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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for GLIS2
Z-value: 2.11
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Transcription factors associated with GLIS2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GLIS2 | hg19_v2_chr16_+_4382225_4382225 | 0.86 | 1.2e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_55795493 Show fit | 16.67 |
ENST00000309383.1
|
BR serine/threonine kinase 1 |
|
| chrX_-_30326445 Show fit | 9.25 |
ENST00000378963.1
|
nuclear receptor subfamily 0, group B, member 1 |
|
| chr11_+_844067 Show fit | 8.34 |
ENST00000397406.1
ENST00000409543.2 ENST00000525201.1 |
tetraspanin 4 |
|
| chr19_+_45417504 Show fit | 8.19 |
ENST00000588750.1
ENST00000588802.1 |
apolipoprotein C-I |
|
| chr6_-_32908792 Show fit | 8.13 |
ENST00000418107.2
|
major histocompatibility complex, class II, DM beta |
|
| chr11_-_117695449 Show fit | 8.00 |
ENST00000292079.2
|
FXYD domain containing ion transport regulator 2 |
|
| chr19_+_45417921 Show fit | 7.56 |
ENST00000252491.4
ENST00000592885.1 ENST00000589781.1 |
apolipoprotein C-I |
|
| chr2_+_37571717 Show fit | 7.27 |
ENST00000338415.3
ENST00000404976.1 |
glutaminyl-peptide cyclotransferase |
|
| chr19_+_45973120 Show fit | 7.11 |
ENST00000592811.1
ENST00000586615.1 |
FBJ murine osteosarcoma viral oncogene homolog B |
|
| chr19_+_45417812 Show fit | 6.80 |
ENST00000592535.1
|
apolipoprotein C-I |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLIS2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.2 | 28.9 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.2 | 16.9 | GO:0031572 | G2 DNA damage checkpoint(GO:0031572) |
| 0.1 | 14.8 | GO:0007219 | Notch signaling pathway(GO:0007219) |
| 4.3 | 12.9 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 4.1 | 12.4 | GO:0017186 | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) |
| 0.1 | 12.3 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 1.3 | 11.7 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.3 | 11.1 | GO:0051412 | response to corticosterone(GO:0051412) |
| 0.6 | 10.0 | GO:0030238 | male sex determination(GO:0030238) |
| 1.5 | 9.2 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 26.6 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 23.5 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.2 | 16.4 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 15.0 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.6 | 12.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 11.3 | GO:0097546 | ciliary base(GO:0097546) |
| 0.7 | 9.3 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 8.9 | GO:0005901 | caveola(GO:0005901) |
| 0.3 | 8.0 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.2 | 7.2 | GO:0000145 | exocyst(GO:0000145) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 26.6 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.7 | 18.1 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 15.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 14.3 | GO:0004857 | enzyme inhibitor activity(GO:0004857) |
| 4.1 | 12.4 | GO:0016603 | glutaminyl-peptide cyclotransferase activity(GO:0016603) |
| 0.4 | 12.4 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.4 | 12.3 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 11.9 | GO:0020037 | heme binding(GO:0020037) |
| 0.2 | 10.1 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.0 | 8.8 | GO:0005178 | integrin binding(GO:0005178) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 12.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 9.1 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.2 | 8.0 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 7.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 7.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 5.9 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.3 | 5.8 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 5.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 5.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.9 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 10.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 9.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 8.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 7.5 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.5 | 7.1 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.2 | 6.7 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.3 | 6.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.2 | 5.2 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.1 | 4.8 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |