ISMARA results: FOSL1

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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOSL1

Z-value: 3.75

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Transcription factors associated with FOSL1

Gene Symbol	Gene ID	Gene Info
FOSL1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000175592.4	FOS like 1, AP-1 transcription factor subunit

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOSL1	hg19_v2_chr11_-_65667884_65667895	0.94	6.5e-10	Click!

Activity profile of FOSL1 motif

Sorted Z-values of FOSL1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_95007193 Show fit	42.94	ENST00000370207.4 ENST00000334047.7	F3 Ensembl NCBI GeneCards UniProt NextProt Show fit	coagulation factor III (thromboplastin, tissue factor)
chr17_-_39769005 Show fit	39.27	ENST00000301653.4 ENST00000593067.1	KRT16 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 16
chr3_-_151034734 Show fit	38.53	ENST00000260843.4	GPR87 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 87
chr17_-_39743139 Show fit	33.59	ENST00000167586.6	KRT14 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 14
chr1_+_183155373 Show fit	32.68	ENST00000493293.1 ENST00000264144.4	LAMC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	laminin, gamma 2
chr2_+_113875466 Show fit	27.41	ENST00000361779.3 ENST00000259206.5 ENST00000354115.2	IL1RN Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 1 receptor antagonist
chr17_-_39781054 Show fit	27.09	ENST00000463128.1	KRT17 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 17
chr17_-_39780819 Show fit	26.69	ENST00000311208.8	KRT17 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 17
chr18_+_21452804 Show fit	26.09	ENST00000269217.6	LAMA3 Ensembl NCBI GeneCards UniProt NextProt Show fit	laminin, alpha 3
chr16_-_2908155 Show fit	25.62	ENST00000571228.1 ENST00000161006.3	PRSS22 Ensembl NCBI GeneCards UniProt NextProt Show fit	protease, serine, 22

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	104.5	GO:0031581	hemidesmosome assembly(GO:0031581)
2.8	98.4	GO:0061436	establishment of skin barrier(GO:0061436)
2.6	76.6	GO:0051798	positive regulation of hair follicle development(GO:0051798)
0.8	57.1	GO:0018149	peptide cross-linking(GO:0018149)
14.3	42.9	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
6.0	42.1	GO:0071461	cellular response to redox state(GO:0071461)
5.9	35.2	GO:0045110	intermediate filament bundle assembly(GO:0045110)
1.5	33.8	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
4.1	32.8	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
3.5	31.8	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)

Showing 1 to 10 of 207 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	114.1	GO:0001533	cornified envelope(GO:0001533)
0.0	69.6	GO:0005615	extracellular space(GO:0005615)
5.4	59.7	GO:0005610	laminin-5 complex(GO:0005610)
1.3	44.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.4	43.3	GO:0045178	basal part of cell(GO:0045178)
0.2	32.8	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.2	31.4	GO:0070821	tertiary granule membrane(GO:0070821)
7.5	30.0	GO:0005607	laminin-2 complex(GO:0005607)
1.5	27.0	GO:0031089	platelet dense granule lumen(GO:0031089)
0.1	26.4	GO:0005769	early endosome(GO:0005769)

Showing 1 to 10 of 105 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	124.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.7	101.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
9.8	78.5	GO:0042289	MHC class II protein binding(GO:0042289)
0.2	52.4	GO:0008201	heparin binding(GO:0008201)
0.2	50.6	GO:0030674	protein binding, bridging(GO:0030674)
3.5	42.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2	35.0	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
1.5	33.8	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2	28.9	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	27.6	GO:0003779	actin binding(GO:0003779)

Showing 1 to 10 of 147 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	136.1	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
3.6	101.8	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.9	66.6	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3	43.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	39.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	22.7	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.3	21.7	PID RAS PATHWAY	Regulation of Ras family activation
0.3	20.1	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	17.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	16.2	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms

Showing 1 to 10 of 49 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	116.4	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.2	52.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.9	42.9	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.2	25.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.2	24.5	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.6	18.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.5	14.6	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.6	14.5	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.6	13.8	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.5	13.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Showing 1 to 10 of 55 entries

Results for FOSL1

Z-value: 3.75

Motif logo

Transcription factors associated with FOSL1

Activity-expression correlation:

Activity profile of FOSL1 motif

Sorted Z-values of FOSL1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOSL1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: