ISMARA results: CUX2

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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CUX2

Z-value: 1.36

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Transcription factors associated with CUX2

Gene Symbol	Gene ID	Gene Info
CUX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000111249.9	cut like homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CUX2	hg19_v2_chr12_+_111471828_111471975	0.19	4.2e-01	Click!

Activity profile of CUX2 motif

Sorted Z-values of CUX2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_35673853 Show fit	2.56	ENST00000378357.4	CA9 Ensembl NCBI GeneCards UniProt NextProt Show fit	carbonic anhydrase IX
chr1_+_196788887 Show fit	2.25	ENST00000320493.5 ENST00000367424.4 ENST00000367421.3	CFHR1 Ensembl NCBI GeneCards UniProt NextProt Show fit CFHR2 Ensembl NCBI GeneCards UniProt NextProt Show fit	complement factor H-related 1 complement factor H-related 2
chr18_+_61445007 Show fit	2.04	ENST00000447428.1 ENST00000546027.1	SERPINB7 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr12_+_123944070 Show fit	1.99	ENST00000412157.2	SNRNP35 Ensembl NCBI GeneCards UniProt NextProt Show fit	small nuclear ribonucleoprotein 35kDa (U11/U12)
chr11_-_59633951 Show fit	1.94	ENST00000257264.3	TCN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcobalamin I (vitamin B12 binding protein, R binder family)
chr17_-_64216748 Show fit	1.94	ENST00000585162.1	APOH Ensembl NCBI GeneCards UniProt NextProt Show fit	apolipoprotein H (beta-2-glycoprotein I)
chr19_-_36297632 Show fit	1.90	ENST00000588266.2	PRODH2 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline dehydrogenase (oxidase) 2
chr11_+_57365150 Show fit	1.88	ENST00000457869.1 ENST00000340687.6 ENST00000378323.4 ENST00000378324.2 ENST00000403558.1	SERPING1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chrM_+_4431 Show fit	1.88	ENST00000361453.3	MT-ND2 Ensembl NCBI GeneCards UniProt NextProt Show fit	mitochondrially encoded NADH dehydrogenase 2
chr1_-_186649543 Show fit	1.85	ENST00000367468.5	PTGS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	3.9	GO:0090362	positive regulation of platelet-derived growth factor production(GO:0090362)
0.0	3.3	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2	3.1	GO:0045919	positive regulation of cytolysis(GO:0045919)
0.2	2.9	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.0	2.9	GO:0010107	potassium ion import(GO:0010107)
0.3	2.7	GO:1904715	negative regulation of chaperone-mediated autophagy(GO:1904715)
0.0	2.6	GO:0033574	response to testosterone(GO:0033574)
0.0	2.5	GO:0060337	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.8	2.3	GO:1904235	regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.5	2.2	GO:0001808	negative regulation of type IV hypersensitivity(GO:0001808)

Showing 1 to 10 of 196 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.4	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	4.4	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3	3.8	GO:0005577	fibrinogen complex(GO:0005577)
0.0	3.8	GO:0035580	specific granule lumen(GO:0035580)
0.3	3.6	GO:0000243	commitment complex(GO:0000243)
0.1	2.7	GO:0031089	platelet dense granule lumen(GO:0031089)
0.1	2.6	GO:0031528	microvillus membrane(GO:0031528)
0.0	2.4	GO:0072562	blood microparticle(GO:0072562)
0.2	2.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.1	1.9	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)

Showing 1 to 10 of 61 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	3.3	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1	2.9	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2	2.8	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.5	2.7	GO:0050473	arachidonate 15-lipoxygenase activity(GO:0050473)
0.0	2.4	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	2.3	GO:0016504	peptidase activator activity(GO:0016504)
0.4	2.2	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.4	2.2	GO:0042015	interleukin-20 binding(GO:0042015)
0.2	2.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)

Showing 1 to 10 of 138 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	5.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	4.0	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	2.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.8	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	1.8	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	1.8	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	1.7	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	1.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	1.0	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Showing 1 to 10 of 16 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2	2.9	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.2	2.8	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	2.6	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.0	2.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	2.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	2.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	2.0	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	2.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	1.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation

Showing 1 to 10 of 43 entries

Results for CUX2

Z-value: 1.36

Motif logo

Transcription factors associated with CUX2

Activity-expression correlation:

Activity profile of CUX2 motif

Sorted Z-values of CUX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CUX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: