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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DMC1

Z-value: 0.57

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.5 DNA meiotic recombinase 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966123_38966163-0.697.5e-04Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_50677255 3.00 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr19_-_42947121 2.69 ENST00000601181.1
CXCL17
chemokine (C-X-C motif) ligand 17
chr11_+_71846764 1.99 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
FOLR3
folate receptor 3 (gamma)
chr11_+_71846748 1.21 ENST00000445078.2
FOLR3
folate receptor 3 (gamma)
chr10_-_98031265 1.18 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr2_-_31637560 0.98 ENST00000379416.3
XDH
xanthine dehydrogenase
chr10_-_98031310 0.97 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr14_-_21491477 0.91 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
NDRG2
NDRG family member 2
chr1_+_12290121 0.85 ENST00000358136.3
ENST00000356315.4
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr10_-_62332357 0.82 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_+_38333263 0.80 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr3_+_9944492 0.79 ENST00000383814.3
ENST00000454190.2
ENST00000454992.1
IL17RE
interleukin 17 receptor E
chr3_+_101546827 0.77 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr10_+_11047259 0.76 ENST00000379261.4
ENST00000416382.2
CELF2
CUGBP, Elav-like family member 2
chr4_+_2800722 0.74 ENST00000508385.1
SH3BP2
SH3-domain binding protein 2
chr2_-_85641162 0.71 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
CAPG
capping protein (actin filament), gelsolin-like
chr3_+_9944303 0.61 ENST00000421412.1
ENST00000295980.3
IL17RE
interleukin 17 receptor E
chr21_-_35281399 0.59 ENST00000418933.1
ATP5O
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr14_-_21492251 0.55 ENST00000554398.1
NDRG2
NDRG family member 2
chr4_-_76944621 0.54 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr2_+_201173667 0.53 ENST00000409755.3
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr14_-_21492113 0.53 ENST00000554094.1
NDRG2
NDRG family member 2
chr17_+_4846101 0.52 ENST00000576965.1
RNF167
ring finger protein 167
chr3_-_99569821 0.50 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr2_+_171640291 0.45 ENST00000409885.1
ERICH2
glutamate-rich 2
chr15_-_42448788 0.43 ENST00000382396.4
ENST00000397272.3
PLA2G4F
phospholipase A2, group IVF
chr11_-_85779971 0.43 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chrX_+_105855160 0.42 ENST00000372544.2
ENST00000372548.4
CXorf57
chromosome X open reading frame 57
chr18_+_11857439 0.42 ENST00000602628.1
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr19_+_1041212 0.42 ENST00000433129.1
ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr11_-_85780086 0.42 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
PICALM
phosphatidylinositol binding clathrin assembly protein
chr3_-_156840776 0.42 ENST00000471357.1
LINC00880
long intergenic non-protein coding RNA 880
chr2_-_61244550 0.35 ENST00000421319.1
PUS10
pseudouridylate synthase 10
chr10_-_74856608 0.31 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr7_-_22539771 0.29 ENST00000406890.2
ENST00000424363.1
STEAP1B
STEAP family member 1B
chr5_+_55149356 0.28 ENST00000490985.1
ENST00000354961.4
IL31RA
interleukin 31 receptor A
chr14_+_21492331 0.28 ENST00000533984.1
ENST00000532213.2
AL161668.5
AL161668.5
chr2_-_75788038 0.27 ENST00000393913.3
ENST00000410113.1
EVA1A
eva-1 homolog A (C. elegans)
chr16_-_85969774 0.26 ENST00000598933.1
RP11-542M13.3
RP11-542M13.3
chr3_-_141747950 0.25 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_-_109025849 0.25 ENST00000228463.6
SELPLG
selectin P ligand
chr12_-_53901266 0.23 ENST00000609999.1
ENST00000267017.3
NPFF
neuropeptide FF-amide peptide precursor
chr2_-_197675000 0.22 ENST00000342506.2
C2orf66
chromosome 2 open reading frame 66
chr5_-_149465990 0.21 ENST00000543093.1
CSF1R
colony stimulating factor 1 receptor
chr8_-_101734907 0.19 ENST00000318607.5
ENST00000521865.1
ENST00000520804.1
ENST00000522720.1
ENST00000521067.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr18_-_5396271 0.18 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chrX_-_134305322 0.16 ENST00000276241.6
ENST00000344129.2
CXorf48
cancer/testis antigen 55
chr19_-_3600549 0.15 ENST00000589966.1
TBXA2R
thromboxane A2 receptor
chr6_+_88054530 0.15 ENST00000388923.4
C6orf163
chromosome 6 open reading frame 163
chr22_+_21133469 0.15 ENST00000406799.1
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr6_+_46661575 0.13 ENST00000450697.1
TDRD6
tudor domain containing 6
chr12_-_71031185 0.12 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB
protein tyrosine phosphatase, receptor type, B
chr3_-_141747459 0.11 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr7_+_6793740 0.10 ENST00000403107.1
ENST00000404077.1
ENST00000435395.1
ENST00000418406.1
RSPH10B2
radial spoke head 10 homolog B2 (Chlamydomonas)
chr2_-_61244308 0.10 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr6_-_31670723 0.09 ENST00000440843.2
ENST00000375842.4
ABHD16A
abhydrolase domain containing 16A
chr6_-_62996066 0.08 ENST00000281156.4
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr19_+_44617511 0.08 ENST00000262894.6
ENST00000588926.1
ENST00000592780.1
ZNF225
zinc finger protein 225
chr19_+_1041187 0.07 ENST00000531467.1
ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr7_-_150884332 0.07 ENST00000275838.1
ENST00000422024.1
ENST00000434669.1
ASB10
ankyrin repeat and SOCS box containing 10
chr1_-_19811132 0.05 ENST00000433834.1
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr2_+_136343943 0.05 ENST00000409606.1
R3HDM1
R3H domain containing 1
chr4_+_106473768 0.05 ENST00000265154.2
ENST00000420470.2
ARHGEF38
Rho guanine nucleotide exchange factor (GEF) 38
chr17_+_31318886 0.05 ENST00000269053.3
ENST00000394638.1
SPACA3
sperm acrosome associated 3
chr1_-_9714644 0.04 ENST00000377320.3
C1orf200
chromosome 1 open reading frame 200
chr1_-_111061797 0.03 ENST00000369771.2
KCNA10
potassium voltage-gated channel, shaker-related subfamily, member 10
chr2_+_61244697 0.03 ENST00000401576.1
ENST00000295030.5
ENST00000414712.2
PEX13
peroxisomal biogenesis factor 13
chr7_-_6010263 0.03 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr1_-_47131521 0.03 ENST00000542495.1
ENST00000532925.1
ATPAF1
ATP synthase mitochondrial F1 complex assembly factor 1
chr14_-_36536396 0.02 ENST00000546376.1
RP11-116N8.4
RP11-116N8.4
chr14_+_21525981 0.02 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr12_-_71031220 0.02 ENST00000334414.6
PTPRB
protein tyrosine phosphatase, receptor type, B
chr20_+_2796948 0.02 ENST00000361033.1
ENST00000380585.1
TMEM239
transmembrane protein 239
chrX_-_63450480 0.01 ENST00000362002.2
ASB12
ankyrin repeat and SOCS box containing 12
chr6_+_26383404 0.00 ENST00000416795.2
ENST00000494184.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr7_+_107332334 0.00 ENST00000541474.1
ENST00000544569.1
SLC26A4
solute carrier family 26 (anion exchanger), member 4
chr6_+_116782527 0.00 ENST00000368606.3
ENST00000368605.1
FAM26F
family with sequence similarity 26, member F

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0046110 xanthine metabolic process(GO:0046110)
0.2 3.2 GO:0015884 folic acid transport(GO:0015884)
0.2 0.5 GO:1901076 positive regulation of engulfment of apoptotic cell(GO:1901076)
0.2 1.4 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.1 0.8 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 3.2 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.1 0.8 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 2.0 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 0.2 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.1 0.2 GO:0070253 somatostatin secretion(GO:0070253)
0.1 0.2 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 3.8 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.4 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.3 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.1 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.4 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.0 0.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.4 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.6 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.2 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.0 0.2 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.3 GO:0043031 negative regulation of macrophage activation(GO:0043031)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 0.3 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.8 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.5 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 3.2 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 3.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.6 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 0.2 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 GO:0005542 folic acid binding(GO:0005542)
0.1 1.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.5 GO:0034188 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 1.0 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.1 2.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 0.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.2 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 3.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.0 0.3 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.3 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 0.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 3.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.4 PID LPA4 PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 2.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.6 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors