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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for GRHL1

Z-value: 2.25

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
ENSG00000134317.13 grainyhead like transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GRHL1hg19_v2_chr2_+_10091783_100918110.961.3e-11Click!

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_95940186 14.55 ENST00000403131.2
ENST00000317668.4
ENST00000317620.9
prominin 2
chr1_-_201368707 14.10 ENST00000391967.2
ladinin 1
chr1_+_35247859 13.83 ENST00000373362.3
gap junction protein, beta 3, 31kDa
chr1_-_201368653 13.13 ENST00000367313.3
ladinin 1
chr3_-_172241250 12.58 ENST00000420541.2
ENST00000241261.2
tumor necrosis factor (ligand) superfamily, member 10
chr2_+_95940220 12.05 ENST00000542147.1
prominin 2
chr18_+_61254221 10.47 ENST00000431153.1
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr19_+_10736183 9.48 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
solute carrier family 44 (choline transporter), member 2
chr9_+_71736177 7.70 ENST00000606364.1
ENST00000453658.2
tight junction protein 2
chr5_-_132299290 7.09 ENST00000378595.3
AF4/FMR2 family, member 4
chr20_-_18038521 6.63 ENST00000278780.6
ovo-like zinc finger 2
chr1_-_153113927 6.59 ENST00000368752.4
small proline-rich protein 2B
chr8_+_144821557 6.06 ENST00000534398.1
FAM83H antisense RNA 1 (head to head)
chr15_+_94774767 5.96 ENST00000543482.1
multiple C2 domains, transmembrane 2
chr19_+_12035878 5.96 ENST00000254321.5
ENST00000538752.1
ENST00000590798.1
zinc finger protein 700
zinc finger protein 763
Uncharacterized protein; Zinc finger protein 763
chr5_+_125758865 5.93 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chr14_-_24732738 5.61 ENST00000558074.1
ENST00000560226.1
transglutaminase 1
chr5_+_125758813 5.53 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr13_-_20806440 5.52 ENST00000400066.3
ENST00000400065.3
ENST00000356192.6
gap junction protein, beta 6, 30kDa
chr8_-_130799134 5.30 ENST00000276708.4
gasdermin C
chr7_-_80551671 5.05 ENST00000419255.2
ENST00000544525.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_+_155023757 4.64 ENST00000356955.2
ENST00000449910.2
ENST00000359280.4
ENST00000360674.4
ENST00000368412.3
ENST00000355956.2
ENST00000368410.2
ENST00000271836.6
ENST00000368413.1
ENST00000531455.1
ENST00000447332.3
ADAM metallopeptidase domain 15
chr20_-_61002584 4.50 ENST00000252998.1
RBBP8 N-terminal like
chr3_+_101568349 4.48 ENST00000326151.5
ENST00000326172.5
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr9_+_5450503 4.42 ENST00000381573.4
ENST00000381577.3
CD274 molecule
chr19_+_19496728 4.40 ENST00000537887.1
ENST00000417582.2
GATA zinc finger domain containing 2A
chr5_-_132299313 4.35 ENST00000265343.5
AF4/FMR2 family, member 4
chr2_+_113816215 4.26 ENST00000346807.3
interleukin 36 receptor antagonist
chr2_-_85641162 4.25 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
capping protein (actin filament), gelsolin-like
chr9_+_77703414 4.22 ENST00000346234.6
osteoclast stimulating factor 1
chr5_+_125759140 3.84 ENST00000543198.1
GRAM domain containing 3
chr11_-_67442079 3.56 ENST00000349015.3
aldehyde dehydrogenase 3 family, member B2
chr16_+_2564254 3.52 ENST00000565223.1
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr4_-_68995571 3.27 ENST00000356291.2
transmembrane protease, serine 11F
chr6_+_168227611 3.25 ENST00000344191.4
ENST00000351017.4
ENST00000392108.3
ENST00000366806.2
ENST00000392112.1
ENST00000400824.4
ENST00000447894.2
ENST00000400822.3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr19_-_12405606 3.19 ENST00000356109.5
zinc finger protein 44
chr14_-_62217779 3.03 ENST00000554254.1
HIF1A antisense RNA 2
chr18_+_20494078 2.85 ENST00000579124.1
ENST00000577588.1
ENST00000582354.1
ENST00000581819.1
retinoblastoma binding protein 8
chr1_-_28384598 2.74 ENST00000373864.1
eyes absent homolog 3 (Drosophila)
chr19_+_19496624 2.58 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATA zinc finger domain containing 2A
chr1_+_210406121 2.57 ENST00000367012.3
SERTA domain containing 4
chr4_-_99850243 2.49 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
eukaryotic translation initiation factor 4E
chr19_-_12405689 2.36 ENST00000355684.5
zinc finger protein 44
chr6_+_168227552 2.23 ENST00000400825.4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr11_-_93583697 2.21 ENST00000409977.1
V-set and transmembrane domain containing 5
chr22_+_18560675 1.99 ENST00000329627.7
peroxisomal biogenesis factor 26
chr12_+_123874589 1.93 ENST00000437502.1
SET domain containing (lysine methyltransferase) 8
chr11_-_67442196 1.92 ENST00000525827.1
aldehyde dehydrogenase 3 family, member B2
chr12_+_118814185 1.89 ENST00000543473.1
suppressor of defective silencing 3 homolog (S. cerevisiae)
chr7_-_102184083 1.85 ENST00000379357.5
polymerase (RNA) II (DNA directed) polypeptide J3
chr9_-_77703115 1.79 ENST00000361092.4
ENST00000376808.4
nicotinamide riboside kinase 1
chr3_-_58643483 1.46 ENST00000483787.1
family with sequence similarity 3, member D
chr14_-_23540826 1.38 ENST00000357481.2
apoptotic chromatin condensation inducer 1
chr18_+_9475001 1.29 ENST00000019317.4
ralA binding protein 1
chr3_+_186383741 1.28 ENST00000232003.4
histidine-rich glycoprotein
chr19_+_58038683 1.12 ENST00000240719.3
ENST00000376233.3
ENST00000594943.1
ENST00000602149.1
zinc finger protein 549
chr19_-_11849697 1.10 ENST00000586121.1
ENST00000431998.1
ENST00000341191.6
ENST00000545749.1
ENST00000440527.1
zinc finger protein 823
chr9_+_130565568 1.08 ENST00000423577.1
folylpolyglutamate synthase
chr3_-_113415441 1.07 ENST00000491165.1
ENST00000316407.4
KIAA2018
chr7_-_102283238 0.99 ENST00000340457.8
uroplakin 3B-like
chr14_-_23540747 0.98 ENST00000555566.1
ENST00000338631.6
ENST00000557515.1
ENST00000397341.3
apoptotic chromatin condensation inducer 1
chr18_+_12093838 0.98 ENST00000587848.2
ankyrin repeat domain 62
chr11_+_706595 0.97 ENST00000531348.1
ENST00000530636.1
EPS8-like 2
chr10_+_96443204 0.96 ENST00000339022.5
cytochrome P450, family 2, subfamily C, polypeptide 18
chr18_-_55470320 0.87 ENST00000536015.1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr4_+_26859300 0.84 ENST00000494628.2
stromal interaction molecule 2
chr10_+_81838792 0.84 ENST00000372273.3
transmembrane protein 254
chr9_+_130565487 0.74 ENST00000373225.3
ENST00000431857.1
folylpolyglutamate synthase
chr18_-_35145728 0.67 ENST00000361795.5
ENST00000603232.1
CUGBP, Elav-like family member 4
chr19_-_12146483 0.66 ENST00000455504.2
ENST00000547560.1
ENST00000552904.1
ENST00000419886.2
ENST00000550507.1
ENST00000344980.6
ENST00000550745.1
ENST00000411841.1
zinc finger protein 433
chr19_+_12035913 0.64 ENST00000591944.1
Uncharacterized protein; Zinc finger protein 763
chr3_-_58643458 0.58 ENST00000498347.1
family with sequence similarity 3, member D
chr1_+_44440575 0.48 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr8_+_22601 0.37 ENST00000522481.3
ENST00000518652.1
Uncharacterized protein
chr10_+_81838411 0.32 ENST00000372281.3
ENST00000372277.3
ENST00000372275.1
ENST00000372274.1
transmembrane protein 254
chr1_+_206643806 0.32 ENST00000537984.1
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr6_+_32121218 0.29 ENST00000414204.1
ENST00000361568.2
ENST00000395523.1
palmitoyl-protein thioesterase 2
chr4_-_110736505 0.24 ENST00000609440.1
RP11-602N24.3
chr18_-_35145689 0.20 ENST00000591287.1
ENST00000601019.1
ENST00000601392.1
CUGBP, Elav-like family member 4
chr22_+_18560743 0.19 ENST00000399744.3
peroxisomal biogenesis factor 26
chr3_+_161214596 0.15 ENST00000327928.4
otolin 1
chr18_-_35145981 0.15 ENST00000420428.2
ENST00000412753.1
CUGBP, Elav-like family member 4
chr7_-_138794081 0.14 ENST00000464606.1
zinc finger CCCH-type, antiviral 1
chr1_+_40723779 0.13 ENST00000372759.3
zinc metallopeptidase STE24
chr16_-_23568651 0.13 ENST00000563232.1
ENST00000563459.1
ENST00000449606.1
glutamyl-tRNA synthetase 2, mitochondrial
chr11_+_119038897 0.10 ENST00000454811.1
ENST00000449394.1
NLR family member X1
chr12_+_18414446 0.10 ENST00000433979.1
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr1_-_234667504 0.09 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
chrX_-_119603138 0.08 ENST00000200639.4
ENST00000371335.4
ENST00000538785.1
ENST00000434600.2
lysosomal-associated membrane protein 2
chr11_+_119039069 0.08 ENST00000422249.1
NLR family member X1
chr19_-_4043154 0.06 ENST00000535853.1
AC016586.1

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 26.6 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
3.5 10.5 GO:1902173 negative regulation of keratinocyte apoptotic process(GO:1902173)
1.1 6.6 GO:0060214 endocardium formation(GO:0060214)
0.8 5.6 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.8 7.7 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.7 2.8 GO:0035188 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.6 1.8 GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.6 9.5 GO:0015871 choline transport(GO:0015871)
0.5 4.3 GO:1902714 antifungal humoral response(GO:0019732) negative regulation of interferon-gamma secretion(GO:1902714)
0.5 12.6 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.5 5.1 GO:0003350 pulmonary myocardium development(GO:0003350)
0.4 1.3 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.4 4.4 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.3 3.5 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.3 0.9 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.2 2.4 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.2 4.6 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.2 5.5 GO:0006068 ethanol catabolic process(GO:0006068)
0.2 4.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.2 2.2 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.1 2.7 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 13.8 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 6.6 GO:0018149 peptide cross-linking(GO:0018149)
0.1 5.5 GO:0051602 response to electrical stimulus(GO:0051602)
0.1 1.0 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.8 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.7 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.1 10.8 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1 7.0 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 2.5 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.1 GO:0071586 prenylated protein catabolic process(GO:0030327) CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.0 1.8 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 0.1 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424)
0.0 2.0 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 1.0 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.3 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.5 GO:0007035 vacuolar acidification(GO:0007035)
0.0 6.0 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 1.9 GO:0016575 histone deacetylation(GO:0016575)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 26.6 GO:0044393 microspike(GO:0044393)
0.7 19.4 GO:0005922 connexon complex(GO:0005922)
0.4 4.0 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.4 11.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 2.4 GO:0061574 ASAP complex(GO:0061574)
0.2 4.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.2 7.0 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 12.2 GO:0001533 cornified envelope(GO:0001533)
0.2 27.2 GO:0005604 basement membrane(GO:0005604)
0.1 2.5 GO:0033391 chromatoid body(GO:0033391)
0.1 1.9 GO:0016580 Sin3 complex(GO:0016580)
0.1 10.9 GO:0043202 lysosomal lumen(GO:0043202)
0.1 2.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.9 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 9.5 GO:0035579 specific granule membrane(GO:0035579)
0.0 5.5 GO:0005811 lipid particle(GO:0005811)
0.0 1.3 GO:0036019 endolysosome(GO:0036019)
0.0 7.7 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 3.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 3.0 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 5.4 GO:0005615 extracellular space(GO:0005615)
0.0 0.9 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 9.5 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.9 4.3 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.7 13.8 GO:0005243 gap junction channel activity(GO:0005243)
0.6 1.8 GO:0008841 tetrahydrofolylpolyglutamate synthase activity(GO:0004326) dihydrofolate synthase activity(GO:0008841)
0.4 5.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.3 5.5 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 26.6 GO:0015485 cholesterol binding(GO:0015485)
0.2 2.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 12.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 5.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 7.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 2.8 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 4.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 11.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.7 GO:0042835 BRE binding(GO:0042835)
0.1 1.9 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 0.9 GO:1901612 cardiolipin binding(GO:1901612)
0.1 6.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 31.4 GO:0045296 cadherin binding(GO:0045296)
0.0 1.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0004818 glutamate-tRNA ligase activity(GO:0004818)
0.0 1.0 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 8.9 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.3 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 7.0 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.9 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 2.2 GO:0051117 ATPase binding(GO:0051117)
0.0 2.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 3.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 12.6 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 5.5 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 4.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 17.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 7.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 7.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.8 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.3 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 2.5 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.9 PID P53 REGULATION PATHWAY p53 pathway
0.0 5.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 19.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.4 12.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.3 7.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3 9.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 4.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.1 4.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 2.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 2.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 2.8 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases