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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CREB1
Z-value: 2.19
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Transcription factors associated with CREB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB1 | hg19_v2_chr2_+_208394658_208394692 | 0.70 | 6.1e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.4 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.4 | 7.2 | GO:0000733 | DNA strand renaturation(GO:0000733) |
| 0.7 | 6.4 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.6 | 5.9 | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway(GO:0060339) |
| 0.1 | 5.5 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.1 | 5.4 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 1.7 | 5.2 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.1 | 5.1 | GO:0033120 | positive regulation of RNA splicing(GO:0033120) |
| 0.1 | 4.6 | GO:0006625 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.1 | 4.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 8.7 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.2 | 6.4 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.1 | 6.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 6.1 | GO:0016235 | aggresome(GO:0016235) |
| 1.9 | 5.7 | GO:0075341 | host cell PML body(GO:0075341) |
| 0.0 | 5.3 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.3 | 5.2 | GO:0008278 | cohesin complex(GO:0008278) |
| 0.1 | 5.2 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.1 | 5.0 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 4.0 | GO:0035861 | site of double-strand break(GO:0035861) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 1.0 | 8.1 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
| 0.1 | 8.1 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.2 | 6.4 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.2 | 5.7 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 5.6 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 1.8 | 5.3 | GO:0016730 | ferredoxin-NADP+ reductase activity(GO:0004324) NADPH-adrenodoxin reductase activity(GO:0015039) oxidoreductase activity, acting on iron-sulfur proteins as donors(GO:0016730) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(GO:0016731) |
| 1.3 | 5.2 | GO:0016429 | tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429) |
| 0.1 | 4.8 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.2 | 4.0 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.8 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 2.0 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 1.8 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 1.6 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 1.0 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.0 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 1.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.4 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.1 | 6.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 5.7 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 5.0 | REACTOME RNA POL III TRANSCRIPTION | Genes involved in RNA Polymerase III Transcription |
| 0.0 | 4.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 4.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.9 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.1 | 3.8 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 3.6 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 3.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |