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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ELF3_EHF
Z-value: 2.49
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Transcription factors associated with ELF3_EHF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EHF | hg19_v2_chr11_+_34643600_34643750 | 0.95 | 6.8e-11 | Click! |
| ELF3 | hg19_v2_chr1_+_201979743_201979772 | -0.81 | 1.3e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_119993979 Show fit | 11.87 |
ENST00000524816.3
ENST00000525327.1 |
tripartite motif containing 29 |
|
| chr19_+_52901094 Show fit | 9.64 |
ENST00000391788.2
ENST00000436397.1 ENST00000391787.2 ENST00000360465.3 ENST00000494167.2 ENST00000493272.1 |
zinc finger protein 528 |
|
| chr11_+_35211511 Show fit | 9.50 |
ENST00000524922.1
|
CD44 molecule (Indian blood group) |
|
| chr12_-_123187890 Show fit | 9.39 |
ENST00000328880.5
|
hydroxycarboxylic acid receptor 2 |
|
| chr12_-_123201337 Show fit | 8.58 |
ENST00000528880.2
|
hydroxycarboxylic acid receptor 3 |
|
| chr11_-_58345569 Show fit | 7.85 |
ENST00000528954.1
ENST00000528489.1 |
leupaxin |
|
| chr12_+_7072354 Show fit | 7.59 |
ENST00000537269.1
|
U47924.27 |
|
| chr3_-_121379739 Show fit | 7.52 |
ENST00000428394.2
ENST00000314583.3 |
hematopoietic cell-specific Lyn substrate 1 |
|
| chr12_-_50616122 Show fit | 7.32 |
ENST00000552823.1
ENST00000552909.1 |
LIM domain and actin binding 1 |
|
| chr10_-_98031310 Show fit | 7.24 |
ENST00000427367.2
ENST00000413476.2 |
B-cell linker |
Network of associatons between targets according to the STRING database.
First level regulatory network of ELF3_EHF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 18.7 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.8 | 18.3 | GO:1904327 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.3 | 14.2 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 0.1 | 13.2 | GO:1900181 | negative regulation of protein localization to nucleus(GO:1900181) |
| 0.1 | 12.3 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.2 | 11.6 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 1.6 | 9.4 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.4 | 9.0 | GO:0060044 | negative regulation of cardiac muscle cell proliferation(GO:0060044) |
| 0.4 | 8.2 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.7 | 7.6 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.5 | GO:0016604 | nuclear body(GO:0016604) |
| 2.3 | 18.7 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 1.5 | 18.3 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.2 | 16.2 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.1 | 14.3 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 13.9 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 13.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.6 | 12.4 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.3 | 11.7 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.3 | 10.5 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 89.8 | GO:0003700 | transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 20.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 18.8 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.8 | 18.7 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.5 | 18.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.4 | 16.0 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 15.2 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.2 | 13.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.5 | 12.7 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 1.4 | 12.4 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 26.8 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.5 | 18.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 13.3 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 10.2 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 9.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 9.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 8.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 8.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 7.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 7.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 19.4 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.8 | 15.9 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.3 | 13.8 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.5 | 12.0 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 11.4 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.2 | 9.2 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 8.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 8.2 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 7.8 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |