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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GLIS3

Z-value: 0.65

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Transcription factors associated with GLIS3

Gene Symbol Gene ID Gene Info
GLIS3
ENSG00000107249.17 GLIS family zinc finger 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GLIS3hg19_v2_chr9_-_4299874_42999160.961.4e-11Click!

Activity profile of GLIS3 motif

Sorted Z-values of GLIS3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_247095236 1.93 ENST00000478568.1
AHCTF1
AT hook containing transcription factor 1
chr19_+_48828582 1.54 ENST00000270221.6
ENST00000596315.1
EMP3
epithelial membrane protein 3
chr21_+_38071430 1.51 ENST00000290399.6
SIM2
single-minded family bHLH transcription factor 2
chr7_+_150758304 1.14 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr17_-_33446820 0.99 ENST00000592577.1
ENST00000590016.1
ENST00000345365.6
ENST00000360276.3
ENST00000357906.3
RAD51D
RAD51 paralog D
chr7_+_150758642 0.98 ENST00000488420.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr19_-_10613862 0.94 ENST00000592055.1
KEAP1
kelch-like ECH-associated protein 1
chr1_-_45988542 0.89 ENST00000424390.1
PRDX1
peroxiredoxin 1
chr12_+_109577202 0.87 ENST00000377848.3
ENST00000377854.5
ACACB
acetyl-CoA carboxylase beta
chr19_-_10613361 0.86 ENST00000591039.1
ENST00000591419.1
KEAP1
kelch-like ECH-associated protein 1
chr6_+_44191290 0.83 ENST00000371755.3
ENST00000371740.5
ENST00000371731.1
ENST00000393841.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr11_+_68451943 0.81 ENST00000265643.3
GAL
galanin/GMAP prepropeptide
chr7_+_65958693 0.78 ENST00000445681.1
ENST00000452565.1
GS1-124K5.4
GS1-124K5.4
chr20_+_61867235 0.78 ENST00000342412.6
ENST00000217169.3
BIRC7
baculoviral IAP repeat containing 7
chr17_+_80818231 0.78 ENST00000576996.1
TBCD
tubulin folding cofactor D
chr6_+_24495067 0.76 ENST00000357578.3
ENST00000546278.1
ENST00000491546.1
ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chr19_-_48673552 0.74 ENST00000536218.1
ENST00000596549.1
LIG1
ligase I, DNA, ATP-dependent
chr9_+_131903916 0.72 ENST00000419582.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr9_+_131904295 0.71 ENST00000434095.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr3_-_160167540 0.69 ENST00000496222.1
ENST00000471396.1
ENST00000471155.1
ENST00000309784.4
TRIM59
tripartite motif containing 59
chr7_-_50518022 0.69 ENST00000356889.4
ENST00000420829.1
ENST00000448788.1
ENST00000395556.2
ENST00000422854.1
ENST00000435566.1
ENST00000433017.1
FIGNL1
fidgetin-like 1
chr6_+_44191507 0.68 ENST00000371724.1
ENST00000371713.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr9_+_131904233 0.65 ENST00000432651.1
ENST00000435132.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr5_+_41925325 0.63 ENST00000296812.2
ENST00000281623.3
ENST00000509134.1
FBXO4
F-box protein 4
chr3_+_127348005 0.60 ENST00000342480.6
PODXL2
podocalyxin-like 2
chr14_+_77228532 0.60 ENST00000167106.4
ENST00000554237.1
VASH1
vasohibin 1
chr6_+_24495185 0.57 ENST00000348925.2
ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chrX_+_118370288 0.57 ENST00000535419.1
PGRMC1
progesterone receptor membrane component 1
chr19_+_40697514 0.56 ENST00000253055.3
MAP3K10
mitogen-activated protein kinase kinase kinase 10
chr11_+_393428 0.56 ENST00000533249.1
ENST00000527442.1
PKP3
plakophilin 3
chr12_+_132312931 0.55 ENST00000360564.1
ENST00000545671.1
ENST00000545790.1
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr10_+_71389983 0.51 ENST00000373279.4
C10orf35
chromosome 10 open reading frame 35
chr1_-_45987526 0.50 ENST00000372079.1
ENST00000262746.1
ENST00000447184.1
ENST00000319248.8
PRDX1
peroxiredoxin 1
chr15_+_91478493 0.48 ENST00000418476.2
UNC45A
unc-45 homolog A (C. elegans)
chr11_+_1463728 0.46 ENST00000544817.1
BRSK2
BR serine/threonine kinase 2
chr22_-_31742218 0.46 ENST00000266269.5
ENST00000405309.3
ENST00000351933.4
PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr9_-_130742792 0.45 ENST00000373095.1
FAM102A
family with sequence similarity 102, member A
chr5_+_172386517 0.44 ENST00000519522.1
RPL26L1
ribosomal protein L26-like 1
chr22_+_50628999 0.40 ENST00000395827.1
TRABD
TraB domain containing
chr16_+_30006615 0.38 ENST00000563197.1
INO80E
INO80 complex subunit E
chrX_+_118370211 0.38 ENST00000217971.7
PGRMC1
progesterone receptor membrane component 1
chr1_-_92371839 0.37 ENST00000370399.2
TGFBR3
transforming growth factor, beta receptor III
chr11_-_68671264 0.35 ENST00000362034.2
MRPL21
mitochondrial ribosomal protein L21
chr3_-_160167301 0.32 ENST00000494486.1
TRIM59
tripartite motif containing 59
chr6_+_33172407 0.31 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr3_-_160167508 0.31 ENST00000479460.1
TRIM59
tripartite motif containing 59
chr8_-_74791051 0.30 ENST00000453587.2
ENST00000602969.1
ENST00000602593.1
ENST00000419880.3
ENST00000517608.1
UBE2W
ubiquitin-conjugating enzyme E2W (putative)
chr2_+_219824357 0.29 ENST00000302625.4
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr11_-_118789613 0.28 ENST00000532899.1
BCL9L
B-cell CLL/lymphoma 9-like
chr8_-_12051576 0.27 ENST00000524571.2
ENST00000533852.2
ENST00000533513.1
ENST00000448228.2
ENST00000534520.1
ENST00000321602.8
FAM86B1
family with sequence similarity 86, member B1
chr12_+_48152774 0.26 ENST00000549243.1
SLC48A1
solute carrier family 48 (heme transporter), member 1
chr4_-_84255935 0.25 ENST00000513463.1
HPSE
heparanase
chr8_-_29120580 0.23 ENST00000524189.1
KIF13B
kinesin family member 13B
chr20_+_18447771 0.22 ENST00000377603.4
POLR3F
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr5_+_172386419 0.21 ENST00000265100.2
ENST00000519239.1
RPL26L1
ribosomal protein L26-like 1
chr11_+_68671310 0.21 ENST00000255078.3
ENST00000539224.1
IGHMBP2
immunoglobulin mu binding protein 2
chr17_-_56605341 0.20 ENST00000583114.1
SEPT4
septin 4
chr12_+_132568814 0.20 ENST00000454179.2
ENST00000389560.2
ENST00000443539.2
ENST00000392352.1
EP400NL
EP400 N-terminal like
chr9_-_98279241 0.20 ENST00000437951.1
ENST00000375274.2
ENST00000430669.2
ENST00000468211.2
PTCH1
patched 1
chr8_-_29120604 0.20 ENST00000521515.1
KIF13B
kinesin family member 13B
chr3_-_25824925 0.19 ENST00000396649.3
ENST00000428257.1
ENST00000280700.5
NGLY1
N-glycanase 1
chr17_-_77925806 0.15 ENST00000574241.2
TBC1D16
TBC1 domain family, member 16
chr19_-_56092187 0.13 ENST00000325421.4
ENST00000592239.1
ZNF579
zinc finger protein 579
chr19_-_49828438 0.12 ENST00000454748.3
ENST00000598828.1
ENST00000335875.4
SLC6A16
solute carrier family 6, member 16
chr20_-_44718538 0.12 ENST00000290231.6
ENST00000372291.3
NCOA5
nuclear receptor coactivator 5
chr19_+_46850251 0.12 ENST00000012443.4
PPP5C
protein phosphatase 5, catalytic subunit
chr17_-_5015129 0.12 ENST00000575898.1
ENST00000416429.2
ZNF232
zinc finger protein 232
chr1_+_110527308 0.12 ENST00000369799.5
AHCYL1
adenosylhomocysteinase-like 1
chr3_+_173116225 0.11 ENST00000457714.1
NLGN1
neuroligin 1
chr7_+_23636992 0.10 ENST00000307471.3
ENST00000409765.1
CCDC126
coiled-coil domain containing 126
chr5_-_137090028 0.08 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr22_-_50964849 0.08 ENST00000543927.1
ENST00000423348.1
SCO2
SCO2 cytochrome c oxidase assembly protein
chr8_+_11627148 0.08 ENST00000436750.3
NEIL2
nei endonuclease VIII-like 2 (E. coli)
chr11_+_5646213 0.07 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr19_+_1495362 0.07 ENST00000395479.4
REEP6
receptor accessory protein 6
chr12_-_57400227 0.07 ENST00000300101.2
ZBTB39
zinc finger and BTB domain containing 39
chr18_+_3451584 0.06 ENST00000551541.1
TGIF1
TGFB-induced factor homeobox 1
chr8_+_11627205 0.05 ENST00000455213.2
ENST00000403422.3
ENST00000528323.1
ENST00000284503.6
NEIL2
nei endonuclease VIII-like 2 (E. coli)
chr1_-_53019059 0.05 ENST00000484723.2
ENST00000524582.1
ZCCHC11
zinc finger, CCHC domain containing 11
chr17_+_7792101 0.04 ENST00000358181.4
ENST00000330494.7
CHD3
chromodomain helicase DNA binding protein 3
chr11_-_8680383 0.04 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr18_+_3451646 0.04 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
TGIF1
TGFB-induced factor homeobox 1
chr11_+_57308979 0.03 ENST00000457912.1
SMTNL1
smoothelin-like 1
chr19_+_46850320 0.03 ENST00000391919.1
PPP5C
protein phosphatase 5, catalytic subunit
chr3_-_25824872 0.03 ENST00000308710.5
NGLY1
N-glycanase 1
chr17_+_5389605 0.03 ENST00000576988.1
ENST00000576570.1
ENST00000573759.1
MIS12
MIS12 kinetochore complex component
chr4_-_74904398 0.03 ENST00000296026.4
CXCL3
chemokine (C-X-C motif) ligand 3
chr22_+_18834324 0.02 ENST00000342005.4
AC008132.13
Uncharacterized protein
chr2_-_241737128 0.01 ENST00000404283.3
KIF1A
kinesin family member 1A
chr16_+_89686991 0.01 ENST00000393092.3
DPEP1
dipeptidase 1 (renal)
chr1_+_1950763 0.01 ENST00000378585.4
GABRD
gamma-aminobutyric acid (GABA) A receptor, delta
chr17_-_79917645 0.00 ENST00000477214.1
NOTUM
notum pectinacetylesterase homolog (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0015862 uridine transport(GO:0015862)
0.3 0.8 GO:0051795 positive regulation of catagen(GO:0051795)
0.3 1.3 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.2 0.6 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 0.9 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.1 1.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 1.0 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.3 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 1.9 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 0.4 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.8 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.1 0.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.6 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.6 GO:0002159 desmosome assembly(GO:0002159)
0.1 1.5 GO:0032060 bleb assembly(GO:0032060)
0.0 0.6 GO:0042756 drinking behavior(GO:0042756)
0.0 1.3 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.2 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.2 GO:0010157 response to chlorate(GO:0010157)
0.0 0.1 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.0 1.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.2 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.8 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.4 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 2.1 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0042045 epithelial fluid transport(GO:0042045)
0.0 0.5 GO:1904152 regulation of retrograde protein transport, ER to cytosol(GO:1904152)
0.0 0.6 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 0.7 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.3 GO:0015886 heme transport(GO:0015886)
0.0 1.5 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 0.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 1.9 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.4 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.3 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 1.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.2 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0032797 SMN complex(GO:0032797)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.1 0.6 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 1.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.8 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.4 GO:0070123 transforming growth factor beta receptor activity, type III(GO:0070123)
0.1 0.3 GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.1 0.3 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 2.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.2 GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity(GO:0000224)
0.1 0.2 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 1.0 GO:0000150 recombinase activity(GO:0000150)
0.0 1.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.2 GO:0005119 smoothened binding(GO:0005119)
0.0 0.2 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.3 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.3 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.8 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.6 GO:0051879 Hsp90 protein binding(GO:0051879)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 2.1 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.9 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.8 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis