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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CDX2
Z-value: 0.91
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Transcription factors associated with CDX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CDX2 | hg19_v2_chr13_-_28545276_28545276 | -0.83 | 5.5e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CDX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.5 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 0.4 | 5.3 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.4 | 4.3 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.2 | 4.2 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 4.2 | GO:0016266 | O-glycan processing(GO:0016266) |
| 1.3 | 3.9 | GO:0061713 | neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) |
| 0.1 | 3.4 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
| 0.0 | 3.2 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 1.0 | 3.0 | GO:0070175 | positive regulation of enamel mineralization(GO:0070175) |
| 0.1 | 3.0 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0005770 | late endosome(GO:0005770) |
| 0.1 | 3.9 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 3.7 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.4 | 3.5 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 3.0 | GO:0005605 | basal lamina(GO:0005605) |
| 0.9 | 2.7 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.0 | 2.6 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 2.0 | GO:0097025 | lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 2.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 1.8 | GO:1990812 | growth cone filopodium(GO:1990812) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 4.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 4.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 1.0 | 3.9 | GO:0061714 | folic acid receptor activity(GO:0061714) |
| 0.1 | 3.5 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.1 | 3.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 2.9 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.4 | 2.7 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 2.7 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.1 | 2.6 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.4 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 4.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 3.6 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 3.2 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 2.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 2.1 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 0.9 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 0.8 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 4.4 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 3.6 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.3 | 2.7 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 2.0 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 1.9 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 1.8 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 1.2 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.0 | 0.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.7 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |