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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for E2F7_E2F1
Z-value: 5.50
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Transcription factors associated with E2F7_E2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F1 | hg19_v2_chr20_-_32274179_32274213 | 0.82 | 1.2e-05 | Click! |
| E2F7 | hg19_v2_chr12_-_77459306_77459365 | 0.66 | 1.7e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F7_E2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 49.4 | GO:0051225 | spindle assembly(GO:0051225) |
| 1.2 | 48.3 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 3.6 | 47.3 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 1.1 | 46.6 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.6 | 42.2 | GO:0036297 | interstrand cross-link repair(GO:0036297) |
| 4.9 | 38.9 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 7.1 | 35.5 | GO:0010520 | regulation of reciprocal meiotic recombination(GO:0010520) |
| 1.0 | 32.6 | GO:0000732 | strand displacement(GO:0000732) |
| 0.9 | 27.5 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
| 2.2 | 25.9 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 65.4 | GO:0042555 | MCM complex(GO:0042555) |
| 0.4 | 44.1 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 4.7 | 41.9 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 3.1 | 39.7 | GO:0000796 | condensin complex(GO:0000796) |
| 11.7 | 35.0 | GO:0032302 | MutSbeta complex(GO:0032302) |
| 2.4 | 33.5 | GO:0070652 | HAUS complex(GO:0070652) |
| 2.4 | 28.4 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.2 | 28.1 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 3.4 | 26.8 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 6.0 | 24.0 | GO:0031436 | BRCA1-BARD1 complex(GO:0031436) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 58.0 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 4.0 | 40.1 | GO:0033170 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 11.7 | 35.0 | GO:0032181 | double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181) |
| 0.4 | 33.2 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.2 | 30.9 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.2 | 30.9 | GO:0042393 | histone binding(GO:0042393) |
| 1.3 | 26.9 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 3.4 | 26.8 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.8 | 26.7 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.1 | 22.7 | GO:0004386 | helicase activity(GO:0004386) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 139.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 1.1 | 54.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.3 | 37.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 35.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 22.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 17.0 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 16.8 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 14.3 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.2 | 13.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 1.1 | 13.1 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 76.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 3.6 | 68.2 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 1.6 | 56.6 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 1.8 | 51.5 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.7 | 51.4 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.4 | 42.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.5 | 40.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 1.0 | 36.3 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.5 | 24.2 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.6 | 22.0 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |