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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DDIT3

Z-value: 0.96

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Transcription factors associated with DDIT3

Gene Symbol Gene ID Gene Info
DDIT3
ENSG00000175197.6 DNA damage inducible transcript 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DDIT3hg19_v2_chr12_-_57914275_57914304-0.417.4e-02Click!

Activity profile of DDIT3 motif

Sorted Z-values of DDIT3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_52867569 2.68 ENST00000252250.6
KRT6C
keratin 6C
chr9_+_110045418 2.45 ENST00000419616.1
RAD23B
RAD23 homolog B (S. cerevisiae)
chr3_+_136676707 2.36 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr3_+_136676851 2.34 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr6_-_86353510 2.23 ENST00000444272.1
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr9_+_112542591 2.12 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
PALM2
PALM2-AKAP2
AKAP2
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr5_+_154135029 2.02 ENST00000518297.1
LARP1
La ribonucleoprotein domain family, member 1
chr15_+_85923797 1.98 ENST00000559362.1
AKAP13
A kinase (PRKA) anchor protein 13
chr16_-_68269971 1.97 ENST00000565858.1
ESRP2
epithelial splicing regulatory protein 2
chr14_-_23446021 1.93 ENST00000553592.1
AJUBA
ajuba LIM protein
chr14_-_23446003 1.71 ENST00000553911.1
AJUBA
ajuba LIM protein
chr11_+_34073269 1.61 ENST00000389645.3
CAPRIN1
cell cycle associated protein 1
chr2_-_208030886 1.51 ENST00000426163.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr5_+_145583107 1.45 ENST00000506502.1
RBM27
RNA binding motif protein 27
chr5_+_72143988 1.42 ENST00000506351.2
TNPO1
transportin 1
chr5_-_131630931 1.38 ENST00000431054.1
P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
chr12_+_64798826 1.38 ENST00000540203.1
XPOT
exportin, tRNA
chr1_+_90308981 1.36 ENST00000527156.1
LRRC8D
leucine rich repeat containing 8 family, member D
chr18_-_55288973 1.35 ENST00000423481.2
ENST00000587194.1
ENST00000591599.1
ENST00000588661.1
NARS
asparaginyl-tRNA synthetase
chr2_-_208030295 1.35 ENST00000458272.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr4_-_99578789 1.32 ENST00000511651.1
ENST00000505184.1
TSPAN5
tetraspanin 5
chr9_-_95055956 1.28 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS
isoleucyl-tRNA synthetase
chr4_-_119274121 1.20 ENST00000296498.3
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr15_-_64126084 1.20 ENST00000560316.1
ENST00000443617.2
ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr15_-_83837983 1.19 ENST00000562702.1
HDGFRP3
Hepatoma-derived growth factor-related protein 3
chr9_+_112542572 1.11 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr2_+_192141611 1.09 ENST00000392316.1
MYO1B
myosin IB
chr14_+_64565442 1.05 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr8_+_26435915 1.03 ENST00000523027.1
DPYSL2
dihydropyrimidinase-like 2
chr9_-_95056010 0.99 ENST00000443024.2
IARS
isoleucyl-tRNA synthetase
chr11_+_34073195 0.99 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr2_-_216300784 0.99 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1
fibronectin 1
chr16_-_18908196 0.98 ENST00000565324.1
ENST00000561947.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr11_-_8739566 0.93 ENST00000533020.1
ST5
suppression of tumorigenicity 5
chr19_-_49258606 0.92 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr19_+_10736183 0.91 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
SLC44A2
solute carrier family 44 (choline transporter), member 2
chr5_+_145583156 0.87 ENST00000265271.5
RBM27
RNA binding motif protein 27
chr8_-_18744528 0.86 ENST00000523619.1
PSD3
pleckstrin and Sec7 domain containing 3
chr11_-_8739383 0.86 ENST00000531060.1
ST5
suppression of tumorigenicity 5
chr5_+_112074029 0.85 ENST00000512211.2
APC
adenomatous polyposis coli
chr6_+_151187074 0.85 ENST00000367308.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr6_+_144606817 0.85 ENST00000433557.1
UTRN
utrophin
chr11_-_8816375 0.85 ENST00000530580.1
ST5
suppression of tumorigenicity 5
chr12_+_32638897 0.84 ENST00000531134.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr3_+_38017264 0.83 ENST00000436654.1
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr2_-_208030647 0.80 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr12_-_25101920 0.80 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr11_+_20044096 0.80 ENST00000533917.1
NAV2
neuron navigator 2
chr8_+_27629459 0.79 ENST00000523566.1
ESCO2
establishment of sister chromatid cohesion N-acetyltransferase 2
chr1_+_114447763 0.76 ENST00000369563.3
DCLRE1B
DNA cross-link repair 1B
chr10_-_92681033 0.73 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr5_-_137878887 0.68 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1
eukaryotic translation termination factor 1
chr13_-_24007815 0.65 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr1_-_67519782 0.63 ENST00000235345.5
SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr17_-_2117600 0.60 ENST00000572369.1
SMG6
SMG6 nonsense mediated mRNA decay factor
chr3_+_130569429 0.59 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chrX_+_149867681 0.58 ENST00000438018.1
ENST00000436701.1
MTMR1
myotubularin related protein 1
chr12_-_25102252 0.57 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr14_-_74226961 0.56 ENST00000286523.5
ENST00000435371.1
ELMSAN1
ELM2 and Myb/SANT-like domain containing 1
chr4_+_6784358 0.51 ENST00000508423.1
KIAA0232
KIAA0232
chr4_+_141178440 0.51 ENST00000394205.3
SCOC
short coiled-coil protein
chr17_+_7477040 0.50 ENST00000581384.1
ENST00000577929.1
EIF4A1
eukaryotic translation initiation factor 4A1
chr4_+_6784401 0.47 ENST00000425103.1
ENST00000307659.5
KIAA0232
KIAA0232
chr19_-_35992780 0.46 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
DMKN
dermokine
chr7_-_56101826 0.45 ENST00000421626.1
PSPH
phosphoserine phosphatase
chr2_+_227700652 0.44 ENST00000341329.3
ENST00000392062.2
ENST00000437454.1
ENST00000443477.1
ENST00000423616.1
ENST00000448992.1
RHBDD1
rhomboid domain containing 1
chr9_+_70971815 0.43 ENST00000396392.1
ENST00000396396.1
PGM5
phosphoglucomutase 5
chr1_+_150954493 0.42 ENST00000368947.4
ANXA9
annexin A9
chr8_+_24151553 0.41 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28
ADAM metallopeptidase domain 28
chr19_+_41497178 0.40 ENST00000324071.4
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr16_+_56965960 0.37 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr8_+_24151620 0.37 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr22_-_27456361 0.36 ENST00000453934.1
CTA-992D9.6
CTA-992D9.6
chr17_-_77967433 0.35 ENST00000571872.1
TBC1D16
TBC1 domain family, member 16
chr11_+_62495541 0.33 ENST00000530625.1
ENST00000513247.2
TTC9C
tetratricopeptide repeat domain 9C
chr11_-_10315741 0.33 ENST00000256190.8
SBF2
SET binding factor 2
chrX_+_9431324 0.33 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr10_-_116444371 0.32 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr3_+_44840679 0.32 ENST00000425755.1
KIF15
kinesin family member 15
chr15_+_85923856 0.32 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
AKAP13
A kinase (PRKA) anchor protein 13
chr7_-_44530479 0.32 ENST00000355451.7
NUDCD3
NudC domain containing 3
chr7_+_44040488 0.31 ENST00000258704.3
SPDYE1
speedy/RINGO cell cycle regulator family member E1
chr1_-_152196669 0.31 ENST00000368801.2
HRNR
hornerin
chr10_+_86004802 0.31 ENST00000359452.4
ENST00000358110.5
ENST00000372092.3
RGR
retinal G protein coupled receptor
chr10_+_60028818 0.30 ENST00000333926.5
CISD1
CDGSH iron sulfur domain 1
chr1_+_174844645 0.28 ENST00000486220.1
RABGAP1L
RAB GTPase activating protein 1-like
chr12_+_50144381 0.28 ENST00000552370.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr20_+_54987168 0.27 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr11_-_104972158 0.27 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr14_+_102276132 0.26 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr3_+_190105909 0.26 ENST00000456423.1
CLDN16
claudin 16
chr12_-_122017542 0.25 ENST00000446152.2
KDM2B
lysine (K)-specific demethylase 2B
chr7_+_18536090 0.23 ENST00000441986.1
HDAC9
histone deacetylase 9
chr3_+_157154578 0.22 ENST00000295927.3
PTX3
pentraxin 3, long
chr6_-_48036363 0.21 ENST00000543600.1
ENST00000398738.2
ENST00000339488.4
PTCHD4
patched domain containing 4
chr8_-_82645082 0.21 ENST00000523361.1
ZFAND1
zinc finger, AN1-type domain 1
chr2_-_63815860 0.19 ENST00000272321.7
ENST00000431065.1
WDPCP
WD repeat containing planar cell polarity effector
chr9_+_110045537 0.16 ENST00000358015.3
RAD23B
RAD23 homolog B (S. cerevisiae)
chr17_-_30228678 0.16 ENST00000261708.4
UTP6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr9_+_80912059 0.14 ENST00000347159.2
ENST00000376588.3
PSAT1
phosphoserine aminotransferase 1
chrX_-_40506766 0.13 ENST00000378421.1
ENST00000440784.2
ENST00000327877.5
ENST00000378426.1
ENST00000378418.2
CXorf38
chromosome X open reading frame 38
chr1_+_33546714 0.13 ENST00000294517.6
ENST00000358680.3
ENST00000373443.3
ENST00000398167.1
ADC
arginine decarboxylase
chr20_+_54987305 0.12 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr7_+_90338547 0.07 ENST00000446790.1
CDK14
cyclin-dependent kinase 14
chr7_-_138363824 0.07 ENST00000419765.3
SVOPL
SVOP-like
chr1_-_114447412 0.07 ENST00000369567.1
ENST00000369566.3
AP4B1
adaptor-related protein complex 4, beta 1 subunit
chr14_+_102276192 0.06 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr12_-_53074182 0.06 ENST00000252244.3
KRT1
keratin 1
chr21_-_46334186 0.06 ENST00000522931.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_63816126 0.05 ENST00000454035.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chrX_+_16188506 0.05 ENST00000329538.5
MAGEB17
melanoma antigen family B, 17
chr10_-_103874692 0.04 ENST00000361198.5
LDB1
LIM domain binding 1
chr5_-_66492562 0.04 ENST00000256447.4
CD180
CD180 molecule
chr17_-_47925379 0.04 ENST00000352793.2
ENST00000334568.4
ENST00000398154.1
ENST00000436235.1
ENST00000326219.5
TAC4
tachykinin 4 (hemokinin)
chr20_+_24929866 0.04 ENST00000480798.1
ENST00000376835.2
CST7
cystatin F (leukocystatin)
chr11_-_56310757 0.04 ENST00000528616.2
OR5M11
olfactory receptor, family 5, subfamily M, member 11
chr1_-_44820880 0.03 ENST00000372257.2
ENST00000457571.1
ENST00000452396.1
ERI3
ERI1 exoribonuclease family member 3
chr15_+_59730348 0.03 ENST00000288228.5
ENST00000559628.1
ENST00000557914.1
ENST00000560474.1
FAM81A
family with sequence similarity 81, member A
chr14_+_32798547 0.02 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr4_+_157997273 0.01 ENST00000541722.1
ENST00000512619.1
GLRB
glycine receptor, beta
chr13_+_24844979 0.00 ENST00000454083.1
SPATA13
spermatogenesis associated 13
chr14_+_32798462 0.00 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.6 2.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.4 2.3 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.3 1.4 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.3 2.0 GO:0072752 cellular response to rapamycin(GO:0072752)
0.3 1.0 GO:1904237 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.3 3.6 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.2 1.4 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 2.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.2 0.8 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1 0.4 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.8 GO:0031860 telomeric loop formation(GO:0031627) telomeric 3' overhang formation(GO:0031860)
0.1 1.0 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.9 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.1 0.8 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.1 0.6 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.1 1.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 1.2 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 0.6 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.1 0.3 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1 0.5 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 2.6 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.1 0.6 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.1 0.9 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 1.4 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 2.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 0.9 GO:0015871 choline transport(GO:0015871)
0.0 2.7 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.7 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.3 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.8 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 2.0 GO:0060441 epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.0 0.3 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.3 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.2 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.6 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.0 0.6 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.7 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.5 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.4 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.0 0.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 1.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.4 GO:0019388 galactose catabolic process(GO:0019388)
0.0 1.3 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.4 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 3.7 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 0.2 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.0 0.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 4.1 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.3 GO:1903830 magnesium ion transmembrane transport(GO:1903830)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0071942 XPC complex(GO:0071942)
0.3 2.2 GO:0097452 GAIT complex(GO:0097452)
0.1 2.0 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.6 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.1 2.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 0.3 GO:0036457 keratohyalin granule(GO:0036457)
0.1 0.3 GO:0005873 plus-end kinesin complex(GO:0005873)
0.1 0.6 GO:0070852 cell body fiber(GO:0070852)
0.1 1.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.0 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:1990037 Lewy body core(GO:1990037)
0.1 0.9 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 1.9 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.3 GO:0072558 NLRP1 inflammasome complex(GO:0072558) protease inhibitor complex(GO:0097179)
0.0 2.7 GO:0045095 keratin filament(GO:0045095)
0.0 6.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.4 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 2.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.9 GO:0030175 filopodium(GO:0030175)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.7 GO:0042015 interleukin-20 binding(GO:0042015)
0.6 2.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.2 0.7 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 1.4 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 1.0 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.2 0.8 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.2 2.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 1.4 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 3.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.9 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 2.0 GO:0008494 translation activator activity(GO:0008494)
0.1 0.7 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 2.2 GO:0008143 poly(A) binding(GO:0008143)
0.1 0.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 1.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.4 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.8 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 2.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.9 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.6 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 2.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.9 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.3 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.6 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 3.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 2.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.6 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0001849 complement component C1q binding(GO:0001849) virion binding(GO:0046790)
0.0 0.8 GO:0017166 vinculin binding(GO:0017166)
0.0 1.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.3 GO:0016504 peptidase activator activity(GO:0016504)
0.0 1.2 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.4 GO:0008391 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.5 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.4 GO:0015464 acetylcholine receptor activity(GO:0015464)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.2 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.1 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.3 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 3.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 1.4 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 2.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 0.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.0 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.0 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 2.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.6 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 2.3 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex