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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for GCM2
Z-value: 1.69
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Transcription factors associated with GCM2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GCM2 | hg19_v2_chr6_-_10882174_10882274 | 0.12 | 6.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_3449821 Show fit | 5.92 |
ENST00000407501.2
ENST00000405385.3 ENST00000546979.1 |
TGFB-induced factor homeobox 1 |
|
| chr4_-_74864386 Show fit | 5.68 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr18_+_3449695 Show fit | 5.25 |
ENST00000343820.5
|
TGFB-induced factor homeobox 1 |
|
| chr5_-_138718973 Show fit | 5.17 |
ENST00000353963.3
ENST00000348729.3 |
solute carrier family 23 (ascorbic acid transporter), member 1 |
|
| chr17_+_17206635 Show fit | 5.16 |
ENST00000389022.4
|
5',3'-nucleotidase, mitochondrial |
|
| chr20_-_23731569 Show fit | 5.16 |
ENST00000304749.2
|
cystatin SN |
|
| chr1_+_20878932 Show fit | 4.90 |
ENST00000332947.4
|
family with sequence similarity 43, member B |
|
| chr19_+_589893 Show fit | 4.58 |
ENST00000251287.2
|
hyperpolarization activated cyclic nucleotide-gated potassium channel 2 |
|
| chr17_-_46703826 Show fit | 4.30 |
ENST00000550387.1
ENST00000311177.5 |
homeobox B9 |
|
| chr18_+_3450161 Show fit | 4.29 |
ENST00000551402.1
ENST00000577543.1 |
TGFB-induced factor homeobox 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GCM2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.1 | GO:0042493 | response to drug(GO:0042493) |
| 0.3 | 7.2 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.2 | 5.8 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 1.4 | 5.5 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
| 0.3 | 5.4 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 1.7 | 5.2 | GO:0015882 | L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904) |
| 0.5 | 5.2 | GO:0046078 | dUMP metabolic process(GO:0046078) |
| 0.2 | 5.2 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.4 | 4.9 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.8 | 4.7 | GO:1903412 | response to bile acid(GO:1903412) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.5 | GO:0044798 | nuclear transcription factor complex(GO:0044798) |
| 0.7 | 5.4 | GO:1990393 | 3M complex(GO:1990393) |
| 0.0 | 5.4 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 5.2 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 1.5 | 4.6 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.0 | 4.2 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.4 | 3.9 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.1 | 3.9 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 3.6 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 3.5 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.9 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 1.2 | 7.2 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.0 | 6.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 6.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.4 | 5.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 1.8 | 5.5 | GO:0015067 | amidinotransferase activity(GO:0015067) glycine amidinotransferase activity(GO:0015068) |
| 0.2 | 5.4 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 1.7 | 5.2 | GO:0070890 | L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890) |
| 0.2 | 5.2 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.4 | 4.7 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 10.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 4.2 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 4.0 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 3.8 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 3.7 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 3.5 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 3.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 3.1 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 15.5 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 7.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 5.4 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.3 | 5.2 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 5.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.3 | 4.7 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.2 | 3.9 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.2 | 3.7 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.2 | 3.4 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 3.2 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |