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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E2F2_E2F5

Z-value: 5.43

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Transcription factors associated with E2F2_E2F5

Gene Symbol Gene ID Gene Info
E2F2
ENSG00000007968.6 E2F transcription factor 2
E2F5
ENSG00000133740.6 E2F transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2F5hg19_v2_chr8_+_86089460_860894830.964.1e-11Click!
E2F2hg19_v2_chr1_-_23857698_238577330.927.7e-09Click!

Activity profile of E2F2_E2F5 motif

Sorted Z-values of E2F2_E2F5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_64673630 21.78 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr20_-_32274179 19.76 ENST00000343380.5
E2F1
E2F transcription factor 1
chr1_-_23857698 19.59 ENST00000361729.2
E2F2
E2F transcription factor 2
chr15_+_32907691 19.34 ENST00000361627.3
ENST00000567348.1
ENST00000563864.1
ENST00000543522.1
ARHGAP11A
Rho GTPase activating protein 11A
chr15_-_64673665 19.09 ENST00000300035.4
KIAA0101
KIAA0101
chr8_-_124408652 18.37 ENST00000287394.5
ATAD2
ATPase family, AAA domain containing 2
chr7_+_94285637 18.35 ENST00000482108.1
ENST00000488574.1
PEG10
paternally expressed 10
chr7_-_94285472 18.01 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
SGCE
sarcoglycan, epsilon
chr7_-_94285402 17.99 ENST00000428696.2
ENST00000445866.2
SGCE
sarcoglycan, epsilon
chr7_-_94285511 17.79 ENST00000265735.7
SGCE
sarcoglycan, epsilon
chr20_-_35724388 17.51 ENST00000344359.3
ENST00000373664.3
RBL1
retinoblastoma-like 1 (p107)
chr10_+_62538248 17.50 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr10_+_62538089 17.46 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr2_+_174219548 16.53 ENST00000347703.3
ENST00000392567.2
ENST00000306721.3
ENST00000410101.3
ENST00000410019.3
CDCA7
cell division cycle associated 7
chr2_-_136633940 16.36 ENST00000264156.2
MCM6
minichromosome maintenance complex component 6
chr22_+_35796108 15.75 ENST00000382011.5
ENST00000416905.1
MCM5
minichromosome maintenance complex component 5
chr20_+_25388293 14.92 ENST00000262460.4
ENST00000429262.2
GINS1
GINS complex subunit 1 (Psf1 homolog)
chr5_-_79950371 14.78 ENST00000511032.1
ENST00000504396.1
ENST00000505337.1
DHFR
dihydrofolate reductase
chr9_-_99180597 14.72 ENST00000375256.4
ZNF367
zinc finger protein 367
chr3_+_127317066 13.27 ENST00000265056.7
MCM2
minichromosome maintenance complex component 2
chr3_+_127317705 13.24 ENST00000480910.1
MCM2
minichromosome maintenance complex component 2
chr8_-_120868078 12.79 ENST00000313655.4
DSCC1
DNA replication and sister chromatid cohesion 1
chr11_-_118966167 11.87 ENST00000530167.1
H2AFX
H2A histone family, member X
chr16_-_3030407 11.79 ENST00000431515.2
ENST00000574385.1
ENST00000576268.1
ENST00000574730.1
ENST00000575632.1
ENST00000573944.1
ENST00000262300.8
PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chr17_+_29158962 11.75 ENST00000321990.4
ATAD5
ATPase family, AAA domain containing 5
chr10_+_96305535 11.28 ENST00000419900.1
ENST00000348459.5
ENST00000394045.1
ENST00000394044.1
ENST00000394036.1
HELLS
helicase, lymphoid-specific
chr22_+_35796056 11.22 ENST00000216122.4
MCM5
minichromosome maintenance complex component 5
chr1_+_212208919 11.08 ENST00000366991.4
ENST00000542077.1
DTL
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr10_+_13203543 10.69 ENST00000378714.3
ENST00000479669.1
ENST00000484800.2
MCM10
minichromosome maintenance complex component 10
chr14_-_50154921 10.67 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr9_-_35079911 10.66 ENST00000448890.1
FANCG
Fanconi anemia, complementation group G
chr11_+_62623512 10.53 ENST00000377892.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr20_+_5931497 10.50 ENST00000378886.2
ENST00000265187.4
MCM8
minichromosome maintenance complex component 8
chr11_+_62623544 10.42 ENST00000377890.2
ENST00000377891.2
ENST00000377889.2
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr3_+_44803209 10.10 ENST00000326047.4
KIF15
kinesin family member 15
chr20_+_5931275 10.09 ENST00000378896.3
ENST00000378883.1
MCM8
minichromosome maintenance complex component 8
chr9_-_131940526 9.85 ENST00000372491.2
IER5L
immediate early response 5-like
chr11_+_62623621 9.83 ENST00000535296.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr11_-_19263145 9.75 ENST00000532666.1
ENST00000527884.1
E2F8
E2F transcription factor 8
chr19_-_10305302 9.56 ENST00000592054.1
DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr7_-_99699538 9.51 ENST00000343023.6
ENST00000303887.5
MCM7
minichromosome maintenance complex component 7
chr9_+_126773880 9.11 ENST00000373615.4
LHX2
LIM homeobox 2
chrX_-_152736013 9.07 ENST00000330912.2
ENST00000338525.2
ENST00000334497.2
ENST00000370232.1
ENST00000370212.3
ENST00000370211.4
TREX2
HAUS7
three prime repair exonuclease 2
HAUS augmin-like complex, subunit 7
chr10_+_96305610 9.02 ENST00000371332.4
ENST00000239026.6
HELLS
helicase, lymphoid-specific
chrX_+_24711997 8.85 ENST00000379068.3
ENST00000379059.3
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chr3_+_44803322 8.56 ENST00000481166.2
KIF15
kinesin family member 15
chr5_-_79950775 8.53 ENST00000439211.2
DHFR
dihydrofolate reductase
chr7_-_158497431 8.39 ENST00000449727.2
ENST00000409339.3
ENST00000409423.1
ENST00000356309.3
NCAPG2
non-SMC condensin II complex, subunit G2
chr1_-_26232951 8.35 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr15_+_40987327 8.30 ENST00000423169.2
ENST00000267868.3
ENST00000557850.1
ENST00000532743.1
ENST00000382643.3
RAD51
RAD51 recombinase
chr2_-_27498186 8.22 ENST00000447008.2
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chrX_+_47092314 8.16 ENST00000218348.3
USP11
ubiquitin specific peptidase 11
chr16_+_3019309 8.14 ENST00000576565.1
PAQR4
progestin and adipoQ receptor family member IV
chr16_-_3030283 8.03 ENST00000572619.1
ENST00000574415.1
ENST00000440027.2
ENST00000572059.1
PKMYT1
protein kinase, membrane associated tyrosine/threonine 1
chrX_+_47092791 8.01 ENST00000377080.3
USP11
ubiquitin specific peptidase 11
chr19_-_10305752 7.93 ENST00000540357.1
ENST00000359526.4
ENST00000340748.4
DNMT1
DNA (cytosine-5-)-methyltransferase 1
chr2_+_10262857 7.89 ENST00000304567.5
RRM2
ribonucleotide reductase M2
chr4_+_178230985 7.76 ENST00000264596.3
NEIL3
nei endonuclease VIII-like 3 (E. coli)
chr4_+_154265784 7.72 ENST00000240488.3
MND1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr15_-_66649010 7.55 ENST00000367709.4
ENST00000261881.4
TIPIN
TIMELESS interacting protein
chr9_-_35080013 7.54 ENST00000378643.3
FANCG
Fanconi anemia, complementation group G
chr8_-_98290087 7.47 ENST00000322128.3
TSPYL5
TSPY-like 5
chr1_+_66458072 7.38 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr4_+_129730947 7.14 ENST00000452328.2
ENST00000504089.1
PHF17
jade family PHD finger 1
chr6_+_24775153 7.11 ENST00000356509.3
ENST00000230056.3
GMNN
geminin, DNA replication inhibitor
chr15_+_66994561 6.99 ENST00000288840.5
SMAD6
SMAD family member 6
chr4_+_129731074 6.99 ENST00000512960.1
ENST00000503785.1
ENST00000514740.1
PHF17
jade family PHD finger 1
chr1_-_26232522 6.94 ENST00000399728.1
STMN1
stathmin 1
chr10_+_112327425 6.90 ENST00000361804.4
SMC3
structural maintenance of chromosomes 3
chr19_+_56653064 6.78 ENST00000593100.1
ZNF444
zinc finger protein 444
chr15_+_66994663 6.72 ENST00000457357.2
SMAD6
SMAD family member 6
chr1_-_36235529 6.63 ENST00000318121.3
ENST00000373220.3
ENST00000520551.1
CLSPN
claspin
chr4_+_129730779 6.38 ENST00000226319.6
PHF17
jade family PHD finger 1
chr1_-_47779762 6.35 ENST00000371877.3
ENST00000360380.3
ENST00000337817.5
ENST00000447475.2
STIL
SCL/TAL1 interrupting locus
chr2_+_10263298 6.23 ENST00000474701.1
RRM2
ribonucleotide reductase M2
chr7_+_26241310 6.17 ENST00000396386.2
CBX3
chromobox homolog 3
chr9_-_123639445 6.03 ENST00000312189.6
PHF19
PHD finger protein 19
chr9_-_123639304 5.94 ENST00000436309.1
PHF19
PHD finger protein 19
chr2_-_47168850 5.84 ENST00000409207.1
MCFD2
multiple coagulation factor deficiency 2
chr11_-_19262486 5.81 ENST00000250024.4
E2F8
E2F transcription factor 8
chrX_+_123095860 5.79 ENST00000428941.1
STAG2
stromal antigen 2
chrX_-_106243294 5.70 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr2_-_27498208 5.48 ENST00000424577.1
ENST00000426569.1
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr13_+_32889605 5.45 ENST00000380152.3
ENST00000544455.1
ENST00000530893.2
BRCA2
breast cancer 2, early onset
chr4_+_129730839 5.38 ENST00000511647.1
PHF17
jade family PHD finger 1
chrX_-_106243451 5.37 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr6_+_27114861 5.35 ENST00000377459.1
HIST1H2AH
histone cluster 1, H2ah
chr8_+_48873453 5.32 ENST00000523944.1
MCM4
minichromosome maintenance complex component 4
chr17_-_17184546 5.32 ENST00000417352.1
COPS3
COP9 signalosome subunit 3
chr8_+_48873479 5.25 ENST00000262105.2
MCM4
minichromosome maintenance complex component 4
chr6_+_24775641 5.23 ENST00000378054.2
ENST00000476555.1
GMNN
geminin, DNA replication inhibitor
chr7_-_44887620 5.17 ENST00000349299.3
ENST00000521529.1
ENST00000308153.4
ENST00000350771.3
ENST00000222690.6
ENST00000381124.5
ENST00000437072.1
ENST00000446531.1
H2AFV
H2A histone family, member V
chr6_-_27775694 5.07 ENST00000377401.2
HIST1H2BL
histone cluster 1, H2bl
chrX_+_48554986 5.07 ENST00000376687.3
ENST00000453214.2
SUV39H1
suppressor of variegation 3-9 homolog 1 (Drosophila)
chrX_+_123095890 5.02 ENST00000435215.1
STAG2
stromal antigen 2
chr15_-_71184724 4.97 ENST00000560604.1
THAP10
THAP domain containing 10
chrX_+_100353153 4.95 ENST00000423383.1
ENST00000218507.5
ENST00000403304.2
ENST00000435570.1
CENPI
centromere protein I
chr3_-_48229846 4.93 ENST00000302506.3
ENST00000351231.3
ENST00000437972.1
CDC25A
cell division cycle 25A
chr19_+_50887585 4.93 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr16_-_85722530 4.84 ENST00000253462.3
GINS2
GINS complex subunit 2 (Psf2 homolog)
chrX_+_123095546 4.84 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
STAG2
stromal antigen 2
chr5_-_176738883 4.75 ENST00000513169.1
ENST00000423571.2
ENST00000502529.1
ENST00000427908.2
MXD3
MAX dimerization protein 3
chr19_+_36706024 4.65 ENST00000443387.2
ZNF146
zinc finger protein 146
chr1_+_240255166 4.64 ENST00000319653.9
FMN2
formin 2
chr17_+_42733730 4.61 ENST00000359945.3
ENST00000425535.1
C17orf104
chromosome 17 open reading frame 104
chr17_-_74733404 4.58 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
SRSF2
serine/arginine-rich splicing factor 2
chr6_+_27775899 4.56 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr11_+_125495862 4.51 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
CHEK1
checkpoint kinase 1
chr15_-_65067773 4.42 ENST00000300069.4
RBPMS2
RNA binding protein with multiple splicing 2
chr10_-_58120996 4.41 ENST00000361148.6
ENST00000395405.1
ENST00000373944.3
ZWINT
ZW10 interacting kinetochore protein
chr6_-_27782548 4.39 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr9_-_123639600 4.38 ENST00000373896.3
PHF19
PHD finger protein 19
chr19_+_36705504 4.35 ENST00000456324.1
ZNF146
zinc finger protein 146
chr17_+_38444115 4.27 ENST00000580824.1
ENST00000577249.1
CDC6
cell division cycle 6
chr17_+_30264014 4.16 ENST00000322652.5
ENST00000580398.1
SUZ12
SUZ12 polycomb repressive complex 2 subunit
chr2_+_17935119 4.15 ENST00000317402.7
GEN1
GEN1 Holliday junction 5' flap endonuclease
chr19_+_35521572 4.10 ENST00000262631.5
SCN1B
sodium channel, voltage-gated, type I, beta subunit
chr17_+_42733803 3.99 ENST00000409122.2
C17orf104
chromosome 17 open reading frame 104
chr5_+_93954039 3.98 ENST00000265140.5
ANKRD32
ankyrin repeat domain 32
chr11_+_47236489 3.96 ENST00000256996.4
ENST00000378603.3
ENST00000378600.3
ENST00000378601.3
DDB2
damage-specific DNA binding protein 2, 48kDa
chr11_+_63742050 3.96 ENST00000314133.3
ENST00000535431.1
COX8A
AP000721.4
cytochrome c oxidase subunit VIIIA (ubiquitous)
Uncharacterized protein
chr12_-_133263893 3.96 ENST00000535270.1
ENST00000320574.5
POLE
polymerase (DNA directed), epsilon, catalytic subunit
chr9_+_86595626 3.91 ENST00000445877.1
ENST00000325875.3
RMI1
RecQ mediated genome instability 1
chr1_-_26233423 3.90 ENST00000357865.2
STMN1
stathmin 1
chr10_-_21786179 3.90 ENST00000377113.5
CASC10
cancer susceptibility candidate 10
chrX_+_153238220 3.86 ENST00000425274.1
TMEM187
transmembrane protein 187
chr1_-_222885770 3.81 ENST00000355727.2
ENST00000340020.6
AIDA
axin interactor, dorsalization associated
chr7_+_94139105 3.76 ENST00000297273.4
CASD1
CAS1 domain containing 1
chr16_+_58426296 3.74 ENST00000426538.2
ENST00000328514.7
ENST00000318129.5
GINS3
GINS complex subunit 3 (Psf3 homolog)
chr2_+_75185619 3.73 ENST00000483063.1
POLE4
polymerase (DNA-directed), epsilon 4, accessory subunit
chr11_+_9595180 3.72 ENST00000450114.2
WEE1
WEE1 G2 checkpoint kinase
chr2_-_47168906 3.72 ENST00000444761.2
ENST00000409147.1
MCFD2
multiple coagulation factor deficiency 2
chr8_-_67525473 3.70 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr2_-_235405679 3.70 ENST00000390645.2
ARL4C
ADP-ribosylation factor-like 4C
chr19_+_35521699 3.67 ENST00000415950.3
SCN1B
sodium channel, voltage-gated, type I, beta subunit
chr14_-_69864993 3.66 ENST00000555373.1
ERH
enhancer of rudimentary homolog (Drosophila)
chr9_+_106856541 3.64 ENST00000286398.7
ENST00000440179.1
ENST00000374793.3
SMC2
structural maintenance of chromosomes 2
chr10_-_25241499 3.63 ENST00000376378.1
ENST00000376376.3
ENST00000320152.6
PRTFDC1
phosphoribosyl transferase domain containing 1
chr4_-_174256276 3.59 ENST00000296503.5
HMGB2
high mobility group box 2
chr7_-_148581251 3.56 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr2_+_47630108 3.55 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
MSH2
mutS homolog 2
chrX_+_106871713 3.52 ENST00000372435.4
ENST00000372428.4
ENST00000372419.3
ENST00000543248.1
PRPS1
phosphoribosyl pyrophosphate synthetase 1
chr9_+_106856831 3.52 ENST00000303219.8
ENST00000374787.3
SMC2
structural maintenance of chromosomes 2
chr3_-_49893958 3.51 ENST00000482243.1
ENST00000331456.2
ENST00000469027.1
TRAIP
TRAF interacting protein
chr2_-_55277654 3.48 ENST00000337526.6
ENST00000317610.7
ENST00000357732.4
RTN4
reticulon 4
chr2_+_17935383 3.48 ENST00000524465.1
ENST00000381254.2
ENST00000532257.1
GEN1
GEN1 Holliday junction 5' flap endonuclease
chr19_+_35521616 3.42 ENST00000595652.1
SCN1B
sodium channel, voltage-gated, type I, beta subunit
chr2_-_55277512 3.41 ENST00000402434.2
RTN4
reticulon 4
chr14_+_74551650 3.39 ENST00000554938.1
LIN52
lin-52 homolog (C. elegans)
chr7_+_26240776 3.39 ENST00000337620.4
CBX3
chromobox homolog 3
chr5_+_36152091 3.37 ENST00000274254.5
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr19_-_6502590 3.36 ENST00000264071.2
TUBB4A
tubulin, beta 4A class IVa
chr7_-_148581360 3.34 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr1_-_100598444 3.34 ENST00000535161.1
ENST00000287482.5
SASS6
spindle assembly 6 homolog (C. elegans)
chr8_-_67525524 3.33 ENST00000517885.1
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr11_-_57102947 3.28 ENST00000526696.1
SSRP1
structure specific recognition protein 1
chr14_+_51706886 3.24 ENST00000457354.2
TMX1
thioredoxin-related transmembrane protein 1
chr3_+_10068095 3.20 ENST00000287647.3
ENST00000383807.1
ENST00000383806.1
ENST00000419585.1
FANCD2
Fanconi anemia, complementation group D2
chr13_-_110438914 3.13 ENST00000375856.3
IRS2
insulin receptor substrate 2
chr7_+_26241325 3.13 ENST00000456948.1
ENST00000409747.1
CBX3
chromobox homolog 3
chr11_+_4116054 3.07 ENST00000423050.2
RRM1
ribonucleotide reductase M1
chr11_-_85376121 3.06 ENST00000527447.1
CREBZF
CREB/ATF bZIP transcription factor
chrX_-_53449593 3.04 ENST00000375340.6
ENST00000322213.4
SMC1A
structural maintenance of chromosomes 1A
chr3_-_133380731 3.01 ENST00000260810.5
TOPBP1
topoisomerase (DNA) II binding protein 1
chr16_+_30406423 3.00 ENST00000524644.1
ZNF48
zinc finger protein 48
chr11_+_64808368 3.00 ENST00000531072.1
ENST00000398846.1
SAC3D1
SAC3 domain containing 1
chrX_-_45710920 2.96 ENST00000456532.1
RP5-1158E12.3
RP5-1158E12.3
chr13_-_73301819 2.95 ENST00000377818.3
MZT1
mitotic spindle organizing protein 1
chr20_-_5100591 2.95 ENST00000379143.5
PCNA
proliferating cell nuclear antigen
chr5_-_122758994 2.95 ENST00000306467.5
ENST00000515110.1
CEP120
centrosomal protein 120kDa
chr17_+_57642886 2.90 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DHX40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr6_+_27100811 2.89 ENST00000359193.2
HIST1H2AG
histone cluster 1, H2ag
chr6_-_52149475 2.88 ENST00000419835.2
ENST00000229854.7
ENST00000596288.1
MCM3
minichromosome maintenance complex component 3
chr19_-_6502341 2.81 ENST00000598006.1
ENST00000601152.1
TUBB4A
tubulin, beta 4A class IVa
chr6_+_27782788 2.81 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr15_+_71184931 2.81 ENST00000560369.1
ENST00000260382.5
LRRC49
leucine rich repeat containing 49
chr4_-_130014532 2.78 ENST00000506368.1
ENST00000439369.2
ENST00000503215.1
SCLT1
sodium channel and clathrin linker 1
chr19_+_8455200 2.78 ENST00000601897.1
ENST00000594216.1
RAB11B
RAB11B, member RAS oncogene family
chr3_-_49893907 2.77 ENST00000482582.1
TRAIP
TRAF interacting protein
chr20_+_44563267 2.72 ENST00000372409.3
PCIF1
PDX1 C-terminal inhibiting factor 1
chr1_-_212208842 2.72 ENST00000366992.3
ENST00000366993.3
ENST00000440600.2
ENST00000366994.3
INTS7
integrator complex subunit 7
chr22_-_38966123 2.72 ENST00000439567.1
DMC1
DNA meiotic recombinase 1
chr17_-_17184605 2.70 ENST00000268717.5
COPS3
COP9 signalosome subunit 3
chr9_-_98079965 2.69 ENST00000289081.3
FANCC
Fanconi anemia, complementation group C
chr15_+_44719394 2.68 ENST00000260327.4
ENST00000396780.1
CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr11_+_74303612 2.68 ENST00000527458.1
ENST00000532497.1
ENST00000530511.1
POLD3
polymerase (DNA-directed), delta 3, accessory subunit
chr7_+_6048856 2.68 ENST00000223029.3
ENST00000400479.2
ENST00000395236.2
AIMP2
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr5_+_140019079 2.66 ENST00000252100.6
TMCO6
transmembrane and coiled-coil domains 6
chr19_+_56652643 2.65 ENST00000586123.1
ZNF444
zinc finger protein 444
chr11_+_9406169 2.59 ENST00000379719.3
ENST00000527431.1
IPO7
importin 7
chr13_-_41768654 2.57 ENST00000379483.3
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr1_-_36235559 2.53 ENST00000251195.5
CLSPN
claspin
chr4_+_71859156 2.52 ENST00000286648.5
ENST00000504730.1
ENST00000504952.1
DCK
deoxycytidine kinase
chr3_+_16926441 2.48 ENST00000418129.2
ENST00000396755.2
PLCL2
phospholipase C-like 2
chr10_+_73724123 2.47 ENST00000373115.4
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr7_-_27187393 2.41 ENST00000222728.3
HOXA6
homeobox A6
chr16_-_4323015 2.40 ENST00000204517.6
TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr12_-_122238464 2.36 ENST00000546227.1
RHOF
ras homolog family member F (in filopodia)
chr2_-_219433014 2.35 ENST00000418019.1
ENST00000454775.1
ENST00000338465.5
ENST00000415516.1
ENST00000258399.3
USP37
ubiquitin specific peptidase 37
chr15_+_71185148 2.35 ENST00000443425.2
ENST00000560755.1
LRRC49
leucine rich repeat containing 49

Network of associatons between targets according to the STRING database.

First level regulatory network of E2F2_E2F5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.9 39.4 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
5.8 23.3 GO:0046452 dihydrofolate metabolic process(GO:0046452)
5.5 71.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
5.4 5.4 GO:1990426 homologous recombination-dependent replication fork processing(GO:1990426)
5.4 16.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
5.1 20.3 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
5.0 35.0 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
4.4 30.8 GO:0060356 leucine import(GO:0060356)
3.9 15.8 GO:0006272 leading strand elongation(GO:0006272)
2.8 11.2 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
2.7 19.2 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
2.6 18.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
2.5 7.6 GO:0071140 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
2.3 6.9 GO:1904772 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
2.1 12.8 GO:0034421 post-translational protein acetylation(GO:0034421)
2.0 13.7 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
1.8 1.8 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
1.8 25.6 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
1.8 12.3 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
1.8 87.6 GO:0006270 DNA replication initiation(GO:0006270)
1.6 23.3 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.5 4.6 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
1.4 18.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
1.3 3.9 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
1.3 16.8 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
1.2 3.6 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
1.1 5.6 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
1.1 15.3 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
1.1 7.5 GO:0048478 replication fork protection(GO:0048478)
1.0 9.2 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.0 3.0 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
1.0 4.9 GO:0006287 base-excision repair, gap-filling(GO:0006287)
1.0 13.7 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.9 9.9 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.9 2.7 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.9 3.5 GO:0046101 hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.8 2.5 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.8 6.4 GO:0033504 floor plate development(GO:0033504)
0.8 4.6 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.8 4.5 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.7 2.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.7 2.0 GO:0003032 detection of oxygen(GO:0003032)
0.6 7.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.6 9.9 GO:0021978 telencephalon regionalization(GO:0021978)
0.5 5.9 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.5 17.2 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 7.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.5 1.9 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.5 0.5 GO:0035822 gene conversion(GO:0035822)
0.4 5.1 GO:0036123 histone H3-K9 dimethylation(GO:0036123)
0.4 2.1 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.4 1.2 GO:0051300 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.4 8.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.4 8.0 GO:0000338 protein deneddylation(GO:0000338)
0.4 3.2 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.4 4.0 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.3 3.1 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.3 1.7 GO:0071500 cellular response to nitrosative stress(GO:0071500)
0.3 2.0 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.3 18.9 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.3 1.6 GO:0061074 regulation of neural retina development(GO:0061074)
0.3 1.6 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.3 1.5 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.3 2.1 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.3 3.1 GO:0010746 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.3 4.8 GO:0006266 DNA ligation(GO:0006266)
0.3 4.3 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.3 0.8 GO:0060437 lung growth(GO:0060437)
0.3 2.5 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157)
0.3 5.9 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.3 3.6 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.3 1.3 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.3 2.4 GO:0042148 strand invasion(GO:0042148)
0.2 4.0 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.2 2.8 GO:0045054 constitutive secretory pathway(GO:0045054)
0.2 1.4 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.2 1.3 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.2 18.0 GO:0001541 ovarian follicle development(GO:0001541)
0.2 6.2 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.2 3.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 19.7 GO:0006342 chromatin silencing(GO:0006342)
0.2 7.8 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.2 0.6 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.2 11.3 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.2 4.6 GO:0033197 response to vitamin E(GO:0033197)
0.2 2.7 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.2 1.5 GO:0048104 establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.2 1.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 17.5 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.2 21.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 1.7 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.2 1.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.2 3.7 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.2 2.7 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.2 3.1 GO:0045814 negative regulation of gene expression, epigenetic(GO:0045814)
0.2 4.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.0 GO:0060136 enucleate erythrocyte differentiation(GO:0043353) embryonic process involved in female pregnancy(GO:0060136)
0.1 18.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 1.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 2.4 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 4.9 GO:1902751 positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.1 16.2 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.1 2.1 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 1.6 GO:0009249 protein lipoylation(GO:0009249)
0.1 4.7 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 2.2 GO:0045008 depyrimidination(GO:0045008)
0.1 3.8 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.1 45.7 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 9.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.9 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 3.7 GO:0006221 pyrimidine nucleotide biosynthetic process(GO:0006221)
0.1 0.3 GO:0032240 negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.1 1.0 GO:0016139 glycoside catabolic process(GO:0016139)
0.1 2.7 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.1 8.5 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.4 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 2.3 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 1.6 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.7 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 0.9 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.1 2.3 GO:0007099 centriole replication(GO:0007099)
0.1 1.1 GO:0001675 acrosome assembly(GO:0001675)
0.1 3.7 GO:0032456 endocytic recycling(GO:0032456)
0.1 1.3 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 7.5 GO:0051225 spindle assembly(GO:0051225)
0.1 0.8 GO:0016180 snRNA processing(GO:0016180)
0.1 0.7 GO:0072718 response to cisplatin(GO:0072718)
0.1 0.4 GO:0009048 dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048)
0.1 6.3 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.8 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.1 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 2.4 GO:0006968 cellular defense response(GO:0006968)
0.0 0.7 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 2.6 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 1.2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 1.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.6 GO:0006284 base-excision repair(GO:0006284)
0.0 0.9 GO:0006829 zinc II ion transport(GO:0006829)
0.0 1.0 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.6 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 2.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.9 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 2.4 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 2.3 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 0.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 2.3 GO:0007631 feeding behavior(GO:0007631)
0.0 1.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.0 GO:1902988 neurofibrillary tangle assembly(GO:1902988)
0.0 0.7 GO:0019228 neuronal action potential(GO:0019228)
0.0 1.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 2.0 GO:0042177 negative regulation of protein catabolic process(GO:0042177)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 3.9 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.6 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.2 GO:0007130 synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 35.0 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
6.6 19.8 GO:0035189 Rb-E2F complex(GO:0035189)
5.7 113.4 GO:0042555 MCM complex(GO:0042555)
5.4 53.7 GO:0016012 sarcoglycan complex(GO:0016012)
4.9 19.8 GO:0000811 GINS complex(GO:0000811)
4.7 18.7 GO:0005873 plus-end kinesin complex(GO:0005873)
2.6 18.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
2.1 17.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.8 1.8 GO:0031261 DNA replication preinitiation complex(GO:0031261)
1.8 18.2 GO:0031298 replication fork protection complex(GO:0031298)
1.7 20.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
1.6 9.8 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.6 15.6 GO:0000796 condensin complex(GO:0000796)
1.5 4.6 GO:0035061 interchromatin granule(GO:0035061)
1.5 15.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
1.5 8.9 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.3 49.8 GO:0005721 pericentric heterochromatin(GO:0005721)
1.1 6.9 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
1.1 5.7 GO:0032301 MutSalpha complex(GO:0032301)
1.1 12.8 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.1 14.9 GO:0001673 male germ cell nucleus(GO:0001673)
1.0 3.0 GO:0030893 meiotic cohesin complex(GO:0030893)
1.0 3.0 GO:0031021 interphase microtubule organizing center(GO:0031021)
1.0 2.9 GO:0005663 DNA replication factor C complex(GO:0005663) PCNA-p21 complex(GO:0070557)
0.9 3.5 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.8 5.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.8 31.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.8 13.5 GO:0000800 lateral element(GO:0000800)
0.6 9.1 GO:0070652 HAUS complex(GO:0070652)
0.6 3.4 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.5 32.8 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.5 11.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.5 8.2 GO:0071439 clathrin complex(GO:0071439)
0.5 3.3 GO:0098536 deuterosome(GO:0098536)
0.4 6.2 GO:0033269 internode region of axon(GO:0033269)
0.4 1.7 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.4 1.2 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.4 1.5 GO:0060187 cell pole(GO:0060187)
0.3 1.4 GO:0034457 Mpp10 complex(GO:0034457)
0.2 7.6 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 4.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 3.5 GO:0032039 integrator complex(GO:0032039)
0.2 8.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 0.4 GO:0001740 Barr body(GO:0001740)
0.2 2.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.2 2.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 0.9 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.2 2.2 GO:0005642 annulate lamellae(GO:0005642)
0.1 8.0 GO:0008180 COP9 signalosome(GO:0008180)
0.1 30.8 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.3 GO:0033503 HULC complex(GO:0033503)
0.1 2.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.3 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.5 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 7.2 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 4.1 GO:0051233 spindle midzone(GO:0051233)
0.1 24.1 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 12.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 9.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 0.8 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 1.8 GO:0035102 PRC1 complex(GO:0035102)
0.1 47.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 0.8 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.1 0.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 1.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 10.9 GO:0005814 centriole(GO:0005814)
0.1 1.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.4 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 2.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 2.2 GO:0000793 condensed chromosome(GO:0000793)
0.0 3.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 2.9 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 23.3 GO:0005874 microtubule(GO:0005874)
0.0 0.1 GO:0018444 translation release factor complex(GO:0018444)
0.0 3.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.1 GO:0043198 dendritic shaft(GO:0043198)
0.0 2.8 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 1.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 3.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 2.0 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.0 3.7 GO:0030496 midbody(GO:0030496)
0.0 0.3 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 4.4 GO:0005819 spindle(GO:0005819)
0.0 1.4 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.7 GO:0070698 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity(GO:0030617) type I activin receptor binding(GO:0070698)
4.6 13.7 GO:0015633 zinc transporting ATPase activity(GO:0015633)
3.9 23.3 GO:0051870 methotrexate binding(GO:0051870)
2.9 66.0 GO:0003688 DNA replication origin binding(GO:0003688)
2.8 11.2 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
2.2 17.5 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
2.1 17.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.6 6.2 GO:0036033 mediator complex binding(GO:0036033)
1.5 30.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
1.5 9.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
1.4 35.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
1.3 19.8 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
1.3 20.9 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
1.3 5.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.2 11.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.1 5.7 GO:0032143 single thymine insertion binding(GO:0032143)
1.1 7.9 GO:0000405 bubble DNA binding(GO:0000405)
1.1 12.7 GO:1990226 histone methyltransferase binding(GO:1990226)
1.0 3.0 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
1.0 8.0 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.0 37.0 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
1.0 36.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.9 5.4 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.8 7.6 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.8 4.5 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.7 2.9 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.7 3.6 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.7 2.0 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.5 3.8 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.5 1.6 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.5 1.6 GO:0031177 phosphopantetheine binding(GO:0031177)
0.4 2.5 GO:0004137 deoxycytidine kinase activity(GO:0004137)
0.4 3.5 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.4 17.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 1.4 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.3 2.5 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.3 28.6 GO:0035064 methylated histone binding(GO:0035064)
0.3 23.6 GO:0003684 damaged DNA binding(GO:0003684)
0.3 1.3 GO:0016748 succinyltransferase activity(GO:0016748)
0.2 44.6 GO:0004386 helicase activity(GO:0004386)
0.2 10.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 2.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 1.6 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.2 1.5 GO:0051525 NFAT protein binding(GO:0051525)
0.2 2.1 GO:0070915 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 1.7 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.2 1.4 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.4 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 47.2 GO:0001047 core promoter binding(GO:0001047)
0.1 1.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 2.0 GO:0016174 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) NAD(P)H oxidase activity(GO:0016174)
0.1 3.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 18.7 GO:0003777 microtubule motor activity(GO:0003777)
0.1 3.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.5 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.1 4.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 3.2 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 16.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 3.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 14.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 20.1 GO:0042393 histone binding(GO:0042393)
0.1 7.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 2.1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 4.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 4.6 GO:0005080 protein kinase C binding(GO:0005080)
0.1 3.1 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.1 0.8 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 2.5 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.1 GO:0097016 L27 domain binding(GO:0097016)
0.1 2.8 GO:0031489 myosin V binding(GO:0031489)
0.1 0.8 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.8 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.4 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 1.6 GO:0005112 Notch binding(GO:0005112)
0.1 2.2 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 1.5 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 3.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.8 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 16.3 GO:0015631 tubulin binding(GO:0015631)
0.0 3.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 5.7 GO:0008565 protein transporter activity(GO:0008565)
0.0 4.4 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 12.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 11.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.2 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.8 GO:0048038 quinone binding(GO:0048038)
0.0 6.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 18.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.1 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 2.7 GO:0032947 protein complex scaffold(GO:0032947)
0.0 4.8 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.9 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 2.0 GO:0015399 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 3.8 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 3.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.4 GO:0070717 poly-purine tract binding(GO:0070717)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 48.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.5 39.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.9 70.8 PID ATR PATHWAY ATR signaling pathway
0.8 19.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.8 36.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.4 45.2 PID E2F PATHWAY E2F transcription factor network
0.3 29.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3 29.7 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 9.5 PID ATM PATHWAY ATM pathway
0.2 20.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 15.6 PID PLK1 PATHWAY PLK1 signaling events
0.2 2.0 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 6.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 7.2 PID AURORA B PATHWAY Aurora B signaling
0.1 9.5 PID BMP PATHWAY BMP receptor signaling
0.1 9.5 PID CMYB PATHWAY C-MYB transcription factor network
0.1 2.9 PID BARD1 PATHWAY BARD1 signaling events
0.1 11.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 6.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 3.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 6.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 2.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.1 PID BCR 5PATHWAY BCR signaling pathway
0.0 1.1 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 2.1 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 3.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 133.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
3.5 112.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
2.4 21.4 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
1.8 12.3 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
1.2 9.8 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.0 19.4 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
1.0 23.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.9 29.5 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.9 20.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.9 20.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.5 30.8 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.5 4.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 32.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.4 18.7 REACTOME KINESINS Genes involved in Kinesins
0.4 13.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.3 22.1 REACTOME MEIOSIS Genes involved in Meiosis
0.3 13.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.3 11.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 12.7 REACTOME RNA POL I TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.3 4.1 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.2 9.9 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.2 3.1 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.2 6.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 4.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 7.1 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 9.6 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 2.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 7.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 2.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 1.6 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.1 6.9 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.1 0.8 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 4.9 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 1.7 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 3.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 3.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 6.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 19.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 2.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.9 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 2.5 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.6 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 2.1 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 2.0 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.8 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 2.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import