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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CPEB1
Z-value: 1.18
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Transcription factors associated with CPEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CPEB1 | hg19_v2_chr15_-_83240553_83240576 | 0.91 | 4.1e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_32582293 Show fit | 5.62 |
ENST00000580907.1
ENST00000225831.4 |
chemokine (C-C motif) ligand 2 |
|
| chr4_-_74864386 Show fit | 5.23 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr2_-_228244013 Show fit | 3.71 |
ENST00000304568.3
|
transmembrane 4 L six family member 20 |
|
| chr6_+_62284008 Show fit | 3.56 |
ENST00000544932.1
|
MT-RNR2-like 9 (pseudogene) |
|
| chr2_+_8822113 Show fit | 3.51 |
ENST00000396290.1
ENST00000331129.3 |
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
|
| chr13_-_67802549 Show fit | 3.49 |
ENST00000328454.5
ENST00000377865.2 |
protocadherin 9 |
|
| chr15_+_66994561 Show fit | 3.15 |
ENST00000288840.5
|
SMAD family member 6 |
|
| chr17_-_46806540 Show fit | 3.12 |
ENST00000290295.7
|
homeobox B13 |
|
| chr12_+_52203789 Show fit | 3.05 |
ENST00000599343.1
|
HCG1997999; cDNA FLJ33996 fis, clone DFNES2008881 |
|
| chr12_+_54410664 Show fit | 2.89 |
ENST00000303406.4
|
homeobox C4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CPEB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | GO:0009952 | anterior/posterior pattern specification(GO:0009952) |
| 0.1 | 6.5 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.2 | 6.4 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.1 | 6.3 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.2 | 5.8 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 1.9 | 5.6 | GO:2000502 | negative regulation of natural killer cell chemotaxis(GO:2000502) |
| 0.2 | 5.4 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.4 | 4.8 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.6 | 4.0 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.1 | 4.0 | GO:0031648 | protein destabilization(GO:0031648) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.8 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.0 | 4.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 3.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.5 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 3.0 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 3.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.7 | 2.8 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.1 | 2.8 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 2.7 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.9 | 2.6 | GO:0005588 | collagen type V trimer(GO:0005588) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.9 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.2 | 5.9 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 5.0 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 4.8 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.3 | 4.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 1.5 | 4.6 | GO:0050429 | calcium-dependent phospholipase C activity(GO:0050429) |
| 0.0 | 4.2 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.3 | 3.6 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 3.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 1.1 | 3.2 | GO:0070698 | transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity(GO:0030617) type I activin receptor binding(GO:0070698) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 4.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 4.7 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 4.6 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 4.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 3.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 2.9 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 2.8 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 2.7 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 2.5 | PID IL3 PATHWAY | IL3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 6.7 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.1 | 6.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 4.8 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 4.4 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.1 | 3.5 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 3.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 3.3 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 3.0 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 2.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |