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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for FOSL2_SMARCC1
Z-value: 1.55
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Transcription factors associated with FOSL2_SMARCC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000075426.7 | FOS like 2, AP-1 transcription factor subunit | |
| ENSG00000173473.6 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMARCC1 | hg19_v2_chr3_-_47823298_47823423 | 0.76 | 1.1e-04 | Click! |
| FOSL2 | hg19_v2_chr2_+_28615669_28615733 | 0.68 | 8.9e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_39769005 Show fit | 23.28 |
ENST00000301653.4
ENST00000593067.1 |
keratin 16 |
|
| chr18_+_21452804 Show fit | 18.23 |
ENST00000269217.6
|
laminin, alpha 3 |
|
| chr18_+_21452964 Show fit | 17.70 |
ENST00000587184.1
|
laminin, alpha 3 |
|
| chr2_+_113875466 Show fit | 14.34 |
ENST00000361779.3
ENST00000259206.5 ENST00000354115.2 |
interleukin 1 receptor antagonist |
|
| chr7_+_129932974 Show fit | 13.33 |
ENST00000445470.2
ENST00000222482.4 ENST00000492072.1 ENST00000473956.1 ENST00000493259.1 ENST00000486598.1 |
carboxypeptidase A4 |
|
| chr3_-_151034734 Show fit | 9.03 |
ENST00000260843.4
|
G protein-coupled receptor 87 |
|
| chr7_+_73245193 Show fit | 8.73 |
ENST00000340958.2
|
claudin 4 |
|
| chr1_-_156675368 Show fit | 8.21 |
ENST00000368222.3
|
cellular retinoic acid binding protein 2 |
|
| chr17_-_39743139 Show fit | 7.84 |
ENST00000167586.6
|
keratin 14 |
|
| chr6_-_113953705 Show fit | 7.66 |
ENST00000452675.1
|
RP11-367G18.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOSL2_SMARCC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 49.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.6 | 29.7 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 1.0 | 25.9 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.5 | 14.2 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 1.5 | 13.5 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 2.2 | 13.1 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 0.0 | 12.4 | GO:0016573 | histone acetylation(GO:0016573) |
| 0.6 | 12.1 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 1.1 | 11.7 | GO:0042904 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.6 | 11.4 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 38.5 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.3 | 21.9 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.8 | 14.2 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 14.2 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.0 | 13.4 | GO:0005769 | early endosome(GO:0005769) |
| 0.1 | 13.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 3.1 | 9.2 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.0 | 9.2 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.3 | 8.9 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.1 | 8.4 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 44.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 22.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 18.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 18.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 4.8 | 14.3 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 2.0 | 14.2 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 1.0 | 13.8 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.4 | 13.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 11.1 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 9.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 48.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 25.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 15.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 13.1 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.1 | 8.7 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 8.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 7.0 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.1 | 6.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 6.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 6.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 57.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 18.8 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.5 | 13.2 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.4 | 8.9 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.2 | 8.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.3 | 7.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 7.3 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 7.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.4 | 6.3 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.2 | 5.3 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |