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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ESR1
Z-value: 1.44
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Transcription factors associated with ESR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESR1 | hg19_v2_chr6_+_152128371_152128454 | -0.84 | 3.5e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_175223313 Show fit | 7.18 |
ENST00000359546.4
|
complexin 2 |
|
| chr4_-_155511887 Show fit | 4.93 |
ENST00000302053.3
ENST00000403106.3 |
fibrinogen alpha chain |
|
| chr10_+_54074033 Show fit | 4.63 |
ENST00000373970.3
|
dickkopf WNT signaling pathway inhibitor 1 |
|
| chr14_+_105992906 Show fit | 4.57 |
ENST00000392519.2
|
transmembrane protein 121 |
|
| chr11_+_67777751 Show fit | 4.57 |
ENST00000316367.6
ENST00000007633.8 ENST00000342456.6 |
aldehyde dehydrogenase 3 family, member B1 |
|
| chr8_+_144640477 Show fit | 4.20 |
ENST00000262580.4
|
gasdermin D |
|
| chr11_-_117699413 Show fit | 4.13 |
ENST00000528014.1
|
FXYD domain containing ion transport regulator 2 |
|
| chr11_+_844406 Show fit | 4.05 |
ENST00000397404.1
|
tetraspanin 4 |
|
| chr15_+_50474385 Show fit | 3.63 |
ENST00000267842.5
|
solute carrier family 27 (fatty acid transporter), member 2 |
|
| chr20_-_32262165 Show fit | 3.54 |
ENST00000606690.1
ENST00000246190.6 ENST00000439478.1 ENST00000375238.4 |
N-terminal EF-hand calcium binding protein 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESR1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.3 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 1.3 | 7.7 | GO:0051673 | membrane disruption in other organism(GO:0051673) |
| 0.0 | 7.4 | GO:0006414 | translational elongation(GO:0006414) |
| 1.4 | 7.0 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
| 0.1 | 7.0 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.3 | 6.2 | GO:0036376 | sodium ion export from cell(GO:0036376) |
| 0.2 | 5.7 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.2 | 5.7 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 1.1 | 5.4 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 1.0 | 5.0 | GO:0090341 | negative regulation of secretion of lysosomal enzymes(GO:0090341) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.4 | GO:0044429 | mitochondrial part(GO:0044429) |
| 1.1 | 11.4 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.1 | 9.0 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.2 | 8.7 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 8.5 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.4 | 7.4 | GO:0072559 | NLRP3 inflammasome complex(GO:0072559) |
| 0.2 | 6.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.4 | 4.9 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 4.9 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 4.8 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 8.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.4 | 8.0 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.6 | 7.4 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.3 | 6.2 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.4 | 6.1 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.2 | 5.7 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 1.8 | 5.4 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.6 | 5.0 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.1 | 5.0 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.5 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 5.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 5.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 5.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 5.1 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 4.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.5 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 3.5 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 3.4 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.6 | 9.2 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 8.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 6.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.3 | 6.2 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 5.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.3 | 4.8 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 4.7 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.2 | 4.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 3.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |