ISMARA results: E2F2

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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E2F2_E2F5

Z-value: 5.43

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Transcription factors associated with E2F2_E2F5

Gene Symbol	Gene ID	Gene Info
E2F2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000007968.6	E2F transcription factor 2
E2F5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000133740.6	E2F transcription factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E2F5	hg19_v2_chr8_+_86089460_86089483	0.96	4.1e-11	Click!
E2F2	hg19_v2_chr1_-_23857698_23857733	0.92	7.7e-09	Click!

Activity profile of E2F2_E2F5 motif

Sorted Z-values of E2F2_E2F5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr15_-_64673630 Show fit	21.78	ENST00000558008.1 ENST00000559519.1 ENST00000380258.2	KIAA0101 Ensembl NCBI GeneCards UniProt NextProt Show fit	KIAA0101
chr20_-_32274179 Show fit	19.76	ENST00000343380.5	E2F1 Ensembl NCBI GeneCards UniProt NextProt Show fit	E2F transcription factor 1
chr1_-_23857698 Show fit	19.59	ENST00000361729.2	E2F2 Ensembl NCBI GeneCards UniProt NextProt Show fit	E2F transcription factor 2
chr15_+_32907691 Show fit	19.34	ENST00000361627.3 ENST00000567348.1 ENST00000563864.1 ENST00000543522.1	ARHGAP11A Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho GTPase activating protein 11A
chr15_-_64673665 Show fit	19.09	ENST00000300035.4	KIAA0101 Ensembl NCBI GeneCards UniProt NextProt Show fit	KIAA0101
chr8_-_124408652 Show fit	18.37	ENST00000287394.5	ATAD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATPase family, AAA domain containing 2
chr7_+_94285637 Show fit	18.35	ENST00000482108.1 ENST00000488574.1	PEG10 Ensembl NCBI GeneCards UniProt NextProt Show fit	paternally expressed 10
chr7_-_94285472 Show fit	18.01	ENST00000437425.2 ENST00000447873.1 ENST00000415788.2	SGCE Ensembl NCBI GeneCards UniProt NextProt Show fit	sarcoglycan, epsilon
chr7_-_94285402 Show fit	17.99	ENST00000428696.2 ENST00000445866.2	SGCE Ensembl NCBI GeneCards UniProt NextProt Show fit	sarcoglycan, epsilon
chr7_-_94285511 Show fit	17.79	ENST00000265735.7	SGCE Ensembl NCBI GeneCards UniProt NextProt Show fit	sarcoglycan, epsilon

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	87.6	GO:0006270	DNA replication initiation(GO:0006270)
5.5	71.0	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.1	45.7	GO:0007160	cell-matrix adhesion(GO:0007160)
7.9	39.4	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
5.0	35.0	GO:0014038	regulation of Schwann cell differentiation(GO:0014038)
4.4	30.8	GO:0060356	leucine import(GO:0060356)
1.8	25.6	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
5.8	23.3	GO:0046452	dihydrofolate metabolic process(GO:0046452)
1.6	23.3	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.2	21.9	GO:0010923	negative regulation of phosphatase activity(GO:0010923)

Showing 1 to 10 of 157 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.7	113.4	GO:0042555	MCM complex(GO:0042555)
5.4	53.7	GO:0016012	sarcoglycan complex(GO:0016012)
1.3	49.8	GO:0005721	pericentric heterochromatin(GO:0005721)
0.1	47.5	GO:0005667	transcription factor complex(GO:0005667)
7.0	35.0	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
0.5	32.8	GO:0044815	nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.8	31.8	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.1	30.8	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.1	24.1	GO:0000775	chromosome, centromeric region(GO:0000775)
0.0	23.3	GO:0005874	microtubule(GO:0005874)

Showing 1 to 10 of 88 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	66.0	GO:0003688	DNA replication origin binding(GO:0003688)
0.1	47.2	GO:0001047	core promoter binding(GO:0001047)
0.2	44.6	GO:0004386	helicase activity(GO:0004386)
1.0	37.0	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
1.0	36.4	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
1.4	35.0	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
1.5	30.8	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.3	28.6	GO:0035064	methylated histone binding(GO:0035064)
0.3	23.6	GO:0003684	damaged DNA binding(GO:0003684)
3.9	23.3	GO:0051870	methotrexate binding(GO:0051870)

Showing 1 to 10 of 102 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	70.8	PID ATR PATHWAY	ATR signaling pathway
3.0	48.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4	45.2	PID E2F PATHWAY	E2F transcription factor network
1.5	39.4	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.8	36.7	PID FANCONI PATHWAY	Fanconi anemia pathway
0.3	29.7	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.3	29.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	20.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.8	19.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	15.6	PID PLK1 PATHWAY	PLK1 signaling events

Showing 1 to 10 of 30 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.7	133.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
3.5	112.1	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.4	32.5	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.5	30.8	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.9	29.5	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
1.0	23.5	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3	22.1	REACTOME MEIOSIS	Genes involved in Meiosis
2.4	21.4	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.9	20.6	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.9	20.0	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks

Showing 1 to 10 of 52 entries

Results for E2F2_E2F5

Z-value: 5.43

Motif logo

Transcription factors associated with E2F2_E2F5

Activity-expression correlation:

Activity profile of E2F2_E2F5 motif

Sorted Z-values of E2F2_E2F5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: