ISMARA results: FOXO3

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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for FOXO3_FOXD2

Z-value: 0.81

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Transcription factors associated with FOXO3_FOXD2

Gene Symbol	Gene ID	Gene Info
FOXO3 Ensembl NCBI GeneCards UniProt	ENSG00000118689.10	forkhead box O3
FOXD2 Ensembl NCBI GeneCards UniProt	ENSG00000186564.5	forkhead box D2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FOXD2	hg19_v2_chr1_+_47901689_47901689	0.48	3.4e-02	Click!
FOXO3	hg19_v2_chr6_+_108977520_108977549	0.35	1.3e-01	Click!

Activity profile of FOXO3_FOXD2 motif

Sorted Z-values of FOXO3_FOXD2 motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_9745786 Show fit	4.86	ENST00000304773.5	GLP2R Ensembl NCBI GeneCards UniProt Show fit	glucagon-like peptide 2 receptor
chr13_-_67802549 Show fit	4.16	ENST00000328454.5 ENST00000377865.2	PCDH9 Ensembl NCBI GeneCards UniProt Show fit	protocadherin 9
chr3_+_172468749 Show fit	3.02	ENST00000366254.2 ENST00000415665.1 ENST00000438041.1	ECT2 Ensembl NCBI GeneCards UniProt Show fit	epithelial cell transforming sequence 2 oncogene
chr8_+_31497271 Show fit	3.00	ENST00000520407.1	NRG1 Ensembl NCBI GeneCards UniProt Show fit	neuregulin 1
chr3_+_172468505 Show fit	2.34	ENST00000427830.1 ENST00000417960.1 ENST00000428567.1 ENST00000366090.2 ENST00000426894.1	ECT2 Ensembl NCBI GeneCards UniProt Show fit	epithelial cell transforming sequence 2 oncogene
chr1_+_200011711 Show fit	2.32	ENST00000544748.1	NR5A2 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor subfamily 5, group A, member 2
chr11_+_1151573 Show fit	2.26	ENST00000534821.1 ENST00000356191.2	MUC5AC Ensembl NCBI GeneCards UniProt Show fit	mucin 5AC, oligomeric mucus/gel-forming
chr3_+_172468472 Show fit	2.23	ENST00000232458.5 ENST00000392692.3	ECT2 Ensembl NCBI GeneCards UniProt Show fit	epithelial cell transforming sequence 2 oncogene
chr7_-_99698338 Show fit	2.08	ENST00000354230.3 ENST00000425308.1	MCM7 Ensembl NCBI GeneCards UniProt Show fit	minichromosome maintenance complex component 7
chr19_+_41725140 Show fit	2.06	ENST00000359092.3	AXL Ensembl NCBI GeneCards UniProt Show fit	AXL receptor tyrosine kinase
chr10_+_31610064 Show fit	2.05	ENST00000446923.2 ENST00000559476.1	ZEB1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger E-box binding homeobox 1
chr9_+_118916082 Show fit	1.89	ENST00000328252.3	PAPPA Ensembl NCBI GeneCards UniProt Show fit	pregnancy-associated plasma protein A, pappalysin 1
chr11_-_115375107 Show fit	1.86	ENST00000545380.1 ENST00000452722.3 ENST00000537058.1 ENST00000536727.1 ENST00000542447.2 ENST00000331581.6	CADM1 Ensembl NCBI GeneCards UniProt Show fit	cell adhesion molecule 1
chr1_+_120839412 Show fit	1.86	ENST00000355228.4	FAM72B Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 72, member B
chr4_-_141075330 Show fit	1.85	ENST00000509479.2	MAML3 Ensembl NCBI GeneCards UniProt Show fit	mastermind-like 3 (Drosophila)
chr5_-_137674000 Show fit	1.75	ENST00000510119.1 ENST00000513970.1	CDC25C Ensembl NCBI GeneCards UniProt Show fit	cell division cycle 25C
chr8_-_117886563 Show fit	1.74	ENST00000519837.1 ENST00000522699.1	RAD21 Ensembl NCBI GeneCards UniProt Show fit	RAD21 homolog (S. pombe)
chr1_+_84630574 Show fit	1.72	ENST00000413538.1 ENST00000417530.1	PRKACB Ensembl NCBI GeneCards UniProt Show fit	protein kinase, cAMP-dependent, catalytic, beta
chr2_+_74120094 Show fit	1.67	ENST00000409731.3 ENST00000345517.3 ENST00000409918.1 ENST00000442912.1 ENST00000409624.1	ACTG2 Ensembl NCBI GeneCards UniProt Show fit	actin, gamma 2, smooth muscle, enteric
chr8_-_117886732 Show fit	1.65	ENST00000517485.1	RAD21 Ensembl NCBI GeneCards UniProt Show fit	RAD21 homolog (S. pombe)
chr8_-_117886612 Show fit	1.59	ENST00000520992.1	RAD21 Ensembl NCBI GeneCards UniProt Show fit	RAD21 homolog (S. pombe)
chr6_-_127780510 Show fit	1.59	ENST00000487331.2 ENST00000483725.3	KIAA0408 Ensembl NCBI GeneCards UniProt Show fit	KIAA0408
chr16_-_57832004 Show fit	1.57	ENST00000562503.1	KIFC3 Ensembl NCBI GeneCards UniProt Show fit	kinesin family member C3
chr12_-_102591604 Show fit	1.56	ENST00000329406.4	PMCH Ensembl NCBI GeneCards UniProt Show fit	pro-melanin-concentrating hormone
chr2_-_190044480 Show fit	1.55	ENST00000374866.3	COL5A2 Ensembl NCBI GeneCards UniProt Show fit	collagen, type V, alpha 2
chr2_-_27434756 Show fit	1.55	ENST00000426119.1 ENST00000412471.1	SLC5A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr15_+_80733570 Show fit	1.55	ENST00000533983.1 ENST00000527771.1 ENST00000525103.1	ARNT2 Ensembl NCBI GeneCards UniProt Show fit	aryl-hydrocarbon receptor nuclear translocator 2
chr1_+_66796401 Show fit	1.51	ENST00000528771.1	PDE4B Ensembl NCBI GeneCards UniProt Show fit	phosphodiesterase 4B, cAMP-specific
chr18_-_2982869 Show fit	1.51	ENST00000584915.1	LPIN2 Ensembl NCBI GeneCards UniProt Show fit	lipin 2
chr14_-_23288930 Show fit	1.49	ENST00000554517.1 ENST00000285850.7 ENST00000397529.2 ENST00000555702.1	SLC7A7 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr2_-_27434635 Show fit	1.47	ENST00000401463.1	SLC5A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr17_+_67410832 Show fit	1.45	ENST00000590474.1	MAP2K6 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase 6
chr2_-_27434611 Show fit	1.45	ENST00000408041.1	SLC5A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr6_+_62284008 Show fit	1.44	ENST00000544932.1	MTRNR2L9 Ensembl NCBI GeneCards UniProt Show fit	MT-RNR2-like 9 (pseudogene)
chr8_+_31496809 Show fit	1.39	ENST00000518104.1 ENST00000519301.1	NRG1 Ensembl NCBI GeneCards UniProt Show fit	neuregulin 1
chr12_-_15865844 Show fit	1.38	ENST00000543612.1	EPS8 Ensembl NCBI GeneCards UniProt Show fit	epidermal growth factor receptor pathway substrate 8
chr2_+_196521903 Show fit	1.36	ENST00000541054.1	SLC39A10 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 39 (zinc transporter), member 10
chr12_-_116714564 Show fit	1.31	ENST00000548743.1	MED13L Ensembl NCBI GeneCards UniProt Show fit	mediator complex subunit 13-like
chr6_-_42016385 Show fit	1.26	ENST00000502771.1 ENST00000508143.1 ENST00000514588.1 ENST00000510503.1 ENST00000415497.2 ENST00000372988.4	CCND3 Ensembl NCBI GeneCards UniProt Show fit	cyclin D3
chr5_+_133859996 Show fit	1.26	ENST00000512386.1	PHF15 Ensembl NCBI GeneCards UniProt Show fit	jade family PHD finger 2
chrX_+_9431324 Show fit	1.26	ENST00000407597.2 ENST00000424279.1 ENST00000536365.1 ENST00000441088.1 ENST00000380961.1 ENST00000415293.1	TBL1X Ensembl NCBI GeneCards UniProt Show fit	transducin (beta)-like 1X-linked
chr8_-_40755333 Show fit	1.26	ENST00000297737.6 ENST00000315769.7	ZMAT4 Ensembl NCBI GeneCards UniProt Show fit	zinc finger, matrin-type 4
chr1_+_199996733 Show fit	1.21	ENST00000236914.3	NR5A2 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor subfamily 5, group A, member 2
chr14_+_74551650 Show fit	1.20	ENST00000554938.1	LIN52 Ensembl NCBI GeneCards UniProt Show fit	lin-52 homolog (C. elegans)
chr15_-_70994612 Show fit	1.19	ENST00000558758.1 ENST00000379983.2 ENST00000560441.1	UACA Ensembl NCBI GeneCards UniProt Show fit	uveal autoantigen with coiled-coil domains and ankyrin repeats
chrX_-_19688475 Show fit	1.18	ENST00000541422.1	SH3KBP1 Ensembl NCBI GeneCards UniProt Show fit	SH3-domain kinase binding protein 1
chr18_+_3449330 Show fit	1.16	ENST00000549253.1	TGIF1 Ensembl NCBI GeneCards UniProt Show fit	TGFB-induced factor homeobox 1
chr16_-_57831676 Show fit	1.14	ENST00000465878.2 ENST00000539578.1 ENST00000561524.1	KIFC3 Ensembl NCBI GeneCards UniProt Show fit	kinesin family member C3
chr5_-_142783175 Show fit	1.14	ENST00000231509.3 ENST00000394464.2	NR3C1 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr6_-_108278456 Show fit	1.13	ENST00000429168.1	SEC63 Ensembl NCBI GeneCards UniProt Show fit	SEC63 homolog (S. cerevisiae)
chr4_-_139163491 Show fit	1.11	ENST00000280612.5	SLC7A11 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr6_-_136847610 Show fit	1.10	ENST00000454590.1 ENST00000432797.2	MAP7 Ensembl NCBI GeneCards UniProt Show fit	microtubule-associated protein 7
chr12_+_96588279 Show fit	1.10	ENST00000552142.1	ELK3 Ensembl NCBI GeneCards UniProt Show fit	ELK3, ETS-domain protein (SRF accessory protein 2)
chr1_+_84630645 Show fit	1.09	ENST00000394839.2	PRKACB Ensembl NCBI GeneCards UniProt Show fit	protein kinase, cAMP-dependent, catalytic, beta
chr9_+_137987825 Show fit	1.08	ENST00000545657.1	OLFM1 Ensembl NCBI GeneCards UniProt Show fit	olfactomedin 1
chr8_+_71485681 Show fit	1.06	ENST00000391684.1	AC120194.1 Ensembl NCBI GeneCards UniProt Show fit	AC120194.1
chr2_+_196521845 Show fit	1.06	ENST00000359634.5 ENST00000412905.1	SLC39A10 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 39 (zinc transporter), member 10
chr8_-_80993010 Show fit	1.05	ENST00000537855.1 ENST00000520527.1 ENST00000517427.1 ENST00000448733.2 ENST00000379097.3	TPD52 Ensembl NCBI GeneCards UniProt Show fit	tumor protein D52
chr1_+_198126093 Show fit	1.04	ENST00000367385.4 ENST00000442588.1 ENST00000538004.1	NEK7 Ensembl NCBI GeneCards UniProt Show fit	NIMA-related kinase 7
chr7_+_134832808 Show fit	1.04	ENST00000275767.3	TMEM140 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 140
chr10_+_95848824 Show fit	1.03	ENST00000371385.3 ENST00000371375.1	PLCE1 Ensembl NCBI GeneCards UniProt Show fit	phospholipase C, epsilon 1
chr2_+_189157536 Show fit	1.03	ENST00000409580.1 ENST00000409637.3	GULP1 Ensembl NCBI GeneCards UniProt Show fit	GULP, engulfment adaptor PTB domain containing 1
chr17_-_64225508 Show fit	1.03	ENST00000205948.6	APOH Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein H (beta-2-glycoprotein I)
chr17_+_73455788 Show fit	1.03	ENST00000581519.1	KIAA0195 Ensembl NCBI GeneCards UniProt Show fit	KIAA0195
chr7_+_77469439 Show fit	1.01	ENST00000450574.1 ENST00000416283.2 ENST00000248550.7	PHTF2 Ensembl NCBI GeneCards UniProt Show fit	putative homeodomain transcription factor 2
chr2_+_196440692 Show fit	1.01	ENST00000458054.1	SLC39A10 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 39 (zinc transporter), member 10
chr8_-_117886955 Show fit	1.00	ENST00000297338.2	RAD21 Ensembl NCBI GeneCards UniProt Show fit	RAD21 homolog (S. pombe)
chr18_-_25616519 Show fit	1.00	ENST00000399380.3	CDH2 Ensembl NCBI GeneCards UniProt Show fit	cadherin 2, type 1, N-cadherin (neuronal)
chr2_+_196522032 Show fit	0.99	ENST00000418005.1	SLC39A10 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 39 (zinc transporter), member 10
chr12_-_53343560 Show fit	0.99	ENST00000548998.1	KRT8 Ensembl NCBI GeneCards UniProt Show fit	keratin 8
chr2_-_26205550 Show fit	0.99	ENST00000405914.1	KIF3C Ensembl NCBI GeneCards UniProt Show fit	kinesin family member 3C
chr19_+_41768561 Show fit	0.98	ENST00000599719.1 ENST00000601309.1	HNRNPUL1 Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein U-like 1
chr2_+_172950227 Show fit	0.97	ENST00000341900.6	DLX1 Ensembl NCBI GeneCards UniProt Show fit	distal-less homeobox 1
chr2_+_152266392 Show fit	0.96	ENST00000444746.2 ENST00000453091.2 ENST00000428287.2 ENST00000433166.2 ENST00000420714.3 ENST00000243326.5 ENST00000414861.2	RIF1 Ensembl NCBI GeneCards UniProt Show fit	RAP1 interacting factor homolog (yeast)
chr1_-_246729544 Show fit	0.96	ENST00000544618.1 ENST00000366514.4	TFB2M Ensembl NCBI GeneCards UniProt Show fit	transcription factor B2, mitochondrial
chr17_+_72426891 Show fit	0.96	ENST00000392627.1	GPRC5C Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor, family C, group 5, member C
chr3_+_69985734 Show fit	0.95	ENST00000314557.6 ENST00000394351.3	MITF Ensembl NCBI GeneCards UniProt Show fit	microphthalmia-associated transcription factor
chr2_+_198380763 Show fit	0.95	ENST00000448447.2 ENST00000409360.1	MOB4 Ensembl NCBI GeneCards UniProt Show fit	MOB family member 4, phocein
chr4_-_111120334 Show fit	0.95	ENST00000503885.1	ELOVL6 Ensembl NCBI GeneCards UniProt Show fit	ELOVL fatty acid elongase 6
chr5_+_175288631 Show fit	0.95	ENST00000509837.1	CPLX2 Ensembl NCBI GeneCards UniProt Show fit	complexin 2
chr6_-_152623231 Show fit	0.94	ENST00000540663.1 ENST00000537033.1	SYNE1 Ensembl NCBI GeneCards UniProt Show fit	spectrin repeat containing, nuclear envelope 1
chr16_-_57831914 Show fit	0.93	ENST00000421376.2	KIFC3 Ensembl NCBI GeneCards UniProt Show fit	kinesin family member C3
chr3_-_33700589 Show fit	0.92	ENST00000461133.3 ENST00000496954.2	CLASP2 Ensembl NCBI GeneCards UniProt Show fit	cytoplasmic linker associated protein 2
chr14_-_102605983 Show fit	0.91	ENST00000334701.7	HSP90AA1 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein 90kDa alpha (cytosolic), class A member 1
chr1_+_84630053 Show fit	0.91	ENST00000394838.2 ENST00000370682.3 ENST00000432111.1	PRKACB Ensembl NCBI GeneCards UniProt Show fit	protein kinase, cAMP-dependent, catalytic, beta
chr17_+_57642886 Show fit	0.91	ENST00000251241.4 ENST00000451169.2 ENST00000425628.3 ENST00000584385.1 ENST00000580030.1	DHX40 Ensembl NCBI GeneCards UniProt Show fit	DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr5_-_16742330 Show fit	0.90	ENST00000505695.1 ENST00000427430.2	MYO10 Ensembl NCBI GeneCards UniProt Show fit	myosin X
chr6_-_136847099 Show fit	0.90	ENST00000438100.2	MAP7 Ensembl NCBI GeneCards UniProt Show fit	microtubule-associated protein 7
chr8_+_26150628 Show fit	0.90	ENST00000523925.1 ENST00000315985.7	PPP2R2A Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 2, regulatory subunit B, alpha
chr2_+_152266604 Show fit	0.89	ENST00000430328.2	RIF1 Ensembl NCBI GeneCards UniProt Show fit	RAP1 interacting factor homolog (yeast)
chr2_-_240230890 Show fit	0.89	ENST00000446876.1	HDAC4 Ensembl NCBI GeneCards UniProt Show fit	histone deacetylase 4
chr10_-_94301107 Show fit	0.89	ENST00000436178.1	IDE Ensembl NCBI GeneCards UniProt Show fit	insulin-degrading enzyme
chrX_+_106163626 Show fit	0.88	ENST00000336803.1	CLDN2 Ensembl NCBI GeneCards UniProt Show fit	claudin 2
chr2_+_109223595 Show fit	0.88	ENST00000410093.1	LIMS1 Ensembl NCBI GeneCards UniProt Show fit	LIM and senescent cell antigen-like domains 1
chr17_-_1418972 Show fit	0.88	ENST00000571274.1	INPP5K Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate-5-phosphatase K
chr1_+_84629976 Show fit	0.88	ENST00000446538.1 ENST00000370684.1 ENST00000436133.1	PRKACB Ensembl NCBI GeneCards UniProt Show fit	protein kinase, cAMP-dependent, catalytic, beta
chr12_-_53343633 Show fit	0.87	ENST00000546826.1	KRT8 Ensembl NCBI GeneCards UniProt Show fit	keratin 8
chr5_-_146833485 Show fit	0.86	ENST00000398514.3	DPYSL3 Ensembl NCBI GeneCards UniProt Show fit	dihydropyrimidinase-like 3
chr7_-_27213893 Show fit	0.86	ENST00000283921.4	HOXA10 Ensembl NCBI GeneCards UniProt Show fit	homeobox A10
chr7_-_95225768 Show fit	0.86	ENST00000005178.5	PDK4 Ensembl NCBI GeneCards UniProt Show fit	pyruvate dehydrogenase kinase, isozyme 4
chr1_+_206138884 Show fit	0.86	ENST00000341209.5 ENST00000607379.1	FAM72A Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 72, member A
chr2_+_44396000 Show fit	0.85	ENST00000409895.4 ENST00000409432.3 ENST00000282412.4 ENST00000378551.2 ENST00000345249.4	PPM1B Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr4_+_95174445 Show fit	0.85	ENST00000509418.1	SMARCAD1 Ensembl NCBI GeneCards UniProt Show fit	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr3_-_185826718 Show fit	0.84	ENST00000413301.1 ENST00000421809.1	ETV5 Ensembl NCBI GeneCards UniProt Show fit	ets variant 5
chr6_+_12290586 Show fit	0.84	ENST00000379375.5	EDN1 Ensembl NCBI GeneCards UniProt Show fit	endothelin 1
chr5_-_64920115 Show fit	0.84	ENST00000381018.3 ENST00000274327.7	TRIM23 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 23
chr16_-_84150410 Show fit	0.82	ENST00000569907.1	MBTPS1 Ensembl NCBI GeneCards UniProt Show fit	membrane-bound transcription factor peptidase, site 1
chr17_-_38721711 Show fit	0.82	ENST00000578085.1 ENST00000246657.2	CCR7 Ensembl NCBI GeneCards UniProt Show fit	chemokine (C-C motif) receptor 7
chr2_+_161993465 Show fit	0.82	ENST00000457476.1	TANK Ensembl NCBI GeneCards UniProt Show fit	TRAF family member-associated NFKB activator
chr2_+_28974489 Show fit	0.80	ENST00000455580.1	PPP1CB Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 1, catalytic subunit, beta isozyme
chr10_-_98347063 Show fit	0.80	ENST00000443638.1	TM9SF3 Ensembl NCBI GeneCards UniProt Show fit	transmembrane 9 superfamily member 3
chr3_-_123512688 Show fit	0.79	ENST00000475616.1	MYLK Ensembl NCBI GeneCards UniProt Show fit	myosin light chain kinase
chr8_-_29208183 Show fit	0.78	ENST00000240100.2	DUSP4 Ensembl NCBI GeneCards UniProt Show fit	dual specificity phosphatase 4
chr12_-_53343602 Show fit	0.78	ENST00000546897.1 ENST00000552551.1	KRT8 Ensembl NCBI GeneCards UniProt Show fit	keratin 8
chr15_+_41549105 Show fit	0.78	ENST00000560965.1	CHP1 Ensembl NCBI GeneCards UniProt Show fit	calcineurin-like EF-hand protein 1
chr2_+_197577841 Show fit	0.78	ENST00000409270.1	CCDC150 Ensembl NCBI GeneCards UniProt Show fit	coiled-coil domain containing 150
chr16_+_56782118 Show fit	0.78	ENST00000566678.1	NUP93 Ensembl NCBI GeneCards UniProt Show fit	nucleoporin 93kDa
chr2_+_189157498 Show fit	0.77	ENST00000359135.3	GULP1 Ensembl NCBI GeneCards UniProt Show fit	GULP, engulfment adaptor PTB domain containing 1
chrX_-_20237059 Show fit	0.77	ENST00000457145.1	RPS6KA3 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr5_+_140186647 Show fit	0.77	ENST00000512229.2 ENST00000356878.4 ENST00000530339.1	PCDHA4 Ensembl NCBI GeneCards UniProt Show fit	protocadherin alpha 4
chr14_+_58894404 Show fit	0.77	ENST00000554463.1 ENST00000555833.1	KIAA0586 Ensembl NCBI GeneCards UniProt Show fit	KIAA0586
chr16_-_84150392 Show fit	0.76	ENST00000570012.1	MBTPS1 Ensembl NCBI GeneCards UniProt Show fit	membrane-bound transcription factor peptidase, site 1
chr16_+_53469525 Show fit	0.76	ENST00000544405.2	RBL2 Ensembl NCBI GeneCards UniProt Show fit	retinoblastoma-like 2 (p130)
chr19_+_41725088 Show fit	0.76	ENST00000301178.4	AXL Ensembl NCBI GeneCards UniProt Show fit	AXL receptor tyrosine kinase
chr17_+_79369249 Show fit	0.76	ENST00000574717.2	RP11-1055B8.6 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr5_+_169064245 Show fit	0.75	ENST00000256935.8	DOCK2 Ensembl NCBI GeneCards UniProt Show fit	dedicator of cytokinesis 2
chr12_+_6603253 Show fit	0.75	ENST00000382457.4 ENST00000545962.1	NCAPD2 Ensembl NCBI GeneCards UniProt Show fit	non-SMC condensin I complex, subunit D2
chr1_+_199996702 Show fit	0.75	ENST00000367362.3	NR5A2 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor subfamily 5, group A, member 2
chr2_+_173955327 Show fit	0.74	ENST00000422149.1	MLTK Ensembl NCBI GeneCards UniProt Show fit	Mitogen-activated protein kinase kinase kinase MLT
chr9_-_88896977 Show fit	0.73	ENST00000311534.6	ISCA1 Ensembl NCBI GeneCards UniProt Show fit	iron-sulfur cluster assembly 1
chr4_-_111120132 Show fit	0.73	ENST00000506625.1	ELOVL6 Ensembl NCBI GeneCards UniProt Show fit	ELOVL fatty acid elongase 6
chr9_-_119162885 Show fit	0.73	ENST00000445861.2	PAPPA-AS1 Ensembl NCBI GeneCards UniProt Show fit	PAPPA antisense RNA 1
chr12_+_13349711 Show fit	0.72	ENST00000538364.1 ENST00000396301.3	EMP1 Ensembl NCBI GeneCards UniProt Show fit	epithelial membrane protein 1
chr12_-_120189900 Show fit	0.72	ENST00000546026.1	CIT Ensembl NCBI GeneCards UniProt Show fit	citron (rho-interacting, serine/threonine kinase 21)
chr2_+_177502438 Show fit	0.71	ENST00000443670.1	AC017048.4 Ensembl NCBI GeneCards UniProt Show fit	long intergenic non-protein coding RNA 1117
chr4_-_89442940 Show fit	0.71	ENST00000527353.1	PIGY Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis, class Y
chr3_+_69928256 Show fit	0.71	ENST00000394355.2	MITF Ensembl NCBI GeneCards UniProt Show fit	microphthalmia-associated transcription factor
chr8_-_27469383 Show fit	0.71	ENST00000519742.1	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chr11_-_46848393 Show fit	0.71	ENST00000526496.1	CKAP5 Ensembl NCBI GeneCards UniProt Show fit	cytoskeleton associated protein 5
chr17_-_57229155 Show fit	0.70	ENST00000584089.1	SKA2 Ensembl NCBI GeneCards UniProt Show fit	spindle and kinetochore associated complex subunit 2
chr1_+_45212051 Show fit	0.70	ENST00000372222.3	KIF2C Ensembl NCBI GeneCards UniProt Show fit	kinesin family member 2C
chr16_+_56781814 Show fit	0.69	ENST00000568656.1	NUP93 Ensembl NCBI GeneCards UniProt Show fit	nucleoporin 93kDa
chr7_+_151791037 Show fit	0.69	ENST00000419245.1	GALNT11 Ensembl NCBI GeneCards UniProt Show fit	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr12_+_121416437 Show fit	0.69	ENST00000402929.1 ENST00000535955.1 ENST00000538626.1 ENST00000543427.1	HNF1A Ensembl NCBI GeneCards UniProt Show fit	HNF1 homeobox A
chr2_+_97481974 Show fit	0.68	ENST00000377060.3 ENST00000305510.3	CNNM3 Ensembl NCBI GeneCards UniProt Show fit	cyclin M3
chr5_+_169011033 Show fit	0.68	ENST00000513795.1	SPDL1 Ensembl NCBI GeneCards UniProt Show fit	spindle apparatus coiled-coil protein 1
chr15_-_88799948 Show fit	0.68	ENST00000394480.2	NTRK3 Ensembl NCBI GeneCards UniProt Show fit	neurotrophic tyrosine kinase, receptor, type 3
chr4_-_40632844 Show fit	0.68	ENST00000505414.1	RBM47 Ensembl NCBI GeneCards UniProt Show fit	RNA binding motif protein 47
chr9_+_131903916 Show fit	0.67	ENST00000419582.1	PPP2R4 Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 2A activator, regulatory subunit 4
chrX_-_10851762 Show fit	0.67	ENST00000380785.1 ENST00000380787.1	MID1 Ensembl NCBI GeneCards UniProt Show fit	midline 1 (Opitz/BBB syndrome)
chr12_+_54410664 Show fit	0.67	ENST00000303406.4	HOXC4 Ensembl NCBI GeneCards UniProt Show fit	homeobox C4
chr1_-_160231451 Show fit	0.67	ENST00000495887.1	DCAF8 Ensembl NCBI GeneCards UniProt Show fit	DDB1 and CUL4 associated factor 8
chr17_-_26662440 Show fit	0.67	ENST00000578122.1	IFT20 Ensembl NCBI GeneCards UniProt Show fit	intraflagellar transport 20 homolog (Chlamydomonas)
chr2_+_172309634 Show fit	0.67	ENST00000339506.3	DCAF17 Ensembl NCBI GeneCards UniProt Show fit	DDB1 and CUL4 associated factor 17
chr17_+_4618734 Show fit	0.66	ENST00000571206.1	ARRB2 Ensembl NCBI GeneCards UniProt Show fit	arrestin, beta 2
chr12_-_52585765 Show fit	0.65	ENST00000313234.5 ENST00000394815.2	KRT80 Ensembl NCBI GeneCards UniProt Show fit	keratin 80
chr9_+_131904295 Show fit	0.65	ENST00000434095.1	PPP2R4 Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 2A activator, regulatory subunit 4
chrX_-_20236970 Show fit	0.64	ENST00000379548.4	RPS6KA3 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr2_+_132479948 Show fit	0.63	ENST00000355171.4	C2orf27A Ensembl NCBI GeneCards UniProt Show fit	chromosome 2 open reading frame 27A
chr19_-_6502341 Show fit	0.62	ENST00000598006.1 ENST00000601152.1	TUBB4A Ensembl NCBI GeneCards UniProt Show fit	tubulin, beta 4A class IVa
chr20_-_22566089 Show fit	0.62	ENST00000377115.4	FOXA2 Ensembl NCBI GeneCards UniProt Show fit	forkhead box A2
chr4_+_183370146 Show fit	0.62	ENST00000510504.1	TENM3 Ensembl NCBI GeneCards UniProt Show fit	teneurin transmembrane protein 3
chr12_-_57472522 Show fit	0.61	ENST00000379391.3 ENST00000300128.4	TMEM194A Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 194A
chr15_-_31283618 Show fit	0.61	ENST00000563714.1	MTMR10 Ensembl NCBI GeneCards UniProt Show fit	myotubularin related protein 10
chr14_+_23067166 Show fit	0.61	ENST00000216327.6 ENST00000542041.1	ABHD4 Ensembl NCBI GeneCards UniProt Show fit	abhydrolase domain containing 4
chr16_+_57139933 Show fit	0.61	ENST00000566259.1	CPNE2 Ensembl NCBI GeneCards UniProt Show fit	copine II
chr11_+_844067 Show fit	0.61	ENST00000397406.1 ENST00000409543.2 ENST00000525201.1	TSPAN4 Ensembl NCBI GeneCards UniProt Show fit	tetraspanin 4
chr15_-_59041954 Show fit	0.61	ENST00000439637.1 ENST00000558004.1	ADAM10 Ensembl NCBI GeneCards UniProt Show fit	ADAM metallopeptidase domain 10
chr1_+_198126209 Show fit	0.60	ENST00000367383.1	NEK7 Ensembl NCBI GeneCards UniProt Show fit	NIMA-related kinase 7
chr10_+_70847852 Show fit	0.60	ENST00000242465.3	SRGN Ensembl NCBI GeneCards UniProt Show fit	serglycin
chr9_+_131904233 Show fit	0.60	ENST00000432651.1 ENST00000435132.1	PPP2R4 Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 2A activator, regulatory subunit 4
chr1_-_153514241 Show fit	0.60	ENST00000368718.1 ENST00000359215.1	S100A5 Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein A5
chr7_+_151791074 Show fit	0.60	ENST00000447796.1	GALNT11 Ensembl NCBI GeneCards UniProt Show fit	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chrX_+_117629766 Show fit	0.60	ENST00000276204.6 ENST00000276202.7	DOCK11 Ensembl NCBI GeneCards UniProt Show fit	dedicator of cytokinesis 11
chr12_+_20963632 Show fit	0.59	ENST00000540853.1 ENST00000261196.2	SLCO1B3 Ensembl NCBI GeneCards UniProt Show fit	solute carrier organic anion transporter family, member 1B3
chr1_+_45212074 Show fit	0.59	ENST00000372217.1	KIF2C Ensembl NCBI GeneCards UniProt Show fit	kinesin family member 2C
chr5_-_142783365 Show fit	0.59	ENST00000508760.1	NR3C1 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr5_-_40755987 Show fit	0.58	ENST00000337702.4	TTC33 Ensembl NCBI GeneCards UniProt Show fit	tetratricopeptide repeat domain 33
chr2_+_11817713 Show fit	0.58	ENST00000449576.2	LPIN1 Ensembl NCBI GeneCards UniProt Show fit	lipin 1
chr8_-_101321584 Show fit	0.58	ENST00000523167.1	RNF19A Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr14_+_56127960 Show fit	0.58	ENST00000553624.1	KTN1 Ensembl NCBI GeneCards UniProt Show fit	kinectin 1 (kinesin receptor)
chr13_-_31038370 Show fit	0.57	ENST00000399489.1 ENST00000339872.4	HMGB1 Ensembl NCBI GeneCards UniProt Show fit	high mobility group box 1
chr12_+_121416489 Show fit	0.57	ENST00000541395.1 ENST00000544413.1	HNF1A Ensembl NCBI GeneCards UniProt Show fit	HNF1 homeobox A
chr15_-_56757329 Show fit	0.57	ENST00000260453.3	MNS1 Ensembl NCBI GeneCards UniProt Show fit	meiosis-specific nuclear structural 1
chr14_+_32547434 Show fit	0.57	ENST00000556191.1 ENST00000554090.1	ARHGAP5 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 5
chr20_+_10199468 Show fit	0.57	ENST00000254976.2 ENST00000304886.2	SNAP25 Ensembl NCBI GeneCards UniProt Show fit	synaptosomal-associated protein, 25kDa
chr12_+_64798826 Show fit	0.57	ENST00000540203.1	XPOT Ensembl NCBI GeneCards UniProt Show fit	exportin, tRNA
chr17_-_26662464 Show fit	0.57	ENST00000579419.1 ENST00000585313.1 ENST00000395418.3 ENST00000578985.1 ENST00000577498.1 ENST00000585089.1 ENST00000357896.3	IFT20 Ensembl NCBI GeneCards UniProt Show fit	intraflagellar transport 20 homolog (Chlamydomonas)
chr14_+_56127989 Show fit	0.56	ENST00000555573.1	KTN1 Ensembl NCBI GeneCards UniProt Show fit	kinectin 1 (kinesin receptor)
chr9_-_88897426 Show fit	0.56	ENST00000375991.4 ENST00000326094.4	ISCA1 Ensembl NCBI GeneCards UniProt Show fit	iron-sulfur cluster assembly 1
chr20_-_22559211 Show fit	0.56	ENST00000564492.1	LINC00261 Ensembl NCBI GeneCards UniProt Show fit	long intergenic non-protein coding RNA 261
chr15_-_63449663 Show fit	0.56	ENST00000439025.1	RPS27L Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S27-like
chr10_-_92681033 Show fit	0.56	ENST00000371697.3	ANKRD1 Ensembl NCBI GeneCards UniProt Show fit	ankyrin repeat domain 1 (cardiac muscle)
chr1_-_12679171 Show fit	0.56	ENST00000606790.1	RP11-474O21.5 Ensembl NCBI GeneCards UniProt Show fit	RP11-474O21.5
chr10_+_115469134 Show fit	0.55	ENST00000452490.2	CASP7 Ensembl NCBI GeneCards UniProt Show fit	caspase 7, apoptosis-related cysteine peptidase
chr10_-_32217717 Show fit	0.55	ENST00000396144.4 ENST00000375245.4 ENST00000344936.2 ENST00000375250.5	ARHGAP12 Ensembl NCBI GeneCards UniProt Show fit	Rho GTPase activating protein 12
chr12_+_12764773 Show fit	0.55	ENST00000228865.2	CREBL2 Ensembl NCBI GeneCards UniProt Show fit	cAMP responsive element binding protein-like 2
chr10_-_14596140 Show fit	0.54	ENST00000496330.1	FAM107B Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 107, member B
chr4_-_40632881 Show fit	0.54	ENST00000511598.1	RBM47 Ensembl NCBI GeneCards UniProt Show fit	RNA binding motif protein 47
chr13_+_28712614 Show fit	0.54	ENST00000380958.3	PAN3 Ensembl NCBI GeneCards UniProt Show fit	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXO3_FOXD2

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	4.4	GO:1903615	regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.8	4.9	GO:0015887	biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887)
0.6	4.2	GO:0061113	pancreas morphogenesis(GO:0061113)
0.6	5.9	GO:0097338	response to clozapine(GO:0097338)
0.6	1.7	GO:0035623	renal glucose absorption(GO:0035623)
0.5	1.6	GO:1903225	negative regulation of endodermal cell differentiation(GO:1903225)
0.5	4.4	GO:0021842	directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.5	2.8	GO:2000669	negative regulation of dendritic cell apoptotic process(GO:2000669)
0.5	6.0	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
0.4	1.1	GO:0031204	posttranslational protein targeting to membrane, translocation(GO:0031204)
0.4	3.6	GO:0045218	zonula adherens maintenance(GO:0045218)
0.3	7.8	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.3	1.0	GO:0061075	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.3	1.9	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.3	1.7	GO:0090131	mesenchyme migration(GO:0090131)
0.3	1.4	GO:0072709	cellular response to sorbitol(GO:0072709)
0.3	0.8	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.3	0.8	GO:2000523	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.3	1.9	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.2	1.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.2	1.2	GO:0010157	response to chlorate(GO:0010157)
0.2	0.9	GO:1901143	insulin catabolic process(GO:1901143)
0.2	1.5	GO:0000821	regulation of arginine metabolic process(GO:0000821)
0.2	2.0	GO:0045602	negative regulation of endothelial cell differentiation(GO:0045602)
0.2	0.6	GO:0033364	mast cell secretory granule organization(GO:0033364)
0.2	0.8	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.2	0.8	GO:1990926	short-term synaptic potentiation(GO:1990926)
0.2	0.8	GO:0019442	tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.2	1.3	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.2	0.9	GO:0043335	protein unfolding(GO:0043335)
0.2	0.5	GO:0050760	negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.2	1.1	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.2	2.3	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.2	0.3	GO:1902263	apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.2	0.7	GO:0048691	modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.2	0.5	GO:0098507	polynucleotide 5' dephosphorylation(GO:0098507)
0.2	2.0	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2	2.5	GO:1901078	negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2	2.5	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.2	1.5	GO:0090521	glomerular visceral epithelial cell migration(GO:0090521)
0.2	0.5	GO:1902299	pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2	0.6	GO:1903824	regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824)
0.2	1.0	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.2	1.3	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.2	0.5	GO:1904404	cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.2	0.8	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.2	0.6	GO:0045014	carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.2	1.7	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.2	0.8	GO:2000567	memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.2	2.6	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.1	0.9	GO:2001153	regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
0.1	1.8	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	0.6	GO:0002270	plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072)
0.1	1.1	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.1	0.6	GO:0045209	MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.1	0.5	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.1	1.7	GO:0018243	protein O-linked glycosylation via threonine(GO:0018243)
0.1	0.7	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.1	1.8	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.8	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1	0.6	GO:0042998	positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.1	1.5	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1	0.9	GO:0008063	Toll signaling pathway(GO:0008063)
0.1	1.1	GO:0071386	cellular response to corticosterone stimulus(GO:0071386)
0.1	0.4	GO:0046013	T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.1	0.7	GO:0021993	initiation of neural tube closure(GO:0021993)
0.1	0.4	GO:0046725	negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.1	0.9	GO:2000158	positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1	1.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.1	1.1	GO:0072502	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1	0.9	GO:0070445	oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.1	1.5	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.1	1.1	GO:0003190	atrioventricular valve formation(GO:0003190)
0.1	0.5	GO:1901545	cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.1	0.3	GO:0098972	dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.1	0.4	GO:0006542	glutamine biosynthetic process(GO:0006542)
0.1	0.4	GO:0044537	regulation of circulating fibrinogen levels(GO:0044537)
0.1	0.8	GO:0048133	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1	0.7	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1	0.4	GO:0060151	peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.1	0.7	GO:1902998	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1	1.4	GO:0090091	positive regulation of extracellular matrix disassembly(GO:0090091)
0.1	1.2	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
0.1	5.1	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.1	0.8	GO:0055048	regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.1	1.4	GO:0036500	ATF6-mediated unfolded protein response(GO:0036500)
0.1	0.4	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1	0.2	GO:1904017	cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.1	0.4	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
0.1	0.7	GO:0002318	myeloid progenitor cell differentiation(GO:0002318)
0.1	0.5	GO:0070982	L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982)
0.1	0.2	GO:1901876	regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1	0.6	GO:0006642	triglyceride mobilization(GO:0006642)
0.1	0.3	GO:1901350	cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.1	0.6	GO:1902527	positive regulation of protein monoubiquitination(GO:1902527)
0.1	1.3	GO:0070986	left/right axis specification(GO:0070986)
0.1	0.5	GO:0072733	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.1	0.8	GO:0001768	establishment of T cell polarity(GO:0001768)
0.1	0.8	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.1	1.1	GO:1904778	regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.1	0.5	GO:0086048	membrane depolarization during bundle of His cell action potential(GO:0086048)
0.1	0.8	GO:1903944	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1	0.3	GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1	0.4	GO:2000124	regulation of endocannabinoid signaling pathway(GO:2000124)
0.1	0.4	GO:0071486	cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.1	0.9	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1	0.4	GO:1903899	lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1	1.0	GO:0090292	nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.2	GO:0032915	positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1	0.8	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.1	0.8	GO:0071763	nuclear membrane organization(GO:0071763)
0.1	0.4	GO:0036022	limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.1	0.3	GO:0046340	diacylglycerol catabolic process(GO:0046340)
0.1	0.9	GO:0043249	erythrocyte maturation(GO:0043249)
0.1	0.8	GO:0071374	cellular response to parathyroid hormone stimulus(GO:0071374)
0.1	0.9	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1	0.3	GO:0098886	modification of dendritic spine(GO:0098886)
0.1	1.6	GO:1904355	positive regulation of telomere capping(GO:1904355)
0.1	0.3	GO:0002725	negative regulation of T cell cytokine production(GO:0002725)
0.1	0.5	GO:0006572	tyrosine catabolic process(GO:0006572)
0.1	0.9	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.1	0.7	GO:0042045	epithelial fluid transport(GO:0042045)
0.1	0.3	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.1	0.7	GO:2000675	negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1	0.4	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.1	0.3	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.1	0.4	GO:0048625	myoblast fate commitment(GO:0048625)
0.1	0.2	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.1	0.3	GO:0071955	recycling endosome to Golgi transport(GO:0071955)
0.1	3.0	GO:0030318	melanocyte differentiation(GO:0030318)
0.1	0.3	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1	0.3	GO:0060809	mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.0	0.6	GO:0090204	protein localization to nuclear pore(GO:0090204)
0.0	0.8	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.0	0.6	GO:0021520	spinal cord motor neuron cell fate specification(GO:0021520)
0.0	0.4	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.2	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.7	GO:0018298	protein-chromophore linkage(GO:0018298)
0.0	0.5	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.2	GO:0000415	negative regulation of histone H3-K36 methylation(GO:0000415)
0.0	0.4	GO:0045333	cellular respiration(GO:0045333)
0.0	0.1	GO:0031548	regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0	0.7	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.2	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0	0.2	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0	0.7	GO:0035372	protein localization to microtubule(GO:0035372)
0.0	0.2	GO:0005986	sucrose biosynthetic process(GO:0005986)
0.0	0.4	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.9	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.7	GO:0002315	marginal zone B cell differentiation(GO:0002315)
0.0	0.2	GO:0046984	regulation of translational initiation by iron(GO:0006447) regulation of hemoglobin biosynthetic process(GO:0046984)
0.0	0.3	GO:0000066	mitochondrial ornithine transport(GO:0000066)
0.0	0.3	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.2	GO:0098707	ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0	1.2	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.1	GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.0	0.5	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654)
0.0	0.7	GO:0098719	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0	0.3	GO:0072092	ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093)
0.0	0.4	GO:1900121	negative regulation of receptor binding(GO:1900121)
0.0	1.2	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.0	0.7	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.4	GO:0061002	negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0	1.7	GO:1902751	positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0	0.9	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	1.3	GO:0070306	lens fiber cell differentiation(GO:0070306)
0.0	0.4	GO:0007144	female meiosis I(GO:0007144)
0.0	0.2	GO:1902963	regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0	0.1	GO:0043988	histone H3-S10 phosphorylation(GO:0043987) histone H3-S28 phosphorylation(GO:0043988)
0.0	0.2	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0	0.4	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
0.0	0.2	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.2	GO:0033138	positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0	0.4	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.0	0.3	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0002740	negative regulation of cytokine secretion involved in immune response(GO:0002740)
0.0	0.1	GO:0098926	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0	0.3	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.3	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.8	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.0	0.8	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.0	0.8	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0	0.2	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.3	GO:0060318	regulation of definitive erythrocyte differentiation(GO:0010724) definitive erythrocyte differentiation(GO:0060318)
0.0	0.5	GO:0038180	nerve growth factor signaling pathway(GO:0038180)
0.0	1.5	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0	0.2	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0	0.7	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.3	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.4	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.1	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0	0.2	GO:1905150	regulation of voltage-gated sodium channel activity(GO:1905150)
0.0	0.3	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0007223	Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0	0.8	GO:0072663	protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0	0.2	GO:0007494	midgut development(GO:0007494)
0.0	0.2	GO:0006497	protein lipidation(GO:0006497)
0.0	1.3	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0	0.1	GO:0048858	cell projection morphogenesis(GO:0048858)
0.0	0.8	GO:0043555	regulation of translation in response to stress(GO:0043555)
0.0	0.7	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0	0.3	GO:0016191	synaptic vesicle uncoating(GO:0016191)
0.0	0.8	GO:0005980	glycogen catabolic process(GO:0005980)
0.0	0.0	GO:0042439	ethanolamine-containing compound metabolic process(GO:0042439)
0.0	0.3	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.3	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.6	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.2	GO:0098535	de novo centriole assembly(GO:0098535)
0.0	0.3	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.2	GO:1901386	negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0	0.8	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.2	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.3	GO:0038007	netrin-activated signaling pathway(GO:0038007)
0.0	0.8	GO:0072600	establishment of protein localization to Golgi(GO:0072600)
0.0	4.7	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	0.8	GO:0036152	phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0	0.4	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.5	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.2	GO:0010976	positive regulation of neuron projection development(GO:0010976)
0.0	0.4	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.0	0.2	GO:0070574	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.3	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)
0.0	0.6	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.5	GO:0006450	regulation of translational fidelity(GO:0006450)
0.0	0.2	GO:2000811	negative regulation of anoikis(GO:2000811)
0.0	0.2	GO:0030916	otic vesicle formation(GO:0030916)
0.0	0.2	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0	0.5	GO:0071539	protein localization to centrosome(GO:0071539)
0.0	0.4	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	0.4	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0	0.3	GO:0035635	entry of bacterium into host cell(GO:0035635)
0.0	0.2	GO:0032264	IMP salvage(GO:0032264)
0.0	0.4	GO:0006825	copper ion transport(GO:0006825)
0.0	0.4	GO:0032060	bleb assembly(GO:0032060)
0.0	0.5	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.0	1.3	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0	0.9	GO:1901224	positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0	0.1	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	1.4	GO:0006911	phagocytosis, engulfment(GO:0006911)
0.0	0.1	GO:0010286	heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.0	0.4	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.8	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.3	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.4	GO:0010039	response to iron ion(GO:0010039)
0.0	0.3	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)
0.0	0.0	GO:1990654	sebum secreting cell proliferation(GO:1990654)
0.0	0.4	GO:1901741	positive regulation of myoblast fusion(GO:1901741)
0.0	0.7	GO:0006409	tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0	1.3	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.7	GO:0006506	GPI anchor biosynthetic process(GO:0006506)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	1.0	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.2	GO:0042073	intraciliary transport(GO:0042073)
0.0	0.6	GO:0001919	regulation of receptor recycling(GO:0001919)
0.0	0.3	GO:0047497	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.4	GO:0051353	positive regulation of oxidoreductase activity(GO:0051353)
0.0	1.2	GO:0006970	response to osmotic stress(GO:0006970)
0.0	0.1	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441) kynurenine metabolic process(GO:0070189)
0.0	0.7	GO:0031110	regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:0061743	motor learning(GO:0061743)
0.0	0.4	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.2	GO:0007220	Notch receptor processing(GO:0007220)
0.0	0.1	GO:0035934	corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0	0.2	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0032930	positive regulation of superoxide anion generation(GO:0032930)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.2	GO:0000052	citrulline metabolic process(GO:0000052)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	7.6	GO:0097149	centralspindlin complex(GO:0097149)
0.6	5.6	GO:0000798	nuclear cohesin complex(GO:0000798)
0.5	1.6	GO:0005588	collagen type V trimer(GO:0005588)
0.5	2.3	GO:0070701	mucus layer(GO:0070701)
0.4	1.2	GO:1902636	kinociliary basal body(GO:1902636)
0.3	1.4	GO:0042721	mitochondrial inner membrane protein insertion complex(GO:0042721)
0.2	6.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.2	1.2	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.2	0.5	GO:0036387	nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.2	2.1	GO:0001940	male pronucleus(GO:0001940)
0.2	3.8	GO:0005915	zonula adherens(GO:0005915)
0.1	0.9	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1	0.5	GO:0031251	PAN complex(GO:0031251)
0.1	1.2	GO:0044294	dendritic growth cone(GO:0044294)
0.1	0.8	GO:0000799	nuclear condensin complex(GO:0000799)
0.1	0.5	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.1	1.1	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1	0.3	GO:0097444	spine apparatus(GO:0097444)
0.1	0.3	GO:0034657	GID complex(GO:0034657)
0.1	1.5	GO:0042587	glycogen granule(GO:0042587)
0.1	2.1	GO:0042555	MCM complex(GO:0042555)
0.1	0.5	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1	0.8	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1	2.0	GO:0033643	host cell part(GO:0033643)
0.1	1.4	GO:0016342	catenin complex(GO:0016342)
0.1	0.4	GO:0005712	chiasma(GO:0005712)
0.1	1.4	GO:0005828	kinetochore microtubule(GO:0005828)
0.1	4.3	GO:0030673	axolemma(GO:0030673)
0.1	0.8	GO:0055028	cortical microtubule(GO:0055028)
0.1	1.1	GO:0033269	internode region of axon(GO:0033269)
0.1	0.5	GO:1990812	growth cone filopodium(GO:1990812)
0.1	1.4	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.1	0.2	GO:0048269	methionine adenosyltransferase complex(GO:0048269)
0.1	1.8	GO:0032982	myosin filament(GO:0032982)
0.1	1.0	GO:0097418	neurofibrillary tangle(GO:0097418)
0.1	1.1	GO:0008091	spectrin(GO:0008091)
0.1	2.6	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	1.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.1	0.8	GO:0000137	Golgi cis cisterna(GO:0000137)
0.1	5.7	GO:0031526	brush border membrane(GO:0031526)
0.1	1.9	GO:0000930	gamma-tubulin complex(GO:0000930)
0.1	0.9	GO:0032433	filopodium tip(GO:0032433)
0.1	1.3	GO:0042627	chylomicron(GO:0042627)
0.0	0.6	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.6	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.4	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.7	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.7	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.4	GO:0005587	collagen type IV trimer(GO:0005587)
0.0	0.9	GO:0031597	cytosolic proteasome complex(GO:0031597)
0.0	1.0	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	2.5	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.0	0.9	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.0	1.1	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.6	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.8	GO:0031265	CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0	1.7	GO:0016592	mediator complex(GO:0016592)
0.0	0.4	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0	0.2	GO:0098536	deuterosome(GO:0098536)
0.0	0.9	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.8	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	1.8	GO:0097542	ciliary tip(GO:0097542)
0.0	0.4	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.6	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.3	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.5	GO:0042588	zymogen granule(GO:0042588)
0.0	1.0	GO:0032420	stereocilium(GO:0032420)
0.0	0.3	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.2	GO:0061617	MICOS complex(GO:0061617)
0.0	0.2	GO:0036021	endolysosome lumen(GO:0036021)
0.0	2.9	GO:0044291	cell-cell contact zone(GO:0044291)
0.0	1.8	GO:0031941	filamentous actin(GO:0031941)
0.0	0.1	GO:0035339	SPOTS complex(GO:0035339)
0.0	1.3	GO:0005876	spindle microtubule(GO:0005876)
0.0	1.5	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	0.2	GO:0072487	MSL complex(GO:0072487)
0.0	1.1	GO:0035861	site of double-strand break(GO:0035861)
0.0	0.3	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.2	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.0	1.9	GO:0018995	host(GO:0018995) host cell(GO:0043657)
0.0	0.6	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	1.2	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	0.6	GO:0032040	small-subunit processome(GO:0032040)
0.0	0.5	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.2	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.5	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	0.1	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.3	GO:0034709	methylosome(GO:0034709)
0.0	0.4	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.2	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.6	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	1.0	GO:0045095	keratin filament(GO:0045095)
0.0	1.1	GO:0005643	nuclear pore(GO:0005643)
0.0	2.5	GO:0000922	spindle pole(GO:0000922)
0.0	0.8	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	0.7	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	1.9	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	1.3	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.0	0.4	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	0.0	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.0	0.1	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.2	GO:0097440	apical dendrite(GO:0097440)
0.0	0.4	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.2	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	2.3	GO:0005795	Golgi stack(GO:0005795)
0.0	0.3	GO:0031932	TORC2 complex(GO:0031932)
0.0	2.3	GO:0005819	spindle(GO:0005819)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	4.9	GO:0004967	glucagon receptor activity(GO:0004967)
0.6	4.9	GO:0008523	sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.4	1.5	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.4	4.4	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.3	2.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.3	1.5	GO:0050115	myosin-light-chain-phosphatase activity(GO:0050115)
0.3	0.9	GO:0031626	beta-endorphin binding(GO:0031626)
0.3	2.5	GO:0038051	glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.3	0.8	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.3	5.9	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.2	1.2	GO:0002046	opsin binding(GO:0002046)
0.2	1.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.2	1.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.2	0.7	GO:0031859	platelet activating factor receptor binding(GO:0031859)
0.2	0.9	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.2	0.6	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2	0.5	GO:0086057	voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.2	1.2	GO:0005119	smoothened binding(GO:0005119)
0.2	0.8	GO:0031708	endothelin B receptor binding(GO:0031708)
0.2	0.5	GO:0004651	polynucleotide 5'-phosphatase activity(GO:0004651)
0.2	0.5	GO:0051499	D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.2	1.0	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2	0.5	GO:0061663	NEDD8 ligase activity(GO:0061663)
0.2	0.5	GO:0010698	acetyltransferase activator activity(GO:0010698)
0.1	1.6	GO:0019237	centromeric DNA binding(GO:0019237)
0.1	2.8	GO:0032036	myosin heavy chain binding(GO:0032036)
0.1	0.7	GO:0008466	glycogenin glucosyltransferase activity(GO:0008466)
0.1	1.5	GO:0102338	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1	0.8	GO:0023025	MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.1	0.3	GO:0030617	transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity(GO:0030617)
0.1	0.9	GO:0042577	lipid phosphatase activity(GO:0042577)
0.1	0.9	GO:0035800	deubiquitinase activator activity(GO:0035800)
0.1	1.1	GO:0030348	syntaxin-3 binding(GO:0030348)
0.1	0.4	GO:0036134	thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1	0.3	GO:0010309	acireductone dioxygenase [iron(II)-requiring] activity(GO:0010309)
0.1	0.5	GO:0044378	non-sequence-specific DNA binding, bending(GO:0044378)
0.1	0.8	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.1	0.9	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.1	3.2	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1	0.4	GO:0004923	leukemia inhibitory factor receptor activity(GO:0004923)
0.1	0.4	GO:0016211	glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1	0.4	GO:0016639	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1	0.5	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1	1.3	GO:0035374	chondroitin sulfate binding(GO:0035374)
0.1	0.3	GO:0001596	angiotensin type I receptor activity(GO:0001596)
0.1	3.8	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	0.9	GO:0060002	plus-end directed microfilament motor activity(GO:0060002)
0.1	0.6	GO:0010858	calcium-dependent protein kinase regulator activity(GO:0010858)
0.1	1.5	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	0.3	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.7	GO:0016167	glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1	0.8	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.5	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.1	1.5	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.1	1.0	GO:0042731	PH domain binding(GO:0042731)
0.1	0.9	GO:0030911	TPR domain binding(GO:0030911)
0.1	2.5	GO:0051010	microtubule plus-end binding(GO:0051010)
0.1	0.7	GO:0043515	kinetochore binding(GO:0043515)
0.1	0.5	GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.1	0.3	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.1	0.7	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1	1.4	GO:0048156	tau protein binding(GO:0048156)
0.1	0.4	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1	0.6	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	11.0	GO:0017048	Rho GTPase binding(GO:0017048)
0.1	0.2	GO:0004727	prenylated protein tyrosine phosphatase activity(GO:0004727)
0.1	0.9	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.1	0.9	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.1	0.3	GO:0003938	IMP dehydrogenase activity(GO:0003938)
0.1	0.3	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1	0.7	GO:0009881	photoreceptor activity(GO:0009881)
0.1	1.7	GO:0005112	Notch binding(GO:0005112)
0.1	0.2	GO:0033878	hormone-sensitive lipase activity(GO:0033878)
0.1	0.6	GO:0071253	connexin binding(GO:0071253)
0.1	0.4	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.7	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	2.1	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.8	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.2	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.4	GO:0004534	5'-3' exoribonuclease activity(GO:0004534)
0.0	1.5	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	1.4	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.6	GO:0003720	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.2	GO:0003963	RNA-3'-phosphate cyclase activity(GO:0003963)
0.0	0.3	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0	0.1	GO:0005169	neurotrophin TRKB receptor binding(GO:0005169)
0.0	0.7	GO:0015386	potassium:proton antiporter activity(GO:0015386)
0.0	2.5	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.6	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	1.5	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.2	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0	0.5	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0050146	nucleoside phosphotransferase activity(GO:0050146)
0.0	0.3	GO:0051748	UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.0	0.2	GO:0004998	transferrin receptor activity(GO:0004998)
0.0	1.7	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.4	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.9	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	0.4	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.3	GO:0033188	sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0	0.1	GO:0098770	FBXO family protein binding(GO:0098770)
0.0	0.6	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.9	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.3	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.0	0.6	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	1.3	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.2	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.6	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.4	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.3	GO:0070137	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.2	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.1	GO:0005018	platelet-derived growth factor alpha-receptor activity(GO:0005018)
0.0	0.3	GO:0043426	MRF binding(GO:0043426)
0.0	1.2	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.1	GO:0051373	FATZ binding(GO:0051373)
0.0	1.0	GO:0071837	HMG box domain binding(GO:0071837)
0.0	0.8	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	0.7	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.2	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	3.8	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0	1.0	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	1.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.8	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.6	GO:0008494	translation activator activity(GO:0008494)
0.0	1.7	GO:0050699	WW domain binding(GO:0050699)
0.0	0.5	GO:0031432	titin binding(GO:0031432)
0.0	3.1	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.4	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.3	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.5	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.4	GO:0070491	repressing transcription factor binding(GO:0070491)
0.0	0.1	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.9	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.2	GO:0016403	dimethylargininase activity(GO:0016403)
0.0	0.2	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.0	2.8	GO:0030165	PDZ domain binding(GO:0030165)
0.0	0.3	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0	0.9	GO:0005521	lamin binding(GO:0005521)
0.0	1.9	GO:0097110	scaffold protein binding(GO:0097110)
0.0	0.2	GO:1990226	histone methyltransferase binding(GO:1990226)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	1.1	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	0.1	GO:0050659	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0	0.3	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.2	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.5	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	3.0	GO:0008565	protein transporter activity(GO:0008565)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.2	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.3	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0	0.8	GO:0019894	kinesin binding(GO:0019894)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	1.5	GO:0003777	microtubule motor activity(GO:0003777)
0.0	0.5	GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0	0.3	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.5	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.3	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.4	GO:0000983	transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	2.4	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.6	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	1.1	GO:0030145	manganese ion binding(GO:0030145)
0.0	0.2	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.3	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.5	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.3	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	2.4	GO:0004386	helicase activity(GO:0004386)
0.0	0.2	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0	0.4	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.9	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	1.4	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0	0.4	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0	0.3	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.5	GO:0042287	MHC protein binding(GO:0042287)
0.0	0.2	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.0	GO:0005174	CD40 receptor binding(GO:0005174)
0.0	0.2	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	2.3	GO:0017124	SH3 domain binding(GO:0017124)
0.0	0.7	GO:0070888	E-box binding(GO:0070888)
0.0	0.5	GO:0042169	SH2 domain binding(GO:0042169)
0.0	2.1	GO:0042393	histone binding(GO:0042393)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.1	1.2	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.1	5.1	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	11.0	PID PLK1 PATHWAY	PLK1 signaling events
0.1	0.8	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.1	3.5	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	1.4	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.1	5.1	PID IL3 PATHWAY	IL3-mediated signaling events
0.1	5.6	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	1.4	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	2.7	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.7	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.3	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	3.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	2.8	PID AURORA B PATHWAY	Aurora B signaling
0.0	0.9	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	3.6	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	1.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.9	PID AURORA A PATHWAY	Aurora A signaling
0.0	1.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	2.5	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	1.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.8	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	2.1	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.0	0.6	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	1.0	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	2.1	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.3	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	1.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.1	PID IFNG PATHWAY	IFN-gamma pathway
0.0	1.4	PID RAS PATHWAY	Regulation of Ras family activation
0.0	1.9	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	0.7	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	2.5	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.5	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	1.1	PID ATR PATHWAY	ATR signaling pathway
0.0	0.8	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.6	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.6	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.6	PID ENDOTHELIN PATHWAY	Endothelins
0.0	0.3	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	0.7	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	0.6	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	0.6	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	1.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.6	PID ATM PATHWAY	ATM pathway
0.0	0.3	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.3	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.9	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.2	8.0	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	1.8	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.1	4.8	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	3.8	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.1	2.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	0.7	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1	4.4	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.1	2.0	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1	4.9	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.1	8.2	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	1.7	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.1	1.4	REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA	Genes involved in Activation of Chaperones by ATF6-alpha
0.1	7.3	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	0.8	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.1	2.2	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.1	1.5	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1	1.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	1.1	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.1	0.9	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1	0.5	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1	1.4	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.1	1.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	2.7	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	1.3	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	2.8	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	2.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	1.0	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	1.5	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.9	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	1.3	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	2.2	REACTOME KINESINS	Genes involved in Kinesins
0.0	2.6	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.9	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.4	REACTOME OPSINS	Genes involved in Opsins
0.0	0.8	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	1.5	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	2.1	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.9	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	1.9	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.2	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	2.7	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	1.5	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	2.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.6	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	1.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	1.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	1.5	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	2.3	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.7	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	1.7	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	1.5	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.7	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	1.4	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.9	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.5	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.8	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.6	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.3	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.7	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.2	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.0	0.5	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.4	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.3	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.5	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	1.7	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	0.3	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.5	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.4	REACTOME APC C CDC20 MEDIATED DEGRADATION OF CYCLIN B	Genes involved in APC/C:Cdc20 mediated degradation of Cyclin B
0.0	1.4	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	0.9	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.8	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.3	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.5	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.2	REACTOME SIGNALING BY NOTCH2	Genes involved in Signaling by NOTCH2
0.0	0.9	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	0.3	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.3	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.3	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.4	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0	0.4	REACTOME MEIOSIS	Genes involved in Meiosis
0.0	1.2	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	0.3	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation

Results for FOXO3_FOXD2

Z-value: 0.81

Motif logo

Transcription factors associated with FOXO3_FOXD2

Activity-expression correlation:

Activity profile of FOXO3_FOXD2 motif

Sorted Z-values of FOXO3_FOXD2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of FOXO3_FOXD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: