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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HLF_TEF

Z-value: 0.71

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Transcription factors associated with HLF_TEF

Gene Symbol Gene ID Gene Info
HLF
ENSG00000108924.9 HLF transcription factor, PAR bZIP family member
TEF
ENSG00000167074.10 TEF transcription factor, PAR bZIP family member

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HLFhg19_v2_chr17_+_53343171_533432070.651.8e-03Click!
TEFhg19_v2_chr22_+_41777927_41777971-0.531.7e-02Click!

Activity profile of HLF_TEF motif

Sorted Z-values of HLF_TEF motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_27469383 3.14 ENST00000519742.1
CLU
clusterin
chr8_-_27469196 2.80 ENST00000546343.1
ENST00000560566.1
CLU
clusterin
chr8_-_27468945 2.77 ENST00000405140.3
CLU
clusterin
chr8_-_27468842 2.76 ENST00000523500.1
CLU
clusterin
chr8_-_27468717 2.62 ENST00000520796.1
ENST00000520491.1
CLU
clusterin
chr2_-_240230890 1.58 ENST00000446876.1
HDAC4
histone deacetylase 4
chr17_-_19651654 1.53 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_-_41984835 1.51 ENST00000520406.1
ENST00000518478.1
ENST00000522172.1
ENST00000461854.1
ENST00000521178.1
ENST00000520305.1
ENST00000523501.1
ENST00000520241.1
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr19_+_17413663 1.49 ENST00000594999.1
MRPL34
mitochondrial ribosomal protein L34
chr17_-_19651668 1.31 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_-_19651598 1.29 ENST00000570414.1
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr6_-_64029879 1.26 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN
lengsin, lens protein with glutamine synthetase domain
chr20_+_33759854 1.17 ENST00000216968.4
PROCR
protein C receptor, endothelial
chr12_+_52430894 1.15 ENST00000546842.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr9_-_34665983 1.14 ENST00000416454.1
ENST00000544078.2
ENST00000421828.2
ENST00000423809.1
RP11-195F19.5
HCG2040265, isoform CRA_a; Uncharacterized protein; cDNA FLJ50015
chr3_+_101504200 1.11 ENST00000422132.1
NXPE3
neurexophilin and PC-esterase domain family, member 3
chr1_-_226496772 1.10 ENST00000359525.2
ENST00000460719.1
LIN9
lin-9 homolog (C. elegans)
chr18_+_32621324 1.09 ENST00000300249.5
ENST00000538170.2
ENST00000588910.1
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr17_+_685513 0.99 ENST00000304478.4
RNMTL1
RNA methyltransferase like 1
chr17_-_41623075 0.98 ENST00000545089.1
ETV4
ets variant 4
chr14_-_23285069 0.92 ENST00000554758.1
ENST00000397528.4
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_-_244013384 0.92 ENST00000366539.1
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr5_-_58882219 0.87 ENST00000505453.1
ENST00000360047.5
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_41623691 0.82 ENST00000545954.1
ETV4
ets variant 4
chr17_-_41623716 0.81 ENST00000319349.5
ETV4
ets variant 4
chr17_-_41623259 0.78 ENST00000538265.1
ENST00000591713.1
ETV4
ets variant 4
chr7_-_44887620 0.77 ENST00000349299.3
ENST00000521529.1
ENST00000308153.4
ENST00000350771.3
ENST00000222690.6
ENST00000381124.5
ENST00000437072.1
ENST00000446531.1
H2AFV
H2A histone family, member V
chr17_-_36956155 0.77 ENST00000269554.3
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr14_-_23285011 0.74 ENST00000397532.3
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr3_-_158390282 0.73 ENST00000264265.3
LXN
latexin
chr11_+_69061594 0.73 ENST00000441339.2
ENST00000308946.3
ENST00000535407.1
MYEOV
myeloma overexpressed
chr21_+_45138941 0.73 ENST00000398081.1
ENST00000468090.1
ENST00000291565.4
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr5_+_172332220 0.73 ENST00000518247.1
ENST00000326654.2
ERGIC1
endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
chr16_-_54962704 0.72 ENST00000502066.2
ENST00000560912.1
ENST00000558952.1
CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr7_+_23145884 0.71 ENST00000409689.1
ENST00000410047.1
KLHL7
kelch-like family member 7
chr6_+_24126350 0.70 ENST00000378491.4
ENST00000378478.1
ENST00000378477.2
NRSN1
neurensin 1
chr16_-_53537105 0.68 ENST00000568596.1
ENST00000570004.1
ENST00000564497.1
ENST00000300245.4
ENST00000394657.7
AKTIP
AKT interacting protein
chr17_-_26941179 0.68 ENST00000301037.5
ENST00000530121.1
ENST00000525510.1
ENST00000577790.1
ENST00000531839.1
ENST00000534850.1
SGK494
RP11-192H23.4
uncharacterized serine/threonine-protein kinase SgK494
Uncharacterized protein
chr9_-_123639445 0.66 ENST00000312189.6
PHF19
PHD finger protein 19
chr1_+_154378049 0.66 ENST00000512471.1
IL6R
interleukin 6 receptor
chr9_-_123639304 0.65 ENST00000436309.1
PHF19
PHD finger protein 19
chr1_+_45212051 0.64 ENST00000372222.3
KIF2C
kinesin family member 2C
chr8_+_90914073 0.63 ENST00000297438.2
OSGIN2
oxidative stress induced growth inhibitor family member 2
chr14_-_23284703 0.61 ENST00000555911.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr12_+_52431016 0.61 ENST00000553200.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr2_-_225362533 0.60 ENST00000451538.1
CUL3
cullin 3
chr1_+_45212074 0.60 ENST00000372217.1
KIF2C
kinesin family member 2C
chr2_-_167232484 0.59 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr16_-_54962415 0.56 ENST00000501177.3
ENST00000559598.2
CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr9_-_130712995 0.55 ENST00000373084.4
FAM102A
family with sequence similarity 102, member A
chr17_+_73089382 0.54 ENST00000538213.2
ENST00000584118.1
SLC16A5
solute carrier family 16 (monocarboxylate transporter), member 5
chr10_+_90660832 0.54 ENST00000371924.1
STAMBPL1
STAM binding protein-like 1
chr8_+_110552337 0.53 ENST00000337573.5
EBAG9
estrogen receptor binding site associated, antigen, 9
chr17_-_41623009 0.53 ENST00000393664.2
ETV4
ets variant 4
chr3_+_141103634 0.51 ENST00000507722.1
ZBTB38
zinc finger and BTB domain containing 38
chr17_-_685559 0.50 ENST00000301329.6
GLOD4
glyoxalase domain containing 4
chr5_-_140013275 0.50 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14
CD14 molecule
chr1_+_90308981 0.50 ENST00000527156.1
LRRC8D
leucine rich repeat containing 8 family, member D
chr1_+_169079823 0.49 ENST00000367813.3
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_+_183989157 0.49 ENST00000541912.1
NUP35
nucleoporin 35kDa
chr2_+_183989083 0.49 ENST00000295119.4
NUP35
nucleoporin 35kDa
chr8_+_19536083 0.49 ENST00000519803.1
RP11-1105O14.1
RP11-1105O14.1
chr9_-_123639600 0.47 ENST00000373896.3
PHF19
PHD finger protein 19
chr17_-_73266616 0.46 ENST00000579194.1
ENST00000581777.1
MIF4GD
MIF4G domain containing
chr4_+_75230853 0.45 ENST00000244869.2
EREG
epiregulin
chr14_+_102276132 0.44 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr3_-_45883558 0.43 ENST00000445698.1
ENST00000296135.6
LZTFL1
leucine zipper transcription factor-like 1
chr9_-_88356789 0.43 ENST00000357081.3
ENST00000376081.4
ENST00000337006.4
ENST00000376109.3
AGTPBP1
ATP/GTP binding protein 1
chr17_-_685493 0.42 ENST00000536578.1
ENST00000301328.5
ENST00000576419.1
GLOD4
glyoxalase domain containing 4
chr7_-_15601595 0.42 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chrX_+_9431324 0.42 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr20_-_35329063 0.41 ENST00000422536.1
NDRG3
NDRG family member 3
chr15_+_49913201 0.41 ENST00000329873.5
ENST00000558653.1
ENST00000559164.1
ENST00000560632.1
ENST00000559405.1
ENST00000251250.6
DTWD1
DTW domain containing 1
chr17_+_73455788 0.41 ENST00000581519.1
KIAA0195
KIAA0195
chr15_+_63050785 0.40 ENST00000472902.1
TLN2
talin 2
chr12_-_122017542 0.38 ENST00000446152.2
KDM2B
lysine (K)-specific demethylase 2B
chr20_-_33732952 0.38 ENST00000541621.1
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr13_-_45010939 0.38 ENST00000261489.2
TSC22D1
TSC22 domain family, member 1
chr8_+_94752349 0.37 ENST00000391680.1
RBM12B-AS1
RBM12B antisense RNA 1
chr8_-_102216925 0.36 ENST00000517844.1
ZNF706
zinc finger protein 706
chr2_-_46769694 0.33 ENST00000522587.1
ATP6V1E2
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr2_-_112614424 0.32 ENST00000427997.1
ANAPC1
anaphase promoting complex subunit 1
chr11_+_105948216 0.32 ENST00000278618.4
AASDHPPT
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr16_+_70332956 0.32 ENST00000288071.6
ENST00000393657.2
ENST00000355992.3
ENST00000567706.1
DDX19B
RP11-529K1.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
Uncharacterized protein
chr1_-_226496898 0.30 ENST00000481685.1
LIN9
lin-9 homolog (C. elegans)
chr14_+_96722539 0.30 ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr5_+_134303591 0.30 ENST00000282611.6
CATSPER3
cation channel, sperm associated 3
chr16_-_70323422 0.30 ENST00000261772.8
AARS
alanyl-tRNA synthetase
chr19_+_1450112 0.29 ENST00000590469.1
ENST00000233607.2
ENST00000238483.4
ENST00000590877.1
APC2
adenomatosis polyposis coli 2
chr14_-_23284675 0.29 ENST00000555959.1
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr5_-_43557791 0.29 ENST00000338972.4
ENST00000511321.1
ENST00000515338.1
PAIP1
poly(A) binding protein interacting protein 1
chr3_+_62304648 0.28 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
C3orf14
chromosome 3 open reading frame 14
chr8_+_42396936 0.28 ENST00000416469.2
SMIM19
small integral membrane protein 19
chr2_+_46769798 0.28 ENST00000238738.4
RHOQ
ras homolog family member Q
chr9_-_88356733 0.27 ENST00000376083.3
AGTPBP1
ATP/GTP binding protein 1
chr12_+_48592134 0.27 ENST00000595310.1
DKFZP779L1853
DKFZP779L1853
chr20_-_56285595 0.26 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr12_+_93963590 0.26 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr2_+_65663812 0.26 ENST00000606978.1
ENST00000377977.3
ENST00000536804.1
AC074391.1
AC074391.1
chr12_-_120966943 0.26 ENST00000552443.1
ENST00000547736.1
ENST00000445328.2
ENST00000547943.1
ENST00000288532.6
COQ5
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
chr17_+_70036164 0.25 ENST00000602013.1
AC007461.1
Uncharacterized protein
chr22_+_48972118 0.25 ENST00000358295.5
FAM19A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
chr14_+_32476072 0.24 ENST00000556949.1
RP11-187E13.2
Uncharacterized protein
chr19_+_33865218 0.24 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr13_-_28545276 0.21 ENST00000381020.7
CDX2
caudal type homeobox 2
chr3_-_58200398 0.21 ENST00000318316.3
ENST00000460422.1
ENST00000483681.1
DNASE1L3
deoxyribonuclease I-like 3
chr3_+_158787041 0.21 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr5_-_140013224 0.21 ENST00000498971.2
CD14
CD14 molecule
chr4_+_157997273 0.21 ENST00000541722.1
ENST00000512619.1
GLRB
glycine receptor, beta
chr3_+_186330712 0.20 ENST00000411641.2
ENST00000273784.5
AHSG
alpha-2-HS-glycoprotein
chr14_+_75894714 0.20 ENST00000559060.1
JDP2
Jun dimerization protein 2
chr16_-_54962625 0.19 ENST00000559432.1
CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr19_-_46389359 0.19 ENST00000302165.3
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr7_+_23146271 0.19 ENST00000545771.1
KLHL7
kelch-like family member 7
chr15_+_81293254 0.19 ENST00000267984.2
MESDC1
mesoderm development candidate 1
chr4_+_96012614 0.19 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr4_+_48807155 0.19 ENST00000504654.1
OCIAD1
OCIA domain containing 1
chr3_+_62304712 0.19 ENST00000494481.1
C3orf14
chromosome 3 open reading frame 14
chr14_+_65453432 0.19 ENST00000246166.2
FNTB
farnesyltransferase, CAAX box, beta
chr1_-_114429997 0.19 ENST00000471267.1
ENST00000393320.3
BCL2L15
BCL2-like 15
chr3_+_148447887 0.19 ENST00000475347.1
ENST00000474935.1
ENST00000461609.1
AGTR1
angiotensin II receptor, type 1
chr7_-_37026108 0.18 ENST00000396045.3
ELMO1
engulfment and cell motility 1
chr1_-_114430169 0.18 ENST00000393316.3
BCL2L15
BCL2-like 15
chr2_+_102608306 0.18 ENST00000332549.3
IL1R2
interleukin 1 receptor, type II
chr17_-_41322332 0.18 ENST00000590740.1
RP11-242D8.1
RP11-242D8.1
chr17_+_76037081 0.18 ENST00000588549.1
TNRC6C
trinucleotide repeat containing 6C
chr12_-_122884553 0.17 ENST00000535290.1
CLIP1
CAP-GLY domain containing linker protein 1
chr16_+_70680439 0.17 ENST00000288098.2
IL34
interleukin 34
chr9_-_128246769 0.17 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr14_+_75894391 0.17 ENST00000419727.2
JDP2
Jun dimerization protein 2
chr9_+_110045537 0.17 ENST00000358015.3
RAD23B
RAD23 homolog B (S. cerevisiae)
chr5_-_54830871 0.17 ENST00000307259.8
PPAP2A
phosphatidic acid phosphatase type 2A
chr7_-_45026200 0.17 ENST00000577700.1
ENST00000580458.1
ENST00000579383.1
ENST00000584686.1
ENST00000585030.1
ENST00000582727.1
SNHG15
small nucleolar RNA host gene 15 (non-protein coding)
chr19_-_41945804 0.16 ENST00000221943.9
ENST00000597457.1
ENST00000589970.1
ENST00000595425.1
ENST00000438807.3
ENST00000589102.1
ENST00000592922.2
ATP5SL
ATP5S-like
chr19_+_52076425 0.16 ENST00000436511.2
ZNF175
zinc finger protein 175
chr10_-_82049424 0.16 ENST00000372213.3
MAT1A
methionine adenosyltransferase I, alpha
chr14_+_60716159 0.16 ENST00000325658.3
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr7_+_20686946 0.16 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr2_+_103378472 0.15 ENST00000412401.2
TMEM182
transmembrane protein 182
chr4_+_41937131 0.15 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chr1_+_229440129 0.14 ENST00000366688.3
SPHAR
S-phase response (cyclin related)
chr17_-_61850894 0.14 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chr1_+_65730385 0.14 ENST00000263441.7
ENST00000395325.3
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr4_+_139694701 0.14 ENST00000502606.1
RP11-98O2.1
RP11-98O2.1
chr2_-_99279928 0.13 ENST00000414521.2
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr5_+_12574944 0.13 ENST00000505877.1
ENST00000513051.1
ENST00000505196.1
CT49
cancer/testis antigen 49 (non-protein coding)
chr3_+_157154578 0.13 ENST00000295927.3
PTX3
pentraxin 3, long
chr18_+_77160282 0.13 ENST00000318065.5
ENST00000545796.1
ENST00000592223.1
ENST00000329101.4
ENST00000586434.1
NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr14_-_22005343 0.13 ENST00000327430.3
SALL2
spalt-like transcription factor 2
chr3_+_188817891 0.13 ENST00000412373.1
TPRG1
tumor protein p63 regulated 1
chr19_-_1155118 0.13 ENST00000590998.1
SBNO2
strawberry notch homolog 2 (Drosophila)
chr7_-_45026159 0.13 ENST00000584327.1
ENST00000438705.3
SNHG15
small nucleolar RNA host gene 15 (non-protein coding)
chr7_+_135347215 0.13 ENST00000507606.1
C7orf73
chromosome 7 open reading frame 73
chr12_-_53074182 0.12 ENST00000252244.3
KRT1
keratin 1
chr21_+_35107346 0.12 ENST00000456489.1
ITSN1
intersectin 1 (SH3 domain protein)
chr21_+_35736302 0.12 ENST00000290310.3
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr19_+_50922187 0.12 ENST00000595883.1
ENST00000597855.1
ENST00000596074.1
ENST00000439922.2
ENST00000594685.1
ENST00000270632.7
SPIB
Spi-B transcription factor (Spi-1/PU.1 related)
chr10_-_65028817 0.11 ENST00000542921.1
JMJD1C
jumonji domain containing 1C
chr9_+_27524283 0.11 ENST00000276943.2
IFNK
interferon, kappa
chr3_+_88188254 0.11 ENST00000309495.5
ZNF654
zinc finger protein 654
chr10_-_65028938 0.11 ENST00000402544.1
JMJD1C
jumonji domain containing 1C
chr12_-_12714006 0.10 ENST00000541207.1
DUSP16
dual specificity phosphatase 16
chr5_+_95998070 0.10 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
CAST
calpastatin
chr9_+_101705893 0.10 ENST00000375001.3
COL15A1
collagen, type XV, alpha 1
chr3_-_190580404 0.10 ENST00000442080.1
GMNC
geminin coiled-coil domain containing
chr9_+_136399929 0.10 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chr10_+_94050913 0.10 ENST00000358935.2
MARCH5
membrane-associated ring finger (C3HC4) 5
chr11_-_105948129 0.10 ENST00000526793.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr14_+_60715928 0.09 ENST00000395076.4
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr11_+_62495997 0.09 ENST00000316461.4
TTC9C
tetratricopeptide repeat domain 9C
chr6_-_46459099 0.08 ENST00000371374.1
RCAN2
regulator of calcineurin 2
chr7_-_45026419 0.08 ENST00000578968.1
ENST00000580528.1
SNHG15
small nucleolar RNA host gene 15 (non-protein coding)
chr5_-_140013241 0.08 ENST00000519715.1
CD14
CD14 molecule
chr11_-_105948040 0.07 ENST00000534815.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr12_+_57623477 0.07 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr14_-_72458326 0.07 ENST00000542853.1
AC005477.1
AC005477.1
chr4_+_96012585 0.07 ENST00000502683.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr1_+_75594119 0.07 ENST00000294638.5
LHX8
LIM homeobox 8
chr6_-_116447283 0.07 ENST00000452729.1
ENST00000243222.4
COL10A1
collagen, type X, alpha 1
chr6_-_86353510 0.07 ENST00000444272.1
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr4_-_96470350 0.07 ENST00000504962.1
ENST00000453304.1
ENST00000506749.1
UNC5C
unc-5 homolog C (C. elegans)
chr7_-_73153178 0.07 ENST00000437775.2
ENST00000222800.3
ABHD11
abhydrolase domain containing 11
chr6_+_97010424 0.06 ENST00000541107.1
ENST00000450218.1
ENST00000326771.2
FHL5
four and a half LIM domains 5
chr12_+_57624085 0.06 ENST00000553474.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr7_-_141401951 0.06 ENST00000536163.1
KIAA1147
KIAA1147
chr12_-_12714025 0.06 ENST00000539940.1
DUSP16
dual specificity phosphatase 16
chr16_+_3508096 0.06 ENST00000577013.1
ENST00000570819.1
NAA60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
chr12_-_75603643 0.06 ENST00000549446.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr13_-_29292956 0.06 ENST00000266943.6
SLC46A3
solute carrier family 46, member 3
chr17_+_61851157 0.05 ENST00000578681.1
ENST00000583590.1
DDX42
DEAD (Asp-Glu-Ala-Asp) box helicase 42
chr17_-_34524157 0.05 ENST00000378354.4
ENST00000394484.1
CCL3L3
chemokine (C-C motif) ligand 3-like 3
chr21_+_19617140 0.05 ENST00000299295.2
ENST00000338326.3
CHODL
chondrolectin
chr15_+_58430368 0.05 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr15_+_58430567 0.05 ENST00000536493.1
AQP9
aquaporin 9
chr13_+_28813645 0.05 ENST00000282391.5
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr6_+_72926145 0.05 ENST00000425662.2
ENST00000453976.2
RIMS1
regulating synaptic membrane exocytosis 1
chr12_-_88423164 0.05 ENST00000298699.2
ENST00000550553.1
C12orf50
chromosome 12 open reading frame 50
chr5_+_95997769 0.05 ENST00000338252.3
ENST00000508830.1
CAST
calpastatin
chr6_-_74231303 0.05 ENST00000309268.6
EEF1A1
eukaryotic translation elongation factor 1 alpha 1
chr8_+_110656344 0.05 ENST00000499579.1
RP11-422N16.3
Uncharacterized protein

Network of associatons between targets according to the STRING database.

First level regulatory network of HLF_TEF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 14.1 GO:1902998 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.3 1.3 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.3 2.6 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.2 0.7 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.1 0.4 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 1.8 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.1 1.8 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.6 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.1 0.8 GO:0071727 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.1 1.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.7 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.3 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.7 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.1 0.9 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 0.7 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.3 GO:0002384 hepatic immune response(GO:0002384)
0.1 1.6 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.4 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 0.4 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.2 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.8 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 0.9 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.2 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.4 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.2 GO:0045209 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.2 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0 0.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 4.1 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.1 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.0 0.3 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 0.2 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.2 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.7 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0 0.9 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.1 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979) regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.0 0.1 GO:0001878 response to yeast(GO:0001878) negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.0 0.3 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.4 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.1 GO:0070884 calcineurin-NFAT signaling cascade(GO:0033173) regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.5 GO:0044070 regulation of anion transport(GO:0044070)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 0.4 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.0 0.3 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 1.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.7 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.0 0.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.2 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.2 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 14.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 0.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.7 GO:0070695 FHF complex(GO:0070695)
0.1 0.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.2 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.1 0.6 GO:0005827 polar microtubule(GO:0005827)
0.1 1.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.0 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 2.5 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0071942 XPC complex(GO:0071942)
0.0 0.3 GO:0036128 CatSper complex(GO:0036128)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 3.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.5 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.3 GO:0016342 catenin complex(GO:0016342)
0.0 0.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.4 14.1 GO:0051787 misfolded protein binding(GO:0051787)
0.3 1.3 GO:0016880 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.2 0.7 GO:0008478 pyridoxal kinase activity(GO:0008478)
0.2 0.8 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.2 1.6 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 0.6 GO:0031208 POZ domain binding(GO:0031208)
0.1 2.6 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.3 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.1 1.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.1 0.8 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.1 0.3 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.2 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 0.3 GO:0032427 GBD domain binding(GO:0032427)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.4 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.2 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.9 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 1.1 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.3 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.1 GO:0005275 amine transmembrane transporter activity(GO:0005275)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.5 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.7 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.0 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.3 GO:0008494 translation activator activity(GO:0008494)
0.0 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.5 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 1.8 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849) virion binding(GO:0046790)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.0 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 9.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 3.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.1 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 1.8 PID AURORA B PATHWAY Aurora B signaling
0.0 0.3 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 13.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.9 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 3.1 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.8 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.9 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.2 REACTOME KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.4 REACTOME PI3K EVENTS IN ERBB4 SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.0 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation