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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HDX

Z-value: 0.49

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.9 highly divergent homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HDXhg19_v2_chrX_-_83757399_837574870.761.0e-04Click!

Activity profile of HDX motif

Sorted Z-values of HDX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_113594279 3.91 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr1_-_153363452 3.62 ENST00000368732.1
ENST00000368733.3
S100A8
S100 calcium binding protein A8
chr18_+_29027696 2.50 ENST00000257189.4
DSG3
desmoglein 3
chr2_+_113735575 2.16 ENST00000376489.2
ENST00000259205.4
IL36G
interleukin 36, gamma
chr9_+_6215799 2.09 ENST00000417746.2
ENST00000456383.2
IL33
interleukin 33
chr1_-_209825674 1.76 ENST00000367030.3
ENST00000356082.4
LAMB3
laminin, beta 3
chr2_+_169926047 1.45 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr19_-_41934635 1.17 ENST00000321702.2
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr19_-_58485895 0.96 ENST00000314391.3
C19orf18
chromosome 19 open reading frame 18
chr3_-_51533966 0.82 ENST00000504652.1
VPRBP
Vpr (HIV-1) binding protein
chr8_+_24151620 0.79 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr14_+_71788096 0.64 ENST00000557151.1
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr3_+_107241882 0.64 ENST00000416476.2
BBX
bobby sox homolog (Drosophila)
chr1_+_47489240 0.60 ENST00000371901.3
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr16_+_1877204 0.37 ENST00000427358.2
FAHD1
fumarylacetoacetate hydrolase domain containing 1
chr10_-_14372870 0.36 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr13_+_97928395 0.33 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chr6_+_42584847 0.31 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr12_+_10460417 0.23 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr11_+_9685604 0.18 ENST00000447399.2
ENST00000318950.6
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr10_+_45406627 0.17 ENST00000389583.4
TMEM72
transmembrane protein 72
chr8_+_145065705 0.16 ENST00000533044.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr12_-_118797475 0.12 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr7_+_144015218 0.11 ENST00000408951.1
OR2A1
olfactory receptor, family 2, subfamily A, member 1
chr1_-_222014008 0.10 ENST00000431729.1
RP11-191N8.2
RP11-191N8.2
chr22_+_40440804 0.09 ENST00000441751.1
ENST00000301923.9
TNRC6B
trinucleotide repeat containing 6B
chr3_-_100565249 0.05 ENST00000495591.1
ENST00000383691.4
ENST00000466947.1
ABI3BP
ABI family, member 3 (NESH) binding protein
chr22_+_45714672 0.03 ENST00000424557.1
FAM118A
family with sequence similarity 118, member A
chr1_+_117602925 0.03 ENST00000369466.4
TTF2
transcription termination factor, RNA polymerase II
chr5_+_157602404 0.02 ENST00000522975.1
CTC-436K13.1
CTC-436K13.1
chrX_+_27608490 0.01 ENST00000451261.2
DCAF8L2
DDB1 and CUL4 associated factor 8-like 2
chr1_+_84629976 0.01 ENST00000446538.1
ENST00000370684.1
ENST00000436133.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_-_66675371 0.00 ENST00000393955.2
PC
pyruvate carboxylase

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.9 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.4 2.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.2 1.2 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.2 3.6 GO:0032119 sequestering of zinc ion(GO:0032119)
0.1 1.5 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.3 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.2 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 1.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 2.5 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0005610 laminin-5 complex(GO:0005610)
0.1 2.5 GO:0030057 desmosome(GO:0030057)
0.0 3.6 GO:0045111 intermediate filament cytoskeleton(GO:0045111)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.6 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 6.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 1.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.1 1.5 GO:0047035 alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 0.4 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.6 GO:0070330 aromatase activity(GO:0070330)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 1.8 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 3.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.8 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization