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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for EPAS1_BCL3
Z-value: 1.60
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Transcription factors associated with EPAS1_BCL3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EPAS1 | hg19_v2_chr2_+_46524537_46524553 | -0.82 | 8.8e-06 | Click! |
| BCL3 | hg19_v2_chr19_+_45251804_45251840 | 0.19 | 4.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_37351424 Show fit | 3.46 |
ENST00000522718.1
|
RP11-150O12.1 |
|
| chr19_+_45973120 Show fit | 3.33 |
ENST00000592811.1
ENST00000586615.1 |
FBJ murine osteosarcoma viral oncogene homolog B |
|
| chr14_+_71108460 Show fit | 2.73 |
ENST00000256367.2
|
tetratricopeptide repeat domain 9 |
|
| chr16_-_31147020 Show fit | 2.55 |
ENST00000568261.1
ENST00000567797.1 ENST00000317508.6 |
protease, serine, 8 |
|
| chr12_-_86230315 Show fit | 2.44 |
ENST00000361228.3
|
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 |
|
| chr18_+_61254570 Show fit | 2.44 |
ENST00000344731.5
|
serpin peptidase inhibitor, clade B (ovalbumin), member 13 |
|
| chr5_+_52776228 Show fit | 2.38 |
ENST00000256759.3
|
follistatin |
|
| chr8_-_37351344 Show fit | 2.29 |
ENST00000520422.1
|
RP11-150O12.1 |
|
| chr16_+_71660079 Show fit | 2.16 |
ENST00000565261.1
ENST00000268485.3 ENST00000299952.4 |
MARVEL domain containing 3 |
|
| chr18_+_61254221 Show fit | 2.16 |
ENST00000431153.1
|
serpin peptidase inhibitor, clade B (ovalbumin), member 13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EPAS1_BCL3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.7 | GO:1902173 | negative regulation of keratinocyte apoptotic process(GO:1902173) |
| 0.2 | 5.0 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.2 | 4.2 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 4.2 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.4 | 4.0 | GO:1904327 | protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379) |
| 0.3 | 4.0 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.1 | 3.4 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 1.0 | 3.1 | GO:1990764 | regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764) |
| 0.1 | 3.0 | GO:0051412 | response to corticosterone(GO:0051412) |
| 0.2 | 2.8 | GO:1902414 | protein localization to cell junction(GO:1902414) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 4.5 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 4.5 | GO:0030315 | T-tubule(GO:0030315) |
| 0.3 | 4.0 | GO:0072379 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.1 | 3.7 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 3.7 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 3.6 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.0 | 3.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 3.1 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.1 | 2.8 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 7.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 5.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 4.9 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.2 | 3.9 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.3 | 3.8 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.2 | 3.7 | GO:0048185 | activin binding(GO:0048185) |
| 0.0 | 3.5 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 3.5 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 3.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.7 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 3.8 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 3.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 3.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 3.1 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 2.0 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 1.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.0 | 3.5 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 3.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 2.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 2.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 2.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 2.6 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 2.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 1.7 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 1.6 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |