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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXC1

Z-value: 0.62

Motif logo

Transcription factors associated with FOXC1

Gene Symbol Gene ID Gene Info
ENSG00000054598.5 forkhead box C1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FOXC1hg19_v2_chr6_+_1610681_16106810.464.4e-02Click!

Activity profile of FOXC1 motif

Sorted Z-values of FOXC1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_161056762 2.81 ENST00000428609.2
ENST00000409967.2
integrin, beta 6
chr2_-_161056802 2.71 ENST00000283249.2
ENST00000409872.1
integrin, beta 6
chr13_-_86373536 2.48 ENST00000400286.2
SLIT and NTRK-like family, member 6
chr4_-_102267953 2.20 ENST00000523694.2
ENST00000507176.1
protein phosphatase 3, catalytic subunit, alpha isozyme
chr3_+_189349162 2.01 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
tumor protein p63
chr11_+_34654011 1.81 ENST00000531794.1
ets homologous factor
chr14_+_37126765 1.75 ENST00000402703.2
paired box 9
chr2_+_113885138 1.70 ENST00000409930.3
interleukin 1 receptor antagonist
chr2_-_208030295 1.62 ENST00000458272.1
Kruppel-like factor 7 (ubiquitous)
chr10_+_112631699 1.43 ENST00000444997.1
programmed cell death 4 (neoplastic transformation inhibitor)
chr8_-_134309335 1.43 ENST00000522890.1
ENST00000323851.7
ENST00000518176.1
ENST00000354944.5
ENST00000537882.1
ENST00000522476.1
ENST00000518066.1
ENST00000521544.1
ENST00000518480.1
ENST00000523892.1
N-myc downstream regulated 1
chr5_-_24645078 1.37 ENST00000264463.4
cadherin 10, type 2 (T2-cadherin)
chr8_-_134309823 1.29 ENST00000414097.2
N-myc downstream regulated 1
chr6_+_18387570 1.28 ENST00000259939.3
ring finger protein 144B
chr2_-_214013353 1.23 ENST00000451136.2
ENST00000421754.2
ENST00000374327.4
ENST00000413091.3
IKAROS family zinc finger 2 (Helios)
chr4_-_102268708 1.22 ENST00000525819.1
protein phosphatase 3, catalytic subunit, alpha isozyme
chr5_+_166711804 1.19 ENST00000518659.1
ENST00000545108.1
teneurin transmembrane protein 2
chr12_-_106480587 1.11 ENST00000548902.1
NUAK family, SNF1-like kinase, 1
chr3_-_168865522 1.08 ENST00000464456.1
MDS1 and EVI1 complex locus
chr6_-_56716686 1.06 ENST00000520645.1
dystonin
chr12_-_29936731 1.04 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
transmembrane and tetratricopeptide repeat containing 1
chr21_+_39628852 1.03 ENST00000398938.2
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_+_220701456 0.98 ENST00000366918.4
ENST00000402574.1
MAP/microtubule affinity-regulating kinase 1
chr2_+_28974531 0.98 ENST00000420282.1
protein phosphatase 1, catalytic subunit, beta isozyme
chr1_-_109935819 0.95 ENST00000538502.1
sortilin 1
chr10_-_25010795 0.94 ENST00000416305.1
ENST00000376410.2
Rho GTPase activating protein 21
chr1_-_228135599 0.85 ENST00000272164.5
wingless-type MMTV integration site family, member 9A
chr18_+_21033239 0.85 ENST00000581585.1
ENST00000577501.1
RIO kinase 3
chr3_+_38032216 0.84 ENST00000416303.1
villin-like
chr4_-_74486347 0.81 ENST00000342081.3
Ras association (RalGDS/AF-6) domain family member 6
chr5_-_127674883 0.80 ENST00000507835.1
fibrillin 2
chr13_+_52598827 0.79 ENST00000521776.2
UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
chr6_+_15401075 0.77 ENST00000541660.1
jumonji, AT rich interactive domain 2
chr12_-_31479107 0.77 ENST00000542983.1
family with sequence similarity 60, member A
chr4_-_102268484 0.76 ENST00000394853.4
protein phosphatase 3, catalytic subunit, alpha isozyme
chr10_+_112631547 0.74 ENST00000280154.7
ENST00000393104.2
programmed cell death 4 (neoplastic transformation inhibitor)
chr11_-_46639436 0.74 ENST00000532281.1
harbinger transposase derived 1
chr19_-_4831701 0.73 ENST00000248244.5
toll-like receptor adaptor molecule 1
chr1_-_100231349 0.73 ENST00000287474.5
ENST00000414213.1
ferric-chelate reductase 1
chr2_+_28974489 0.72 ENST00000455580.1
protein phosphatase 1, catalytic subunit, beta isozyme
chr1_-_116383738 0.69 ENST00000320238.3
nescient helix loop helix 2
chr10_+_114710425 0.68 ENST00000352065.5
ENST00000369395.1
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr21_+_39628655 0.67 ENST00000398925.1
ENST00000398928.1
ENST00000328656.4
ENST00000443341.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr4_-_74486109 0.66 ENST00000395777.2
Ras association (RalGDS/AF-6) domain family member 6
chr5_+_40841410 0.64 ENST00000381677.3
caspase recruitment domain family, member 6
chr5_-_115872124 0.64 ENST00000515009.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr3_-_49131614 0.64 ENST00000450685.1
glutamine-rich 1
chr2_-_208030647 0.64 ENST00000309446.6
Kruppel-like factor 7 (ubiquitous)
chr11_+_10477733 0.61 ENST00000528723.1
adenosine monophosphate deaminase 3
chr3_-_71632894 0.61 ENST00000493089.1
forkhead box P1
chr22_-_38699003 0.59 ENST00000451964.1
casein kinase 1, epsilon
chr5_-_115872142 0.58 ENST00000510263.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr13_-_99667960 0.58 ENST00000448493.2
dedicator of cytokinesis 9
chr4_-_99578789 0.58 ENST00000511651.1
ENST00000505184.1
tetraspanin 5
chr20_+_9049303 0.56 ENST00000407043.2
ENST00000441846.1
phospholipase C, beta 4
chr16_+_53920795 0.56 ENST00000431610.2
ENST00000460382.1
fat mass and obesity associated
chr1_-_149982624 0.56 ENST00000417191.1
ENST00000369135.4
OTU domain containing 7B
chr17_-_48546232 0.55 ENST00000258969.4
chondroadherin
chr6_+_45296048 0.54 ENST00000465038.2
ENST00000352853.5
ENST00000541979.1
ENST00000371438.1
runt-related transcription factor 2
chr5_+_135468516 0.53 ENST00000507118.1
ENST00000511116.1
ENST00000545279.1
ENST00000545620.1
SMAD family member 5
chr1_+_39670423 0.53 ENST00000536367.1
microtubule-actin crosslinking factor 1
chr22_+_41487711 0.53 ENST00000263253.7
E1A binding protein p300
chr3_-_16524357 0.53 ENST00000432519.1
raftlin, lipid raft linker 1
chr17_+_41363854 0.52 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
transmembrane protein 106A
chr18_+_21032781 0.52 ENST00000339486.3
RIO kinase 3
chr17_-_48546324 0.51 ENST00000508540.1
chondroadherin
chr1_-_94079648 0.51 ENST00000370247.3
breast cancer anti-estrogen resistance 3
chr1_-_243349684 0.51 ENST00000522895.1
centrosomal protein 170kDa
chr12_+_27849378 0.50 ENST00000310791.2
RAB15 effector protein
chr1_-_28384598 0.50 ENST00000373864.1
eyes absent homolog 3 (Drosophila)
chr15_+_74911430 0.49 ENST00000562670.1
ENST00000564096.1
CDC-like kinase 3
chr17_+_8924837 0.49 ENST00000173229.2
netrin 1
chr9_+_127054254 0.49 ENST00000422297.1
NIMA-related kinase 6
chr8_+_120079478 0.48 ENST00000332843.2
collectin sub-family member 10 (C-type lectin)
chrX_+_105936982 0.48 ENST00000418562.1
ring finger protein 128, E3 ubiquitin protein ligase
chr1_+_61542922 0.47 ENST00000407417.3
nuclear factor I/A
chr6_+_47666275 0.46 ENST00000327753.3
ENST00000283303.2
G protein-coupled receptor 115
chr13_+_98086445 0.44 ENST00000245304.4
RAP2A, member of RAS oncogene family
chr5_-_131132658 0.44 ENST00000514667.1
ENST00000511848.1
ENST00000510461.1
Folliculin-interacting protein 1
folliculin interacting protein 1
chr2_-_207023918 0.43 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr5_+_40841276 0.43 ENST00000254691.5
caspase recruitment domain family, member 6
chr12_-_116714564 0.43 ENST00000548743.1
mediator complex subunit 13-like
chr11_-_8739566 0.43 ENST00000533020.1
suppression of tumorigenicity 5
chr3_-_187454281 0.43 ENST00000232014.4
B-cell CLL/lymphoma 6
chr2_-_207024134 0.43 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr12_-_12714025 0.42 ENST00000539940.1
dual specificity phosphatase 16
chr22_+_46449674 0.42 ENST00000381051.2
hsa-mir-4763
chr6_+_45296391 0.42 ENST00000371436.6
ENST00000576263.1
runt-related transcription factor 2
chr21_+_39628780 0.42 ENST00000417042.1
potassium inwardly-rectifying channel, subfamily J, member 15
chr5_-_36241900 0.42 ENST00000381937.4
ENST00000514504.1
NAD kinase 2, mitochondrial
chr15_-_30114622 0.42 ENST00000495972.2
ENST00000346128.6
tight junction protein 1
chr1_+_12524965 0.42 ENST00000471923.1
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr4_+_71588372 0.42 ENST00000536664.1
RUN and FYVE domain containing 3
chr6_+_108882069 0.42 ENST00000406360.1
forkhead box O3
chr19_+_52848659 0.42 ENST00000327920.8
zinc finger protein 610
chr11_+_10476851 0.41 ENST00000396553.2
adenosine monophosphate deaminase 3
chr12_+_99038919 0.41 ENST00000551964.1
apoptotic peptidase activating factor 1
chr16_+_4666475 0.41 ENST00000591895.1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr2_+_210518057 0.41 ENST00000452717.1
microtubule-associated protein 2
chr4_-_99578776 0.40 ENST00000515287.1
tetraspanin 5
chr2_+_28974603 0.40 ENST00000441461.1
ENST00000358506.2
protein phosphatase 1, catalytic subunit, beta isozyme
chr12_-_12714006 0.39 ENST00000541207.1
dual specificity phosphatase 16
chr14_-_61191049 0.38 ENST00000556952.3
SIX homeobox 4
chr14_-_89960395 0.38 ENST00000555034.1
ENST00000553904.1
forkhead box N3
chr13_-_36050819 0.37 ENST00000379919.4
mab-21-like 1 (C. elegans)
chr4_-_153303658 0.37 ENST00000296555.5
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr17_+_17685422 0.37 ENST00000395774.1
retinoic acid induced 1
chr4_-_147443043 0.37 ENST00000394059.4
ENST00000502607.1
ENST00000335472.7
ENST00000432059.2
ENST00000394062.3
solute carrier family 10, member 7
chr3_+_57875711 0.37 ENST00000442599.2
sarcolemma associated protein
chr5_-_124082279 0.37 ENST00000513986.1
zinc finger protein 608
chr4_-_102268628 0.36 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
protein phosphatase 3, catalytic subunit, alpha isozyme
chr2_+_210517895 0.36 ENST00000447185.1
microtubule-associated protein 2
chr2_-_207024233 0.35 ENST00000423725.1
ENST00000233190.6
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr10_-_104913367 0.35 ENST00000423468.2
5'-nucleotidase, cytosolic II
chr2_+_33359687 0.35 ENST00000402934.1
ENST00000404525.1
ENST00000407925.1
latent transforming growth factor beta binding protein 1
chr10_+_13652047 0.34 ENST00000601460.1
Uncharacterized protein
chr1_-_94312706 0.34 ENST00000370244.1
breast cancer anti-estrogen resistance 3
chr2_-_220042825 0.34 ENST00000409789.1
cyclin Pas1/PHO80 domain containing 1
chr1_+_43855545 0.34 ENST00000372450.4
ENST00000310739.4
seizure threshold 2 homolog (mouse)
chr15_+_96869165 0.34 ENST00000421109.2
nuclear receptor subfamily 2, group F, member 2
chr3_-_128902729 0.33 ENST00000451728.2
ENST00000446936.2
ENST00000502976.1
ENST00000500450.2
ENST00000441626.2
CCHC-type zinc finger, nucleic acid binding protein
chr9_-_89562104 0.32 ENST00000298743.7
growth arrest-specific 1
chr4_+_57774042 0.32 ENST00000309042.7
RE1-silencing transcription factor
chr9_-_136933615 0.31 ENST00000371834.2
bromodomain containing 3
chr22_-_43036607 0.31 ENST00000505920.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr2_-_8977714 0.31 ENST00000319688.5
ENST00000489024.1
ENST00000256707.3
ENST00000427284.1
ENST00000418530.1
ENST00000473731.1
kinase D-interacting substrate, 220kDa
chr1_+_155099927 0.31 ENST00000368407.3
ephrin-A1
chr2_+_172309634 0.31 ENST00000339506.3
DDB1 and CUL4 associated factor 17
chr5_-_36242119 0.31 ENST00000511088.1
ENST00000282512.3
ENST00000506945.1
NAD kinase 2, mitochondrial
chr3_-_49131788 0.30 ENST00000395443.2
ENST00000411682.1
glutamine-rich 1
chr10_+_114710516 0.30 ENST00000542695.1
ENST00000346198.4
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr16_+_67552303 0.30 ENST00000562116.1
family with sequence similarity 65, member A
chr8_+_11666649 0.29 ENST00000528643.1
ENST00000525777.1
farnesyl-diphosphate farnesyltransferase 1
chrX_-_117107680 0.29 ENST00000447671.2
ENST00000262820.3
kelch-like family member 13
chr2_+_181845532 0.29 ENST00000602475.1
ubiquitin-conjugating enzyme E2E 3
chr5_+_179135246 0.29 ENST00000508787.1
calnexin
chr3_-_133969673 0.28 ENST00000427044.2
receptor-like tyrosine kinase
chr2_+_33359646 0.28 ENST00000390003.4
ENST00000418533.2
latent transforming growth factor beta binding protein 1
chr11_-_8739383 0.28 ENST00000531060.1
suppression of tumorigenicity 5
chr6_-_52926539 0.27 ENST00000350082.5
ENST00000356971.3
intestinal cell (MAK-like) kinase
chr5_+_159614374 0.27 ENST00000393980.4
fatty acid binding protein 6, ileal
chr19_-_13900972 0.26 ENST00000397557.1
Uncharacterized protein
chr1_+_174846570 0.26 ENST00000392064.2
RAB GTPase activating protein 1-like
chr2_+_28974668 0.26 ENST00000296122.6
ENST00000395366.2
protein phosphatase 1, catalytic subunit, beta isozyme
chr12_+_93096759 0.26 ENST00000544406.2
chromosome 12 open reading frame 74
chr11_+_27076764 0.26 ENST00000525090.1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr12_-_122018114 0.25 ENST00000539394.1
lysine (K)-specific demethylase 2B
chr9_+_127054217 0.25 ENST00000394199.2
ENST00000546191.1
NIMA-related kinase 6
chr1_+_39670360 0.24 ENST00000494012.1
microtubule-actin crosslinking factor 1
chr5_-_39424961 0.24 ENST00000503513.1
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr1_+_43855560 0.24 ENST00000562955.1
seizure threshold 2 homolog (mouse)
chr3_-_195310802 0.24 ENST00000421243.1
ENST00000453131.1
apolipoprotein D
chr19_+_3880581 0.24 ENST00000450849.2
ENST00000301260.6
ENST00000398448.3
ataxia, cerebellar, Cayman type
chr4_-_186696425 0.24 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
sorbin and SH3 domain containing 2
chr6_-_42418999 0.23 ENST00000340840.2
ENST00000354325.2
transcriptional regulating factor 1
chr3_+_57875738 0.23 ENST00000417128.1
ENST00000438794.1
sarcolemma associated protein
chr8_-_116673894 0.23 ENST00000395713.2
trichorhinophalangeal syndrome I
chr8_-_114449112 0.23 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CUB and Sushi multiple domains 3
chr3_-_128902759 0.23 ENST00000422453.2
ENST00000504813.1
ENST00000512338.1
CCHC-type zinc finger, nucleic acid binding protein
chr7_+_151038850 0.23 ENST00000355851.4
ENST00000566856.1
ENST00000470229.1
negative regulator of ubiquitin-like proteins 1
chr5_+_176692466 0.22 ENST00000508029.1
ENST00000503056.1
nuclear receptor binding SET domain protein 1
chr7_-_139876734 0.22 ENST00000006967.5
lysine (K)-specific demethylase 7A
chr12_+_93115281 0.22 ENST00000549856.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr8_-_71157595 0.22 ENST00000519724.1
nuclear receptor coactivator 2
chr12_-_53994805 0.22 ENST00000328463.7
activating transcription factor 7
chr3_-_141868357 0.22 ENST00000489671.1
ENST00000475734.1
ENST00000467072.1
ENST00000499676.2
transcription factor Dp-2 (E2F dimerization partner 2)
chr4_+_71587669 0.21 ENST00000381006.3
ENST00000226328.4
RUN and FYVE domain containing 3
chr12_+_10365082 0.21 ENST00000545859.1
GABA(A) receptor-associated protein like 1
chr20_+_44509857 0.21 ENST00000372523.1
ENST00000372520.1
zinc finger, SWIM-type containing 1
chr12_+_10365404 0.21 ENST00000266458.5
ENST00000421801.2
ENST00000544284.1
ENST00000545047.1
ENST00000543602.1
ENST00000545887.1
GABA(A) receptor-associated protein like 1
chr2_+_33359473 0.21 ENST00000432635.1
latent transforming growth factor beta binding protein 1
chr7_-_139477500 0.21 ENST00000406875.3
ENST00000428878.2
homeodomain interacting protein kinase 2
chr4_+_28437071 0.20 ENST00000509416.1
RP11-123O22.1
chrX_+_22050546 0.20 ENST00000379374.4
phosphate regulating endopeptidase homolog, X-linked
chr18_+_32073253 0.19 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
dystrobrevin, alpha
chr4_-_83765613 0.19 ENST00000503937.1
SEC31 homolog A (S. cerevisiae)
chr3_-_141868293 0.18 ENST00000317104.7
ENST00000494358.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_+_93096619 0.18 ENST00000397833.3
chromosome 12 open reading frame 74
chr8_-_141931287 0.18 ENST00000517887.1
protein tyrosine kinase 2
chr2_+_181845763 0.18 ENST00000602499.1
ubiquitin-conjugating enzyme E2E 3
chr3_-_24207039 0.17 ENST00000280696.5
thyroid hormone receptor, beta
chr2_-_207078154 0.17 ENST00000447845.1
G protein-coupled receptor 1
chr12_-_49453557 0.17 ENST00000547610.1
lysine (K)-specific methyltransferase 2D
chr1_+_22778337 0.17 ENST00000404138.1
ENST00000400239.2
ENST00000375647.4
ENST00000374651.4
zinc finger and BTB domain containing 40
chr6_-_134639042 0.17 ENST00000461976.2
serum/glucocorticoid regulated kinase 1
chr5_-_39425222 0.17 ENST00000320816.6
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr20_+_58203664 0.17 ENST00000541461.1
phosphatase and actin regulator 3
chr7_+_151038785 0.16 ENST00000413040.2
ENST00000568733.1
negative regulator of ubiquitin-like proteins 1
chr3_-_15382875 0.16 ENST00000408919.3
SH3-domain binding protein 5 (BTK-associated)
chr3_-_134092561 0.16 ENST00000510560.1
ENST00000504234.1
ENST00000515172.1
angiomotin like 2
chr9_+_71944241 0.16 ENST00000257515.8
family with sequence similarity 189, member A2
chr10_+_114710211 0.16 ENST00000349937.2
ENST00000369397.4
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr8_-_23261589 0.16 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
lysyl oxidase-like 2
chr18_-_53070913 0.16 ENST00000568186.1
ENST00000564228.1
transcription factor 4
chr5_+_65222500 0.16 ENST00000511297.1
ENST00000506030.1
erbb2 interacting protein
chrX_-_117107542 0.16 ENST00000371878.1
kelch-like family member 13
chr11_-_108464465 0.16 ENST00000525344.1
exophilin 5
chr17_+_71229346 0.15 ENST00000535032.2
ENST00000582793.1
chromosome 17 open reading frame 80
chr18_+_19749386 0.15 ENST00000269216.3
GATA binding protein 6
chr1_-_153931052 0.15 ENST00000368630.3
ENST00000368633.1
CREB regulated transcription coactivator 2

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.7 2.2 GO:1904761 negative regulation of myofibroblast differentiation(GO:1904761)
0.5 5.5 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.5 2.0 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.4 2.5 GO:0060005 vestibular reflex(GO:0060005)
0.3 1.4 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.3 1.1 GO:1900154 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
0.2 2.7 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.2 0.8 GO:0045208 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.2 1.7 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 0.6 GO:0042245 RNA repair(GO:0042245)
0.1 1.6 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 1.0 GO:0006196 AMP catabolic process(GO:0006196)
0.1 1.2 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 0.3 GO:0036518 chemorepulsion of dopaminergic neuron axon(GO:0036518)
0.1 0.4 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 0.9 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.5 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 2.4 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 1.5 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.4 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.1 0.4 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1 0.3 GO:2000705 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.4 GO:1901350 cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.1 0.6 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.1 0.6 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.1 0.9 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 1.1 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 0.7 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.3 GO:0009956 radial pattern formation(GO:0009956)
0.1 0.6 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 0.3 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.1 0.6 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.4 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.2 GO:1904017 cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.1 0.7 GO:0045359 positive regulation of chemokine biosynthetic process(GO:0045080) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1 0.6 GO:1902510 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) regulation of apoptotic DNA fragmentation(GO:1902510)
0.1 1.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 0.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 0.2 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.2 GO:0045763 negative regulation of cellular amino acid metabolic process(GO:0045763)
0.1 0.3 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.1 0.3 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.1 1.2 GO:0097264 self proteolysis(GO:0097264)
0.1 0.8 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.1 0.2 GO:0007493 endodermal cell fate determination(GO:0007493)
0.0 1.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.2 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0 0.3 GO:0035026 leading edge cell differentiation(GO:0035026)
0.0 0.3 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) notochord formation(GO:0014028)
0.0 0.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0045081 negative regulation of interleukin-10 biosynthetic process(GO:0045081)
0.0 0.2 GO:0018277 protein deamination(GO:0018277)
0.0 0.4 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0 0.8 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.2 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.2 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.1 GO:0036451 cap mRNA methylation(GO:0036451)
0.0 0.5 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 2.1 GO:0010107 potassium ion import(GO:0010107)
0.0 0.2 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.9 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.4 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.2 GO:0001555 oocyte growth(GO:0001555)
0.0 0.2 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.1 GO:1902896 terminal web assembly(GO:1902896)
0.0 1.1 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.4 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.7 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.9 GO:0042481 regulation of odontogenesis(GO:0042481)
0.0 0.2 GO:0051832 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) negative regulation of lung blood pressure(GO:0061767)
0.0 1.0 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.4 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 0.3 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.0 0.1 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.0 0.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.4 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.2 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.1 GO:0002249 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 0.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.0 0.8 GO:2000772 regulation of cellular senescence(GO:2000772)
0.0 1.2 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.4 GO:0072189 ureter development(GO:0072189)
0.0 0.2 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.9 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.6 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.2 GO:0050773 regulation of dendrite development(GO:0050773)
0.0 0.8 GO:0051693 actin filament capping(GO:0051693)
0.0 0.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.2 GO:0070836 caveola assembly(GO:0070836)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 2.0 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.3 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.5 4.5 GO:0005955 calcineurin complex(GO:0005955)
0.2 1.2 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.2 1.1 GO:0031673 H zone(GO:0031673)
0.2 2.4 GO:0042587 glycogen granule(GO:0042587)
0.1 1.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.6 GO:0043293 apoptosome(GO:0043293)
0.1 1.4 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.6 GO:1990130 Iml1 complex(GO:1990130)
0.1 1.7 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.7 GO:0097342 ripoptosome(GO:0097342)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 1.5 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.7 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.8 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 2.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.6 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.2 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.5 GO:0005921 gap junction(GO:0005921)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.4 GO:0032839 dendrite cytoplasm(GO:0032839)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.5 2.4 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.3 4.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 0.9 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.6 GO:0035514 DNA demethylase activity(GO:0035514)
0.1 0.8 GO:0050436 microfibril binding(GO:0050436)
0.1 2.0 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 0.7 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 0.4 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.1 1.0 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 1.4 GO:0089720 caspase binding(GO:0089720)
0.1 2.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.8 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 0.3 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.1 0.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.3 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 0.4 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 2.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.2 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 1.2 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0030375 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.0 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 5.4 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.7 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.0 0.2 GO:0046790 virion binding(GO:0046790)
0.0 1.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.5 GO:0005537 mannose binding(GO:0005537)
0.0 0.8 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0031862 prostanoid receptor binding(GO:0031862)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.6 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.4 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 1.0 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 1.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 1.0 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.7 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 1.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.3 GO:0032052 bile acid binding(GO:0032052)
0.0 0.3 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.4 GO:0035326 enhancer binding(GO:0035326)
0.0 0.3 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.4 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 1.1 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 4.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 2.1 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 3.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.5 PID ALK2 PATHWAY ALK2 signaling events
0.0 2.4 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.5 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.1 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.1 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.4 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.7 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 1.2 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 2.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 2.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.0 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 5.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.5 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.6 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 1.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation