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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CENPB
Z-value: 1.16
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Transcription factors associated with CENPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CENPB | hg19_v2_chr20_-_3767324_3767443 | 0.76 | 9.8e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CENPB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 7.3 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.2 | 5.7 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 3.7 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 3.0 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.0 | 2.6 | GO:0014902 | myotube differentiation(GO:0014902) |
| 0.6 | 2.5 | GO:0042369 | vitamin D catabolic process(GO:0042369) |
| 0.1 | 2.5 | GO:0014002 | astrocyte development(GO:0014002) |
| 0.2 | 2.4 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.6 | 2.3 | GO:1902361 | mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 3.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 3.1 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 2.8 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 2.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.2 | 1.9 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.1 | 1.9 | GO:0034709 | methylosome(GO:0034709) |
| 0.0 | 1.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.3 | 1.8 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.1 | 1.8 | GO:0042555 | MCM complex(GO:0042555) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.1 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.2 | 7.3 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 1.2 | 3.7 | GO:0016731 | ferredoxin-NADP+ reductase activity(GO:0004324) NADPH-adrenodoxin reductase activity(GO:0015039) oxidoreductase activity, acting on iron-sulfur proteins as donors(GO:0016730) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(GO:0016731) |
| 0.0 | 2.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.5 | 2.5 | GO:0070576 | vitamin D 24-hydroxylase activity(GO:0070576) |
| 0.3 | 2.3 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.0 | 2.3 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.1 | 2.1 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 2.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 1.9 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 4.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.6 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 1.9 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 1.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 1.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.6 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 7.3 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.2 | 3.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 2.5 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 2.4 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 1.9 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 1.9 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.0 | 1.8 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 1.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 1.7 | REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |