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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for GATA5
Z-value: 0.90
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Transcription factors associated with GATA5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GATA5 | hg19_v2_chr20_-_61051026_61051057 | -0.88 | 3.6e-07 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_79115503 Show fit | 2.93 |
ENST00000370747.4
ENST00000438486.1 ENST00000545124.1 |
interferon-induced protein 44 |
|
| chr4_-_110723134 Show fit | 2.59 |
ENST00000510800.1
ENST00000512148.1 |
complement factor I |
|
| chr5_+_147443534 Show fit | 2.26 |
ENST00000398454.1
ENST00000359874.3 ENST00000508733.1 ENST00000256084.7 |
serine peptidase inhibitor, Kazal type 5 |
|
| chr10_+_118187379 Show fit | 2.17 |
ENST00000369230.3
|
pancreatic lipase-related protein 3 |
|
| chr4_-_110723335 Show fit | 2.12 |
ENST00000394634.2
|
complement factor I |
|
| chr3_+_118905564 Show fit | 2.03 |
ENST00000460625.1
|
uroplakin 1B |
|
| chr17_-_74639886 Show fit | 1.97 |
ENST00000156626.7
|
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 |
|
| chr4_-_110723194 Show fit | 1.96 |
ENST00000394635.3
|
complement factor I |
|
| chrX_-_73061339 Show fit | 1.74 |
ENST00000602863.1
|
X inactive specific transcript (non-protein coding) |
|
| chr21_+_39668478 Show fit | 1.72 |
ENST00000398927.1
|
potassium inwardly-rectifying channel, subfamily J, member 15 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GATA5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.9 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.1 | 4.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 2.6 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.1 | 2.5 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.3 | 2.3 | GO:0002784 | regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786) |
| 0.0 | 1.7 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 1.7 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 1.4 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.3 | 0.9 | GO:0030187 | melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187) |
| 0.0 | 0.9 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.3 | 2.3 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.1 | 1.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.9 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 0.8 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.8 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.2 | 0.7 | GO:0070288 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
| 0.0 | 0.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.7 | GO:0090533 | cation-transporting ATPase complex(GO:0090533) |
| 0.0 | 0.6 | GO:0033270 | paranode region of axon(GO:0033270) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 4.9 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 2.6 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.1 | 2.6 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 2.5 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 2.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.7 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 1.6 | GO:0001848 | complement binding(GO:0001848) |
| 0.0 | 1.3 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.0 | 1.2 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.6 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.8 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.7 | PID CD40 PATHWAY | CD40/CD40L signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 1.7 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.3 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 1.1 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.0 | 1.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.9 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 0.8 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.8 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.8 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 0.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |