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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DMBX1

Z-value: 0.32

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Transcription factors associated with DMBX1

Gene Symbol Gene ID Gene Info
DMBX1
ENSG00000197587.6 diencephalon/mesencephalon homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMBX1hg19_v2_chr1_+_46972668_469726690.416.9e-02Click!

Activity profile of DMBX1 motif

Sorted Z-values of DMBX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_223725723 0.58 ENST00000535678.1
ACSL3
acyl-CoA synthetase long-chain family member 3
chr2_-_175711133 0.38 ENST00000409597.1
ENST00000413882.1
CHN1
chimerin 1
chr17_-_19651654 0.37 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_-_19651598 0.36 ENST00000570414.1
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr8_-_23282797 0.35 ENST00000524144.1
LOXL2
lysyl oxidase-like 2
chr17_-_19651668 0.34 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr8_-_23282820 0.34 ENST00000520871.1
LOXL2
lysyl oxidase-like 2
chr2_-_220252068 0.33 ENST00000430206.1
ENST00000429013.1
DNPEP
aspartyl aminopeptidase
chr3_+_111393501 0.31 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr4_+_169552748 0.31 ENST00000504519.1
ENST00000512127.1
PALLD
palladin, cytoskeletal associated protein
chr3_-_149293990 0.29 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr17_+_16945820 0.28 ENST00000577514.1
MPRIP
myosin phosphatase Rho interacting protein
chr5_+_71403280 0.27 ENST00000511641.2
MAP1B
microtubule-associated protein 1B
chr3_-_137851220 0.26 ENST00000236709.3
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr15_+_63414760 0.25 ENST00000557972.1
LACTB
lactamase, beta
chr3_-_11685345 0.25 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr1_+_120839005 0.24 ENST00000369390.3
ENST00000452190.1
FAM72B
family with sequence similarity 72, member B
chr1_-_143913143 0.24 ENST00000400889.1
FAM72D
family with sequence similarity 72, member D
chr1_+_206138457 0.23 ENST00000367128.3
ENST00000431655.2
FAM72A
family with sequence similarity 72, member A
chr16_-_31076332 0.23 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
ZNF668
zinc finger protein 668
chr6_-_33297013 0.22 ENST00000453407.1
DAXX
death-domain associated protein
chr15_-_60771280 0.22 ENST00000560072.1
ENST00000560406.1
ENST00000560520.1
ENST00000261520.4
ENST00000439632.1
NARG2
NMDA receptor regulated 2
chr2_-_27486951 0.21 ENST00000432351.1
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr1_-_47655686 0.21 ENST00000294338.2
PDZK1IP1
PDZK1 interacting protein 1
chr2_-_220252530 0.19 ENST00000521459.1
DNPEP
aspartyl aminopeptidase
chr3_+_99986036 0.19 ENST00000471098.1
TBC1D23
TBC1 domain family, member 23
chr12_-_76461249 0.18 ENST00000551524.1
NAP1L1
nucleosome assembly protein 1-like 1
chr3_-_49058479 0.18 ENST00000440857.1
DALRD3
DALR anticodon binding domain containing 3
chr15_-_85201779 0.17 ENST00000360476.3
ENST00000394588.3
NMB
neuromedin B
chr15_+_63413990 0.17 ENST00000261893.4
LACTB
lactamase, beta
chr14_+_50234309 0.16 ENST00000298307.5
KLHDC2
kelch domain containing 2
chr2_+_97454321 0.16 ENST00000540067.1
CNNM4
cyclin M4
chr10_-_101491828 0.16 ENST00000370483.5
ENST00000016171.5
COX15
cytochrome c oxidase assembly homolog 15 (yeast)
chr16_-_31076273 0.15 ENST00000426488.2
ZNF668
zinc finger protein 668
chrX_-_64754611 0.15 ENST00000374807.5
ENST00000374811.3
ENST00000374804.5
ENST00000312391.8
LAS1L
LAS1-like (S. cerevisiae)
chr5_-_54988448 0.15 ENST00000503817.1
ENST00000512595.1
SLC38A9
solute carrier family 38, member 9
chr3_-_19975665 0.14 ENST00000295824.9
ENST00000389256.4
EFHB
EF-hand domain family, member B
chr22_+_31002990 0.14 ENST00000423350.1
TCN2
transcobalamin II
chr14_-_23395623 0.14 ENST00000556043.1
PRMT5
protein arginine methyltransferase 5
chr2_+_37571845 0.14 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr1_+_81001398 0.13 ENST00000418041.1
ENST00000443104.1
RP5-887A10.1
RP5-887A10.1
chr3_+_111393659 0.13 ENST00000477665.1
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr22_-_43411106 0.13 ENST00000453643.1
ENST00000263246.3
ENST00000337959.4
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr2_+_73461364 0.12 ENST00000540468.1
ENST00000539919.1
ENST00000258091.5
CCT7
chaperonin containing TCP1, subunit 7 (eta)
chr10_-_99030395 0.12 ENST00000355366.5
ENST00000371027.1
ARHGAP19
Rho GTPase activating protein 19
chr8_-_110656995 0.12 ENST00000276646.9
ENST00000533065.1
SYBU
syntabulin (syntaxin-interacting)
chr2_-_70780572 0.11 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr12_-_49581152 0.11 ENST00000550811.1
TUBA1A
tubulin, alpha 1a
chr3_+_138340067 0.11 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr2_+_73461410 0.11 ENST00000399032.2
ENST00000398422.2
ENST00000537131.1
ENST00000538797.1
CCT7
chaperonin containing TCP1, subunit 7 (eta)
chr12_-_118628315 0.10 ENST00000540561.1
TAOK3
TAO kinase 3
chr1_-_47779762 0.10 ENST00000371877.3
ENST00000360380.3
ENST00000337817.5
ENST00000447475.2
STIL
SCL/TAL1 interrupting locus
chr6_-_26250835 0.10 ENST00000446824.2
HIST1H3F
histone cluster 1, H3f
chr2_-_14541060 0.10 ENST00000418420.1
ENST00000417751.1
LINC00276
long intergenic non-protein coding RNA 276
chr10_-_35104185 0.09 ENST00000374789.3
ENST00000374788.3
ENST00000346874.4
ENST00000374794.3
ENST00000350537.4
ENST00000374790.3
ENST00000374776.1
ENST00000374773.1
ENST00000545693.1
ENST00000545260.1
ENST00000340077.5
PARD3
par-3 family cell polarity regulator
chr1_+_180875711 0.09 ENST00000434447.1
RP11-46A10.2
RP11-46A10.2
chr4_-_170679024 0.08 ENST00000393381.2
C4orf27
chromosome 4 open reading frame 27
chr1_-_16563641 0.08 ENST00000375599.3
RSG1
REM2 and RAB-like small GTPase 1
chr9_+_74920408 0.08 ENST00000451152.1
RP11-63P12.6
RP11-63P12.6
chr6_+_10585979 0.08 ENST00000265012.4
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr4_+_41937131 0.07 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chr10_+_74451883 0.07 ENST00000373053.3
ENST00000357157.6
MCU
mitochondrial calcium uniporter
chr9_+_74920335 0.07 ENST00000451596.2
ENST00000436054.1
RP11-63P12.6
RP11-63P12.6
chr17_+_60536002 0.07 ENST00000582809.1
TLK2
tousled-like kinase 2
chr19_+_17448348 0.06 ENST00000324894.8
ENST00000358792.7
ENST00000600625.1
GTPBP3
GTP binding protein 3 (mitochondrial)
chr19_-_17186229 0.06 ENST00000253669.5
ENST00000448593.2
HAUS8
HAUS augmin-like complex, subunit 8
chr4_+_108815402 0.06 ENST00000503385.1
SGMS2
sphingomyelin synthase 2
chr17_-_12921270 0.05 ENST00000578071.1
ENST00000426905.3
ENST00000395962.2
ENST00000583371.1
ENST00000338034.4
ELAC2
elaC ribonuclease Z 2
chr9_+_107266455 0.05 ENST00000334726.2
OR13F1
olfactory receptor, family 13, subfamily F, member 1
chr19_-_17185848 0.05 ENST00000593360.1
HAUS8
HAUS augmin-like complex, subunit 8
chr3_+_49058444 0.05 ENST00000326925.6
ENST00000395458.2
NDUFAF3
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr11_-_45940343 0.04 ENST00000532681.1
PEX16
peroxisomal biogenesis factor 16
chr3_-_149470229 0.04 ENST00000473414.1
COMMD2
COMM domain containing 2
chr5_+_175740083 0.04 ENST00000332772.4
SIMC1
SUMO-interacting motifs containing 1
chr17_-_4643161 0.04 ENST00000574412.1
CXCL16
chemokine (C-X-C motif) ligand 16
chr4_-_54232144 0.03 ENST00000388940.4
ENST00000503450.1
ENST00000401642.3
SCFD2
sec1 family domain containing 2
chr12_+_53693812 0.03 ENST00000549488.1
C12orf10
chromosome 12 open reading frame 10
chr12_-_56321397 0.02 ENST00000557259.1
ENST00000549939.1
WIBG
within bgcn homolog (Drosophila)
chr15_+_93443419 0.02 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr17_+_4643337 0.01 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr2_-_70780770 0.01 ENST00000444975.1
ENST00000445399.1
ENST00000418333.2
TGFA
transforming growth factor, alpha
chr15_-_60683326 0.01 ENST00000559350.1
ENST00000558986.1
ENST00000560389.1
ANXA2
annexin A2
chr15_-_49102781 0.00 ENST00000558591.1
CEP152
centrosomal protein 152kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of DMBX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:2001247 positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.2 0.7 GO:0018277 protein deamination(GO:0018277)
0.1 0.2 GO:0072738 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.0 0.1 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0 0.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.1 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.1 GO:0072684 mitochondrial tRNA 3'-trailer cleavage, endonucleolytic(GO:0072684)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.0 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.3 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0 0.2 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 0.1 GO:0033504 floor plate development(GO:0033504)
0.0 0.1 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.3 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0070836 caveola assembly(GO:0070836)
0.0 0.3 GO:0061162 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.7 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.2 GO:0015633 zinc transporting ATPase activity(GO:0015633)
0.0 0.1 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0 0.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.6 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.0 GO:0032184 SUMO polymer binding(GO:0032184)