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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CBFB

Z-value: 0.91

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Transcription factors associated with CBFB

Gene Symbol Gene ID Gene Info
CBFB
ENSG00000067955.9 core-binding factor subunit beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CBFBhg19_v2_chr16_+_67063855_670638730.945.3e-10Click!

Activity profile of CBFB motif

Sorted Z-values of CBFB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_209859510 4.58 ENST00000367028.2
ENST00000261465.1
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr20_+_44637526 3.62 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr14_+_85996507 3.48 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr14_+_85996471 3.21 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr6_-_75912508 3.00 ENST00000416123.2
COL12A1
collagen, type XII, alpha 1
chrX_+_115567767 2.43 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr3_-_99569821 2.34 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chrX_+_68048803 2.16 ENST00000204961.4
EFNB1
ephrin-B1
chr6_-_113953705 2.13 ENST00000452675.1
RP11-367G18.1
RP11-367G18.1
chr5_-_39203093 2.11 ENST00000515010.1
FYB
FYN binding protein
chr11_-_58343319 1.95 ENST00000395074.2
LPXN
leupaxin
chr19_-_14048804 1.87 ENST00000254320.3
ENST00000586075.1
PODNL1
podocan-like 1
chr15_-_64665911 1.87 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr14_-_85996332 1.64 ENST00000380722.1
RP11-497E19.1
RP11-497E19.1
chr3_+_156799587 1.61 ENST00000469196.1
RP11-6F2.5
RP11-6F2.5
chr5_+_35856951 1.58 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr15_+_49715449 1.57 ENST00000560979.1
FGF7
fibroblast growth factor 7
chr10_-_29811456 1.55 ENST00000535393.1
SVIL
supervillin
chr13_+_76210448 1.53 ENST00000377499.5
LMO7
LIM domain 7
chr6_+_42847649 1.53 ENST00000424341.2
ENST00000602561.1
RPL7L1
ribosomal protein L7-like 1
chr15_+_67390920 1.44 ENST00000559092.1
ENST00000560175.1
SMAD3
SMAD family member 3
chr6_+_45296391 1.37 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr1_+_89246647 1.35 ENST00000544045.1
PKN2
protein kinase N2
chr11_+_114310102 1.33 ENST00000265881.5
REXO2
RNA exonuclease 2
chr12_-_54778471 1.32 ENST00000550120.1
ENST00000394313.2
ENST00000547210.1
ZNF385A
zinc finger protein 385A
chr12_-_54778444 1.30 ENST00000551771.1
ZNF385A
zinc finger protein 385A
chr12_+_25205446 1.30 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr14_+_72064945 1.30 ENST00000537413.1
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr12_-_54778244 1.29 ENST00000549937.1
ZNF385A
zinc finger protein 385A
chr15_+_73976545 1.14 ENST00000318443.5
ENST00000537340.2
ENST00000318424.5
CD276
CD276 molecule
chr11_+_114310164 1.12 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
REXO2
RNA exonuclease 2
chr1_+_47264711 1.11 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
CYP4B1
cytochrome P450, family 4, subfamily B, polypeptide 1
chr5_+_131409476 1.08 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr12_+_25205568 0.96 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr4_+_74347400 0.93 ENST00000226355.3
AFM
afamin
chr11_-_66104237 0.92 ENST00000530056.1
RIN1
Ras and Rab interactor 1
chr11_-_66103932 0.92 ENST00000311320.4
RIN1
Ras and Rab interactor 1
chr1_-_179112189 0.83 ENST00000512653.1
ENST00000344730.3
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr5_-_108745689 0.83 ENST00000361189.2
PJA2
praja ring finger 2, E3 ubiquitin protein ligase
chr11_-_66103867 0.81 ENST00000424433.2
RIN1
Ras and Rab interactor 1
chr2_-_127977654 0.81 ENST00000409327.1
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr14_-_61116168 0.79 ENST00000247182.6
SIX1
SIX homeobox 1
chr12_+_25205155 0.78 ENST00000550945.1
LRMP
lymphoid-restricted membrane protein
chr5_+_67576109 0.77 ENST00000522084.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr11_+_18343800 0.72 ENST00000453096.2
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr12_-_4754339 0.71 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr4_-_156297949 0.70 ENST00000515654.1
MAP9
microtubule-associated protein 9
chr9_+_15422702 0.69 ENST00000380821.3
ENST00000421710.1
SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr2_-_207024233 0.69 ENST00000423725.1
ENST00000233190.6
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr8_+_28747884 0.67 ENST00000287701.10
ENST00000444075.1
ENST00000403668.2
ENST00000519662.1
ENST00000558662.1
ENST00000523613.1
ENST00000560599.1
ENST00000397358.3
HMBOX1
homeobox containing 1
chr2_-_64881018 0.65 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr19_-_14049184 0.61 ENST00000339560.5
PODNL1
podocan-like 1
chr16_+_53088885 0.61 ENST00000566029.1
ENST00000447540.1
CHD9
chromodomain helicase DNA binding protein 9
chr18_-_53089723 0.58 ENST00000561992.1
ENST00000562512.2
TCF4
transcription factor 4
chr15_-_33447055 0.58 ENST00000559047.1
ENST00000561249.1
FMN1
formin 1
chr5_-_137878887 0.55 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1
eukaryotic translation termination factor 1
chr11_+_114310237 0.55 ENST00000539119.1
REXO2
RNA exonuclease 2
chr12_-_53594227 0.47 ENST00000550743.2
ITGB7
integrin, beta 7
chr21_-_36421626 0.46 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr12_-_4754356 0.41 ENST00000540967.1
AKAP3
A kinase (PRKA) anchor protein 3
chr1_-_179112173 0.32 ENST00000408940.3
ENST00000504405.1
ABL2
c-abl oncogene 2, non-receptor tyrosine kinase
chr12_-_4754318 0.31 ENST00000536414.1
AKAP3
A kinase (PRKA) anchor protein 3
chr13_-_103019744 0.31 ENST00000437115.2
FGF14-IT1
FGF14 intronic transcript 1 (non-protein coding)
chr1_+_39876151 0.29 ENST00000530275.1
KIAA0754
KIAA0754
chr1_+_196621156 0.28 ENST00000359637.2
CFH
complement factor H
chr21_-_36421535 0.28 ENST00000416754.1
ENST00000437180.1
ENST00000455571.1
RUNX1
runt-related transcription factor 1
chr2_+_207024306 0.28 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr1_+_248058889 0.25 ENST00000360358.3
OR2W3
olfactory receptor, family 2, subfamily W, member 3
chr14_-_24977457 0.25 ENST00000250378.3
ENST00000206446.4
CMA1
chymase 1, mast cell
chr21_-_36421401 0.24 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr1_-_184723942 0.24 ENST00000318130.8
EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr11_-_18343725 0.21 ENST00000531848.1
HPS5
Hermansky-Pudlak syndrome 5
chr2_+_68592305 0.20 ENST00000234313.7
PLEK
pleckstrin
chr22_+_42665742 0.20 ENST00000332965.3
ENST00000415205.1
ENST00000446578.1
Z83851.3
Z83851.3
chr1_+_159770292 0.16 ENST00000536257.1
ENST00000321935.6
FCRL6
Fc receptor-like 6
chr18_-_53089538 0.16 ENST00000566777.1
TCF4
transcription factor 4
chr15_+_64386261 0.16 ENST00000560829.1
SNX1
sorting nexin 1
chrX_-_49041242 0.14 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
PRICKLE3
prickle homolog 3 (Drosophila)
chr3_+_187957646 0.13 ENST00000457242.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr11_-_1912084 0.13 ENST00000391480.1
C11orf89
chromosome 11 open reading frame 89
chr9_-_123342415 0.13 ENST00000349780.4
ENST00000360190.4
ENST00000360822.3
ENST00000359309.3
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr11_-_18343669 0.12 ENST00000396253.3
ENST00000349215.3
ENST00000438420.2
HPS5
Hermansky-Pudlak syndrome 5
chr13_-_28674693 0.10 ENST00000537084.1
ENST00000241453.7
ENST00000380982.4
FLT3
fms-related tyrosine kinase 3
chr8_-_28747717 0.07 ENST00000416984.2
INTS9
integrator complex subunit 9
chr12_-_14849470 0.06 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr20_+_54987168 0.04 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr8_-_28747424 0.03 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
INTS9
integrator complex subunit 9

Network of associatons between targets according to the STRING database.

First level regulatory network of CBFB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 6.7 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.6 5.1 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.6 3.9 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.4 1.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.3 2.7 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 1.4 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.2 0.8 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.2 1.9 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.2 4.6 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.1 1.6 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 1.1 GO:0018879 biphenyl metabolic process(GO:0018879)
0.1 1.5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 1.4 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.5 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.1 1.1 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 0.3 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.1 0.6 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 1.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 2.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.7 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 3.0 GO:0030199 collagen fibril organization(GO:0030199)
0.0 2.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 3.0 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.0 2.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.6 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.8 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.2 GO:0097466 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 2.2 GO:0001755 neural crest cell migration(GO:0001755)
0.0 0.2 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.0 2.5 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.8 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.7 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.7 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 3.1 GO:0006903 vesicle targeting(GO:0006903)
0.0 2.4 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.1 GO:0010863 positive regulation of phospholipase C activity(GO:0010863)
0.0 1.3 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.9 GO:0051180 vitamin transport(GO:0051180)
0.0 0.1 GO:0035726 myeloid progenitor cell differentiation(GO:0002318) common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0005595 collagen type XII trimer(GO:0005595)
0.1 1.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 0.7 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.1 1.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 0.5 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.1 1.5 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.8 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.7 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 0.3 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 0.7 GO:0000439 core TFIIH complex(GO:0000439)
0.0 3.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 3.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.9 GO:0002102 podosome(GO:0002102)
0.0 3.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.4 GO:0031526 brush border membrane(GO:0031526)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 1.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.4 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 6.0 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.4 1.6 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.3 6.7 GO:0045499 chemorepellent activity(GO:0045499)
0.3 3.0 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.2 0.9 GO:0008431 vitamin E binding(GO:0008431)
0.2 1.4 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 0.8 GO:0005502 11-cis retinal binding(GO:0005502) all-trans retinal binding(GO:0005503)
0.1 2.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 0.8 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.1 0.6 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 3.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 3.0 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 1.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.7 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.7 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 1.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.8 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 2.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 3.9 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 3.6 GO:0005518 collagen binding(GO:0005518)
0.0 0.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 1.4 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.4 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 2.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 2.9 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 2.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.7 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.1 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.4 PID RHOA PATHWAY RhoA signaling pathway
0.0 2.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.6 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 2.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 4.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 2.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.5 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 2.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 1.1 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 2.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.4 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.7 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 1.1 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.7 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle