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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CREB5_CREM_JUNB
Z-value: 0.94
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Transcription factors associated with CREB5_CREM_JUNB
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000146592.12 | cAMP responsive element binding protein 5 | |
| ENSG00000095794.15 | cAMP responsive element modulator | |
| ENSG00000171223.4 | JunB proto-oncogene, AP-1 transcription factor subunit |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| JUNB | hg19_v2_chr19_+_12902289_12902310 | -0.94 | 8.9e-10 | Click! |
| CREB5 | hg19_v2_chr7_+_28725585_28725608 | 0.77 | 7.0e-05 | Click! |
| CREM | hg19_v2_chr10_+_35484053_35484076 | -0.75 | 1.5e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_156030937 Show fit | 7.85 |
ENST00000361084.5
|
RAB25, member RAS oncogene family |
|
| chr17_-_7165662 Show fit | 7.14 |
ENST00000571881.2
ENST00000360325.7 |
claudin 7 |
|
| chr22_-_44258360 Show fit | 6.14 |
ENST00000330884.4
ENST00000249130.5 |
sulfotransferase family 4A, member 1 |
|
| chr12_-_123380610 Show fit | 5.47 |
ENST00000535765.1
|
vacuolar protein sorting 37 homolog B (S. cerevisiae) |
|
| chr4_-_187647773 Show fit | 4.55 |
ENST00000509647.1
|
FAT atypical cadherin 1 |
|
| chr6_+_139456226 Show fit | 4.39 |
ENST00000367658.2
|
headcase homolog (Drosophila) |
|
| chr1_-_209975494 Show fit | 4.00 |
ENST00000456314.1
|
interferon regulatory factor 6 |
|
| chr7_+_30174574 Show fit | 3.78 |
ENST00000409688.1
|
maturin, neural progenitor differentiation regulator homolog (Xenopus) |
|
| chr5_-_175965008 Show fit | 3.74 |
ENST00000537487.1
|
ring finger protein 44 |
|
| chr7_-_129592471 Show fit | 3.68 |
ENST00000473814.2
ENST00000490974.1 |
ubiquitin-conjugating enzyme E2H |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB5_CREM_JUNB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.1 | GO:0031069 | hair follicle morphogenesis(GO:0031069) |
| 0.1 | 8.7 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.2 | 8.5 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.2 | 8.5 | GO:0034035 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 0.1 | 8.2 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.3 | 7.0 | GO:0031268 | pseudopodium organization(GO:0031268) |
| 0.6 | 6.6 | GO:0002329 | pre-B cell differentiation(GO:0002329) |
| 0.2 | 6.6 | GO:0060644 | mammary gland epithelial cell differentiation(GO:0060644) |
| 0.3 | 6.5 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.1 | 5.6 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 9.8 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.2 | 9.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 7.8 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 7.1 | GO:0000785 | chromatin(GO:0000785) |
| 0.1 | 6.8 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 6.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 6.4 | GO:0016605 | PML body(GO:0016605) |
| 0.3 | 5.8 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.3 | 5.8 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 5.6 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.9 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.3 | 8.5 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 7.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.9 | 7.1 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.1 | 6.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.9 | 6.6 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.4 | 6.6 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.0 | 6.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 5.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 5.4 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 7.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 7.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 6.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 6.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 6.3 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 5.8 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 5.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 4.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.3 | 8.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 7.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 7.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 7.1 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.3 | 6.5 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 6.4 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.4 | 5.4 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.2 | 5.4 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 5.4 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |