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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CTCF_CTCFL
Z-value: 2.40
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Transcription factors associated with CTCF_CTCFL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CTCFL | hg19_v2_chr20_-_56100179_56100265 | 0.16 | 5.1e-01 | Click! |
| CTCF | hg19_v2_chr16_+_67596310_67596353 | 0.10 | 6.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CTCF_CTCFL
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 30.8 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 4.7 | 23.3 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.2 | 20.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 3.1 | 18.5 | GO:1903412 | response to bile acid(GO:1903412) |
| 0.5 | 17.5 | GO:0036109 | alpha-linolenic acid metabolic process(GO:0036109) linoleic acid metabolic process(GO:0043651) |
| 1.1 | 13.3 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 1.1 | 12.0 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.2 | 11.4 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 0.1 | 11.1 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
| 0.1 | 10.7 | GO:0051384 | response to glucocorticoid(GO:0051384) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 56.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 2.1 | 23.0 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.3 | 21.1 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.1 | 17.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 4.0 | 15.8 | GO:0097232 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 1.2 | 12.0 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.5 | 11.2 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 11.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 1.0 | 10.5 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 10.5 | GO:0030133 | transport vesicle(GO:0030133) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 28.8 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.1 | 25.5 | GO:0008017 | microtubule binding(GO:0008017) |
| 1.5 | 18.2 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.1 | 14.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 13.8 | GO:0000982 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) |
| 0.3 | 13.6 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.1 | 12.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 12.2 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 2.4 | 12.0 | GO:0003947 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947) |
| 0.4 | 12.0 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 21.9 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.2 | 18.5 | PID FGF PATHWAY | FGF signaling pathway |
| 0.2 | 17.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 16.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 11.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.3 | 9.8 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 9.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 9.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.4 | 9.2 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 24.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.7 | 19.5 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 1.1 | 18.5 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.6 | 17.5 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.3 | 15.3 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.2 | 14.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 12.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 12.0 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 9.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 9.3 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |