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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for GATA2
Z-value: 1.25
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Transcription factors associated with GATA2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA2 | hg19_v2_chr3_-_128207349_128207386 | 0.86 | 1.2e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_101542462 Show fit | 7.28 |
ENST00000370449.4
ENST00000370434.1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
|
| chr6_-_127780510 Show fit | 3.12 |
ENST00000487331.2
ENST00000483725.3 |
KIAA0408 |
|
| chr2_+_42275153 Show fit | 2.87 |
ENST00000294964.5
|
protein kinase domain containing, cytoplasmic |
|
| chr15_+_66797627 Show fit | 2.70 |
ENST00000565627.1
ENST00000564179.1 |
zwilch kinetochore protein |
|
| chr17_-_15165854 Show fit | 2.41 |
ENST00000395936.1
ENST00000395938.2 |
peripheral myelin protein 22 |
|
| chr2_-_169769787 Show fit | 2.26 |
ENST00000451987.1
|
SPC25, NDC80 kinetochore complex component |
|
| chr5_-_75919217 Show fit | 2.11 |
ENST00000504899.1
|
coagulation factor II (thrombin) receptor-like 2 |
|
| chr17_+_4853442 Show fit | 2.04 |
ENST00000522301.1
|
enolase 3 (beta, muscle) |
|
| chr15_+_59910132 Show fit | 1.98 |
ENST00000559200.1
|
glucosaminyl (N-acetyl) transferase 3, mucin type |
|
| chr3_-_149095652 Show fit | 1.83 |
ENST00000305366.3
|
transmembrane 4 L six family member 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.3 | GO:0050787 | antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787) |
| 0.0 | 6.9 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.6 | 4.6 | GO:1902847 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.2 | 4.2 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.4 | 3.5 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.1 | 3.5 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.1 | 3.4 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.1 | 3.3 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.2 | 3.2 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.2 | 3.2 | GO:0098870 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.3 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.3 | 7.2 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.0 | 4.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 3.9 | GO:0043218 | compact myelin(GO:0043218) |
| 0.0 | 3.9 | GO:0005902 | microvillus(GO:0005902) |
| 0.9 | 3.7 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.0 | 3.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.5 | 3.3 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.3 | 3.2 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 3.2 | GO:0005814 | centriole(GO:0005814) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.4 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 0.1 | 4.7 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.5 | 3.4 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.0 | 3.4 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 3.2 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 3.1 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.1 | 3.1 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.3 | 2.8 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.0 | 2.7 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 2.6 | GO:0005112 | Notch binding(GO:0005112) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 2.8 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 2.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.5 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 2.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 2.4 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 2.3 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.3 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.0 | 2.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 7.0 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 6.1 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 4.7 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.1 | 4.2 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 3.5 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 3.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 3.4 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 3.4 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 3.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |