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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Z-value: 1.23
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Transcription factors associated with FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000251493.2 | forkhead box D1 | |
| ENSG00000150907.6 | forkhead box O1 | |
| ENSG00000204060.4 | forkhead box O6 | |
| ENSG00000176165.7 | forkhead box G1 | |
| ENSG00000114861.14 | forkhead box P1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXP1 | hg19_v2_chr3_-_71114066_71114114 | 0.90 | 8.5e-08 | Click! |
| FOXO1 | hg19_v2_chr13_-_41240717_41240735 | 0.74 | 1.9e-04 | Click! |
| FOXO6 | hg19_v2_chr1_+_41827594_41827594 | -0.70 | 5.3e-04 | Click! |
| FOXG1 | hg19_v2_chr14_+_29234870_29235050 | 0.12 | 6.2e-01 | Click! |
| FOXD1 | hg19_v2_chr5_-_72744336_72744359 | -0.01 | 9.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_75668916 Show fit | 6.72 |
ENST00000481390.1
|
plasminogen activator, urokinase |
|
| chr1_+_145438469 Show fit | 6.72 |
ENST00000369317.4
|
thioredoxin interacting protein |
|
| chr1_-_27816556 Show fit | 6.24 |
ENST00000536657.1
|
WAS protein family, member 2 |
|
| chr12_+_13349650 Show fit | 5.93 |
ENST00000256951.5
ENST00000431267.2 ENST00000542474.1 ENST00000544053.1 |
epithelial membrane protein 1 |
|
| chr22_-_31688381 Show fit | 5.27 |
ENST00000487265.2
|
phosphoinositide-3-kinase interacting protein 1 |
|
| chr17_+_26662679 Show fit | 4.94 |
ENST00000578158.1
|
tumor necrosis factor, alpha-induced protein 1 (endothelial) |
|
| chr12_+_13349711 Show fit | 4.65 |
ENST00000538364.1
ENST00000396301.3 |
epithelial membrane protein 1 |
|
| chr1_-_161337662 Show fit | 4.54 |
ENST00000367974.1
|
chromosome 1 open reading frame 192 |
|
| chr16_-_84150410 Show fit | 4.52 |
ENST00000569907.1
|
membrane-bound transcription factor peptidase, site 1 |
|
| chr12_-_116714564 Show fit | 4.46 |
ENST00000548743.1
|
mediator complex subunit 13-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD1_FOXO1_FOXO6_FOXG1_FOXP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.7 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 1.9 | 11.4 | GO:0032625 | interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619) |
| 0.3 | 10.1 | GO:0032060 | bleb assembly(GO:0032060) |
| 1.8 | 9.2 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 1.8 | 9.2 | GO:0042539 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 0.3 | 8.6 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 1.1 | 8.0 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 0.6 | 7.9 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 1.0 | 7.8 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
| 0.2 | 7.6 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.6 | GO:0030478 | actin cap(GO:0030478) |
| 0.5 | 8.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.8 | 7.9 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.1 | 7.6 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.2 | 7.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 6.3 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 6.0 | GO:0005795 | Golgi stack(GO:0005795) |
| 1.0 | 5.8 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 5.6 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.2 | 5.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.9 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 15.3 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.2 | 14.5 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 14.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 10.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 9.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 9.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 3.1 | 9.2 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.7 | 9.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 8.7 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 11.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 11.8 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 11.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 11.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 7.6 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.2 | 7.5 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 4.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 4.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 4.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.1 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.1 | 9.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 7.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.3 | 7.0 | REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
| 0.1 | 6.8 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 6.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 6.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 6.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 6.1 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 5.8 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |