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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for E4F1

Z-value: 0.79

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Transcription factors associated with E4F1

Gene Symbol Gene ID Gene Info
E4F1
ENSG00000167967.11 E4F transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E4F1hg19_v2_chr16_+_2273645_2273717-0.876.9e-07Click!

Activity profile of E4F1 motif

Sorted Z-values of E4F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_7165662 4.81 ENST00000571881.2
ENST00000360325.7
CLDN7
claudin 7
chr20_+_33292068 2.75 ENST00000374810.3
ENST00000374809.2
ENST00000451665.1
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr2_-_216300784 2.08 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1
fibronectin 1
chr11_+_111411384 1.76 ENST00000375615.3
ENST00000525126.1
ENST00000436913.2
ENST00000533265.1
LAYN
layilin
chr7_+_30174426 1.75 ENST00000324453.8
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr7_+_30174668 1.59 ENST00000415604.1
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr6_+_139456226 1.56 ENST00000367658.2
HECA
headcase homolog (Drosophila)
chr20_+_33292507 1.55 ENST00000414082.1
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr8_+_94929168 1.55 ENST00000518107.1
ENST00000396200.3
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr4_+_47487285 1.52 ENST00000273859.3
ENST00000504445.1
ATP10D
ATPase, class V, type 10D
chr8_+_94929273 1.52 ENST00000518573.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr8_+_94929077 1.48 ENST00000297598.4
ENST00000520614.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr5_-_95297678 1.44 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr17_+_41476327 1.43 ENST00000320033.4
ARL4D
ADP-ribosylation factor-like 4D
chr7_+_30174574 1.42 ENST00000409688.1
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr6_+_28048753 1.36 ENST00000377325.1
ZNF165
zinc finger protein 165
chr8_+_94929110 1.35 ENST00000520728.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr20_-_44420507 1.34 ENST00000243938.4
WFDC3
WAP four-disulfide core domain 3
chr5_-_95297534 1.21 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr1_+_85527987 1.17 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63
WD repeat domain 63
chr12_+_111471828 1.13 ENST00000261726.6
CUX2
cut-like homeobox 2
chr15_-_41047421 1.11 ENST00000560460.1
ENST00000338376.3
ENST00000560905.1
RMDN3
regulator of microtubule dynamics 3
chr9_+_131644398 1.07 ENST00000372599.3
LRRC8A
leucine rich repeat containing 8 family, member A
chr6_-_34664612 1.05 ENST00000374023.3
ENST00000374026.3
C6orf106
chromosome 6 open reading frame 106
chr2_-_222436988 1.00 ENST00000409854.1
ENST00000281821.2
ENST00000392071.4
ENST00000443796.1
EPHA4
EPH receptor A4
chr9_+_131644388 0.99 ENST00000372600.4
LRRC8A
leucine rich repeat containing 8 family, member A
chr1_+_2005425 0.95 ENST00000461106.2
PRKCZ
protein kinase C, zeta
chr9_+_131644781 0.94 ENST00000259324.5
LRRC8A
leucine rich repeat containing 8 family, member A
chr20_+_58179582 0.94 ENST00000371015.1
ENST00000395639.4
PHACTR3
phosphatase and actin regulator 3
chr1_+_70820451 0.93 ENST00000361764.4
ENST00000359875.5
ENST00000370940.5
ENST00000531950.1
ENST00000432224.1
HHLA3
HERV-H LTR-associating 3
chr4_+_75311019 0.91 ENST00000502307.1
AREG
amphiregulin
chr21_-_40720974 0.90 ENST00000380748.1
HMGN1
high mobility group nucleosome binding domain 1
chr11_+_111410998 0.85 ENST00000533999.1
LAYN
layilin
chr7_-_129592471 0.85 ENST00000473814.2
ENST00000490974.1
UBE2H
ubiquitin-conjugating enzyme E2H
chr3_+_185304059 0.84 ENST00000427465.2
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr14_+_94492674 0.83 ENST00000203664.5
ENST00000553723.1
OTUB2
OTU domain, ubiquitin aldehyde binding 2
chr17_-_4643114 0.81 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr22_+_39101728 0.79 ENST00000216044.5
ENST00000484657.1
GTPBP1
GTP binding protein 1
chr1_+_2004901 0.79 ENST00000400921.2
PRKCZ
protein kinase C, zeta
chr21_-_40720995 0.78 ENST00000380749.5
HMGN1
high mobility group nucleosome binding domain 1
chr2_-_222437049 0.78 ENST00000541600.1
EPHA4
EPH receptor A4
chr11_+_18720316 0.73 ENST00000280734.2
TMEM86A
transmembrane protein 86A
chr12_-_93835665 0.72 ENST00000552442.1
ENST00000550657.1
UBE2N
ubiquitin-conjugating enzyme E2N
chr1_+_2005126 0.71 ENST00000495347.1
PRKCZ
protein kinase C, zeta
chr7_-_100026280 0.70 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
ZCWPW1
zinc finger, CW type with PWWP domain 1
chr22_-_41252962 0.70 ENST00000216218.3
ST13
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
chr1_+_39456895 0.69 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr8_-_116680833 0.67 ENST00000220888.5
TRPS1
trichorhinophalangeal syndrome I
chr3_+_184053703 0.67 ENST00000450976.1
ENST00000418281.1
ENST00000340957.5
ENST00000433578.1
FAM131A
family with sequence similarity 131, member A
chr4_+_75310851 0.66 ENST00000395748.3
ENST00000264487.2
AREG
amphiregulin
chr11_-_77185094 0.66 ENST00000278568.4
ENST00000356341.3
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr5_-_133706695 0.65 ENST00000521755.1
ENST00000523054.1
ENST00000435240.2
ENST00000609654.1
ENST00000536186.1
ENST00000609383.1
CDKL3
cyclin-dependent kinase-like 3
chr22_-_38902300 0.63 ENST00000403230.1
DDX17
DEAD (Asp-Glu-Ala-Asp) box helicase 17
chr7_-_129592700 0.62 ENST00000472396.1
ENST00000355621.3
UBE2H
ubiquitin-conjugating enzyme E2H
chr3_+_140660743 0.58 ENST00000453248.2
SLC25A36
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr6_+_44355257 0.57 ENST00000371477.3
CDC5L
cell division cycle 5-like
chr12_+_122516626 0.56 ENST00000319080.7
MLXIP
MLX interacting protein
chr7_-_140624499 0.56 ENST00000288602.6
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr17_+_42385927 0.55 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
RUNDC3A
RUN domain containing 3A
chr19_+_1941117 0.54 ENST00000255641.8
CSNK1G2
casein kinase 1, gamma 2
chr2_-_220408430 0.53 ENST00000243776.6
CHPF
chondroitin polymerizing factor
chr6_+_33176265 0.52 ENST00000374656.4
RING1
ring finger protein 1
chr17_+_25621102 0.52 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
WSB1
WD repeat and SOCS box containing 1
chr20_-_5591626 0.51 ENST00000379019.4
GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr6_+_15249128 0.51 ENST00000397311.3
JARID2
jumonji, AT rich interactive domain 2
chr3_+_185303962 0.48 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr6_-_163148780 0.48 ENST00000366892.1
ENST00000366898.1
ENST00000366897.1
ENST00000366896.1
PARK2
parkin RBR E3 ubiquitin protein ligase
chr17_-_4643161 0.47 ENST00000574412.1
CXCL16
chemokine (C-X-C motif) ligand 16
chr6_-_27440460 0.45 ENST00000377419.1
ZNF184
zinc finger protein 184
chr3_+_140660634 0.45 ENST00000446041.2
ENST00000507429.1
ENST00000324194.6
SLC25A36
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr3_+_150126101 0.45 ENST00000361875.3
ENST00000361136.2
TSC22D2
TSC22 domain family, member 2
chr12_-_51566562 0.44 ENST00000548108.1
TFCP2
transcription factor CP2
chr1_-_47184723 0.44 ENST00000371933.3
EFCAB14
EF-hand calcium binding domain 14
chr22_-_38902325 0.44 ENST00000396821.3
ENST00000381633.3
DDX17
DEAD (Asp-Glu-Ala-Asp) box helicase 17
chr6_-_163148700 0.43 ENST00000366894.1
ENST00000338468.3
PARK2
parkin RBR E3 ubiquitin protein ligase
chr3_+_38206975 0.43 ENST00000446845.1
ENST00000311806.3
OXSR1
oxidative stress responsive 1
chr6_+_47445467 0.41 ENST00000359314.5
CD2AP
CD2-associated protein
chr6_-_53213587 0.40 ENST00000542638.1
ENST00000370913.5
ENST00000541407.1
ELOVL5
ELOVL fatty acid elongase 5
chr6_-_27440837 0.39 ENST00000211936.6
ZNF184
zinc finger protein 184
chr1_-_8086343 0.37 ENST00000474874.1
ENST00000469499.1
ENST00000377482.5
ERRFI1
ERBB receptor feedback inhibitor 1
chr22_+_32340481 0.35 ENST00000397492.1
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr20_+_34203794 0.35 ENST00000374273.3
SPAG4
sperm associated antigen 4
chr1_-_47184745 0.35 ENST00000544071.1
EFCAB14
EF-hand calcium binding domain 14
chr6_-_53213780 0.34 ENST00000304434.6
ENST00000370918.4
ELOVL5
ELOVL fatty acid elongase 5
chr6_-_29595779 0.33 ENST00000355973.3
ENST00000377012.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr22_+_32340447 0.33 ENST00000248975.5
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr12_-_51566592 0.32 ENST00000257915.5
ENST00000548115.1
TFCP2
transcription factor CP2
chr6_+_163148973 0.31 ENST00000366888.2
PACRG
PARK2 co-regulated
chr15_+_50716576 0.28 ENST00000560297.1
ENST00000307179.4
ENST00000396444.3
ENST00000433963.1
ENST00000425032.3
USP8
ubiquitin specific peptidase 8
chr2_-_64881018 0.28 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr16_-_27561209 0.27 ENST00000356183.4
ENST00000561623.1
GTF3C1
general transcription factor IIIC, polypeptide 1, alpha 220kDa
chr22_+_18121356 0.27 ENST00000317582.5
ENST00000543133.1
ENST00000538149.1
ENST00000337612.5
ENST00000493680.1
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr6_-_30523865 0.25 ENST00000433809.1
GNL1
guanine nucleotide binding protein-like 1
chr8_-_94928861 0.24 ENST00000607097.1
MIR378D2
microRNA 378d-2
chr17_+_7476136 0.24 ENST00000582169.1
ENST00000578754.1
ENST00000578495.1
ENST00000293831.8
ENST00000380512.5
ENST00000585024.1
ENST00000583802.1
ENST00000577269.1
ENST00000584784.1
ENST00000582746.1
EIF4A1
eukaryotic translation initiation factor 4A1
chr7_-_137686791 0.22 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
CREB3L2
cAMP responsive element binding protein 3-like 2
chr22_+_18121562 0.22 ENST00000355028.3
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chrX_-_83757399 0.21 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
HDX
highly divergent homeobox
chr12_-_51566849 0.20 ENST00000549867.1
ENST00000307660.4
TFCP2
transcription factor CP2
chr10_+_64893039 0.20 ENST00000277746.6
ENST00000435510.2
NRBF2
nuclear receptor binding factor 2
chr19_-_59066327 0.20 ENST00000596708.1
ENST00000601220.1
ENST00000597848.1
CHMP2A
charged multivesicular body protein 2A
chr10_-_50970322 0.20 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr1_-_32110467 0.20 ENST00000440872.2
ENST00000373703.4
PEF1
penta-EF-hand domain containing 1
chr8_-_66754172 0.19 ENST00000401827.3
PDE7A
phosphodiesterase 7A
chr16_+_27561449 0.18 ENST00000261588.4
KIAA0556
KIAA0556
chr6_+_127588020 0.18 ENST00000309649.3
ENST00000610162.1
ENST00000610153.1
ENST00000608991.1
ENST00000480444.1
RNF146
ring finger protein 146
chr6_-_32812420 0.17 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr17_-_80231557 0.16 ENST00000392334.2
ENST00000314028.6
CSNK1D
casein kinase 1, delta
chr9_-_99381660 0.15 ENST00000375240.3
ENST00000463569.1
CDC14B
cell division cycle 14B
chr11_-_67276100 0.15 ENST00000301488.3
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr12_+_107168342 0.15 ENST00000392837.4
RIC8B
RIC8 guanine nucleotide exchange factor B
chrX_+_152224766 0.14 ENST00000370265.4
ENST00000447306.1
PNMA3
paraneoplastic Ma antigen 3
chr4_-_76598544 0.13 ENST00000515457.1
ENST00000357854.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr5_+_122424816 0.13 ENST00000407847.4
PRDM6
PR domain containing 6
chr19_-_59066452 0.12 ENST00000312547.2
CHMP2A
charged multivesicular body protein 2A
chr20_+_44420570 0.12 ENST00000372622.3
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr12_-_93836028 0.12 ENST00000318066.2
UBE2N
ubiquitin-conjugating enzyme E2N
chrX_-_153237258 0.12 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr4_-_186456766 0.11 ENST00000284771.6
PDLIM3
PDZ and LIM domain 3
chr17_+_7211656 0.11 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr1_-_70820357 0.11 ENST00000370944.4
ENST00000262346.6
ANKRD13C
ankyrin repeat domain 13C
chr20_-_44600810 0.11 ENST00000322927.2
ENST00000426788.1
ZNF335
zinc finger protein 335
chr4_-_186456652 0.10 ENST00000284767.5
ENST00000284770.5
PDLIM3
PDZ and LIM domain 3
chr10_-_50970382 0.10 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr16_+_68057179 0.09 ENST00000567100.1
ENST00000432752.1
ENST00000569289.1
ENST00000564781.1
DUS2
dihydrouridine synthase 2
chr11_-_33183048 0.08 ENST00000438862.2
CSTF3
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chr17_-_80231300 0.08 ENST00000398519.5
ENST00000580446.1
CSNK1D
casein kinase 1, delta
chr4_-_54930790 0.07 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr20_-_62258394 0.07 ENST00000370077.1
GMEB2
glucocorticoid modulatory element binding protein 2
chr17_+_4643300 0.07 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr16_+_68057153 0.06 ENST00000358896.6
ENST00000568099.2
DUS2
dihydrouridine synthase 2
chr16_+_68056844 0.05 ENST00000565263.1
DUS2
dihydrouridine synthase 2
chr5_-_32444828 0.05 ENST00000265069.8
ZFR
zinc finger RNA binding protein
chrX_+_153672468 0.05 ENST00000393600.3
FAM50A
family with sequence similarity 50, member A
chr20_+_44420617 0.05 ENST00000449078.1
ENST00000456939.1
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr14_-_23388338 0.05 ENST00000555209.1
ENST00000554256.1
ENST00000557403.1
ENST00000557549.1
ENST00000555676.1
ENST00000557571.1
ENST00000557464.1
ENST00000554618.1
ENST00000556862.1
ENST00000555722.1
ENST00000346528.5
ENST00000542016.2
ENST00000399922.2
ENST00000557227.1
ENST00000359890.3
RBM23
RNA binding motif protein 23
chr3_+_139654018 0.02 ENST00000458420.3
CLSTN2
calsyntenin 2
chr19_+_45349432 0.01 ENST00000252485.4
PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr1_+_109289279 0.01 ENST00000370008.3
STXBP3
syntaxin binding protein 3
chrX_-_153236819 0.00 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)

Network of associatons between targets according to the STRING database.

First level regulatory network of E4F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:1904237 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.4 1.8 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.3 5.9 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.3 3.0 GO:0002329 pre-B cell differentiation(GO:0002329)
0.2 2.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.2 0.5 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.2 1.6 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.1 0.4 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.1 0.6 GO:1990637 response to prolactin(GO:1990637)
0.1 4.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.7 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.1 0.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1 1.3 GO:0035562 protein desumoylation(GO:0016926) negative regulation of chromatin binding(GO:0035562)
0.1 0.3 GO:1903722 regulation of centriole elongation(GO:1903722)
0.1 1.7 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.1 0.4 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1 1.3 GO:0010818 T cell chemotaxis(GO:0010818)
0.1 0.8 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.1 0.7 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 1.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.5 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 1.7 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 1.0 GO:0007614 short-term memory(GO:0007614)
0.0 0.8 GO:0033182 regulation of histone ubiquitination(GO:0033182)
0.0 0.5 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.4 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.3 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.7 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 4.3 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 2.4 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.2 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.1 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.5 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 0.8 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 0.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.4 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 0.6 GO:0030517 negative regulation of axon extension(GO:0030517)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 2.1 GO:0005577 fibrinogen complex(GO:0005577)
0.1 2.4 GO:0045179 apical cortex(GO:0045179)
0.1 4.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 0.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.5 GO:0001739 sex chromatin(GO:0001739)
0.0 1.8 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.8 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 2.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 5.6 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 1.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.8 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.7 GO:0071437 invadopodium(GO:0071437)
0.0 1.2 GO:0030286 dynein complex(GO:0030286)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.9 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.2 0.5 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.2 0.5 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.2 1.3 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 1.8 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.6 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 3.0 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 0.7 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1 0.3 GO:0000992 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.1 2.4 GO:0043274 phospholipase binding(GO:0043274)
0.1 0.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 2.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.8 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 0.7 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.5 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.1 1.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.5 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 2.6 GO:0016504 peptidase activator activity(GO:0016504)
0.0 1.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 6.2 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.6 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.7 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 2.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.8 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.8 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.4 PID VEGFR1 PATHWAY VEGFR1 specific signals

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 4.8 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 2.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.8 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 2.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.5 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.7 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.7 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)