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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for HMGA1
Z-value: 1.38
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Transcription factors associated with HMGA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMGA1 | hg19_v2_chr6_+_34204642_34204664 | 0.16 | 5.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_225811747 Show fit | 7.22 |
ENST00000409592.3
|
dedicator of cytokinesis 10 |
|
| chr12_+_20963632 Show fit | 6.11 |
ENST00000540853.1
ENST00000261196.2 |
solute carrier organic anion transporter family, member 1B3 |
|
| chr7_-_35013217 Show fit | 4.91 |
ENST00000446375.1
|
dpy-19-like 1 (C. elegans) |
|
| chr12_+_20963647 Show fit | 4.70 |
ENST00000381545.3
|
solute carrier organic anion transporter family, member 1B3 |
|
| chr5_+_92919043 Show fit | 4.13 |
ENST00000327111.3
|
nuclear receptor subfamily 2, group F, member 1 |
|
| chr2_-_228244013 Show fit | 3.95 |
ENST00000304568.3
|
transmembrane 4 L six family member 20 |
|
| chr4_+_88896819 Show fit | 3.73 |
ENST00000237623.7
ENST00000395080.3 ENST00000508233.1 ENST00000360804.4 |
secreted phosphoprotein 1 |
|
| chr4_+_41540160 Show fit | 3.45 |
ENST00000503057.1
ENST00000511496.1 |
LIM and calponin homology domains 1 |
|
| chrX_-_20236970 Show fit | 3.24 |
ENST00000379548.4
|
ribosomal protein S6 kinase, 90kDa, polypeptide 3 |
|
| chr12_+_41136144 Show fit | 3.12 |
ENST00000548005.1
ENST00000552248.1 |
contactin 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMGA1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.7 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.4 | 7.2 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.4 | 4.9 | GO:0018406 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.1 | 4.5 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.1 | 4.4 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 0.9 | 3.7 | GO:2000863 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 0.2 | 3.4 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.0 | 3.3 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.3 | 3.1 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.2 | 3.1 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.4 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 6.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 4.7 | GO:0000145 | exocyst(GO:0000145) |
| 0.3 | 4.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.3 | 4.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 3.4 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 3.3 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 3.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 2.7 | GO:0030496 | midbody(GO:0030496) |
| 0.1 | 2.6 | GO:0043194 | axon initial segment(GO:0043194) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.2 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.2 | 5.9 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 4.5 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.4 | 4.1 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.0 | 3.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 3.2 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 3.0 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.0 | 2.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 2.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 2.6 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 6.7 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 5.6 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 5.0 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 4.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 3.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 2.6 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 2.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 11.9 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 11.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 5.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 5.0 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 4.6 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 4.3 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 3.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 3.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 3.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 3.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |