
RP11-211G3.2
chr11_-_119234876 0.04 ENST00000525735.1
USP2
ubiquitin specific peptidase 2
chr20_+_31749574 0.04 ENST00000253362.2
BPIFA2
BPI fold containing family A, member 2
chr15_-_58358607 0.04 ENST00000249750.4
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr17_-_60142609 0.04 ENST00000397786.2
MED13
mediator complex subunit 13
chr2_-_179914760 0.03 ENST00000420890.2
ENST00000409284.1
ENST00000443758.1
ENST00000446116.1
CCDC141
coiled-coil domain containing 141
chr18_+_19749386 0.03 ENST00000269216.3
GATA6
GATA binding protein 6
chr8_+_97773202 0.03 ENST00000519484.1
CPQ
carboxypeptidase Q
chr11_-_110583912 0.02 ENST00000533353.1
ENST00000527598.1
ARHGAP20
Rho GTPase activating protein 20
chr17_-_8702667 0.02 ENST00000329805.4
MFSD6L
major facilitator superfamily domain containing 6-like
chr10_-_95504 0.02 ENST00000447903.2
TUBB8
tubulin, beta 8 class VIII
chr5_-_142023766 0.02 ENST00000394496.2
FGF1
fibroblast growth factor 1 (acidic)
chr9_+_35792151 0.02 ENST00000342694.2
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr6_+_12717892 0.02 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chr8_+_37553261 0.01 ENST00000331569.4
ZNF703
zinc finger protein 703
chr1_+_63063152 0.01 ENST00000371129.3
ANGPTL3
angiopoietin-like 3
chr9_-_86593238 0.01 ENST00000351839.3
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr14_-_94942548 0.01 ENST00000298845.7
SERPINA9
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
chr17_-_41738931 0.00 ENST00000329168.3
ENST00000549132.1
MEOX1
mesenchyme homeobox 1
chr8_+_97773457 0.00 ENST00000521142.1
CPQ
carboxypeptidase Q

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0046521 sphingoid catabolic process(GO:0046521)
0.2 1.3 GO:0051673 membrane disruption in other organism(GO:0051673)
0.2 1.0 GO:1901545 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.1 0.9 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.1 2.0 GO:0060613 fat pad development(GO:0060613)
0.1 0.4 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.1 0.6 GO:0001555 oocyte growth(GO:0001555)
0.1 0.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.5 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.4 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 0.8 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.2 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.1 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.0 0.2 GO:1900827 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.7 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:0042668 auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.5 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.0 0.5 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.4 GO:0034380 cartilage condensation(GO:0001502) high-density lipoprotein particle assembly(GO:0034380)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0061767 negative regulation of lung blood pressure(GO:0061767)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0000125 PCAF complex(GO:0000125)
0.1 0.9 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.5 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.4 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.1 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.0 2.0 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.5 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.1 0.7 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 1.3 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.8 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 1.0 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.5 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 3.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.2 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 2.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.8 PID MYC PATHWAY C-MYC pathway
0.0 2.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.0 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.7 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis