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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CLOCK
Z-value: 1.59
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Transcription factors associated with CLOCK
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CLOCK | hg19_v2_chr4_-_56412713_56412799 | 0.85 | 2.7e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CLOCK
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.8 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.4 | 5.9 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.1 | 5.8 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.3 | 5.7 | GO:0015816 | glycine transport(GO:0015816) |
| 0.3 | 5.4 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 1.7 | 5.1 | GO:0045041 | B cell cytokine production(GO:0002368) protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.9 | 4.7 | GO:1904764 | negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764) |
| 0.3 | 4.6 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.5 | 4.5 | GO:0072553 | terminal button organization(GO:0072553) |
| 0.0 | 4.5 | GO:0006334 | nucleosome assembly(GO:0006334) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 26.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 7.9 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.2 | 7.6 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 7.3 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.1 | 7.0 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.7 | 6.8 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 6.0 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 5.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 5.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.6 | 5.1 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.6 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.7 | 6.8 | GO:0004372 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.2 | 6.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 6.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.4 | 5.7 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.7 | 5.3 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.9 | 5.1 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.4 | 4.7 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.2 | 4.6 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 4.4 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 9.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 8.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 5.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 3.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 3.1 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 2.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 2.7 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 2.5 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.2 | 5.8 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.1 | 5.6 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 5.0 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 4.9 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.2 | 4.6 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 4.5 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 4.0 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.1 | 3.9 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 3.6 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |